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1.
Cell Death Discov ; 7(1): 339, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34750369

RESUMO

The uncontrolled inflammatory response caused by a disorder in inflammation resolution is one of the reasons for acute respiratory distress syndrome (ARDS). The macrophage pool markedly expands when inflammatory monocytes, known as recruited macrophages, migrate from the circulation to the lung. The persistent presence of recruited macrophages leads to chronic inflammation in the resolution phase of inflammation. On the contrary, elimination of the recruited macrophages at the injury site leads to the rapid resolution of inflammation. Resolvin D1 (RvD1) is an endogenous lipid mediator derived from docosahexaenoic acid. Mice were administered RvD1 via the tail vein 3 and 4 days after stimulation with lipopolysaccharide. RvD1 reduced the levels of the inflammatory factors in the lung tissue, promoted the anti-inflammatory M2 phenotype, and enhanced the phagocytic function of recruited macrophages to alleviate acute lung injury. We also found that the number of macrophages was decreased in BAL fluid after treatment with RvD1. RvD1 increased the apoptosis of recruited macrophages partly via the FasL-FasR/caspase-3 signaling pathway, and this effect could be blocked by Boc-2, an ALX/PRP2 inhibitor. Taken together, our findings reinforce the concept of therapeutic targeting leading to the apoptosis of recruited macrophages. Thus, RvD1 may provide a new therapy for the resolution of ARDS.

2.
J Pharmacol Exp Ther ; 379(2): 156-165, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34465632

RESUMO

Acute respiratory distress syndrome (ARDS), a common and fatal clinical condition, is characterized by the destruction of epithelium and augmented permeability of the alveolar-capillary barrier. Resolvin conjugates in tissue regeneration 1 (RCTR1) is an endogenous lipid mediator derived from docosahexaenoic acid , exerting proresolution effects in the process of inflammation. In our research, we evaluated the role of RCTR1 in alveolar fluid clearance (AFC) in lipopolysaccharide-induced ARDS/acute lung injury (ALI) rat model. Rats were injected with RCTR1 (5 µg/kg) via caudal veins 8 hours after lipopolysaccharide (LPS) (14 mg/kg) treatment, and then AFC was estimated after 1 hour of ventilation. Primary type II alveolar epithelial cells were incubated with LPS (1 ug/ml) with or without RCTR1 (10 nM) for 8 hours. Our results showed that RCTR1 significantly enhanced the survival rate, promoted the AFC, and alleviated LPS-induced ARDS/ALI in vivo. Furthermore, RCTR1 remarkably elevated the protein expression of sodium channels and Na, K-ATPase and the activity of Na, K-ATPase in vivo and in vitro. Additionally, RCTR1 also decreased neural precursor cell expressed developmentally downregulated 4-2 (Nedd4-2) level via upregulating Ser473-phosphorylated-Akt expression. Besides this, inhibitors of receptor for lipoxin A4 (ALX), cAMP, and phosphatidylinositol 3-kinase (PI3K) (BOC-2, KH-7, and LY294002) notably inhibited the effects of RCTR1 on AFC. In summary, RCTR1 enhances the protein levels of sodium channels and Na, K-ATPase and the Na, K-ATPase activity to improve AFC in ALI through ALX/cAMP/PI3K/Nedd4-2 pathway, suggesting that RCTR1 may become a therapeutic drug for ARDS/ALI. SIGNIFICANCE STATEMENT: RCTR1, an endogenous lipid mediator, enhanced the rate of AFC to accelerate the resolution of inflammation in the LPS-induced murine lung injury model. RCTR1 upregulates the expression of epithelial sodium channels (ENaCs) and Na, K-ATPase in vivo and in vitro to accelerate the AFC. The efficacy of RCTR1 on the ENaC and Na, K-ATPase level was in an ALX/cAMP/PI3K/Nedd4-2-dependent manner.

3.
Chin J Integr Med ; 27(8): 563-569, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34319572

RESUMO

Early studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical resistance. New devices are developing to increase the reliability of electrical skin impedance measurements for counteracting the factors including skin dryness, skin thickness, size of the sensing electrode, pressure applied on the electrode, interelectrode distance, room temperature, and humidity. Morphological studies have identified that blood vessels, hair follicles, and nervous components are enhanced in the meridians/acupoints, which represent areas of potentially high neuronal activity. Recent evidence shows that nitric oxide (NO) concentrations are enhanced in skin acupoints/meridians. L-arginine-derived NO synthesis modifies skin norepinephrine (NE) synthesis/release in acupoints/meridians, and NO-NE activations play an important role in mediating the skin conductance responses to electrical stimulation. NOergic signaling molecules interact with gap junction and transient receptor potential vanilloid type-1. Other studies reported that the high conductance at acupoints is a result of the release of the neuropeptides substance P and calcitonin gene-related peptide during neurogenic inflammation in the referred pain area. Pathological body conditions caused considerable changes in skin conductance or impedance at acupoints. Although systematic research with an improved equipment and research design to avoid the influencing factors are requested for a definite answer in this field, the results from anatomical and biochemical studies consistently show that acupoints exist higher levels of nervous components, and NOergic signaling molecules and neuropeptides involved in the skin low resistance at acupoints. The increased interest in the acupoints/meridians has led to an open-minded attitude towards understanding this system, which is fundamental important to establish the valid aspects of scientific basis of Chinese medicine mechanisms and therapies.


Assuntos
Pontos de Acupuntura , Impedância Elétrica , Meridianos , Neuropeptídeos , Reprodutibilidade dos Testes
4.
Nat Neurosci ; 24(7): 1035-1045, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33972800

RESUMO

Advanced technologies for controlled delivery of light to targeted locations in biological tissues are essential to neuroscience research that applies optogenetics in animal models. Fully implantable, miniaturized devices with wireless control and power-harvesting strategies offer an appealing set of attributes in this context, particularly for studies that are incompatible with conventional fiber-optic approaches or battery-powered head stages. Limited programmable control and narrow options in illumination profiles constrain the use of existing devices. The results reported here overcome these drawbacks via two platforms, both with real-time user programmability over multiple independent light sources, in head-mounted and back-mounted designs. Engineering studies of the optoelectronic and thermal properties of these systems define their capabilities and key design considerations. Neuroscience applications demonstrate that induction of interbrain neuronal synchrony in the medial prefrontal cortex shapes social interaction within groups of mice, highlighting the power of real-time subject-specific programmability of the wireless optogenetic platforms introduced here.


Assuntos
Optogenética/instrumentação , Comportamento Social , Tecnologia sem Fio/instrumentação , Animais , Camundongos
5.
Proc Natl Acad Sci U S A ; 118(18)2021 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-33903240

RESUMO

Inorganic semiconductor-based microscale light-emitting diodes (micro-LEDs) have been widely considered the key solution to next-generation, ubiquitous lighting and display systems, with their efficiency, brightness, contrast, stability, and dynamic response superior to liquid crystal or organic-based counterparts. However, the reduction of micro-LED sizes leads to the deteriorated device performance and increased difficulties in manufacturing. Here, we report a tandem device scheme based on stacked red, green, and blue (RGB) micro-LEDs, for the realization of full-color lighting and displays. Thin-film micro-LEDs (size ∼100 µm, thickness ∼5 µm) based on III-V compound semiconductors are vertically assembled via epitaxial liftoff and transfer printing. A thin-film dielectric-based optical filter serves as a wavelength-selective interface for performance enhancement. Furthermore, we prototype arrays of tandem RGB micro-LEDs and demonstrate display capabilities. These materials and device strategies provide a viable path to advanced lighting and display systems.

6.
Sci Adv ; 6(50)2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33310851

RESUMO

Peripheral nerve regeneration remains one of the greatest challenges in regenerative medicine. Deprivation of sensory and/or motor functions often occurs with severe injuries even treated by the most advanced microsurgical intervention. Although electrical stimulation represents an essential nonpharmacological therapy that proved to be beneficial for nerve regeneration, the postoperative delivery at surgical sites remains daunting. Here, a fully biodegradable, self-electrified, and miniaturized device composed of dissolvable galvanic cells on a biodegradable scaffold is achieved, which can offer both structural guidance and electrical cues for peripheral nerve regeneration. The electroactive device can provide sustained electrical stimuli beyond intraoperative window, which can promote calcium activity, repopulation of Schwann cells, and neurotrophic factors. Successful motor functional recovery is accomplished with the electroactive device in behaving rodent models. The presented materials options and device schemes provide important insights into self-powered electronic medicine that can be critical for various types of tissue regeneration and functional restoration.

7.
Opt Express ; 28(21): 32124-32131, 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33115175

RESUMO

Very limited 1-3 pairs of quantum-wells (QWs) are preferred for GaN-based laser diodes (LDs), which require more careful engineering of the carrier transport than LEDs. In this work, the first-barrier doping level of QWs is found to significantly affect the carrier confinement and distribution for GaN-based LDs. The first-barrier doping exceeding 2×1018 cm-3 will make the bottom QW return to the parasitic state, yielding unexpected photons absorption and even Auger recombination. The underlying physical mechanism is discussed in terms of the calculated energy-band diagram, carrier confinement, and distribution. And all the experimental findings are consistent with the physical model.

8.
Huan Jing Ke Xue ; 41(9): 3899-3907, 2020 Sep 08.
Artigo em Chinês | MEDLINE | ID: mdl-33124268

RESUMO

To study the seasonal pollution characteristics and sources of water-soluble inorganic ions in atmospheric PM2.5 in Suqian City, 171 samples were collected at three monitoring points, which were in the water vapor channel, from May 2017 to January 2018. The mass concentrations of PM2.5 and nine water-soluble inorganic ions were analyzed. The results showed that the annual average concentration of water-soluble inorganic ions in PM2.5 in Suqian City was (44.08±34.61) µg ·m-3, accounting for 41.8% of PM2.5. The concentrations of these species were in the order of ρ(NO3-) > ρ(SO42-) > ρ(NH4+) > ρ(ρl-) > ρ(Na+) > ρ(Ca2+) > ρ(K+) > ρ(F-) > ρ(Mg2+); NO3-, SO42-, and NH4+ accounted for 75.6% of the total water-soluble ions. The annual average ratio of ρ(NO3-) to ρ(SO42-) was 1.53±0.88, indicating that mobile sources contributed more to PM2.5 pollution. Based on the correlation analysis of NH4+ and SO42-, NO3- may exist in the form of (NH4)2 SO4, NH4HSO4, or NH4NO3. According to the principal component analysis, secondary transformation, industrial pollution, biomass burning, and dust were the major sources of water-soluble inorganic ions. PM2.5concentrations were positively related to relative humidity in winter. Water vapor transmission is more likely to promote PM2.5 accumulation in winter.


Assuntos
Poluentes Atmosféricos , Material Particulado , Aerossóis/análise , Poluentes Atmosféricos/análise , Cidades , Monitoramento Ambiental , Íons/análise , Tamanho da Partícula , Material Particulado/análise , Estações do Ano , Água
9.
J Cell Mol Med ; 24(23): 14001-14012, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33098250

RESUMO

Acute respiratory distress syndrome/acute lung injury (ARDS/ALI) is histologically characterized by extensive alveolar barrier disruption and excessive fibroproliferation responses. Protectin DX (PDX) displays anti-inflammatory and potent inflammation pro-resolving actions. We sought to investigate whether PDX attenuates LPS (lipopolysaccharide)-induced lung injury via modulating epithelial cell injury repair, apoptosis and fibroblasts activation. In vivo, PDX was administered intraperitoneally (IP) with 200 ng/per mouse after intratracheal injection of LPS, which remarkedly stimulated proliferation of type II alveolar epithelial cells (AT II cells), reduced the apoptosis of AT II cells, which attenuated lung injury induced by LPS. Moreover, primary type II alveolar cells were isolated and cultured to assess the effects of PDX on wound repair, apoptosis, proliferation and transdifferentiation in vitro. We also investigated the effects of PDX on primary rat lung fibroblast proliferation and myofibroblast differentiation. Our result suggests PDX promotes primary AT II cells wound closure by inducing the proliferation of AT II cells and reducing the apoptosis of AT II cells induced by LPS, and promotes AT II cells transdifferentiation. Furthermore, PDX inhibits transforming growth factor-ß1 (TGF-ß1 ) induced fibroproliferation, fibroblast collagen production and myofibroblast transformation. Furthermore, the effects of PDX on epithelial wound healing and proliferation, fibroblast proliferation and activation partly via the ALX/ PI3K signalling pathway. These data present identify a new mechanism of PDX which targets the airway epithelial cell and fibroproliferation are potential for treatment of ARDS/ALI.


Assuntos
Células Epiteliais Alveolares/efeitos dos fármacos , Células Epiteliais Alveolares/metabolismo , Quinase do Linfoma Anaplásico/metabolismo , Ácidos Docosa-Hexaenoicos/farmacologia , Fosfatidilinositol 3-Quinases/metabolismo , Lesão Pulmonar Aguda/etiologia , Lesão Pulmonar Aguda/metabolismo , Lesão Pulmonar Aguda/patologia , Angiotensina II/metabolismo , Animais , Apoptose/efeitos dos fármacos , Citocinas/metabolismo , Modelos Animais de Doenças , Mediadores da Inflamação , Lipopolissacarídeos/efeitos adversos , Camundongos , Ratos
10.
J Cell Mol Med ; 24(17): 9646-9657, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32757380

RESUMO

Acute respiratory distress syndrome (ARDS) is a fatal disease characterized by excessive infiltration of inflammatory cells. MCTR1 is an endogenously pro-resolution lipid mediator. We tested the hypothesis that MCTR1 accelerates inflammation resolution through resident M2 alveolar macrophage polarization. The mice received MCTR1 via intraperitoneal administration 3 days after LPS stimulation, and then, the bronchoalveolar lavage (BAL) fluid was collected 24 hours later to measure the neutrophil numbers. Flow cytometry was used to sort the resident and recruited macrophages. Post-treatment with MCTR1 offered dramatic benefits in the resolution phase of LPS-induced lung injury, including decreased neutrophil numbers, reduced BAL fluid protein and albumin concentrations and reduced histological injury. In addition, the expression of the M2 markers Arg1, FIZZ1, Remlα, CD206 and Dectin-1 was increased on resident macrophages in the LPS + MCTR1 group. Resident macrophage depletion abrogated the therapeutic effects of MCTR1, and reinjection of the sorted resident macrophages into the lung decreased neutrophil numbers. Finally, treatment with MCTR1 increased STAT6 phosphorylation. The STAT6 inhibitor AS1517499 abolished the beneficial effects of MCTR1. In conclusion, MCTR1 promotes resident M2 alveolar macrophage polarization via the STAT6 pathway to accelerate resolution of LPS-induced lung injury.


Assuntos
Lesão Pulmonar Aguda/induzido quimicamente , Lesão Pulmonar Aguda/metabolismo , Polaridade Celular/fisiologia , Lipopolissacarídeos/farmacologia , Macrófagos Alveolares/metabolismo , Proteínas Oncogênicas/metabolismo , Fator de Transcrição STAT6/metabolismo , Animais , Líquido da Lavagem Broncoalveolar , Inflamação/metabolismo , Pulmão/metabolismo , Ativação de Macrófagos/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Neutrófilos/metabolismo , Síndrome do Desconforto Respiratório/metabolismo , Transdução de Sinais/fisiologia
11.
J Cell Mol Med ; 24(18): 10604-10614, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32735065

RESUMO

Inflammatory cell infiltration contributes to the pathogenesis of acute respiratory distress syndrome (ARDS). Protectin DX (PDX), an endogenous lipid mediator, shows anti-inflammatory and proresolution bioactions. In vivo, the mice were intraperitoneally injected with PDX (0.1 µg/mouse) after intratracheal (1 mg/kg) or intraperitoneal (10 mg/kg) LPS administration. Flow cytometry was used to measure inflammatory cell numbers. Clodronate liposomes were used to deplete resident macrophages. RT-PCR, and ELISA was used to measure MIP-2, MCP-1, TNF-α and MMP9 levels. In vitro, sorted neutrophils, resident and recruited macrophages (1 × 106 ) were cultured with 1 µg/mL LPS and/or 100 nmol/L PDX to assess the chemokine receptor expression. PDX attenuated LPS-induced lung injury via inhibiting recruited macrophage and neutrophil recruitment through repressing resident macrophage MCP-1, MIP-2 expression and release, respectively. Finally, PDX inhibition of neutrophil infiltration and transmembrane was associated with TNF-α/MIP-2/MMP9 signalling pathway. These data suggest that PDX attenuates LPS-stimulated lung injury via reduction of the inflammatory cell recruitment mediated via resident macrophages.


Assuntos
Lesão Pulmonar Aguda/patologia , Ácidos Docosa-Hexaenoicos/uso terapêutico , Macrófagos/efeitos dos fármacos , Lesão Pulmonar Aguda/induzido quimicamente , Administração Intranasal , Animais , Quimiocina CCL2/biossíntese , Quimiocina CCL2/genética , Quimiocina CXCL2/biossíntese , Quimiocina CXCL2/genética , Quimiocina CXCL2/fisiologia , Quimiotaxia de Leucócito/efeitos dos fármacos , Ácido Clodrônico/administração & dosagem , Ácido Clodrônico/farmacologia , Ácidos Docosa-Hexaenoicos/farmacologia , Ácidos Docosa-Hexaenoicos/fisiologia , Inflamação , Injeções Intraperitoneais , Lipopolissacarídeos/administração & dosagem , Lipopolissacarídeos/toxicidade , Lipossomos , Macrófagos/fisiologia , Metaloproteinase 9 da Matriz/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Neutrófilos/efeitos dos fármacos , Receptores CCR2/antagonistas & inibidores , Receptores de Interleucina-8B/antagonistas & inibidores , Transdução de Sinais/efeitos dos fármacos , Migração Transendotelial e Transepitelial/efeitos dos fármacos , Fator de Necrose Tumoral alfa/fisiologia
12.
Nat Commun ; 11(1): 3732, 2020 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-32709868

RESUMO

Advanced ceramic sponge materials with temperature-invariant high compressibility are urgently needed as thermal insulators, energy absorbers, catalyst carriers, and high temperature air filters. However, the application of ceramic sponge materials is severely limited due to their complex preparation process. Here, we present a facile method for large-scale fabrication of highly compressible, temperature resistant SiO2-Al2O3 composite ceramic sponges by blow spinning and subsequent calcination. We successfully produce anisotropic lamellar ceramic sponges with numerous stacked microfiber layers and density as low as 10 mg cm-3. The anisotropic lamellar ceramic sponges exhibit high compression fatigue resistance, strain-independent zero Poisson's ratio, robust fire resistance, temperature-invariant compression resilience from -196 to 1000 °C, and excellent thermal insulation with a thermal conductivity as low as 0.034 W m-1 K-1. In addition, the lamellar structure also endows the ceramic sponges with excellent sound absorption properties, representing a promising alternative to existing thermal insulation and acoustic absorption materials.

13.
Adv Mater ; 32(37): e2001989, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32715525

RESUMO

Conventional organic light-emitting devices without an encapsulation layer are susceptible to degradation when exposed to air, so realization of air-stable intrinsically-stretchable display is a great challenge because the protection of the devices against penetration of moisture and oxygen is even more difficult under stretching. An air-stable intrinsically-stretchable display that is composed of an intrinsically-stretchable electroluminescent device (SELD) integrated with a stretchable color-conversion layer (SCCL) that contains perovskite nanocrystals (PeNCs) is proposed. PeNCs normally decay when exposed to air, but they become resistant to this decay when dispersed in a stretchable elastomer matrix; this change is a result of a compatibility between capping ligands and the elastomer matrix. Counterintuitively, the moisture can efficiently passivate surface defects of PeNCs, to yield significant increases in both photoluminescence intensity and lifetime. A display that can be stretched up to 180% is demonstrated; it is composed of an air-stable SCCL that down-converts the SELD's blue emission and reemits it as green. The work elucidates the basis of moisture-assisted surface passivation of PeNCs and provides a promising strategy to improve the quantum efficiency of PeNCs with the aid of moisture, which allows PeNCs to be applied for air-stable stretchable displays.

14.
Nat Commun ; 11(1): 3207, 2020 06 25.
Artigo em Inglês | MEDLINE | ID: mdl-32587309

RESUMO

Real-time sensing of nitric oxide (NO) in physiological environments is critically important in monitoring neurotransmission, inflammatory responses, cardiovascular systems, etc. Conventional approaches for NO detection relying on indirect colorimetric measurement or built with rigid and permanent materials cannot provide continuous monitoring and/or require additional surgical retrieval of the implants, which comes with increased risks and hospital cost. Herein, we report a flexible, biologically degradable and wirelessly operated electrochemical sensor for real-time NO detection with a low detection limit (3.97 nmol), a wide sensing range (0.01-100 µM), and desirable anti-interference characteristics. The device successfully captures NO evolution in cultured cells and organs, with results comparable to those obtained from the standard Griess assay. Incorporated with a wireless circuit, the sensor platform achieves continuous sensing of NO levels in living mammals for several days. The work may provide essential diagnostic and therapeutic information for health assessment, treatment optimization and postsurgical monitoring.


Assuntos
Óxido Nítrico/análise , Animais , Técnicas Biossensoriais , Técnicas Eletroquímicas , Desenho de Equipamento
15.
Opt Express ; 28(8): 12201-12208, 2020 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-32403718

RESUMO

Silicon photonics has been calling for an electrically pumped on-chip light source at room temperature for decades. A GaN-based microdisk laser diode with whispering gallery modes grown on Si is a promising candidate for compact on-chip light source. By suppressing the unintentional incorporation of carbon impurity in the p-type AlGaN cladding layer of the laser, we have significantly reduced the operation voltage and threshold current of the GaN-on-Si microdisk laser. Meanwhile the radius of the microdisk laser was shrunk to 8 µm to lower the thermal power. The overall junction temperature of the microdisk laser was effectively reduced. As a result, the first continuous-wave electrically pumped InGaN-based microdisk laser grown on Si was achieved at room temperature.

16.
Nanoscale ; 12(13): 7263-7272, 2020 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-32196021

RESUMO

The perovskite structure provides a versatile framework for functional materials and their high-quality heteroepitaxial interfaces. Perovskite halides (PH) have attracted intense interest for their application in optoelectronics. Oxides are another major class of perovskites that are widely used in fuel cells, nonconventional electronics and electrochemistry. Interfacing different perovskite oxides (POs) has led to a multitude of fascinating discoveries. By introducing anionic degree of freedom, we expect that perovskite hetero-anionic-sublattice interfaces can provide a new platform for emergent phenomena that may or may not have homo-oxygen-sublattice interface analogues. In this work, we investigate the interfaces between the all-inorganic PH CsPbBr3, the emerging double perovskite halide (dPH) Cs2TiBr6 and various common POs. Based on the band alignment properties, these POs are considered to be suitable carrier transport materials (CTMs) for CsPbBr3 and Cs2TiBr6 in either light-harvesting or light-emitting devices. In addition, these perovskite hetero-anionic-sublattice interfaces are found to be defect- and dangling bond-free due to compatible crystal lattices, making POs potentially outperform conventional binary transition-metal-oxide and organic CTMs. Besides optoelectronics, the potential of perovskite hetero-anionic-sublattice interfaces for nonconventional electronics is also explored. As examples, two-dimensionally confined electron-hole systems are predicted at the asymmetric interfaces in both Cs2TiBr6:LaAlO3 and CsPbBr3:LaAlO3 superlattice structures. This finding, along with the optically active properties of PHs, may spark novel applications of light-electron interaction in perovskite systems. This work presents new opportunities for perovskite heteroepitaxial interfaces.

17.
Small ; 16(15): e1902827, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31513333

RESUMO

Implantable bioelectronics represent an emerging technology that can be integrated into the human body for diagnostic and therapeutic functions. Power supply devices are an essential component of bioelectronics to ensure their robust performance. However, conventional power sources are usually bulky, rigid, and potentially contain hazardous constituent materials. The fact that biological organisms are soft, curvilinear, and have limited accommodation space poses new challenges for power supply systems to minimize the interface mismatch and still offer sufficient power to meet clinical-grade applications. Here, recent advances in state-of-the-art nonconventional power options for implantable electronics, specifically, miniaturized, flexible, or biodegradable power systems are reviewed. Material strategies and architectural design of a broad array of power devices are discussed, including energy storage systems (batteries and supercapacitors), power devices which harvest sources from the human body (biofuel cells, devices utilizing biopotentials, piezoelectric harvesters, triboelectric devices, and thermoelectric devices), and energy transfer devices which utilize sources in the surrounding environment (ultrasonic energy harvesters, inductive coupling/radiofrequency energy harvesters, and photovoltaic devices). Finally, future challenges and perspectives are given.


Assuntos
Fontes de Energia Bioelétrica , Próteses e Implantes , Eletrônica , Humanos
18.
Microsyst Nanoeng ; 6: 64, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-34567675

RESUMO

Physical and chemical technologies have been continuously progressing advances in neuroscience research. The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable. In this paper, we introduce a wirelessly operated, miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain. Via epitaxial liftoff and transfer printing, microscale light-emitting diodes (micro-LEDs) as light sources and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)-coated diamond films as electrochemical sensors are vertically assembled to form implantable optoelectrochemical probes for real-time optogenetic stimulation and dopamine detection capabilities. A customized, lightweight circuit module is employed for untethered, remote signal control, and data acquisition. After the probe is injected into the ventral tegmental area (VTA) of freely behaving mice, in vivo experiments clearly demonstrate the utilities of the multifunctional optoelectrochemical microprobe system for optogenetic interference of place preferences and detection of dopamine release. The presented options for material and device integrations provide a practical route to simultaneous optical control and electrochemical sensing of complex nervous systems.

19.
China CDC Wkly ; 2(42): 827-831, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-34594776

RESUMO

What is already known about this topic?: Mercury is still used in the manufacture of some thermometers in China. This may pose health risks if exposure is not properly prevented and controlled. What is added by this report?: An onsite investigation of a workplace at a thermometer facility in Jiangsu Province in 2019 found heavily elevated airborne and urinary mercury levels among a massive number of workers exposed to mercury. Traditional and obsolete technology as well as inadequate protection measures for occupational hazards caused this high level of exposure. What are the implications for public health practice?: Employers at thermometer producing facilities need to adopt effective protection measures and implement strict management. Monitoring exposure, adopting better engineering controls, diligent cleaning, and providing recommended personal protective equipment (PPE) along with training to their workers properly can alleviate mercury exposure at their facilities. In addition, transitioning to mercury-free thermometers would eliminate the risk of mercury exposure.

20.
Int Immunopharmacol ; 76: 105877, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31522017

RESUMO

Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are life-threatening critical syndromes characterized by the infiltration of a large number of inflammatory cells that lead to an excessive inflammatory response. Resolvin D1 (RvD1), an endogenous lipid mediator, is believed to have anti-inflammatory and proresolving effects. In the present study, we examined the impact of RvD1 on the pulmonary inflammatory response, neutrophil influx, and lung damage in a murine model of lipopolysaccharide (LPS)-induced ALI. Treatment with RvD1 protected mice against LPS-induced ALI, and compared to untreated mice, RvD1-treated mice exhibited significantly ameliorated lung pathological changes, decreased tumor necrosis factor-α (TNF-α) concentrations and attenuated neutrophil infiltration. In addition, treatment with RvD1 attenuated LPS-induced neutrophil infiltration via the downregulation of CXCL2 expression on resident alveolar macrophages. Finally, BOC-2, which inhibits the RvD1 receptor lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2), reversed the protective effects of RvD1. These data demonstrate that RvD1 ameliorates LPS-induced ALI via the suppression of neutrophil infiltration by an ALX/FPR2-dependent reduction in CXCL2 expression on resident alveolar macrophages.


Assuntos
Lesão Pulmonar Aguda/tratamento farmacológico , Quimiocina CXCL2/antagonistas & inibidores , Ácidos Docosa-Hexaenoicos/farmacologia , Ácidos Docosa-Hexaenoicos/uso terapêutico , Macrófagos Alveolares/efeitos dos fármacos , Lesão Pulmonar Aguda/induzido quimicamente , Lesão Pulmonar Aguda/imunologia , Lesão Pulmonar Aguda/patologia , Animais , Quimiocina CXCL2/genética , Quimiocina CXCL2/imunologia , Lipopolissacarídeos , Pulmão/efeitos dos fármacos , Pulmão/imunologia , Pulmão/patologia , Macrófagos Alveolares/imunologia , Camundongos Endogâmicos C57BL , Infiltração de Neutrófilos/efeitos dos fármacos
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