Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 22
Filtrar
1.
Eur Neurol ; 85(2): 132-135, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34510038

RESUMO

Monoclonal antibodies targeting the calcitonin gene-related peptide have been introduced into the therapeutic arsenal of migraine prophylaxis. Clinical trials report similar efficacy between them, and there is no evidence of switching to another one after failure. We aim to describe our experience in switching from erenumab to galcanezumab after therapeutic failure. We retrospectively reviewed 30 migraine patients who received monoclonal antibodies, with 15 of them switched after failure to achieve reduction in migraine days per month ≥30%. A ≥30% reduction in migraine days per month compared to baseline was observed in 8/15 (4/15 ≥ 50%) patients after switch. Some nonresponsive patients may benefit from switching between monoclonal antibodies with different therapeutic targets.


Assuntos
Anticorpos Monoclonais , Transtornos de Enxaqueca , Anticorpos Monoclonais/uso terapêutico , Peptídeo Relacionado com Gene de Calcitonina/uso terapêutico , Humanos , Transtornos de Enxaqueca/tratamento farmacológico , Estudos Retrospectivos , Espanha , Resultado do Tratamento
2.
PLoS One ; 16(8): e0255818, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34370768

RESUMO

Debates on early metallurgy in Western Europe have frequently focused on the social value of copper (between utilitarian and symbolic) and its purported role in the emergence and consolidation of hierarchies. Recent research shows that generalisations are increasingly untenable and highlights the need for comparative regional studies. Given its location in an intermediate area, the early metallurgy of Northeast Iberia provides an interesting case in point to explore the interaction between the well-characterised traditions of southern Iberia and southern France during the 3rd and 2nd millennia BCE. Here the analytical study of seven Bell Beaker (decorated and undecorated) vessels reused as crucibles at Bauma del Serrrat del Pont (Tortellà, Girona) are presented. We employed pXRF, metallography, SEM-EDS and lead isotope analyses. The results show evidence for copper smelting employing a remarkable variety of ore sources, including Solana del Bepo, Turquesa and Les Ferreres mines, and an extra unknown area. The smelting vessels were manufactured using the same clay, which contained both mineral and organic inclusions. Our results are discussed with reference to all the evidence available for metals and metallurgy in the Northeast, and more broadly in comparison to southern Iberia and southern France, with special emphasis on issues of production organisation and social complexity. Taken together, our results support the notion that copper metallurgy played a predominantly utilitarian role in Bell Beaker societies and highlight idiosyncratic aspects of the metallurgical trajectory in the Northeast. Differences between territories challenge unilinear explanations of technological and social development after the introduction of metallurgy. Separate trajectories can only be explained in relation to area-specific socio-cultural and environmental factors.


Assuntos
Cobre , Metalurgia , Metais , Mineração
3.
Med. paliat ; 27(4): 310-318, oct.-dic. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-202712

RESUMO

INTRODUCCIÓN: Existe un número creciente de pacientes paliativos que prefieren fallecer en casa con apoyo sanitario. Además, los servicios de salud disponen de diversos recursos asistenciales para dar respuesta a las necesidades de salud que presenta esta población. OBJETIVO: Conocer los recursos asistenciales empleados por personas susceptibles de cuidados paliativos (CP) previos a su fallecimiento, tanto de atención primaria (AP) como de urgencias, así como su relación con el seguimiento por la unidad de CP. MATERIAL Y MÉTODOS: Se realizó un estudio observacional retrospectivo sobre la población fallecida durante el año 2015 en el domicilio de Málaga capital, que pertenece a la zona básica de salud de Málaga (Distrito Sanitario Málaga-Guadalhorce). Se recogieron datos sobre las asistencias realizadas durante los seis meses previos al fallecimiento. Las variables principales fueron: visitas por unidad de CP, consultas y visitas de profesionales de AP, visitas de urgencias y emergencias extrahospitalarias, admisiones en urgencias hospitalarias, patologías susceptibles de CP, edad y sexo del paciente. El análisis de datos fue descriptivo con resúmenes numéricos y tablas de frecuencia, e inferencial mediante test de Chi Cuadrado y U de Mann-Whitney. RESULTADOS: Novecientas cincuenta personas fallecieron en su domicilio, de las cuales 417 (43,89 %) fueron incluidas en el estudio por haber sido identificadas como susceptibles de CP siendo 212 atendidas exclusivamente por AP y 205 por AP, así como por unidades de CP. La mediana de tiempo de seguimiento por la unidad de CP fue de 47 días. Algunos datos relevantes a destacar en la media de asistencias que reciben estos pacientes son: llamadas telefónicas por la unidad de CP (6,83), visitas por la unidad de CP (4,71), visitas por Enfermera de familia (4,26), consultas al MdF (3,32), equipo médico del Servicio de Urgencias de Atención Primaria (2,08), hospitalizaciones (1,46), entre otros. En general, en aquellos pacientes seguidos por la unidad de CP hay un aumento del 21,6 % en consultas y visitas por profesionales de AP (agregados), y un aumento del 31,4 % en visitas por las unidades móviles de urgencias (agregadas). Desglosando por tipo de recurso, destaca el aumento en el número de visitas a domicilio de enfermeras de AP y urgencias domiciliarias. CONCLUSIONES: Las personas susceptibles de CP hacen uso frecuente de AP para su asistencia sanitaria, complementándose con los servicios de urgencias a domicilio y admisiones a hospital. En los pacientes con mayor complejidad, que son derivados para el seguimiento por unidades de CP, se constata un incremento de asistencias por profesionales de AP y por los servicios de urgencias, especialmente de sus enfermeras


INTRODUCTION: There is an increasing number of palliative care patients who prefer to die at home with healthcare support. Also, health services offer a great number of care resources to attend to the healthcare needs of this population. OBJECTIVE: To explore the care resources used by patients susceptible to palliative care (PC) before dying, both from primary and emergency care services, as well as their relation to follow-up by PC units. MATERIAL AND METHODS: A retrospective observational study was carried out in a population deceased at home in Málaga city during 2015, adscribed to the Primary Health Care area of Málaga (Málaga-Guadalhorce Health Care District). Data were collected during the last 6 months before death. The most important variables were: visits by the PC unit, consultations and visits by primary care professionals, prehospital emergencies, admissions to the hospital's emergency department, pathologies susceptible to PC, patient age and sex. The data analysis was descriptive with numerical summaries and frequency tables, and inferential using the Chi-squared test and Mann-Whitney U-test. RESULTS: A total of 950 people died at home, of which 417 (43.89 %) were included because of having been susceptible to palliative care. Of these, 212 were attended to exclusively by Primary Care and 205 by both Primary Care and PC units. The median time of follow-up by a PC unit was 47 days. The mean number of visits received by these patients include: 6.83 telephone calls from the PC unit; 4.71 visits by PC unit staff; 4.26 visits by a family nurse; 3.32 visits by the family physician; 2.08 by the primary care emergency service medical team; and 1.46 hospitalizations, among others. Generally, patients followed by a PC unit had a 21.6 % increase in consultations and visits by primary care professionals (aggregated) and a 31.4 % increase in visits by mobile emergency care services (aggregated). This growth is particularly remarkable for primary care and home emergency nurses. CONCLUSIONS: People susceptible to palliative care frequently use Primary Care for their health care, complementing it with home emergency services and hospital admissions. Patients with added complexity referred to PC units are associated with an increased assistance rate by primary care professionals and emergency services, especially nurses


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Serviços Hospitalares de Assistência Domiciliar/economia , Assistência Domiciliar/economia , Cuidados Paliativos na Terminalidade da Vida/economia , Estudos Retrospectivos , Atenção Primária à Saúde/economia , Custos de Cuidados de Saúde/estatística & dados numéricos , Preferência do Paciente/estatística & dados numéricos , Atenção Primária à Saúde/estatística & dados numéricos
4.
PLoS One ; 15(6): e0234627, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32530960

RESUMO

Cuscuta (dodders) is a group of parasitic plants with tremendous economic and ecological significance. Their seeds are often described as "simple" or "unspecialized" because they do not exhibit any classical dispersal syndrome traits. Previous studies of seed morphology and/or anatomy were conducted on relatively few species. We expanded research to 101 species; reconstructed ancestral character states; investigated correlations among seed characters and explored allometric relationships with breeding systems, the size of geographical distribution of species in North America, as well as the survival of seedlings. Seed morphological and anatomical characters permit the separation of subgenera, but not of sections. Identification of Cuscuta species using seed characteristics is difficult but not impossible if their geographical origin is known. Seeds of subg. Monogynella species, exhibit the likely ancestral epidermis type consisting of elongated and interlocked cells, which are morphologically invariant, uninfluenced by dryness/wetness. Subgenera Cuscuta, Pachystigma and Grammica have evolved a seed epidermis with isodiametric cells that can alternate their morphology between two states: pitted when seeds are dry, and papillose after seed imbibition. A seed coat with double palisade architecture throughout the entire seed has also apparently evolved in subgenera Cuscuta, Pachystigma and Grammica, but several species in two clades of the latter subgenus reverted to a single palisade layer outside the hilum area. The same latter species also evolved a peculiar, globose embryo, likely having a storage role, in contrast to the ancestral filiform and coiled embryo present throughout the remainder of the genus. Autogamous species had on average the highest number of seeds per capsule, whereas fully xenogamous taxa had the lowest. No correlation was revealed between the size of the seeds and the size of their geographical distribution in North America, but seedlings of species with larger seeds survived significantly longer than seedlings resulted from smaller seeds. Diversity and evolution of seed traits was discussed in relationship with their putative roles in dormancy, germination and dispersal.


Assuntos
Biodiversidade , Evolução Biológica , Classificação , Cuscuta/anatomia & histologia , Cuscuta/classificação , Sementes/anatomia & histologia , Análise de Variância , Estimativa de Kaplan-Meier , Tamanho do Órgão , Filogenia , Melhoramento Vegetal , Análise de Regressão , Plântula/anatomia & histologia , Sementes/ultraestrutura
5.
PLoS One ; 14(4): e0214218, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30969974

RESUMO

Eleven biconical vessels from the Copper Age sites Pietrele and Blejesti (Romania) have been investigated using p-XRF. In most cases, traces of lead could be measured on their surfaces. Samples of slag-like material from two vessels and the clay of one vessel were investigated using laboratory methods, namely SEM, XRD, LIA and optical microscopy. The vessels were obviously used as a kind of crucible in which slag-like remains and galena ore were detected. It still remains unclear as to what final product was gained by smelting galena in this way. The amount of these such vessels in the Pietrele settlement, their appearance as grave goods in Pietrele and Varaști (Romania), and their supposed occurrence in a number of other Copper Age settlements in Romania and Bulgaria show the significance of this phenomenon. It must have been a widespread and more or less well known practice, an important part of cultural habit during a particular period in the Lower Danube region and likely even farther afield. For the first time, extensive experimentation with lead ore can be shown in a clear chronological horizon, ca. 4400-4300 BCE in southeastern Europe.


Assuntos
Arqueologia , Chumbo/história , Bulgária , Emigração e Imigração/história , Europa (Continente) , História Antiga , Humanos
6.
Appl Spectrosc ; 72(1): 17-27, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28675306

RESUMO

This work is part of a broader research line that aims to develop and implement a nondestructive methodology for the chemical characterization of archaeological metals based on a protocol that combines energy dispersive X-ray fluorescence spectrometry (ED-XRF) with a Monte Carlo (MC) simulation algorithm. In this paper, the ED-XRF-MC protocol has been applied to estimate the chemical composition of a selected group of 26 copper-based artifacts and fragments recovered at Perdigões, one of the larger Chalcolithic sites of southwest Iberia. All the analyzed artifacts have a multilayered structure composed of the alloy substrate and of a superficial layer common in each metal buried for hundreds of years and consisting of the patina mixed with soil. Due to the difficulty in determining the quantitative composition of these alloys in the presence of this complex patina/encrustation layer, the spectrometric protocol applied in this paper allows to simulate and to determine the composition of the bulk alloy without any prior removal of the overlying corrosion patina layer and soil-derived crust, even in the presence of rough and irregular surfaces, thus preserving the physical integrity of the artifacts. The overall results obtained with the ED-XRF-MC protocol indicates that the artifacts from Perdigões are almost pure coppers with a low amount of arsenic (<3.0 wt%) and reduced concentration of elements such as Pb, Bi, and Sb, in agreement with the third millennium metallurgy known in southwestern Iberia. Also based on previously theoretical-experimental studies, the data presented in this paper show how the applied analytical methodology can be a fast and completely nondestructive analytical tool reliable for routine and large-scale chemical analysis of archaeological metals, thus representing a major advance to be broadly applied within the field of cultural heritage studies.

7.
Hum Vaccin Immunother ; 12(1): 30-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26211489

RESUMO

The cost of HPV vaccines and the need for 3 doses remains a barrier for their inclusion in routine vaccination schedules for girls in low and middle income countries. In a non-inferiority study, we aimed to compare the immunogenicity of a standard 3 doses and a 2 doses schedule. We enrolled 450 participants in an open-label non-randomized clinical trial to evaluate the immunogenicity induced at different ages by the licensed HPV6/11/16/18 quadrivalent vaccine in a 2 doses schedule (0-6 months, n = 150 girls aged 9-10 y) and 3 doses schedule (0, 2, and 6 months; n = 150 girls aged 9-10 y and n=150 women aged 18 to 24 years). To assess the antibody response, blood samples were obtained at Month 7 and 21 after the first vaccination from participants in all study groups. cLIA testing was performed at Merck Research Laboratories. Antibody levels were expressed as milli-Merck units (mMU) per ml. Primary outcome was non-inferiority (95% CI, lower bound >0.5) of the geometric mean titers (GMT) ratios for HPV6, HPV11, HPV16 and HPV18 antibodies 7 and 21 months after the first dose among girls receiving 2 doses compared with young women and girls receiving 3 doses. All vaccinees were seropositive for both HPV16 and HPV18 antibodies at month 7. At month 21, 98.5 and 56.6% of women 18-24 y old were seropositive for HPV16 and 18, respectively. For girls in the three doses group, seropositivity rates were 99.3 and 86.3% for HPV16 and 18, respectively. For girls in the two doses group rates were 99.3 and 70.2% for HPV16 and 18, respectively. The two doses schedule was non-inferior compared to the 3 doses schedule in same-age girls and to the group of adult women after 21 months of the first vaccine dose. Our results are in agreement with similar trials evaluating the immune response of a 2 doses schedule of both HPV vaccines, supporting the recent WHO recommendation as well as the Mexican policy to incorporate the 2 doses schedule for girls aged 9-11 y.


Assuntos
Anticorpos Antivirais/sangue , Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18/administração & dosagem , Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18/imunologia , Esquemas de Imunização , Infecções por Papillomavirus/prevenção & controle , Adolescente , Criança , Monitoramento Epidemiológico , Feminino , Humanos , México , Resultado do Tratamento , Adulto Jovem
8.
PhytoKeys ; (75): 1-12, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28127240

RESUMO

A new species, Echeveria coruana, is described and illustrated from the malpaís near San Andrés Corú, Michoacan, Mexico. The species belongs to series Gibbiflorae and the new taxon was compared with Echeveria purhepecha and Echeveria patriotica, with whom it shares the closest morphological affinities. Additionally, Echeveria yalmanantlaensis an endangered species from Sierra of Manantlán Biosphere Reserve, State of Colima, was also discovered near San Andrés Corú and is reported for the first time from the State of Michoacan. The conservation status of both species was (re)evaluated according to the criteria of the International Union for Conservation of Nature.

9.
PLoS One ; 5(10): e13256, 2010 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-20949040

RESUMO

BACKGROUND: Influenza viruses pose a threat to human health because of their potential to cause global disease. Between mid March and mid April a pandemic influenza A virus emerged in Mexico. This report details 202 cases of infection of humans with the 2009 influenza A virus (H1N1)v which occurred in Mexico City as well as the spread of the virus throughout the entire country. METHODOLOGY AND FINDINGS: From May 1st to May 5th nasopharyngeal swabs, derived from 751 patients, were collected at 220 outpatient clinics and 28 hospitals distributed throughout Mexico City. Analysis of samples using real time RT-PCR revealed that 202 patients out of the 751 subjects (26.9%) were confirmed to be infected with the new virus. All confirmed cases of human infection with the strain influenza (H1N1)v suffered respiratory symptoms. The greatest number of confirmed cases during the outbreak of the 2009 influenza A (H1N1)v were seen in neighbourhoods on the northeast side of Mexico City including Iztapalapa, Gustavo A. Madero, Iztacalco, and Tlahuac which are the most populated areas in Mexico City. Using these data, together with data reported by the Mexican Secretariat of Health (MSH) to date, we plot the course of influenza (H1N1)v activity throughout Mexico. CONCLUSIONS: Our data, which is backed up by MSH data, show that the greatest numbers of the 2009 influenza A (H1N1) cases were seen in the most populated areas. We speculate on conditions in Mexico which may have sparked this flu pandemic, the first in 41 years. We accept the hypothesis that high population density and a mass gathering which took in Iztapalapa contributed to the rapid spread of the disease which developed in three peaks of activity throughout the Country.


Assuntos
Surtos de Doenças , Vírus da Influenza A Subtipo H1N1/isolamento & purificação , Influenza Humana/epidemiologia , Humanos , Vírus da Influenza A Subtipo H1N1/genética , Influenza Humana/virologia , México/epidemiologia , Reação em Cadeia da Polimerase Via Transcriptase Reversa
10.
Hum Psychopharmacol ; 25(6): 439-47, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20737517

RESUMO

OBJECTIVE: To explore the relative association of adverse events with health-related quality of life (HRQL) in patients (N = 16 091) with schizophrenia, treated with antipsychotic medication. METHODS: In this post hoc analysis of data from two 3-year observational studies, a mixed effects model with repeated measures was used to evaluate the association between HRQL (EuroQoL visual analogue scale (EQ-VAS)) and pre-specified covariates including: severity of illness, extrapyramidal symptoms, tardive dyskinesia, sexual dysfunction, and clinically significant weight gain (> 7% increase from baseline after > or = 3 months of treatment). RESULTS: Mean EQ-VAS increased from 47.8 +/- 21.7 at baseline to 72.4 +/- 18.4 after 36 months. The rank order of the negative association of adverse events with HRQL was: sexual dysfunction (effect estimate -4.04; 95% CI -4.30 to -3.79), extrapyramidal symptoms (effect estimate -2.09; 95% CI -2.43 to -1.75), and tardive dyskinesia (effect estimate -0.89; 95% CI -1.46 to -0.32). CONCLUSIONS: Differences were observed in the direction and magnitude of the association between each adverse event and HRQL. Recognition of the relative association of adverse events with HRQL may contribute to improved adherence of patients with schizophrenia to antipsychotic therapy.


Assuntos
Antipsicóticos/efeitos adversos , Indicadores Básicos de Saúde , Qualidade de Vida , Esquizofrenia/tratamento farmacológico , Índice de Gravidade de Doença , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Anos de Vida Ajustados por Qualidade de Vida , Psicologia do Esquizofrênico
11.
J Clin Virol ; 48(1): 36-9, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20226730

RESUMO

BACKGROUND: In March 2009, public health surveillance detected increased numbers of influenza-like illness presenting to hospitals in Mexico City. The aetiological agent was subsequently determined to be a novel influenza A (H1N1) triple reassortant, which has spread worldwide. As a consequence the World Health Organisation has declared the first Influenza pandemic of the 21st century. OBJECTIVES: To describe clinically and molecularly the first outbreak of influenza A pH1N1 (2009) during 1-5 May to establish a baseline of epidemiological data for pH1N1. Also, to monitor for the emergence of antiviral resistance, and mutations affecting virulence and transmissibility. STUDY DESIGN: Samples were collected from 751 patients with influenza-like symptoms throughout Mexico City and were tested for influenza A pH1N1 (2009) using real-time PCR. In the samples that were positive for influenza A pH1N1 (2009) fragments from the haemagglutinin (H1) and neuraminidase (N1) genes were sequenced. RESULTS: A total of 203/751 (27%) patients were positive for the pandemic H1N1 (2009) virus (53% male and 47% female). The 0-12-year-old group was the most affected 85/751 (42%). Sequence analysis showed five new variants of the pandemic H1N1 (2009) virus for NA: G249E (GQ292900), M269I (GQ292892), Y274H (GQ292913), T332A (GQ292933), N344K (GQ292882), and four variants for HA: N461K (GQ293006), K505R (GQ292989), I435V (GQ292995), I527N (GQ292997). CONCLUSIONS: We have provided a baseline of epidemiological data from the first outbreak of influenza A pH1N1 (2009) during 1-5 May in Mexico City. The sequencing of partial fragments of the HA and NA genes did not show the presence of previously described mutations affecting known sites of antiviral resistance in seasonal influenza A such as the H275Y (oseltamivir resistance), R293 or N295 etc.


Assuntos
Surtos de Doenças/estatística & dados numéricos , Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética , Vírus da Influenza A Subtipo H1N1/genética , Influenza Humana/virologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Variação Genética , Geografia , Humanos , Lactente , Vírus da Influenza A Subtipo H1N1/isolamento & purificação , Influenza Humana/epidemiologia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Dados de Sequência Molecular , Neuraminidase/genética , RNA Viral/análise
12.
Bioelectromagnetics ; 28(3): 224-30, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17080459

RESUMO

The increasing deployment of mobile communication base stations led to an increasing demand for epidemiological studies on possible health effects of radio frequency emissions. The methodological challenges of such studies have been critically evaluated by a panel of scientists in the fields of radiofrequency engineering/dosimetry and epidemiology. Strengths and weaknesses of previous studies have been identified. Dosimetric concepts and crucial aspects in exposure assessment were evaluated in terms of epidemiological studies on different types of outcomes. We conclude that in principle base station epidemiological studies are feasible. However, the exposure contributions from all relevant radio frequency sources have to be taken into account. The applied exposure assessment method should be piloted and validated. Short to medium term effects on physiology or health related quality of life are best investigated by cohort studies. For long term effects, groups with a potential for high exposure need to first be identified; for immediate effect, human laboratory studies are the preferred approach.


Assuntos
Telefone Celular , Exposição Ambiental , Projetos de Pesquisa Epidemiológica , Saúde Pública , Ondas de Rádio/efeitos adversos , Humanos , Micro-Ondas/efeitos adversos , Sensibilidade e Especificidade
13.
Artigo em Es | IBECS | ID: ibc-28867

RESUMO

El Torno de Pedal ha sido y en muchos lugares del mundo continúa siendo una herramienta básica para el desarrollo de la odontología. Se describen desde un punto de vista mecánico los elementos que generalmente constituyen un Torno de Pedal. Finalmente se describe su funcionamiento (AU)


The foot pedal dental engine was –and still is in a lot of places around the wold– a basic tool for the development of dentistry. The parts that generally make up a foot pedal dental engina are described from a mechanical point of view, as well as its performance (AU)


Assuntos
História do Século XX , Equipamentos Odontológicos , Odontologia/métodos , Equipamentos Odontológicos/história
14.
Pediatr Nephrol ; 17(9): 718-23, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12215824

RESUMO

Many studies have demonstrated a strong association between elevated plasma total homocysteine (tHcys) levels and vascular disease. The aim of the present study was to determine the plasma levels of tHcys in pediatric recipients of renal transplants, to establish possible correlations with renal function, lipid profile, and folate and vitamin B12 status, and to assess whether the C677T and A1298C polymorphisms in the 5, l0-methylenetetrahydrofolate reductase (MTHFR) gene were associated with a particular risk. A total of 26 transplanted children and adolescents were investigated. tHcys levels were elevated in transplanted patients (12.9+/-4.8 micro mol/l) and 73% of these displayed values above the 97th percentile of healthy children. Plasma tHcys correlated negatively with creatinine clearance ( r=-0.58, P<0.001) and plasma vitamin B(12) ( r=-0.40, P<0.05) and positively with plasma triglycerides ( r=0.53, P<0.005). No significant correlations were found between plasma tHcys level and age, gender, time elapsed after transplantation and plasma values of glucose, insulin, folic acid, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, apolipoprotein B, and apolipoprotein A-1. Plasma tHcys level was clearly increased in 3 patients with a MTHFR 677TT/1298AA genotype. In a multiple stepwise regression model plasma creatinine and triglyceride levels and MTHFR 677TT/1298 AA genotype accounted for 60% of the observed plasma tHcys variability. The MTHFR 677CT/1298 AC genotype was not a significant predictor of tHcys plasma levels. We conclude that a moderate degree of hyperhomocysteinemia is often present in renal transplant children and that folate supplementation must be considered in this population.


Assuntos
Hiper-Homocisteinemia/complicações , Transplante de Rim , Adolescente , Glicemia/análise , Criança , Feminino , Ácido Fólico/administração & dosagem , Ácido Fólico/sangue , Genótipo , Homocisteína/sangue , Humanos , Lipídeos/sangue , Masculino , Metilenotetra-Hidrofolato Redutase (NADPH2) , Oxirredutases atuantes sobre Doadores de Grupo CH-NH/genética , Análise de Regressão , Vitamina B 12/sangue
16.
Arch. neurociencias ; 2(4): 269-73, oct.-dic. 1997.
Artigo em Espanhol | LILACS | ID: lil-227207

RESUMO

Dentro de las enfermedades neurológicas crónico-degenerativas en las que se han reportado problemas sexuales está la enfermedad de Parkinson (EP). Diversos autores concuerdan en que las alteraciones sexuales se observan con una frecuencia aproximada de 60 por ciento en este tipo de pacientes. Debido a que los sistemas dopaminérgicos están involucrados tanto en la EP como en la libido, se puede pensar que existen un gran número de estudios acerca del aspecto sexual en los pacientes parkinsónicos; sin embargo no es así. En el presente artículo se hace una revisión de diferentes trabajos que han tratado de buscar factores asociados a la presencia de alteraciones sexuales en pacientes con EP; así como el papel que juega la incapacidad motora, la edad el hecho de tener una enfermedad crónica, la presencia de alteraciones del sistema autónomo, y el tratamiento farmacológico en la disfunción sexual de los pacientes con EP


Assuntos
Orgasmo , Doença de Parkinson/complicações , Doença de Parkinson/fisiopatologia , Doença de Parkinson/terapia , Disfunções Sexuais Fisiológicas/fisiopatologia , Disfunções Sexuais Fisiológicas/terapia , Sistema Nervoso Autônomo/anormalidades , Sistema Nervoso Autônomo/fisiopatologia , Disfunção Erétil/etiologia
20.
Rev. colomb. anestesiol ; 23(1): 73-4, ene.-mar. 1995.
Artigo em Espanhol | LILACS | ID: lil-218173

Assuntos
Humanos , Saúde
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...