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Curr Protein Pept Sci ; 19(3): 302-310, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28059041


Isosteroidal alkaloids are a category of promising bioactive compounds which mostly exist in plants of genus Veratrum and Fritillaria. The pharmacological activities of isosteroidal alkaloids include antihypertensive, antitussive, anti-inflammatory, antithrombosis, among others. Recently, some studies show that this kind of alkaloids exhibited significant antitumor activity. To the best of our knowledge, there is no review focusing on their antitumor activity and mechanism of their antitumor activity. To fill the gap, in this review, we summarized antitumor effects of the isosteroidal alkaloids from genus Veratrum and Fritillaria on different tumors and the mechanisms of their antitumor activity. In conclusion, this kind of alkaloids has extensive antitumor activity, and there are several main mechanisms of their antitumor activity, including the Hedgehog signaling pathway, caspase-3 dependent apoptosis, cell cycle, and autophagy.

Alcaloides/química , Alcaloides/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Fritillaria/química , Neoplasias/tratamento farmacológico , Veratrum/química , Alcaloides/uso terapêutico , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Apoptose/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Ciclo Celular/efeitos dos fármacos , Proteínas Hedgehog/metabolismo , Humanos , Neoplasias/metabolismo , Neoplasias/patologia , Transdução de Sinais/efeitos dos fármacos , Alcaloides de Veratrum/química , Alcaloides de Veratrum/farmacologia , Alcaloides de Veratrum/uso terapêutico
Zhongguo Zhong Yao Za Zhi ; 39(4): 733-7, 2014 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-25204156


OBJECTIVE: To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats. METHOD: Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument. RESULT: Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes. CONCLUSION: Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.

Isquemia Encefálica/tratamento farmacológico , Circulação Cerebrovascular/efeitos dos fármacos , Medicamentos de Ervas Chinesas/administração & dosagem , Animais , Encéfalo/irrigação sanguínea , Encéfalo/efeitos dos fármacos , Isquemia Encefálica/fisiopatologia , Humanos , Masculino , Pós/administração & dosagem , Ratos , Ratos Sprague-Dawley
Chin J Nat Med ; 11(6): 588-95, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24345499


The treatment of cerebral ischemic disease by natural medicines has a long history, and has accumulated a rich theoretical knowledge and treatment experience. The objective of this review is to critically evaluate the experimental research situation of the protective effect of the individual compounds from natural medicine on cerebral ischemia in the past ten years, emphasizing the major mechanisms underlying cerebral ischemic pathophysiology. Sixteen representative compounds from natural medicines which are often used to treat stroke are discussed. The results indicate that these components possess a protective effect on cerebral ischemia, and that these components have different mechanisms, including inhibiting excitotoxicity by ginkgolide B, antiapoptosis of breviscapine, influencing astrocytic activation and proliferation of tanshinone IIA, influencing free radicals by ginsenoside Rd, impairing blood-brain barrier disruption by baicalin, and the anti-inflammatory activity of tetramethylpyrazine. Moreover, some components have multiple neuroprotective mechanisms. Therefore, the combination of individual compounds from natural medicines, considering the mechanisms of cerebral ischemia, may be beneficial to patients with cerebral ischemia in the future. This approach will provide a direction for the further application and exploitation of new drug development in the treatment of cerebral ischemia.

Isquemia Encefálica/prevenção & controle , Medicamentos de Ervas Chinesas/uso terapêutico , Fitoterapia/tendências , Plantas Medicinais/química , Animais , Isquemia Encefálica/tratamento farmacológico , Humanos
Zhongguo Zhong Yao Za Zhi ; 38(8): 1109-15, 2013 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-23944020


This essay summarizes experimental studies on the protective effect of traditional Chinese medicines and their extracts on cerebral ischemia in the past decade. It classifies reported traditional Chinese medicines into three types-plant medicines, animal medicines and mineral medicines, and specifies the advance of their effective components, extracts and their preparations in treating cerebral ischemia.

Isquemia Encefálica/prevenção & controle , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Tradicional Chinesa , Animais , Humanos
J Sep Sci ; 35(19): 2659-64, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23001886


In this study, the bioactive component harpagoside and angroside C in the root of Scrophularia ningpoensis Hemsley was simultaneously separated by high-speed counter-current chromatography (HSCCC). A two-phase solvent system containing chloroform/n-butanol/methanol/water (4:1:3:2, v/v/v/v) was selected following consideration of the partition coefficient of the target compound. The crude extract (200 mg) was loaded onto a 280-mL HSCCC column and yielded 22 mg harpagoside and 31 mg angroside C with the purity of higher than 98 and 98.5%, respectively. It is feasible to isolate active compounds harpagoside and angroside C from S. ningpoensis using HSCCC.

Distribuição Contracorrente/métodos , Glicosídeos/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Piranos/isolamento & purificação , Scrophularia/química , Glicosídeos/análise , Extratos Vegetais/análise , Raízes de Plantas/química , Piranos/análise