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1.
J Cosmet Dermatol ; 2021 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-33964111

RESUMO

A 23-year-old otherwise healthy man presented with four-month history of facial itching cutaneous lesions to our allergy department. As per his own description, the lesions only involve the T zones at the onset, and it had been slowly enlarging and spreading to the forehead, glabellum and both cheek areas for four months with obvious itching. He denied the use of multiple cosmetics and used only moisturizers on a daily basis. The physical examination revealed well-demarcated, erythematous patches with greasy-looking, yellowish scales distributed on forehead, glabellum and both cheek areas without typical telangiectasia (Fig,a).

2.
Front Immunol ; 12: 628512, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33868246

RESUMO

Background: Patients with atopic dermatitis (AD) exhibit phenotypic variability in ethnicity and IgE status. In addition, some patients develop other allergic conditions, such as allergic rhinitis (AR), in subsequent life. Understanding the heterogeneity of AD would be beneficial to phenotype-specific therapies. Methods: Twenty-eight Chinese AD patients and 8 healthy volunteers were enrolled in the study. High-throughput transcriptome sequencing was conducted on lesional and nonlesional skin samples from 10 AD patients and matched normal skin samples from 5 healthy volunteers. Identification of differentially expressed genes (DEGs), KEGG pathway analyses, and sample cluster analyses were conducted in the R software environment using the DEseq2, ClusterProfiler, and pheatmap R packages, respectively. qRT-PCR, Western blotting, and ELISA were used to detect gene expression levels among subtypes. Correlation analysis was performed to further investigate their correlation with disease severity. Results: A total of 25,798 genes were detected per sample. Subgroup differential expression analysis and functional enrichment analysis revealed significant changes in the IL17 signaling pathway in Chinese EAD patients but not in IAD patients. DEGs enriched in cytokine-cytokine receptor interactions and gland secretion were considered to be associated with atopic march. Further investigations confirmed a marked IL17A upregulation in Chinese EAD with a positive relationship with total IgE level and AD severity. In addition, increased IL17A in AD patients with AR demonstrated a closer association with AR severity than IL4R. Moreover, AQP5 and CFTR were decreased in the lesions of AD patients with AR. The CFTR mRNA expression level was negatively associated with the skin IL17A level and AR severity. Conclusion: Our research characterized marked Th17 activation in Chinese EAD patients, and altered expression of IL17A, IL4R, AQP5, and CFTR in AD patients with AR was associated with AR severity. It partially explained the phenotypic differences of AD subtypes and provided potential references for endotype-targeted therapy.

3.
Nanoscale ; 13(13): 6357-6372, 2021 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-33885520

RESUMO

Electronic valley in two-dimensional transition-metal dichalcogenides (2D TMDCs) offers a new degree of freedom for information storage and processing. The valley pseudospin can be optically encoded by photons with specific helicity, enabling the construction of electronic information devices with both high performance and low power consumption. Robust detection, manipulation and transport of the valley pseudospins at room temperature are still challenging because of the short lifetime of valley-polarized carriers and excitons. Integrating 2D TMDCs with nanophotonic objects such as plasmonic nanostructures provides a competitive solution to address the challenge. The research in this field is of practical interest and can also present rich physics of light-matter interactions. In this minireview, recent progress on using nanophotonic strategies to enhance the valley polarization degree, especially at room temperature, is highlighted. Open questions, major challenges, and interesting future developments in manipulating the valley information in 2D semiconductors with the help of nanophotonic structures will also be discussed.

4.
Artigo em Inglês | MEDLINE | ID: mdl-33908755

RESUMO

Plasmonic hotspots can enhance hot charge carrier generation, offering new opportunities for improving the photocatalytic activity. In this work, eight types of heteronanostructures are synthesized by selectively depositing catalytic metals at the different sites of highly asymmetric Au nanocups for the photocatalytic oxidation of o-phenylenediamine. The oxidation of this molecule has so far mainly relied on the use of H2O2 as an oxidizing agent in the presence of an appropriate catalyst. The photocatalytic oxidation under visible light has not been reported before. The Au nanocups with AgPt nanoparticles grown at the opening edge and bottom exhibit the highest photocatalytic activity. The generated hot electrons and holes both participate in the reaction. The hot carriers from the interband and intraband transitions are both utilized. The optimal catalyst shows a favorable activity even under room light. Simulations reveal that the profound electric field enhancement at the hotspots boosts the hot-carrier density in the catalytic nanoparticles, explaining the overwhelming photocatalytic activity of the optimal catalyst.

5.
Thorac Cancer ; 12(9): 1469-1488, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33787090

RESUMO

Perioperative adjuvant treatment has become an increasingly important aspect of the management of patients with non-small cell lung cancer (NSCLC). In particular, the success of immune checkpoint inhibitors, such as antibodies against PD-1 and PD-L1, in patients with lung cancer has increased our expectations for the success of these therapeutics as neoadjuvant immunotherapy. Neoadjuvant therapy is widely used in patients with resectable stage IIIA NSCLC and can reduce primary tumor and lymph node stage, improve the complete resection rate, and eliminate microsatellite foci; however, complete pathological response is rare. Moreover, because the clinical benefit of neoadjuvant therapy is not obvious and may complicate surgery, it has not yet entered the mainstream of clinical treatment. Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment. Nevertheless, neoadjuvant immunotherapy may be accompanied by serious adverse reactions that lead to delay or cancellation of surgery, additional illness, and even death, and have therefore attracted much attention. In this article, we draw on several sources of information, including (i) guidelines on adverse reactions related to immune checkpoint inhibitors, (ii) published data from large-scale clinical studies in thoracic surgery, and (iii) practical experience and published cases, to provide clinical recommendations on adverse events in NSCLC patients induced by perioperative immunotherapy.

6.
Sci Rep ; 11(1): 5460, 2021 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-33750864

RESUMO

The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having hypertensive retinopathy. For the hypertensive cases, the SFCT in patients with hypertensive retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without hypertensive retinopathy (187.04 ± 78.80 µm, P < 0.001). SFCT was significantly associated with the stage of hypertensive retinopathy (P < 0.001), but not significantly associated with diastolic blood pressure (P = 0.94), history (P = 0.95) and years (P = 0.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, hypertensive retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of hypertensive retinopathy.

7.
Chemosphere ; 274: 129769, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33548638

RESUMO

Bisphenol A (BPA), a typical endocrine disrupting chemical, widely exists in water and threatens human health. The degradation of BPA by ozone in water is limited by the gas-mass transfer due to the low solubility of ozone. In this study, a rotating packed bed (RPB) was employed to create a high gravity environment to intensify the ozone mass transfer and BPA degradation. The effects of operational parameters (rotation speed of RPB, pH of the solution, ozone concentration, BPA concentration, gas volumetric flow rate and liquid volumetric flow rate) on BPA degradation efficiency and overall volumetric mass transfer coefficient of ozone were investigated. The results show that RPB effectively promoted the ozone mass transfer and BPA degradation and can be used for the ozonation of micropollutants that have fast reaction rates with ozone. Quenching experiments suggest that both ozone and HO∙ participated in BPA degradation from acidic to alkaline environments. In addition, the effects of co-existing chemicals on BPA degradation efficiency were studied. The addition of H2O2 or Cl- had no obvious impact on BPA degradation; the addition of HCO3- is beneficial for BPA degradation while the addition of fulvic acid suppressed the degradation. These results indicate that the pH value, which affects the reaction rate between ozone and BPA, is a major factor to be considered during the ozonation of BPA in RPB.


Assuntos
Ozônio , Poluentes Químicos da Água , Purificação da Água , Compostos Benzidrílicos , Humanos , Peróxido de Hidrogênio , Fenóis , Poluentes Químicos da Água/análise
8.
Artigo em Inglês | MEDLINE | ID: mdl-33557516

RESUMO

Bimetallic organic frameworks (Bi-MOFs) have been recognized as one of the most ideal precursors to construct metal oxide semiconductor (MOS) composites, owing to their high surface area, various chemical structures, and easy removal of the sacrificial MOF scaffolds through calcination. Herein, we synthesized Zn/Ni Bi-MOF for the first time via a facile ion exchange postsynthetic strategy, formed a three-dimensional framework consisting of infinite one-dimensional chains that is unattainable through the direct solvothermal approach, and then transformed the Zn/Ni Bi-MOF into a unique ZnO/NiO heterostructure through calcination. Notably, the obtained sensor based on a ZnO/NiO heterostructure exhibits an ultrahigh response of 280.2 toward 500 ppm n-propanol at 275 °C (17.2-fold enhancement compared with that of ZnO), remarkable selectivity, and a limit of detection of 200 ppb with a notable response (2.51), which outperforms state-of-the-art n-propanol sensors. The enhanced n-propanol sensing properties may be attributed to the synergistic effects of several points including the heterojunction at the interface between the NiO and ZnO nanoparticles, especially a one-dimensional chain MOF template structure as well as the chemical sensitization effect of NiO. This work provides a promising strategy for the development of a novel Bi-MOF-derived MOS heterostructure or homostructure with well-defined morphology and composition that can be applied to the fields of gas sensing, energy storage, and catalysis.

9.
Microb Drug Resist ; 2021 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-33544031

RESUMO

Polymyxin B and colistin (polymyxin E) are increasingly used as the last line of therapy for infections caused by multidrug-resistant (MDR) gram-negative pathogens. However, nephrotoxicity is still a limiting factor for the use of polymyxin. Therefore, better tolerated and more effective polymyxin derivatives are urgently needed. In this study, we aimed to evaluate the activity of the low-alkalinity polymyxin derivative, AL-6, against MDR Acinetobacter baumannii (Ab) clinical isolates in vitro and A. baumannii ATCC 19606 in vivo. Additionally, we performed a preliminarily study of the antibacterial mechanism. AL-6 showed much higher activity (0.125-0.25 µg/mL) against MDR A. baumannii clinical isolates than polymyxin E2 (PE2, 0.5-1 µg/mL). AL-6 also showed much higher activity (0.5-256 µg/mL) against polymyxin-resistant strains than PE2 (16-1024 µg/mL). Additionally, AL-6 showed slow resistance against A. baumannii. AL-6 also increased the survival rates of mice by 10% at 48 h compared with PE2 (5 mg/kg). AL-6 could be used at a dose of up to 10 mg/kg, increasing the survival rate to 30% at 72 h after infection. A preliminary study of the antibacterial mechanism showed that AL-6 permeabilized the outer membrane and destroyed cell membrane integrity. Moreover, there was a substantial increase in zeta potential (i.e., less negative) upon AL-6 exposure for A. baumannii. Overall, AL-6 carrying only four positive charges showed high activity against A. baumannii in vitro by disrupting cell membrane integrity. Higher doses of AL-6 could increase survival rates of mice. Thus, AL-6 may have potential applications as a bactericidal agent.

10.
J Soc Psychol ; : 1-10, 2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33407041

RESUMO

The study aims to explore the effect of security on social trust and the roles of life satisfaction and ostracism among Chinese adults. Toward this end, the study recruited 1,206 Chinese adults to complete the Security Questionnaire, Social Trust Questionnaire, Satisfaction with Life Scale, and Ostracism Experiences Scale. Results show that (a) security is positively correlated with social trust among Chinese adults, (b) life satisfaction partially mediates the effect of security on social trust, and (c) ostracism moderates the relationship between security and social trust. Furthermore, findings indicate that security can directly predict social trust as well as indirectly predict social trust through life satisfaction for adults in China. Security has a strong predictive effect on social trust - especially for individuals with low levels of ostracism.

11.
Org Lett ; 2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-33492975

RESUMO

A Lewis acid promoted intramolecular Schmidt reaction of N-acylbenzotriazoles with alkyl azides was designed and realized. The benzotriazole was not only employed as an efficient activator for initiating the Schmidt rearrangement but also used as a powerful terminator for the subsequent nucleophilic trapping of the isocyanate ion and/or N-acyliminium ion from the rearrangement. Thirteen δ-azido N-acylbenzotriazoles were investigated, and the conversion afforded the desired benzotriazole-1-carboxamides and lactams with good to excellent yields.

12.
Ying Yong Sheng Tai Xue Bao ; 31(11): 3639-3646, 2020 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-33300713

RESUMO

Calligonum mongolicum is one of the dominant species in the Taklimakan Desert highway shelterbelt, the litter of which plays an important role in carbon cycling. After litter addition, we carried out a laboratory incubation experiment to investigate the dynamics of soil CO2 emission, soil organic carbon (SOC), soluble organic carbon (DOC), pH, and electrical conductivity (EC) under the condition of salt water (SW) and fresh water (FW) with field water holding capacity of 25%, 50%, 75%, and 100%. The results showed that saline water irrigation had an inhibitory effect on soil CO2 emission. Under the four soil water content treatments, the cumulative CO2 emission of freshwater irrigation increased by 1.9%-29.1% compared with that of saline irrigation. Cumulative soil CO2 emissions increased with increasing soil water content. With litter addition, SOC decreased rapidly in the early stage, then gradually increased, and finally tended to be stable. The DOC contents of each treatment following the incubation increased by 41.3%-92.4% compared with that before the incubation. At the end of incubation, soil pH of each treatment increased by 0.20-0.35. The EC increased with the increases of soil water content. Under the four water content conditions and compared with the situation before the incubation, the EC values irrigated with SW increased by 0.11-0.79 mS·cm-1, while those with FW increased or decreased at the end of incubation. Cumulative soil CO2 emission was positively correlated with SOC, DOC, and pH, but not with soil water content. Both saline irrigation and lower water content could inhibit CO2 emission of aeolian sandy soil under litter addition, while EC was significantly affected by the quality of irrigation water and soil water content.

13.
Zhongguo Ying Yong Sheng Li Xue Za Zhi ; 36(4): 379-384, 2020 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-33167103

RESUMO

OBJECTIVE: To quantitatively analyze the effects of direct and indirect stimuli on the contraction of gastrocnemius in vivo and in vitro specimen by self-programming. METHODS: All specimens were divided into four groups: indirect stimuli on specimen in vivo group (n=12), direct stimuli on specimen in vivo group (n=8), indirect stimuli on specimen in vitro group (n=12), direct stimuli on specimen in vitro group (n=8). Indirect stimuli (via sciatic nerve) and direct stimuli (acupuncture needle piercing into gastrocnemius) (stimuli starting from 0 V, cycle 3 s, increment 0.02 V, 150 times) were acted on in vivo and in vitro sciatic nerve gastrocnemius muscle specimen respectively. The effects of electric intensity on the contraction of gastrocnemius were recorded by the experimental system of BL-420F. The data were processed and analyzed by the help of self-programming, to quantitatively obtain key parameters for a single contraction. RESULTS: ① For in vivo specimen, compared with direct stimuli, effects of indirect stimuli were as follows: the threshold intensity, half-intensity and maximal intensity of the specimen were smaller (P<0.05); the amplitude was larger, the contraction period was longer, and the rising slope was smaller (P<0.05). ②For in vitro specimen, compared with direct stimuli, effects of indirect stimuli were as follows: the threshold intensity, half-intensity and maximal intensity of indirect stimuli were smaller (P<0.05); the amplitude was larger, the contraction period was longer, and the rising slope was smaller (P<0.05). ③Compared with in vitro specimen, there was no significant difference among all the above parameters of in vivo specimen, with either direct or indirect stimuli (P>0.05). CONCLUSION: There is no significant difference in the features of single contraction between in vivo and in vitro specimen with either direct or indirect stimuli. However, indirect stimuli can trigger gastrocnemius to produce single contraction more easily than direct stimuli, and the amplitude is larger than that of direct stimuli.

14.
Front Cell Infect Microbiol ; 10: 570658, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33194809

RESUMO

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by neuronal loss and dysfunction of dopaminergic neurons located in the substantia nigra, which contain a variety of misfolded α-synuclein (α-syn). Medications that increase or substitute for dopamine can be used for the treatment of PD. Recently, numerous studies have shown gut microbiota plays a crucial role in regulating and maintaining multiple aspects of host physiology including host metabolism and neurodevelopment. In this review article, the role of gut microbiota in the etiological mechanism of PD will be reviewed. Furthermore, we discussed current pharmaceutical medicine-based methods to prevent and treat PD, followed by describing specific strains that affect the host brain function through the gut-brain axis. We explained in detail how gut microbiota directly produces neurotransmitters or regulate the host biosynthesis of neurotransmitters. The neurotransmitters secreted by the intestinal lumen bacteria may induce epithelial cells to release molecules that, in turn, can regulate neural signaling in the enteric nervous system and subsequently control brain function and behavior through the brain-gut axis. Finally, we proved that the microbial regulation of the host neuronal system. Endogenous α-syn can be transmitted long distance and bidirectional between ENS and brain through the circulatory system which gives us a new option that the possibility of altering the community of gut microbiota in completely new medication option for treating PD.

16.
Opt Express ; 28(22): 32556-32571, 2020 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-33114939

RESUMO

We investigate the optimal quantum state for an atomic gyroscope based on a three-site Bose-Hubbard model. In previous studies, various states such as the uncorrelated state, the BAT state and the NOON state are employed as the probe states to estimate the phase uncertainty. In this article, we present a Hermitian operator H and an equivalent unitary parametrization transformation to calculate the quantum Fisher information for any initial states. Exploiting this equivalent unitary parametrization transformation, we can seek the optimal state that gives the maximal quantum Fisher information on both lossless and lossy conditions. As a result, we find that the squeezed entangled state (SES) and the entangled even squeezed state (EESS) can significantly enhance the precision for moderate loss rates compared with previous proposals.

17.
FEBS J ; 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33058529

RESUMO

Previous studies have shown that high physiological levels of reactive oxygen species (ROS) in the brain promote pupal diapause, which extends the pupal lifespan. However, the molecular mechanisms of ROS generation are unclear. In this paper, we found that mitochondrial ROS (mtROS) levels in the brains of Helicoverpa armigera diapause-destined pupae (DP) were higher and that the expression of cytochrome oxidase subunit IV (COXIV) was lower than in NP. In addition, downregulating COXIV caused mitochondrial dysfunction which elevated mtROS levels. Protein kinase A (PKA) was downregulated in DP, which led to the downregulated expression of the mitochondrial transcription factor TFAM. Low TFAM activity failed to promote COXIV expression and resulted in the high ROS levels that induced diapause. In addition, low sirtuin 2 expression suppressed glucose-6-phosphate dehydrogenase (G6PD) deacetylation at K382, which led to reduced G6PD activity and low NADPH levels, thereby maintaining high levels of ROS. Two proteins, COXIV and G6PD, thus play key roles in the elevated accumulation of ROS that induce diapause and extend the pupal lifespan.

18.
Nanoscale ; 12(40): 20684-20692, 2020 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-33047771

RESUMO

(Gold nanorod core)/(poly(3,4-ethylene-dioxythiophene) (PEDOT) shell) nanostructures are prepared by the surfactant-assisted oxidative polymerization of 3,4-ethylene-dioxythiophene on the surface of gold nanorods (NRs). The PEDOT shell exhibits distinct dielectric properties at doped and undoped states, which allows the manipulation of plasmonic responses of the Au nanorod core. The shift in plasmon resonance induced by the dedoping of PEDOT is found to be associated with the overlap between the plasmon resonance band of the core/shell nanostructure and the spectral region where the largest refractive index variation of PEDOT occurs, as well as with the type of the dedopant. Macroscopic two-dimensional (2D) monolayer arrays of core/shell nanostructures with controlled particle number densities are fabricated on indium tin oxide (ITO)-coated glass substrates by electrophoretic deposition. A reversible plasmonic shift of about 70 nm is obtained on the core/shell nanostructure monolayer array with a number density of around 18 particles per µm2. Our design of colloidal (Au nanorod core)/(PEDOT shell) nanostructures and their 2D monolayer arrays paves the way for the fabrication of high-performance plasmonic switches in large-scale practical usages as well as for the preparation of advanced, programmable chromic materials for a broad range of applications, such as smart windows, anti-counterfeiting tags, and medical and environmental sensors.

19.
Artigo em Inglês | MEDLINE | ID: mdl-32975866

RESUMO

Substrate-supported metal-organic frameworks (MOFs) films are desired to realize their potential in practical applications. Herein, a novel substrate-seeding secondary-growth strategy is developed to prepare composites of uniform MOFs films on aerogel walls. Briefly, the organic ligand is "pre-seeded" onto the aerogel walls, and then a small amount of metal-ion solution is sprayed onto the prepared aerogel. The sprayed solution diffuses along the aerogel walls to form a continuous thin layer, which confines the nucleation reaction, promoting the formation of uniform MOFs films on the aerogel walls. The whole process is simple in operation, highly efficient, and eco-friendly. The resulting hierarchical MOFs/aerogel composites have abundant accessible active sites and enable excellent mass transfer, which endows the composite with outstanding catalytic activity and stability in both liquid-phase CO2 cycloaddition and electrochemical oxygen evolution reaction (OER) process.

20.
Clin Transl Med ; 10(5): e175, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32997414

RESUMO

Pulmonary vascular remodeling is the most important pathological characteristic of pulmonary arterial hypertension (PAH). No effective treatment for PAH is currently available because the mechanism underlying vascular remodeling is not completely clear. CD248, also known as endosialin, is a transmembrane protein that is highly expressed in pericytes and fibroblasts. Here, we evaluated the role of CD248 in pulmonary vascular remodeling and the processes of PAH pathogenesis. Activation of CD248 in pulmonary artery smooth muscle cells (PASMCs) was found to be proportional to the severity of PAH. CD248 contributed to platelet-derived growth factor-BB (PDGF-BB)-induced PASMC proliferation and migration along with the shift to more synthetic phenotypes. In contrast, treatment with Cd248 siRNA or the anti-CD248 therapeutic antibody (ontuxizumab) significantly inhibited the PDGF signaling pathway, obstructed NF-κB p65-mediated transcription of Nox4, and decreased reactive oxygen species production induced by PDGF-BB in PAMSCs. In addition, knockdown of CD248 alleviated pulmonary vascular remodeling in rat PAH models. This study provides novel insights into the dysfunction of PASMCs leading to pulmonary vascular remodeling, and provides evidence for anti-remodeling treatment for PAH via the immediate targeting of CD248.

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