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1.
Adv Mater ; : e2109718, 2022 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-34990512

RESUMO

Membrane distillation has attracted great attention in the development of sustainable desalination and zero-discharge processes because of its possibility to recover 100% water and the potential to integrate with low-grade heat such as solar energy. However, the conventional membrane structures and materials afford limited flux thus obstructing its practical application. Here we report ultrathin nanoporous graphene membranes by selectively forming thin graphene layers on the top edges of highly porous anodic alumina oxide support, which creates short and fast transport pathways for water vapor but not liquid. The process avoids the challenging pore-generation and substrate-transfer processes required to prepare regular graphene membranes. In the direct contact membrane distillation mode under a mild temperature pair of 65°C /25°C, the nanoporous graphene membranes show an average water flux of 421.7 Lm-2 h-1 with over 99.8% salt rejection, which is an order of magnitude higher than any reported polymeric membranes. The mechanism for high water flux is revealed by detailed characterizations and theoretical modeling. Outdoor field tests using Red Sea water heated under direct sunlight radiation show that the membranes have an average water flux of 86.3 Lm-2 h-1 from 8 am. to 8 pm., showing a great potential for real applications in seawater desalination. This article is protected by copyright. All rights reserved.

2.
J Mol Biol ; : 167380, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34838806

RESUMO

While bacteria can be beneficial to our health, their deadly pathogenic potential has been an ever-present concern exacerbated by the emergence of drug-resistant strains. As such, there is a pressing urgency for an enhanced understanding of their gene function and regulation, which could mediate the development of novel antimicrobials. Transcriptomic analyses have been established as insightful and indispensable to the functional characterization of genes and identification of new biological pathways, but in the context of bacterial studies, they remain limited to species-specific datasets. To address this, we integrated the genomic and transcriptomic data of the 17 most notorious and researched bacterial pathogens, creating bacteria.guru, an interactive database that can identify, visualize, and compare gene expression profiles, coexpression networks, functionally enriched clusters, and gene families across species. Through illustrating antibiotic resistance mechanisms in P. aeruginosa, we demonstrate that bacteria.guru could potentially aid in discovering multi-faceted antibiotic targets and, overall, facilitate future bacterial research. AVAILABILITY: The database and coexpression networks are freely available from https://bacteria.guru/. Sample annotations can be found in the supplemental data.

3.
Front Neurol ; 12: 692128, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34764924

RESUMO

Objectives: To investigate the predictive factors for successful recanalization based on digital subtraction angiography and three-dimensional T1W sampling perfection with application-optimized contrasts using different flip angle evolutions (3D T1-SPACE) high-resolution magnetic resonance imaging (MRI) signal features. Methods: Consecutive internal carotid artery occlusion cases with ipsilateral ischemic stroke refractory to therapy who visited our institution between February 2017 and August 2020 were retrospectively analyzed. Epidemiology, symptomatology, imaging morphology on angiography and MRI, peri-procedural complications, technical success rate, and follow-up results were summarized. Factors related to technical success were analyzed using univariate and multivariate analyses. Results: In total, 75 cases (53 men, mean age 57.51 ± 9.71 years) were included. The total successful recanalization rate was 72.00% (54/75), with a complication rate of 13.33% (9/75). Through multivariate analysis, first ischemic stroke in <3 months (OR: 2.57; 95% CI: 1.13-4.58), tapered stump (OR: 4.31; 95% CI: 1.37-13.55), reversed flow of the ophthalmic artery (OR: 2.99; 95% CI: 1.06-8.49), high intraluminal signal on unenhanced T1-SPACE sequence (OR: 16.15; 95% CI: 3.40-76.72), no vessel wall collapse (OR: 17.00; 95% CI: 3.57-81.02), short occlusion length (OR: 9.87; 95% CI: 2.09-46.64), and primary occlusion site at the cervical internal carotid artery (OR: 8.42; 95% CI: 1.04-68.19) were associated with successful recanalization. Conclusion: Besides traditional features such as short ischemic event time, tapered stump, and distal ICA reconstitution by the ophthalmic artery, our study demonstrates that luminal and mural changes determined by 3D SPACE high-resolution MRI could also predict successful endovascular recanalization. Endovascular recanalization for non-acute internal carotid artery occlusion is feasible, but prudent case selection is mandatory considering the high periprocedural complication rate.

4.
Mater Horiz ; 2021 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-34586118

RESUMO

Recent advances in wearable and implantable electronics have increased the demand for biocompatible integrated energy storage systems. Conducting polymers, such as polyaniline (PANi), have been suggested as promising electrode materials for flexible biocompatible energy storage systems, based on their intrinsic structural flexibility and potential polymer chain compatibility with biological interfaces. However, due to structural disorder triggering insufficient electronic conductivity and moderate electrochemical stability, PANi still cannot fully satisfy the requirements for flexible and biocompatible energy storage systems. Herein, we report a biocompatible physiological electrolyte activated flexible supercapacitor encompassing crystalline tetra-aniline (c-TANi) as the active electrode material, which significantly enhances the specific capacitance and electrochemical cycling stability with chloride electrochemical interactions. The crystallization of TANi endows it with sufficient electronic conductivity (8.37 S cm-1) and a unique Cl- dominated redox charge storage mechanism. Notably, a fully self-healable and biocompatible supercapacitor has been assembled by incorporating polyethylene glycol (PEG) with c-TANi as a self-healable electrode and a ferric-ion cross-linked sodium polyacrylate (Fe3+-PANa)/0.9 wt% NaCl as a gel electrolyte. The as-prepared device exhibits a remarkable capacitance retention even after multiple cut/healing cycles. With these attractive features, the c-TANi electrode presents a promising approach to meeting the power requirements for wearable or implantable electronics.

5.
Adv Mater ; 33(29): e2006836, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34096113

RESUMO

Macromolecular films are crucial functional materials widely used in the fields of mechanics, electronics, optoelectronics, and biology, due to their superior properties of chemical stability, small density, high flexibility, and solution-processing ability. Their electronic and mechanical properties, however, are typically much lower than those of crystalline materials, as the macromolecular films have no long-range structural ordering. The state-of-the-art for producing highly ordered macromolecular films is still facing a great challenge due to the complex interactions between adjacent macromolecules. Here, the growth of textured macromolecular films on a designed graphene/high-index copper (Cu) surface is demonstrated. This successful growth is driven by a patterned potential that originates from the different amounts of charge transfer between the graphene and Cu surfaces with, alternately, terraces and step edges. The textured films exhibit a remarkable improvement in remnant ferroelectric polarization and fracture strength. It is also demonstrated that this growth mechanism is universal for different macromolecules. As meter-scale graphene/high-index Cu substrates have recently become available, the results open a new regime for the production and applications of highly ordered macromolecular films with obvious merits of high production and low cost.

6.
Membranes (Basel) ; 10(8)2020 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-32722028

RESUMO

Enhancing the water flux while maintaining the high salt rejection of existing reverse osmosis membranes remains a considerable challenge. Herein, we report the use of a porous carbon nitride (C3N4) nanoparticle to potentially improve both the water flux and salt rejection of the state-of-the-art polyamide (PA) thin film composite (TFC) membranes. The organic-organic covalent bonds endowed C3N4 with great compatibility with the PA layer, which positively influenced the customization of interfacial polymerization (IP). Benefitting from the positive effects of C3N4, a more hydrophilic, more crumpled thin film nanocomposite (TFN) membrane with a larger surface area, and an increased cross-linking degree of PA layer was achieved. Moreover, the uniform porous structure of the C3N4 embedded in the "ridge" sections of the PA layer potentially provided additional water channels. All these factors combined provided unprecedented performance for seawater desalination among all the PA-TFC membranes reported thus far. The water permeance of the optimized TFN membrane is 2.1-folds higher than that of the pristine PA-TFC membrane, while the NaCl rejection increased to 99.5% from 98.0%. Our method provided a promising way to improve the performance of the state-of-art PA-TFC membranes in seawater desalination.

7.
Adv Mater ; 32(16): e1907619, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32108394

RESUMO

Electron microscopy allows the extraction of multidimensional spatiotemporally correlated structural information of diverse materials down to atomic resolution, which is essential for figuring out their structure-property relationships. Unfortunately, the high-energy electrons that carry this important information can cause damage by modulating the structures of the materials. This has become a significant problem concerning the recent boost in materials science applications of a wide range of beam-sensitive materials, including metal-organic frameworks, covalent-organic frameworks, organic-inorganic hybrid materials, 2D materials, and zeolites. To this end, developing electron microscopy techniques that minimize the electron beam damage for the extraction of intrinsic structural information turns out to be a compelling but challenging need. This article provides a comprehensive review on the revolutionary strategies toward the electron microscopic imaging of beam-sensitive materials and associated materials science discoveries, based on the principles of electron-matter interaction and mechanisms of electron beam damage. Finally, perspectives and future trends in this field are put forward.

8.
Sci Adv ; 5(11): eaax6976, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31701005

RESUMO

The synthesis of support materials with suitable coordination sites and confined structures for the controlled growth of ultrasmall metal nanoparticles is of great importance in heterogeneous catalysis. Here, by rational design of a cross-linked ß-cyclodextrin polymer network (CPN), various metal nanoparticles (palladium, silver, platinum, gold, and rhodium) of subnanometer size (<1 nm) and narrow size distribution are formed via a mild and facile procedure. The presence of the metal coordination sites and the network structure are key to the successful synthesis and stabilization of the ultrasmall metal nanoparticles. The as-prepared CPN, loaded with palladium nanoparticles, is used as a heterogeneous catalyst and shows outstanding catalytic performance in the hydrogenation of nitro compounds and Suzuki-Miyaura coupling reaction under mild conditions. The CPN support works synergistically with the metal nanoparticles, achieving high catalytic activity and selectivity. In addition, the catalytic activity of the formed catalyst is controllable.

9.
Sensors (Basel) ; 19(20)2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31658617

RESUMO

Hospitals need to invest a lot of manpower to manually input the contents of medical invoices (nearly 300,000,000 medical invoices a year) into the medical system. In order to help the hospital save money and stabilize work efficiency, this paper designed a system to complete the complicated work using a Gaussian blur and smoothing-convolutional neural network combined with a recurrent neural network (GBS-CR) method. Gaussian blur and smoothing (GBS) is a novel preprocessing method that can fix the breakpoint font in medical invoices. The combination of convolutional neural network (CNN) and recurrent neural network (RNN) was used to raise the recognition rate of the breakpoint font in medical invoices. RNN was designed to be the semantic revision module. In the aspect of image preprocessing, Gaussian blur and smoothing were used to fix the breakpoint font. In the period of making the self-built dataset, a certain proportion of the breakpoint font (the font of breakpoint is 3, the original font is 7) was added, in this paper, so as to optimize the Alexnet-Adam-CNN (AA-CNN) model, which is more suitable for the recognition of the breakpoint font than the traditional CNN model. In terms of the identification methods, we not only adopted the optimized AA-CNN for identification, but also combined RNN to carry out the semantic revisions of the identified results of CNN, meanwhile further improving the recognition rate of the medical invoices. The experimental results show that compared with the state-of-art invoice recognition method, the method presented in this paper has an average increase of 10 to 15 percentage points in recognition rate.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Redes Neurais de Computação , Algoritmos , Humanos , Distribuição Normal , Semântica
10.
Nat Commun ; 10(1): 4913, 2019 10 29.
Artigo em Inglês | MEDLINE | ID: mdl-31664025

RESUMO

Wearable and portable self-powered units have stimulated considerable attention in both the scientific and technological realms. However, their innovative development is still limited by inefficient bulky connections between functional modules, incompatible energy storage systems with poor cycling stability, and real safety concerns. Herein, we demonstrate a flexible solar-charging integrated unit based on the design of printed magnesium ion aqueous asymmetric supercapacitors. This power unit exhibits excellent mechanical robustness, high photo-charging cycling stability (98.7% capacitance retention after 100 cycles), excellent overall energy conversion and storage efficiency (ηoverall = 17.57%), and outstanding input current tolerance. In addition, the Mg ion quasi-solid-state asymmetric supercapacitors show high energy density up to 13.1 mWh cm-3 via pseudocapacitive ion storage as investigated by an operando X-ray diffraction technique. The findings pave a practical route toward the design of future self-powered systems affording favorable safety, long life, and high energy.

11.
ACS Omega ; 4(9): 13972-13980, 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31497715

RESUMO

A simple and low-cost polymer-aided sol-gel method was developed to prepare γ-Al2O3 protective layers for LiNi0.6Co0.2Mn0.2O2 (NCM622) cathode materials. The selected polyvinyl alcohol polymer additive not only facilitates the formation of a uniform and thin γ-Al2O3 layer on the irregular and rough cathode particle surface to protect it from corrosion but also serves as a pore-forming agent to generate micropores in the film after sintering to allow fast transport of lithium ions, which guaranteed the excellent and stable battery performance at high working voltage. Detailed studies in the full battery mode showed that the leached corrosion species from the cathode had a more profound harmful effect to the graphite anode, which seemed to be the dominating factor that caused the battery performance decay.

12.
Sensors (Basel) ; 18(12)2018 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-30513898

RESUMO

In order to solve the problem of face recognition in complex environments being vulnerable to illumination change, object rotation, occlusion, and so on, which leads to the imprecision of target position, a face recognition algorithm with multi-feature fusion is proposed. This study presents a new robust face-matching method named SR-CNN, combining the rotation-invariant texture feature (RITF) vector, the scale-invariant feature transform (SIFT) vector, and the convolution neural network (CNN). Furthermore, a graphics processing unit (GPU) is used to parallelize the model for an optimal computational performance. The Labeled Faces in the Wild (LFW) database and self-collection face database were selected for experiments. It turns out that the true positive rate is improved by 10.97⁻13.24% and the acceleration ratio (the ratio between central processing unit (CPU) operation time and GPU time) is 5⁻6 times for the LFW face database. For the self-collection, the true positive rate increased by 12.65⁻15.31%, and the acceleration ratio improved by a factor of 6⁻7.


Assuntos
Identificação Biométrica/métodos , Face/anatomia & histologia , Reconhecimento Facial , Redes Neurais de Computação , Algoritmos , Bases de Dados Factuais , Humanos , Processamento de Imagem Assistida por Computador/métodos
13.
ACS Appl Mater Interfaces ; 10(50): 44041-44049, 2018 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-30457321

RESUMO

The predominant method to prepare polymer membranes is based on phase inversion. However, this method always leads to a dense skin with low porosity when normal polymers are used. Using the self-assembly of certain block copolymers, it is possible to prepare uniform pores with high porosity, but the prices of these polymers are too high to be afforded in practical applications. Here, we report a novel strategy to prepare highly porous and asymmetric polymer membranes using the widely used poly(vinylidene fluoride) (PVDF) as a prototype. The method combines spinodal decomposition with phase inversion utilizing mixed solvents that have the unique upper critical solution temperature phase behavior. The spinodal decomposition generates a thin surface layer containing a high density of relatively uniform pores in the mesoporous range, and the phase inversion generates a thick bulk layer composed of macrovoids; the two types of structures are interconnected, yielding a highly permeable, selective, and mechanically strong porous membrane. The membranes show an order of magnitude higher water permeance than commercial membranes and efficient molecular sieving of macromolecules. Notably, our strategy provides a general toolbox to prepare highly porous membranes from normal polymers. By blending PVDF with cellulose acetate (CA), a highly porous PVDF/CA membrane was prepared and showed similarly high separation performance, but the higher hydrophilicity of CA improved the membrane flux in the presence of proteins.

14.
J Am Chem Soc ; 140(43): 14342-14349, 2018 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-30289708

RESUMO

Two-dimensional (2D) covalent organic framework (COF) materials have the most suitable microstructure for membrane applications in order to achieve both high flux and high selectivity. Here, we report the synthesis of a crystalline TFP-DHF 2D COF membrane constructed from two precursors of 1,3,5-triformylphloroglucinol (TFP) and 9,9-dihexylfluorene-2,7-diamine (DHF) through the Langmuir-Blodgett (LB) method, for the first timed. A single COF layer is precisely four unit cells thick and can be transferred to different support surfaces layer by layer. The TFP-DHF 2D COF membrane supported on an anodic aluminum oxide (AAO) porous support displayed remarkable permeabilities for both polar and nonpolar organic solvents, which were approximately 100 times higher than that of the amorphous membranes prepared by the same procedure and similar to that for the best of the reported polymer membranes. The transport mechanism through the TFP-DHF 2D COF membrane was found to be a viscous flow coupled with a strong slip boundary enhancement, which was also different from those of the amorphous polymer membranes. The membrane exhibited a steep molecular sieving with a molecular weight retention onset (MWRO) of approximately 600 Da and a molecular weight cutoff (MWCO) of approximately 900 Da. The substantial performance enhancement was attributed to the structural change from an amorphous structure to a well-defined ordered porous structure, which clearly demonstrated the high potential for the application of 2D COFs as the next generation of membrane materials.

15.
ACS Appl Mater Interfaces ; 10(15): 12295-12299, 2018 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-29620857

RESUMO

We demonstrated here a novel and facile synthesis of two-dimensional (2D) covalent organic thin film with pore size around 1.5 nm using a planar, amphiphilic and substituted heptacyclic truxene based triamine and a simple dialdehyde as building blocks by dynamic imine bond formation at the air/water interface using Langmuir-Blodgett (LB) method. Optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM), all unanimously showed the formation of large, molecularly thin and free-standing membrane that can be easily transferred on different substrate surfaces. The 2D membrane supported on a porous polysulfone showed a rejection rate of 64 and 71% for NaCl and MgSO4, respectively, and a clear molecular sieving at molecular size around 1.3 nm, which demonstrated a great potential in the application of pretreatment of seawater desalination and separation of organic molecules.

16.
Neurosci Lett ; 662: 205-212, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-29061392

RESUMO

OBJECTIVE: Cerebral venous sinus thrombosis (CVST) is a life-threatening disease with high misdiagnosis and mortality rates due to its complex etiology and unknown pathophysiology. The present study aimed to establish an animal model suitable for assessing the pathophysiology of CVST and develop treatment methods. METHODS: 40% ferric chloride (FeCl3) was administered for 5min followed by thrombin injection to induce superior sagittal sinus thrombosis (SSST). Digital subtraction angiography (DSA) was performed to ensure thrombosis and evaluate the recanalization rate 7days post-CVST. Neurological evaluation, Evans blue injection, 2,3,5-Triphenyltetrazolium chloride (TTC), and hematoxylin-eosin (H&E) staining were used to assess thrombosis and the accompanying brain parenchyma. RESULTS: SSST was detected in all model rabbits, with a thrombus recanalization rate of 10%. Brain infarction, hemorrhage, cell edema, and disruption of the blood-brain barrier (BBB) were also observed. CONCLUSION: The method of inducing cerebral venous sinus thrombosis by applying 40% FeCl3 and injecting thrombin is feasible and efficient. This experimental model mimics the pathogenesis and pathophysiology of actual CVST.


Assuntos
Cloretos/administração & dosagem , Modelos Animais de Doenças , Compostos Férricos/administração & dosagem , Trombose dos Seios Intracranianos/induzido quimicamente , Trombina/administração & dosagem , Animais , Barreira Hematoencefálica/efeitos dos fármacos , Barreira Hematoencefálica/metabolismo , Encéfalo/efeitos dos fármacos , Encéfalo/patologia , Masculino , Coelhos , Trombose dos Seios Intracranianos/patologia , Trombose dos Seios Intracranianos/fisiopatologia
17.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 48(3): 373-377, 2017 May.
Artigo em Chinês | MEDLINE | ID: mdl-28616909

RESUMO

OBJECTIVES: To investigate the expression of migration-inducing gene 7 (MIG7) in different HCC lines and its relationship with vasculogenic mimicry (VM) formation and metastatic potentiality. METHODS: Employing immunostaining to detect MIG7 protein expression and VM formation in 40 matched pairs of primary and metastatic HCC specimens from 40 patients, and investigating the correlation of VM formation with MIG7 protein expression. Detecting VM formation in HCC lines with different metastatic ability (MHCC-97H, MHCC-97L, Huh-7) and human normal hepatocyte line (L-02) through three-dimensional culture, and detecting MIG7 mRNA expression with RT-PCR, investigating the correlation of MIG7 protein expression with VM formation and HCC metastatic potentiality with Western blot assay; screening the HCC cell line with high MIG7 expression. RESULTS: In 40 matched pairs of HCC tissue, there was a significant positive correlation between MIG7 protein expression and VM formation ( rs=0.595, P<0.01). The capability of VM formation of MHCC-97H with high metastatic potentiality was stronger than that of MHCC-97L with low metastatic potentiality and Huh-7 with non-metastatic potentiality, and there was no VM formation in L-02. The result of RT-PCR and Western blot assay indicated the same. CONCLUSIONS: MIG7 expression in HCC tissue is high and correlated positively with VM formation. MIG7 expression in different HCC cell lines is coincident with theirs VM formation, invasion and metastasis. MIG7 is a potential target for inhibiting the invasion and metastasis of HCC.


Assuntos
Carcinoma Hepatocelular/patologia , Neoplasias Hepáticas/patologia , Proteínas de Neoplasias/metabolismo , Neovascularização Patológica , Carcinoma Hepatocelular/metabolismo , Linhagem Celular Tumoral , Humanos , Neoplasias Hepáticas/metabolismo , Metástase Neoplásica
18.
Chem Commun (Camb) ; 53(52): 7011-7014, 2017 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-28620657

RESUMO

Layered zeolite precursors were successfully exfoliated by brief shearing or sonication with the assistance of commercially available telechelic liquid polybutadienes at room temperature. The exfoliated zeolite nanosheets can form a stable suspension in an organic solvent, providing exciting potential for the fabrication of zeolite membranes, composite materials and hierarchical zeolites.

19.
Nan Fang Yi Ke Da Xue Xue Bao ; 36(11): 1482-1488, 2016 Nov 20.
Artigo em Chinês | MEDLINE | ID: mdl-27881337

RESUMO

OBJECTIVE: To explore the inhibitory effect of migration-inducing gene 7 (Mig-7) gene silencing induced by retroviral-mediated small hairpin RNA (shRNA) on vasculogenic mimicry (VM), invasion and metastasis of human hepatocellular carcinoma (HCC) cells in vitro. METHODS: Two target sequences (Mig-7 shRNA-1 and Mig-7 shRNA-2) and one negative control sequence (Mig-7 shRNA-N) were synthesized. The recombinant retroviral vectors carrying Mig-7 shRNA were constructed, and HCC cell line MHCC-97H were transfected with Mig-7 shRNA-1, Mig-7 shRNA-2, Mig-7 shRNA-N, or the empty vector, or treated with 125 µg/mL recombinant human endostatin (ES). Mig-7 expression in the treated cells was detected using semi-quantitative PCR and Western blotting. The inhibitory effect of Mig-7 silencing on VM formation was investigated in a 3-dimensional cell culture system; the changes in cell adhesion, invasion and migration were assessed with intercellular adhesion assay, Transwell invasion assay and Transwell migration assay, respectively. RESULTS: The expression of Mig-7 at both mRNA and protein levels decreased significantly, VM formation, invasion and metastasis were suppressed, while intercellular adhesion increased significantly in MHCC-97H cells in Mig-7 shRNA-1 and Mig-7 shRNA-2 groups (P<0.05); such changes were not observed in cells transfected with Mig-7 shRNA-N or the empty vector, nor in cells treated with ES. CONCLUSIONS: Mig-7 silencing by retroviral-mediated shRNA significantly inhibits VM formation, invasion and metastasis and increases the intercellular adhesion of the HCC cells, while ES does not have such inhibitory effects.


Assuntos
Carcinoma Hepatocelular/patologia , Inativação Gênica , Neoplasias Hepáticas/patologia , Proteínas de Neoplasias/genética , RNA Interferente Pequeno , Carcinoma Hepatocelular/genética , Linhagem Celular Tumoral , Endostatinas , Vetores Genéticos , Humanos , Neoplasias Hepáticas/genética , RNA Mensageiro , Retroviridae , Transfecção
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