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IEEE Trans Med Imaging ; 40(5): 1363-1376, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33507867


To better understand early brain development in health and disorder, it is critical to accurately segment infant brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). Deep learning-based methods have achieved state-of-the-art performance; h owever, one of the major limitations is that the learning-based methods may suffer from the multi-site issue, that is, the models trained on a dataset from one site may not be applicable to the datasets acquired from other sites with different imaging protocols/scanners. To promote methodological development in the community, the iSeg-2019 challenge ( provides a set of 6-month infant subjects from multiple sites with different protocols/scanners for the participating methods. T raining/validation subjects are from UNC (MAP) and testing subjects are from UNC/UMN (BCP), Stanford University, and Emory University. By the time of writing, there are 30 automatic segmentation methods participated in the iSeg-2019. In this article, 8 top-ranked methods were reviewed by detailing their pipelines/implementations, presenting experimental results, and evaluating performance across different sites in terms of whole brain, regions of interest, and gyral landmark curves. We further pointed out their limitations and possible directions for addressing the multi-site issue. We find that multi-site consistency is still an open issue. We hope that the multi-site dataset in the iSeg-2019 and this review article will attract more researchers to address the challenging and critical multi-site issue in practice.

Artif Intell Med ; 97: 1-8, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31202395


Bone age assessment plays an important role in the endocrinology and genetic investigation of patients. In this paper, we proposed a deep learning-based approach for bone age assessment by integration of the Tanner-Whitehouse (TW3) methods and deep convolution networks based on extracted regions of interest (ROI)-detection and classification using Faster-RCNN and Inception-v4 networks, respectively. The proposed method allows exploration of expert knowledge from TW3 and features engineering from deep convolution networks to enhance the accuracy of bone age assessment. The experimental results showed a mean absolute error of about 0.59 years between expert radiologists and the proposed method, which is the best performance among state-of-the-art methods.

Determinação da Idade pelo Esqueleto/métodos , Aprendizado Profundo , Redes Neurais de Computação , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino
Artigo em Inglês | MEDLINE | ID: mdl-30835215


Accurate segmentation of infant brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is an indispensable foundation for early studying of brain growth patterns and morphological changes in neurodevelopmental disorders. Nevertheless, in the isointense phase (approximately 6-9 months of age), due to inherent myelination and maturation process, WM and GM exhibit similar levels of intensity in both T1-weighted (T1w) and T2-weighted (T2w) MR images, making tissue segmentation very challenging. Despite many efforts were devoted to brain segmentation, only few studies have focused on the segmentation of 6-month infant brain images. With the idea of boosting methodological development in the community, iSeg-2017 challenge ( provides a set of 6-month infant subjects with manual labels for training and testing the participating methods. Among the 21 automatic segmentation methods participating in iSeg-2017, we review the 8 top-ranked teams, in terms of Dice ratio, modified Hausdorff distance and average surface distance, and introduce their pipelines, implementations, as well as source codes. We further discuss limitations and possible future directions. We hope the dataset in iSeg-2017 and this review article could provide insights into methodological development for the community.

Sensors (Basel) ; 18(6)2018 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-29874798


Recently, the wireless sensor network paradigm is shifting toward research aimed at enabling the robust delivery of multimedia content. A challenge is to deliver multimedia content with predefined levels of Quality of Service (QoS) under resource constraints such as bandwidth, energy, and delay. In this paper, we propose a distributed systematic network coding (DSNC) scheme for reliable multimedia content uploading over wireless multimedia sensor networks, in which a large number of multimedia sensor nodes upload their own content to a sink through a cluster head node. The design objective is to increase the reliability and bandwidth-efficient utilization in uploading with low decoding complexity. The proposed scheme consists of two phases: in the first phase, each sensor node distributedly encodes the content into systematic network coding packets and transmits them to the cluster head; then in the second phase, the cluster head encodes all successfully decoded incoming packets from multiple sensor nodes into innovative systematic network coding packets and transmits them to the sink. A bandwidth-efficient and channel-aware error control algorithm is proposed to enhance the bandwidth-efficient utilization by dynamically determining the optimal number of innovative coded packets. For performance analysis and evaluation, we firstly derive the closed-form equations of decoding probability to validate the effectiveness of the proposed uploading scheme. Furthermore, we perform various simulations along with a discussion in terms of three performance metrics: decoding probability, redundancy, and image quality measurement. The analytical and experimental results demonstrate that the performance of our proposed DSNC outperforms the existing uploading schemes.

Biomed Eng Online ; 15(1): 99, 2016 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-27558127


BACKGROUND: This study focuses on osteoarthritis (OA), which affects millions of adults and occurs in knee cartilage. Diagnosis of OA requires accurate segmentation of cartilage structures. Existing approaches to cartilage segmentation of knee imaging suffer from either lack of fully automatic algorithm, sub-par segmentation accuracy, or failure to consider all three cartilage tissues. METHODS: We propose a novel segmentation algorithm for knee cartilages with level set-based segmentation method and novel template data. We used 20 normal subjects from osteoarthritis initiative database to construct new template data. We adopt spatial fuzzy C-mean clustering for automatic initialization of contours. Force function of our algorithm is modified to improve segmentation performance. RESULTS: The proposed algorithm resulted in dice similarity coefficients (DSCs) of 87.1, 84.8 and 81.7 % for the femoral, patellar, and tibial cartilage, respectively from 10 subjects. The DSC results showed improvements of 8.8, 4.3 and 3.5 % for the femoral, patellar, and tibial cartilage respectively compared to existing approaches. Our algorithm could be applied to all three cartilage structures unlike existing approaches that considered only two cartilage tissues. CONCLUSIONS: Our study proposes a novel fully automated segmentation algorithm adapted for three types of knee cartilage tissues. We leverage state-of-the-art level set approach with newly constructed knee template. The experimental results show that the proposed method improves the performance by an average of 5 % over existing methods.

Algoritmos , Processamento de Imagem Assistida por Computador/métodos , Articulação do Joelho/diagnóstico por imagem , Imagem por Ressonância Magnética , Osteoartrite/diagnóstico por imagem , Adulto , Idoso , Automação , Cartilagem Articular/diagnóstico por imagem , Estudos de Casos e Controles , Lógica Fuzzy , Humanos , Pessoa de Meia-Idade , Razão Sinal-Ruído