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J Res Med Sci ; 24: 48, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31160915


Background: Deep venous thrombosis (DVT) is associated with significant morbidity and mortality. Thus, there is a great need to demonstrate a more efficient biomarker that would confirm the diagnosis of DVT. Our work aimed to evaluate the role of platelet-derived growth factor-beta (PDGF-B) as a new marker of DVT and its correlation with other radiological and laboratory tools used for the diagnosis. Materials and Methods: A case-control study enrolled forty patients selected from our university hospital between April 2018 and August 2018, who divided into two groups: Group I (n = 20) consisted of patients diagnosed with acute venous thrombosis and Group II (n = 20) consisted of patients diagnosed with chronic venous thrombosis. Twenty samples were collected from age- and gender-matched apparently healthy controls to be used as a control. Venous duplex ultrasonography, routine laboratory investigations, D-dimer (DD), and protein expression of PDGF-B were performed on all patients. Results: There was a highly significant increase in a protein expression of PDFG-B in all cases of acute and chronic venous thrombosis compared to the control group with P < 0.001; furthermore, it was more specific than DD for the detection of DVT (specificity 95% and 90%, respectively). Conclusion: Our study submits a novel association of PDGF-B plasma levels with DVT, and PDGF-B is considered to be a more specific indicator for DVT than is DD.

Ann Vasc Surg ; 54: 146-151, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30092419


BACKGROUND: The goals of surgical treatment of traumatic femoral artery aneurysm (FAA) are to isolate and excise the aneurysm, prevent distal embolization, and allow effective revascularization. During recent years, endovascular surgery has become a valid alternative to open repair. We aimed to compare early outcomes of the stent graft in the treatment of traumatic FAA and open surgical procedures. METHODS: This was a prospective study on 20 patients admitted to our hospital during the period from April 2016 to September 2017 with specific criteria of traumatic FAA. The patients were randomly divided into 2 groups with a one to one ratio between open repair (group I) and endovascular therapy (group II). We used the duplex scan in early follow-up 1 week and 1 month and 3 months postoperatively. RESULTS: Twenty FAAs were treated as follows: Excision of the aneurysm in patients of group I and repair by primary sutures or bypass with no graft failure occurred intraoperatively. Ten stents were placed in ten FAAs in group II. An early patency rate of 100% in 1 week was found in both groups, and thrombosis in 1 stent graft occurred after 1 month and 3 months (95%). The mean time of surgical operations was 107.5 min, and the mean time of endovascular procedures was 85 min. The group I had a significantly longer mean hospital stay time (8 days) than group II (4.25 days); P value < 0.05. CONCLUSIONS: FAA treatment can be performed easily and safely by surgery or endovascular procedures. Although the endovascular approach has several advantages, the incidence of thrombosis and high cost of stent grafts should be considered.

Falso Aneurisma/cirurgia , Implante de Prótese Vascular , Procedimentos Endovasculares , Artéria Femoral/cirurgia , Lesões do Sistema Vascular/cirurgia , Adulto , Falso Aneurisma/diagnóstico por imagem , Falso Aneurisma/etiologia , Prótese Vascular , Implante de Prótese Vascular/efeitos adversos , Implante de Prótese Vascular/instrumentação , Procedimentos Endovasculares/efeitos adversos , Procedimentos Endovasculares/instrumentação , Feminino , Artéria Femoral/diagnóstico por imagem , Artéria Femoral/lesões , Humanos , Tempo de Internação , Masculino , Duração da Cirurgia , Complicações Pós-Operatórias/etiologia , Estudos Prospectivos , Fatores de Risco , Stents , Fatores de Tempo , Resultado do Tratamento , Ultrassonografia Doppler Dupla , Grau de Desobstrução Vascular , Lesões do Sistema Vascular/diagnóstico por imagem , Lesões do Sistema Vascular/etiologia , Adulto Jovem