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1.
Int J Mol Sci ; 22(17)2021 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-34502276

RESUMO

Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research. In order to take full advantage of its vast therapeutic and preventive potential, detailed studies of the molecular mechanism involved in the antiproliferative and neuroprotective of this IntegroPectin are urgently needed.

2.
Nanomedicine (Lond) ; 16(23): 2061-2074, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34533057

RESUMO

Aim: To assess whether Omeg@Silica microparticles - fish oil from anchovy fillet leftovers (AnchoisOil) encapsulated within mesoporous silica particles - are effective in promoting antitumor effects in lung cancer cells. Methods: Three human non-small-cell lung cancer cell lines (A549, Colo 699 and SK-MES-1) were used. Cells were treated with AnchoisOil dispersed in ethanol (10 and 15 µg/ml) or encapsulated in silica and further formulated in aqueous ethanol. Cell cycle, reactive oxygen species, mitochondrial stress and long-term proliferation were assessed. Results & conclusion: Omeg@Silica microparticles were more effective than fish oil in increasing reactive oxygen species and mitochondrial damage, and in altering the cell cycle and reducing cell proliferation, in lung cancer cells. These in vitro antitumor effects of Omeg@Silica support its investigation in lung cancer therapy.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Linhagem Celular Tumoral , Óleos de Peixe , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Dióxido de Silício
3.
Chem Commun (Camb) ; 57(64): 7863-7868, 2021 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-34287441

RESUMO

Drawing on independent work carried out by academic and industrial researchers using the immobilized TEMPO catalyst SiliaCat TEMPO, in this study we show how shifting the carboxylation process mediated by TEMPO in solution to a process mediated by the above-mentioned hybrid sol-gel catalyst allows the synthesis of insoluble polysaccharide nanofibers of superior quality, eliminating waste. This will dramatically reduce the polysaccharide nanofiber production costs opening the route to large-scale production and uptake of these versatile nanofibers in a variety of functional products where their use has been limited by high cost. The results of this study will be useful for catalysis and biotechnology researchers as well as for chemistry educators teaching green chemistry, nanochemistry, and catalysis using the outcomes of recent research.


Assuntos
Óxidos N-Cíclicos/química , Nanofibras/química , Polissacarídeos/química , Configuração de Carboidratos , Radicais Livres/química , Humanos , Oxirredução , Tamanho da Partícula
4.
Molecules ; 26(3)2021 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-33498706

RESUMO

Isolating cellulose from citrus processing waste without employing chemicals has so far been an unfulfilled goal of chemical research applied to the valorization of a widely available biowaste, annually totaling >100 million tonnes. We have applied hydrodynamic cavitation using a Venturi-type reactor for the extraction of all valued bioproducts of industrial citrus processing waste in water only, directly on a semi-industrial scale. After reporting the discovery of IntegroPectin in the soluble fraction of the aqueous extract, we now report the isolation of a cellulosic material in the water-insoluble fraction of cavitated lemon and grapefruit processing waste. Named "CytroCell", the material is cellulose of low crystallinity, high porosity, good water holding capacity and good dispersibility in water. These properties open the route to mass-scale production of a useful functional material from a cheap and abundant biowaste.


Assuntos
Celulose/química , Citrus/química , Resíduos Industriais/análise , Citrus paradisi/química , Frutas/química , Resíduos/análise
5.
Molecules ; 26(1)2020 Dec 24.
Artigo em Inglês | MEDLINE | ID: mdl-33374383

RESUMO

An HS-SPME GC-MS analysis of the volatile compounds adsorbed at the outer surface of lemon and grapefruit pectins obtained via the hydrodynamic cavitation of industrial waste streams of lemon and grapefruit peels in water suggests important new findings en route to understanding the powerful and broad biological activity of these new pectic materials. In agreement with the ultralow degree of esterification of these pectins, the high amount of highly bioactive α-terpineol and terpinen-4-ol points to limonene (and linalool) decomposition catalyzed by residual citric acid in the citrus waste peel residue of the juice industrial production.


Assuntos
Citrus paradisi/química , Citrus/química , Compostos Orgânicos Voláteis/química , Vias Biossintéticas , Citrus/metabolismo , Citrus paradisi/metabolismo , Frutas/química , Cromatografia Gasosa-Espectrometria de Massas , Estrutura Molecular , Compostos Fitoquímicos/análise , Compostos Fitoquímicos/química , Compostos Orgânicos Voláteis/análise , Compostos Orgânicos Voláteis/metabolismo
6.
Antibiotics (Basel) ; 9(9)2020 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-32911640

RESUMO

Grapefruit and lemon pectin obtained from the respective waste citrus peels via hydrodynamic cavitation in water only are powerful, broad-scope antimicrobials against Gram-negative and -positive bacteria. Dubbed IntegroPectin, these pectic polymers functionalized with citrus flavonoids and terpenes show superior antimicrobial activity when compared to commercial citrus pectin. Similar to commercial pectin, lemon IntegroPectin determined ca. 3-log reduction in Staphylococcus aureus cells, while an enhanced activity of commercial citrus pectin was detected in the case of Pseudomonas aeruginosa cells with a minimal bactericidal concentration (MBC) of 15 mg mL-1. Although grapefruit and lemon IntegroPectin share equal MBC in the case of P. aeruginosa cells, grapefruit IntegroPectin shows boosted activity upon exposure of S. aureus cells with a 40 mg mL-1 biopolymer concentration affording complete killing of the bacterial cells. Insights into the mechanism of action of these biocompatible antimicrobials and their effect on bacterial cells, at the morphological level, were obtained indirectly through Fourier Transform Infrared spectroscopy and directly through scanning electron microscopy. In the era of antimicrobial resistance, these results are of great societal and sanitary relevance since citrus IntegroPectin biomaterials are also devoid of cytotoxic activity, as already shown for lemon IntegroPectin, opening the route to the development of new medical treatments of polymicrobial infections unlikely to develop drug resistance.

7.
ChemMedChem ; 15(23): 2228-2235, 2020 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-32857470

RESUMO

First reported in the late 1930s and partly explained in 1970, the antibacterial activity of pectin remained almost ignored until the late 1990s. The concomitant emergence of research on natural antibacterials and new usages of pectin polysaccharides, including those in medicine widely researched in Russia, has led to a renaissance of research into the physiological properties of this uniquely versatile polysaccharide ubiquitous in plants and fruits. By collecting scattered information, this study provides an updated overview of the subtle factors affecting the behaviour of pectin as an antimicrobial. Less-degraded pectin extracted by acid-free routes, we argue in the conclusions, will soon find applications from new treatments for polymicrobial infections to use as an implantable biomaterial in tissue and bone engineering.

8.
ACS Omega ; 5(28): 17500-17505, 2020 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-32715235

RESUMO

A valued marine oil rich in omega-3 lipids and natural astaxanthin is obtained with remarkably high yield (up to 5 wt %) extending to pink shrimp waste (head and carapace) using the approach to extract fish oil from fish processing byproducts using d-limonene. Biobased limonene is an excellent solvent for both unsaturated lipids and astaxanthin-based carotenoids preventing oxidative degradation during the extraction cycle including solvent separation at 85 °C. Explaining the deep red color of the shrimp oil obtained, computational simulation suggests that d-limonene is also a good solvent for natural astaxanthin abundant in shrimp.

9.
ChemistryOpen ; 9(5): 628-630, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32489768

RESUMO

Pectin extracted via hydrodynamic cavitation in water only from waste lemon peel and further isolated via freeze drying displays significant antibacterial activity against Staphylococcus aureus, a Gram positive pathogen which easily contaminates food. The antibacterial effect of the new IntegroPectin is largely superior to that of commercial citrus pectin, opening the way to advanced applications of a new bioproduct now obtainable in large amounts and at low cost from citrus juice industry's waste.

10.
ACS Omega ; 4(13): 15359-15363, 2019 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-31572834

RESUMO

We investigate selected chemical, technical, and economic aspects of the production of fish oil rich in polyunsaturated omega-3 fatty acids from anchovy filleting leftovers using d-limonene as the extraction solvent at ambient temperature and pressure. Entirely derived from the orange peel prior to orange squeezing for juice production, the bio-based solvent is easily recovered, affording a circular economy process with significant potential for practical applications.

11.
Chem Cent J ; 10: 61, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27790286

RESUMO

BACKGROUND: The introduction of an heterogeneously catalyzed gold-based alcohol oxidation process of broad applicability using a clean primary oxidant would be highly desirable. Gold is non toxic and carbonyl and carboxyl compounds are widely used to produce medicines, plastics, colorants, paints, detergents, fragrances, flavors, and other valued functional products. RESULTS: The sol-gel entrapment of gold nanoparticles in hybrid silica improves gold-based oxidation catalysis applied to the selective oxidation of alcohols with aqueous hydrogen peroxide as eco-friendly primary oxidant. Pronounced physical and chemical stabilization of the sol-gel entrapped Au nanoparticles is reflected in catalyst recyclability. CONCLUSIONS: Potential implications of these findings are significant, especially considering that the highly stable, mesoporous glassy catalyst is ideally suited for application in microreactors for carrying out the reaction under flow. Graphical abstractSelective oxidation of 2-phenylethanol over SiliaCat Au nanoparticle. Hydrogen peroxide is the clean oxidant.

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