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Langmuir ; 26(5): 3522-30, 2010 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-19947616

RESUMO

In this work, the hemocompatibility of a sulfobetaine-like copolymer brush resulting from a mixed-charge copolymerization of the positively charged 11-mercapto-N,N,N-trimethylammonium chloride (TMA) and negatively charged 11-mercaptoundecylsulfonic acid (SA) was studied. Mixed charge distribution in the prepared poly(TMA-co-SA) copolymer brushes was controlled by the regulation of the reaction rate of the surface-initiated atom transfer radical polymerization (ATRP). The adsorption behavior of plasma proteins on a surface grafted with poly(TMA-co-SA) was measured by a surface plasmon resonance (SPR) sensor. The effects of varying temperature, solution pH, and ionic strength on the antifouling characteristics of the mixed-charge copolymer brushes were systematically evaluated, and the protein-fouling resistance was discussed in detail, especially with respect to the effect of ionic strength on the intra- and intermolecular interactions of the poly(TMA-co-SA) with proteins. The adhesion and activation of blood cells on the poly(TMA-co-SA)-grafted surface in contact with human whole blood was also demonstrated. The results suggest that mixed-charge copolymer brushes of poly(TMA-co-SA), which, like zwitterionic homopolymer brushes, have overall charge neutrality, can be used in similar applications for protein-fouling resistance and have excellent hemocompatibility with human whole blood at physiologic temperatures.


Assuntos
Materiais Biocompatíveis/química , Incrustação Biológica , Proteínas Sanguíneas/química , Polímeros/química , Compostos de Amônio Quaternário/química , Compostos de Sulfidrila/química , Adsorção , Materiais Biocompatíveis/síntese química , Células Sanguíneas/citologia , Adesão Celular , Humanos , Concentração de Íons de Hidrogênio , Concentração Osmolar , Polímeros/síntese química , Temperatura
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