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Hua Xi Kou Qiang Yi Xue Za Zhi ; 36(2): 162-166, 2018 Apr 01.
Artigo em Chinês | MEDLINE | ID: mdl-29779277


OBJECTIVE: This study aims to study the effect of the improved partial denture treatment in the rehabilitation of patients with temporomandibular joint disorders (TMD). METHODS: Twenty middle-aged and old patients suffering from osteoarthrosis were treated with the improved partial denture treatment. These patients were followed up during the partial denture treatment and after the rehabilitation. Both the clinical symptoms and Fricton's craniomandibular index were used to evaluate the clinical effects. Data were analyzed using SPSS17.0. RESULTS: The effective rate reached 100% when the patients wore partial dentures for 1 month. All of the 20 patients were comfortable with temporomandibular joint, and they expressed ultimate satisfaction with the denture. The Fricton indexes of 20 patients decreased significantly after the treatment (P<0.05). CONCLUSIONS: Partial denture treatment is an ideal method in rehabilitation for patients with TMD (osteoarthrosis) and dentition defect.

Prótese Parcial , Transtornos da Articulação Temporomandibular , Dentição , Dentaduras , Humanos , Pessoa de Meia-Idade , Articulação Temporomandibular , Transtornos da Articulação Temporomandibular/reabilitação
Biomed Mater ; 13(4): 041001, 2018 04 11.
Artigo em Inglês | MEDLINE | ID: mdl-29516867


Understanding the interaction between biomaterials and the immune system has become increasingly important. Mineralized collagen (MC) has the same chemical components and microstructures to natural bone tissue, and is considered as a better biomaterial for bone prostheses compared to hydroxyapatite (HA). However, there is little information about how MC affects inflammatory responses. In this study, we investigate the inflammatory responses to MC and HA by culturing RAW264.7 cells on their surfaces. We observed that MC increases CD206+ staining and IL-10 (M2 macrophages), whereas HA shows cells expressing more CD86 and secreting more TNF-α. This result indicates that MC may attenuate inflammatory responses to implanted bone prostheses.

Substitutos Ósseos/química , Colágeno/química , Durapatita/química , Macrófagos/metabolismo , Animais , Antígeno B7-2/metabolismo , Materiais Biocompatíveis , Adesão Celular , Citocinas/metabolismo , Inflamação , Interleucina-10/metabolismo , Lectinas Tipo C/metabolismo , Macrófagos/citologia , Receptor de Manose , Lectinas de Ligação a Manose/metabolismo , Camundongos , Monócitos/citologia , Osteogênese , Fenótipo , Células RAW 264.7 , Receptores de Superfície Celular/metabolismo , Fator de Necrose Tumoral alfa/metabolismo