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Water Res ; 197: 117007, 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33813169


The article presented by Wang et al. (2020) intends to elucidate the possible ecological effects of low (0.05-25 µg L-1) and higher (100 µg L-1) concentrations of methamphetamine on adult Oryzias latipes through a battery of assays, including histopathology. However, we found several mistakes and inaccuracies in the findings by means of this method. Given the increasing research effort in the field, the authors' paper may become highly influential in future toxicological research. Despite the authors' undoubted effort invested in their experiment, they did not employ standardized methods for histopathological assessment in the key laboratory experiment presented in their paper.

Chemosphere ; 254: 126882, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32957289


Methamphetamine, mainly consumed as an illicit drug, is a potent addictive psychostimulant that has been detected in surface water at concentrations ranging from nanograms to micrograms per litre, especially in Middle and East Europe. The aim of this study was to expose brown trout (Salmo trutta fario) to environmental (1 µg L-1) and higher (50 µg L-1) concentrations of methamphetamine for 35 days with a four-day depuration phase to assess the possible negative effects on fish health. Degenerative liver and heart alterations, similar to those described in mammals, were observed at both concentrations, although at different intensities. Apoptotic changes in hepatocytes, revealed by activated caspase-3, were found in exposed fish. The parent compound and a metabolite (amphetamine) were detected in fish tissues in both concentration groups, in the order of kidney > liver > brain > muscle > plasma. Bioconcentration factors ranged from 0.13 to 80. A therapeutic plasma concentration was reached for both compounds in the high-concentration treatment. This study indicates that chronic environmental concentrations of methamphetamine can lead to health issues in aquatic organisms.

Metanfetamina/toxicidade , Truta/fisiologia , Poluentes Químicos da Água/toxicidade , Animais , Europa (Continente) , Rim/patologia , Fígado/metabolismo , Truta/metabolismo