Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 323
Filtrar
1.
Opt Express ; 30(8): 13391-13403, 2022 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-35472952

RESUMO

Scalable and low-cost manufacturing of broadband absorbers for use in the long-wave infrared region are of enormous importance in various applications, such as infrared thermal imaging, radiative cooling, thermal photovoltaics and infrared sensor. In recent years, a plethora of broadband absorption metasurfaces made of metal nano-resonators with plasmon resonance have been synthesized. Still, their disadvantages in terms of complex structure, production equipment, and fabrication throughput, limit their future commercial applications. Here, we propose and experimentally demonstrate a broadband large-area all-dielectric metasurface absorber comprised of silicon (Si) arrys of square resonators and a silicon nitride (Si3N4) film in the long-wave infrared region. The multiple Mie resonance modes generated in a single-size Si resonator are utilized to enhance the absorption of the Si3N4 film to achieve broadband absorption. At the same time, the transversal optical (TO) phonon resonance of Si3N4 and the Si resonator's magnetic dipole resonance are coupled to achieve a resonator size-insensitive absorption peak. The metasurface absorber prepared by using maskless laser direct writing technology displays an average absorption of 90.36% and a peak absorption of 97.55% in the infrared region of 8 to 14 µm, and still maintains an average absorption of 88.27% at a inciedent angle of 40°. The experimentally prepared 2 cm × 3 cm patterned metasurface absorber by markless laser direct writing lithography (MLDWL) exhibits spatially selective absorption and the thermal imaging of the sample shows that the maximum temperature difference of 17.3 °C can exist at the boundary.

2.
Front Pediatr ; 10: 546080, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35402349

RESUMO

Objective: Growth hormone receptor (GHR) mediates most GH biological actions. This study is aimed to evaluate whether GHR fl/d3 polymorphism contributes to the inter-individual variability of growth and metabolism in healthy children and adolescents. Methods: A total of 4,730 students aged 6-16 years from Yixing and Suqian City in China were included in this cross-sectional study. Height and body mass index (BMI) were transformed into the form of z-score corresponding to age and gender. Logistic regression was used to evaluate the associations of GHR fl/d3 polymorphism with height, BMI, metabolic traits, and hypertension by estimating the odds ratios (ORs) and 95% confidence intervals (CIs). Results: GHR d3 allele was inversely associated with overweight, total cholesterol (TC) and triglyceride (TG) levels (OR [95% CI] for overweight: 0.754 [0.593-0.959], P = 0.021; OR [95% CI] for TC: 0.744 [0.614-0.902], P = 0.003; OR [95% CI] for TG: 0.812 [0.654-0.998], P = 0.047). GHR d3 allele was associated with decreased odds of pre-hypertension in boys (OR [95% CI]: 0.791 [0.645-0.971], P = 0.025), but associated with increased odds of pre-hypertension and hypertension in girls (ORs [95% CIs]: 1.379 [1.106-1.719], P = 0.004; OR [95% CI]: 1.240 [1.013-1.519], P = 0.037). Interaction of GHR fl/d3 polymorphism with gender contributed to increased odds of pre-hypertension and hypertension (interactive ORs [95% CIs]: 1.735 [1.214-2.481], P = 0.003; OR [95% CI]: 1.509 [1.092-2.086], P = 0.013). Stratification analysis showed that the correlation tendencies of GHR fl/d3 polymorphism and BMI with age were different between two cities with discrepant economic development levels. Conclusion: GHR fl/d3 polymorphism is associated with growth, metabolism, and hypertension in children and adolescents with the gender specificity, and the genetic effect of GHR fl/d3 may be modified by the local socioeconomic levels.

3.
Front Cardiovasc Med ; 9: 819274, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35360026

RESUMO

Background: Dyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain. Objectives: This present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults. Methods: The cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (95%CI) of interaction terms were used to examine additive and multiplicative interactions. Results: In the hypertensive population, Non-HDL-C ≥190 mg/dl, LDL-C/HDL-C ≥2 and HDL-C ≥60 mg/dl were statistically associated with IS, and after adjusting for covariates, HRs (95%CIs) were 1.565 (1.007-2.429), 1.414 (1.034-1.933) and 0.665 (0.450-0.983), respectively. While in the non-hypertension population, no significant association of Non-HDL-C ≥190 mg/dl, LDL-C/HDL-C ≥2, and HDL-C ≥60 was detected with IS (P > 0.05). There was a significant association between TC/HDL-C ≥ 3.6 and the decreased risk of IS in the non-hypertension population, and the HR (95%CI) was 0.479 (0.307-0.750). Whereas, a similar association was not observed in the hypertensive population. HDL-C ≥ 60 mg/dl, Non-HDL-C ≥ 190 mg/dl, TC/HDL-C ≥ 3.6, and TG/HDL-C ≥ 1 have additive and multiplicative interactions with hypertension (P < 0.05). The RERIs (95% CIs) of the additive interaction are -0.93 (-1.882-0.044), 1.394 (0.38-2.407), 0.752 (0.354-1.151) and 0.575 (0.086-1.065), respectively. The HRs (95% CIs) of the multiplicative interaction terms were 0.498 (0.272-0.911), 4.218 (1.230-14.464), 2.423 (1.437-4.086) and 1.701 (1.016-2.848), respectively. Conclusion: High concentration of HDL-C reduces the impact of hypertension on IS, while the high concentration of Non-HDL-C, TC/HDL-C, and TG/HDL-C positively interact with hypertension affecting the incidence of IS. This study provides useful evidence for the combined effects of dyslipidemia and hypertension in predicting IS.

4.
Abdom Radiol (NY) ; 47(5): 1806-1816, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35267069

RESUMO

PURPOSE: To investigate whether systemic inflammatory biomarkers compared with the imaging features interpreted by radiologists can offer complementary value for predicting the risk of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). METHODS: A total of 156 patients with histologically confirmed HCC between Jan 2018 and Dec 2020 were retrospectively enrolled in the primary cohort. Preoperative clinical-inflammatory biomarkers and MR imaging of the patients were recorded and then evaluated as an inflammatory score (Inflam-score) and imaging feature score (Radio-score). Six Inflam-scores and 12 Radio-scores were determined from each patient by univariate analysis. Logistic regression was performed to select risk factors for MVI and establish a predictive nomogram. Decision curve analysis was applied to estimate the incremental value of the Inflam-score to the Radio-score for predicting MVI. RESULTS: Four Radio-scores and 2 Inflam-scores, namely, larger tumor size, non-smooth tumor margin, presence of satellite nodules, presence of peritumoral enhance, higher neutrophil-lymphocyte ratio (NLR), and lower prognostic nutritional index (PNI), were significantly associated with MVI (p < 0.05). An MVI risk prediction nomogram was then constructed with an area under the curve (AUC) of 0.868 (95% CI 0.806-0.931). Adding Inflam-scores to Radio-scores improved the sensitivity of the model from 60.9 to 80.4% in receiver operating characteristic (ROC) curve analysis and led to a net benefit in decision curve analysis. CONCLUSION: Systemic inflammatory biomarkers are complementary tools that provide additional benefit to conventional imaging estimation for predicting MVI in HCC patients.


Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Biomarcadores , Carcinoma Hepatocelular/irrigação sanguínea , Carcinoma Hepatocelular/diagnóstico por imagem , Carcinoma Hepatocelular/cirurgia , Humanos , Neoplasias Hepáticas/patologia , Imageamento por Ressonância Magnética , Invasividade Neoplásica/patologia , Estudos Retrospectivos
5.
Eur Heart J ; 43(18): 1702-1711, 2022 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-35195259

RESUMO

AIMS: To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and comprehensively evaluate its potential in clinical utility for primary prevention in Chinese populations. METHODS AND RESULTS: Using meta-analytic approach and large genome-wide association results for CAD and CAD-related traits in East Asians, a PRS comprising 540 genetic variants was developed in a training set of 2800 patients with CAD and 2055 controls, and was further assessed for risk stratification for CAD integrating with the guideline-recommended clinical risk score in large prospective cohorts comprising 41 271 individuals. During a mean follow-up of 13.0 years, 1303 incident CAD cases were identified. Individuals with high PRS (the highest 20%) had about three-fold higher risk of CAD than the lowest 20% (hazard ratio 2.91, 95% confidence interval 2.43-3.49), with the lifetime risk of 15.9 and 5.8%, respectively. The addition of PRS to the clinical risk score yielded a modest yet significant improvement in C-statistic (1%) and net reclassification improvement (3.5%). We observed significant gradients in both 10-year and lifetime risk of CAD according to the PRS within each clinical risk strata. Particularly, when integrating high PRS, intermediate clinical risk individuals with uncertain clinical decision for intervention would reach the risk levels (10-year of 4.6 vs. 4.8%, lifetime of 17.9 vs. 16.6%) of high clinical risk individuals with intermediate (20-80%) PRS. CONCLUSION: The PRS could stratify individuals into different trajectories of CAD risk, and further refine risk stratification for CAD within each clinical risk strata, demonstrating a great potential to identify high-risk individuals for targeted intervention in clinical utility.


Assuntos
Doença da Artéria Coronariana , China/epidemiologia , Estudos de Coortes , Doença da Artéria Coronariana/epidemiologia , Doença da Artéria Coronariana/genética , Predisposição Genética para Doença/genética , Estudo de Associação Genômica Ampla , Humanos , Herança Multifatorial/genética , Estudos Prospectivos , Medição de Risco/métodos , Fatores de Risco
6.
Rev Sci Instrum ; 93(1): 015004, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35104989

RESUMO

The velocity measurement algorithm based on vision is widely used in unmanned aerial vehicle navigation. Under uneven illumination intensity distribution, the traditional Lucas-Kanade (LK) optical flow (OF) algorithm has problems arising from low computational accuracy and poor adaptability. To solve these problems, we propose a monocular vision integrated velocity measurement system based on the square-root cubature Kalman filter (SRCKF). The LK OF and the optimized oriented FAST and rotated BRIEF (ORB) algorithms are used to process the visual information obtained using a camera. The SRCKF algorithm is tasked with fusing the LK OF and optimized ORB information, thereby improving the accuracy of velocity and alleviating the sensitivity of the LK OF to variations in illumination conditions. Finally, an outdoor unmanned aerial vehicle flight test was undertaken. The experimental results show that the proposed method provides an accurate measurement of the velocity in variable illumination environments.

7.
Methods Appl Fluoresc ; 10(2)2022 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-35168212

RESUMO

A near-infrared (NIR) light-triggered release method for nitric oxide (NO) was developed utilizing core/shell NaYF4: Tm/Yb/Ca@NaGdF4: Nd/Yb up-conversion nanoparticles (UCNPs) bearing a mesoporous silica (mSiO2) shell loaded with the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP). To avoid overheating in biological samples, Nd3+was chosen as a sensitizer, Yb3+ions as the bridging sensitizer, and Tm3+ions as UV-emissive activator while co-doping with Ca2+was done to enhance the luminescence of the activator Tm3+. NO release from SNAP was triggered by an NIR-UV up-conversion process, initiated by 808 nm light absorbed by the Nd3+ions. NO release was confirmed by the Griess method. Under 808 nm irradiation, the viability of the liver cancer cell line HepG2 significantly decreased with increasing UCNPs@mSiO2-SNAP concentration. For a UCNPs@mSiO2-SNAP concentration of 200µg ml-1, the cell survival probability was 47%. These results demonstrate that UCNPs@mSiO2-SNAP can induce the release of apoptosis-inducing NO by NIR irradiation.


Assuntos
Neoplasias Hepáticas , Nanopartículas , Apoptose , Linhagem Celular , Humanos , Luminescência
8.
Appl Opt ; 61(3): 765-774, 2022 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-35200782

RESUMO

Using polarized light sensors to obtain only two-dimensional heading information does meet actual needs in navigation. Instead, an alternative method is proposed that uses the positional information of the Sun and geomagnetic information to calculate the three-dimensional attitude of a vehicle. First, the theoretical background of the polarization mode of skylight is described, and the scheme in using the atmospheric polarization pattern to calculate the solar position is presented. Second, the traditional three-axis attitude-determination (TRIAD) algorithm that exploits the solar position vector and the geomagnetic vector to obtain the three-dimensional attitude and the optimized TRIAD algorithm are introduced. Static and turntable experiments are described that verify the accuracy of the attitude calculation. Experimental results show that when using the optimized TRIAD algorithm, the root mean square errors for the roll angle, pitch angle, and heading angle are 0.1225°, 0.668°, and 1.0234°, respectively. This means that the optimized TRIAD algorithm performs significantly better than the traditional TRIAD algorithm and demonstrates that using the solar position and the geomagnetic information to obtain the three-dimensional attitude of the vehicle is very effective.

9.
Chem Commun (Camb) ; 58(19): 3142-3145, 2022 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-35174829

RESUMO

An unprecedented Ir-catalyzed enantioselective double allylic alkylation of less bulky cyclic imine glycinate (azlactone) was rationally designed and developed, providing various bisallylated chiral amino acid derivatives. Control experiments revealed that this transformation proceeds in a sequential manner featuring quasi-dynamic kinetic resolution of the initially-formed monoallylation intermediates.


Assuntos
Compostos Alílicos/química , Aminoácidos/síntese química , Irídio/química , Lactonas/química , Alquilação , Aminoácidos/química , Catálise , Estrutura Molecular , Estereoisomerismo
10.
Nutr Metab Cardiovasc Dis ; 32(4): 878-888, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35078677

RESUMO

BACKGROUND AND AIMS: We explored the associations among fruit consumption, physical activity, and their dose-response relationship with all-cause and cardiovascular disease (CVD) mortality in type 2 diabetic patients. METHODS AND RESULTS: We prospectively followed 20,340 community-dwelling type 2 diabetic patients aged 21-94 years. Information on diets and physical activity was collected using standardized questionnaires. All-cause and CVD mortality were assessed. Hazard ratios (HRs) for all-cause mortality were estimated with Cox regression models, and HRs for CVD mortality were derived from a competing risk model. Restricted cubic spline regression was used to analyze dose-response relationships. We identified 1362 deaths during 79,844 person-years. Compared to non-consumption, fruit consumption >42.9 g/d was inversely associated with all-cause mortality (HR 0.76; 95% CI 0.64-0.88), CVD mortality (HR 0.69, 0.51-0.94) and stroke mortality (HR 0.57, 0.36-0.89), but not with heart disease mortality (HR 0.93, 0.56-1.52). The HRs comparing the top vs bottom physical activity quartiles were 0.44 (0.37-0.53) for all-cause mortality, 0.46 (0.33-0.64) for CVD mortality, 0.46 (0.29-0.74) for stroke mortality and 0.51 (0.29-0.88) for heart disease mortality. Lower fruit consumption combined with a lower physical activity level was associated with a greater mortality risk. A nonlinear threshold of 80 g fruit/day was identified; all-cause mortality risk was reduced by approximately 24% at this value. A physical activity threshold of eight metabolic equivalents (MET) h/day was also identified, after which the risk of mortality did not decrease. CONCLUSIONS: Fruit consumption and physical activity may reduce all-cause, CVD, and stroke mortality in type 2 diabetic patients.


Assuntos
Doenças Cardiovasculares , Diabetes Mellitus Tipo 2 , Cardiopatias , Acidente Vascular Cerebral , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/diagnóstico , Exercício Físico , Seguimentos , Frutas , Humanos , Estudos Prospectivos , Fatores de Risco
11.
J Sport Health Sci ; 2022 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-35065296

RESUMO

BACKGROUND: The trade-off between the benefits of regular physical activity (PA) and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear. This study aimed to examine whether ambient fine particulate matter (PM2.5) exposure modified the impacts of PA volume and intensity on hypertension risk. METHODS: We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project. PA volume and intensity were assessed by questionnaire, and high-resolution (1×1 km) PM2.5 estimates were generated using a satellite-based model. RESULTS: During 413,516 person-years of follow-up, 12,100 incident hypertension cases were identified. PM2.5 significantly modified the relationship between PA and hypertension incidence (pinteraction < 0.001). Increased PA volume was negatively associated with incident hypertension in the low PM2.5 stratum (<59.8 µg/m3, ptrend < 0.001), with a hazard ratio (95% confidence interval (95%CI)) of 0.81 (0.74-0.88) when comparing the fourth with the first quartile of PA volume. However, the health benefits were not observed in the high PM2.5 stratum (≥59.8 µg/m3, ptrend = 0.370). Moreover, compared with light PA intensity, vigorous intensity was related to a 20% (95%CI: 9%-29%) decreased risk of hypertension for participants exposed to low PM2.5, but a 17% (95%CI: 4%-33%) increased risk for those with high PM2.5 levels. CONCLUSION: PA was associated with a reduced risk of hypertension only among participants with low PM2.5 exposure. Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.

12.
Acta Diabetol ; 59(3): 359-367, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34713323

RESUMO

AIMS: Obesity has been proposed to promote the progression of diabetic retinopathy (DR), but previous studies have not shown consistent results. We aimed to explore the association between generalized and abdominal obesity and DR risk, and to assess the joint effect of these two different types of obesity on DR development. METHODS: A nested case-control study within a large prospective study on type 2 diabetes was conducted in communities in Huai'an City, Jiangsu Province, China. Cases were individuals who had diagnoses of DR during the 6-year follow-up. A total number of 1544 DR cases and 1:1 matched controls were included. Binomial and multinomial logistic regression models were used to investigate the effects of obesity on DR occurrence and DR severity. RESULTS: Compared with individuals in the first tertile of the baseline waist-to-hip ratio (WHR), subjects in the third tertile at baseline had significantly higher risk of DR (OR 1.44, 95% CI 1.17-1.78) during the follow-up period. Conversely, body mass index (BMI) (continuous) had an adjusted OR of 0.97 (95% CI 0.95-0.99) of developing DR. Individuals with low BMI and high WHR levels were identified as a high-risk population with a higher likelihood of developing DR (OR 1.65, 95% CI 1.17-2.33) than those in the lowest BMI category and simultaneously in the first WHR tertile. CONCLUSIONS: Type 2 diabetic individuals with low BMI levels and high WHR levels had a significantly increased risk of developing DR which indicated that isolated abdominal obesity might be involved in the pathogenesis of DR.


Assuntos
Diabetes Mellitus Tipo 2 , Retinopatia Diabética , Índice de Massa Corporal , Estudos de Casos e Controles , China/epidemiologia , Estudos Transversais , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Retinopatia Diabética/epidemiologia , Retinopatia Diabética/etiologia , Humanos , Obesidade/complicações , Obesidade/epidemiologia , Obesidade Abdominal/complicações , Obesidade Abdominal/epidemiologia , Estudos Prospectivos , Fatores de Risco
13.
Sci Total Environ ; 811: 151619, 2022 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-34780816

RESUMO

Mangroves have the potential to affect climate via C sequestration and methane (CH4) emissions. With half of the world's mangroves lost during the 20th century, mangrove restoration in mitigating greenhouse gases has been increasingly recognized. However, the carbon exchanges during restored processes still remain large uncertain. In this study, we analyzed the temporal variations of CO2 and CH4 fluxes and their environmental controls during 2019 and 2020 based on a closed-path eddy covariance (EC) system in a 12-year restored subtropical mangrove wetland, in estuary of the Pearl River, southeastern China. We also estimated the CO2 and CH4 fluxes and their climate effect from the beginning of restoration by Random Forest algorithm (RF). The EC observations showed that annually the 12-year restored mangrove acted as CO2 and CH4 sources, with net CO2 ecosystem exchange (NEE) of 82-175 gC·m- 2·a-1 and CH4 fluxes of 24.7-26.3 gC·m-2·a-1. Low vegetation gross primary productivity (GPP) and high ecosystem respiration (Re) caused net CO2 emissions in the mangroves. The estimation by RF indicated that the mangroves were always a CO2 source after the beginning of restoration, but the annual NEE was linearly decreased from 233 to 131 gC·m-2·a-1 from 2008 to 2020. The annual CH4 emissions continually increased from 19.0 to 25.8 gC·m-2·a-1 after restoration. As a result, the restored mangrove had a positive effect on climate warming, with increased GWP from 1276 to 1386 g CO2-eq ·m-2·a-1 from 2008 to 2020. This is mainly due to lower GPP and higher Re by young restored mangroves, large water area as well as low salinity induced strong CH4 emissions. Our results indicate new sights that young restored mangrove with large area of water surface may act as carbon sources. However, the long-term climate and ecosystem benefits due to mangrove restoration should not be ignored in future.


Assuntos
Dióxido de Carbono , Áreas Alagadas , Dióxido de Carbono/análise , China , Ecossistema , Estuários , Metano/análise , Rios
14.
Environ Sci Pollut Res Int ; 29(14): 20593-20602, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34741264

RESUMO

The extensive application of chemically synthesized anionic surfactants would cause serious pollution of water and increase health risk to humans. However, the adverse impact of anionic surfactant on human cells has never been systematically demonstrated. In this paper, a series of fluorescent anionic surfactants containing a varying length of alkyl chain from C8 to C18 and a fixed hydrophilic head of 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) were synthesized and utilized for visualizing the interaction between surfactants and cells. The obtained molecules exhibited blue fluorescence presenting a decreasing fluorescent intensity with the increasing length of alkyl chain from C8 to C18 while showed the same sequence of HPTS-C16>HPTS-C18>HPTS-C12>HPTS-C8 on either surface activity, cellular adsorption, or cytotoxicity. In opposite, HPTS which contained no hydrophobic chain and thus exhibited no surface activity showed no cellular adsorption and cytotoxicity. It seems that the ligand of the appropriate chain length (C16) onto the hydrophilic HPTS molecules could cause the largest surface activity, the most distinguished cellular adsorption as well as the most adverse cytotoxicity. As reflected by the dynamic fluorescent visualization, the surfactant molecules of HPTS-C16 initially bound with cell membrane and entered into the intracellular lumen before finally localized at the endoplasmic reticulum (ER) and damaged it into a swollen structure. It is most likely that the structure of hydrophobic chain could determine the surface activities of surfactants and hence affect their cellular uptake and cytotoxicity. This study could help us to understand the adverse impact of anionic surfactant on human cells and its correlation with the surface activities or, in another word, the hydrophobic chain length.


Assuntos
Tensoativos , Água , Adsorção , Membrana Celular , Humanos , Interações Hidrofóbicas e Hidrofílicas , Tensoativos/química
16.
Sci China Life Sci ; 65(1): 119-128, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-33893978

RESUMO

Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease (CVD) and all-cause mortality was inconsistent. These associations were examined using a large-scale, population-based Chinese cohort comprising 100,728 participants. A food-frequency questionnaire was used to assess fruit and vegetable consumption. Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates. Cox proportional hazards regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). At the 736,668 person-years of follow-up, 3,677 CVD cases and 5,466 deaths were identified. The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1 (reference), 0.94 (95%CI=0.85-1.04), 0.89 (95%CI=0.80-0.98), and 0.85 (95% CI=0.11-0.95). Moreover, participants in the highest quartile displayed a 13% lower risk of all-cause mortality (HR=0.81; 95% CI=0.80-0.95). A nonlinear dose-response relation was found for CVD, without additional benefits beyond a consumption of 600 g d-1, whereas the all-cause mortality risk decreased along with higher consumption, with a linear trend. These associations remained significant for fruit consumption but not for vegetable consumption. Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all cause mortality. Increasing fruit and vegetable consumption, especially fruit, in the general population would prevent CVD and premature mortality.


Assuntos
Doenças Cardiovasculares/epidemiologia , Dieta , Frutas , Verduras , Adulto , Idoso , Doenças Cardiovasculares/mortalidade , Doenças Cardiovasculares/prevenção & controle , Causas de Morte , China/epidemiologia , Estudos de Coortes , Inquéritos sobre Dietas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade Prematura
17.
Rev Sci Instrum ; 92(11): 113703, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34852566

RESUMO

The quality of polarization images is easy to be affected by the noise in the image acquired by a polarization camera. Consequently, a de-noising method optimized with a Pulse Coupled Neural Network (PCNN) for polarization images is proposed for a Field-Programmable Gate Array (FPGA)-based polarization camera in this paper, in which the polarization image de-noising is implemented using an adaptive PCNN improved by Gray Wolf Optimization (GWO) and Bi-Dimensional Empirical Mode Decomposition (BEMD). Unlike other artificial neural networks, PCNN does not need to be trained, but the parameters of PCNN such as the exponential decay time constant, the synaptic junction strength factor, and the inherent voltage constant play a critical influence on its de-noising performance. GWO is able to start optimization by generating a set of random solutions as the first population and saves the optimized solutions of PCNN. In addition, BEMD can decompose a complicated image into different Bi-Dimensional Intrinsic Mode Functions with local stabilized characteristics according to the input source image, and the decomposition result is able to lower the complexity of heavy noise image analysis. Moreover, the circuit in the polarization camera is accomplished by FPGA so as to obtain the polarization image with higher quality synchronously. These two schemes are combined to attenuate different types of noises and improve the quality of the polarization image significantly. Compared with the state-of-the-art image de-noising algorithms, the noise in the polarization image is suppressed effectively by the proposed optimized image de-noising method according to the indices of peak signal-to-noise ratio, standard deviation, mutual information, structural similarity, and root mean square error.


Assuntos
Redes Neurais de Computação , Processamento de Sinais Assistido por Computador , Algoritmos , Processamento de Imagem Assistida por Computador , Razão Sinal-Ruído
18.
Biomed Environ Sci ; 34(11): 859-870, 2021 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-34955146

RESUMO

OBJECTIVE: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. METHODS: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment. RESULTS: The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio ( OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI): 1.86-3.50]. Compared with individuals in the first quartile (Q 1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q 2, Q 3, and Q 4) were 0.75 (95% CI: 0.58-0.96), 0.59 (95% CI: 0.44-0.79), and 0.62 (95% CI: 0.45-0.8), respectively. Compared with individuals in Q 1 of handgrip strength, the adjusted ORs for Q 2, Q 3, and Q 4 were 0.49 (95% CI: 0.38-0.62), 0.31 (95% CI: 0.23-0.41), and 0.30 (95% CI: 0.21-0.44), respectively. CONCLUSION: Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.


Assuntos
Disfunção Cognitiva/epidemiologia , Força da Mão , Perna (Membro)/anatomia & histologia , Sarcopenia/patologia , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Disfunção Cognitiva/etiologia , Feminino , Humanos , Modelos Logísticos , Masculino
19.
Front Mol Biosci ; 8: 785445, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34938775

RESUMO

Objective: Abnormal lipid metabolism has a close link to the pathophysiology of schizophrenia (SZ). This study mainly aimed to evaluate the association of variants at apolipoprotein A1 (APOA1) and APOA4 with SZ in a Chinese Han population. Methods: The rs5072 of APOA1 and rs1268354 of APOA4 were examined in a case-control study involving 2,680 patients with SZ from the hospital and 2,223 healthy controls screened by physical examination from the community population. The association was estimated with the odds ratio (OR) and 95% confidence intervals (95% CIs) by logistic regression. The APOA1 and APOA4 messenger RNA (mRNA) in peripheral blood leukocytes were measured by real-time PCR and compared between SZ cases and controls. Serum apoA1 levels were detected by turbidimetric inhibition immunoassay and high-density lipoprotein cholesterol (HDL-C) levels were detected by the homogeneous method. Results: Both of the rs5072 of APOA1 and rs1268354 of APOA4 had statistically significant associations with SZ. After adjustment for age and sex, ORs (95% CIs) of the additive model of rs5072 and rs1268354 were 0.82 (0.75-0.90) and 1.120 (1.03-1.23), and p-values were 3.22 × 10-5 and 0.011, respectively. The association of rs5072 with SZ still presented statistical significance even after Bonferroni correction (p-value×6). SZ patients during the episode presented lower levels of apoA1, HDL-C, mRNA of APOA1 common variants and transcript variant 4, and APOA4 mRNA than controls (p < 0.01) while SZ patients in remission showed a significantly decreased APOA1 transcript variant 3 expression level and increased APOA4 mRNA expression level (p < 0.01). mRNA expression levels of APOA1 transcript variant 4 significantly increased with the variations of rs5072 in SZ during the episode (p trend = 0.017). After the SZ patients received an average of 27.50 ± 9.90 days of antipsychotic treatment, the median (interquartile) of serum apoA1 in the SZ episode significantly increased from 1.03 (1.00.1.20) g/L to 1.08 (1.00.1.22) g/L with the p-value of 0.044. Conclusion: Our findings suggest that the genetic variations of APOA1 rs5072 and APOA4 rs1268354 contribute to the susceptibility of SZ, and the expression levels of APOA1 and APOA4 mRNA of peripheral blood leukocytes decreased in SZ patients during the episode while APOA4 increased after antipsychotic treatment.

20.
Front Cardiovasc Med ; 8: 745539, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34901209

RESUMO

Background: Dyslipidemia is one of the modifiable risk factors for cardiovascular diseases (CVD). Identifying subjects with lipid abnormality facilitates preventative interventions. Objectives: To evaluate the effects of lipid indices on the risks of ischemic stroke (IS), coronary heart disease (CHD), CVD, all-cause death, and CVD death. Methods: The cohort study of 4,128 subjects started in May 2009 and followed up to July 2020. Restricted cubic spline (RCS) regression analysis was used to explore the dose-response relationship between lipid indices with outcomes. Cox proportional hazard regression analysis was used to estimate the association with a hazard ratio (HR) and 95% CI. Results: RCS analysis showed that there were significant linear associations of TG with IS, non-high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (ApoB), and total cholesterol (TC)/HDL-C ratio with all-cause death, non-HDL-C and RC with CVD death, and significant non-linear associations of ApoB with IS and CVD, TC, LDL-C, ApoAI, and TC/HDL-C ratio with CHD, and TC with all-cause death (all P <0.1). Cox regression analysis revealed that subjects with TC <155 mg/dl (vs. 155-184 mg/dl), > 185 mg/dl (vs. 155-184 mg/dl), and ApoB <0.7 g/l (vs. ≥0.7 g/l) had higher risks of CHD (P < 0.05), the adjusted HRs (95% CIs) were 1.933 (1.248-2.993), 1.561 (1.077-2.261), and 1.502 (1.01-2.234), respectively. Subjects with ApoAI > 2.1 g/l (vs. 1.6-2.1 g/l) and TG <80 mg/dl (vs. 80-177 mg/dl) had higher risks of CVD and all-cause death (P < 0.05), the adjusted HRs (95% CIs) were 1.476 (1.031-2.115) and 1.234 (1.002-1.519), respectively. Conclusions: Lower or higher levels of TC, higher level of ApoAI, and lower level of ApoB were associated with increased risks of CVD, and lower level of TG was associated with increased all-cause death. Maintaining optimal lipid levels would help to prevent CVD and reduce mortality.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...