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1.
Comp Immunol Microbiol Infect Dis ; 65: 226-233, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31300118

RESUMO

The aim of this study is to verify the action of the aqueous leaf extract Ziziphus joazeiro in the eradication of bacterial and fungal biofilms, and to compare these effects with the stem bark extracts, as well as with conventional standard drugs. The presence of secondary metabolites was observed through phytochemical prospection assays. The effect of the aqueous extract on microbial biofilm formation was observed by OD600 nm absorbance and the crystal violet assay. For bacterial and fungal biofilms, chlorhexidine gluconate and fluconazole, respectively, were used as positive controls. Phytochemical characterization showed the presence of secondary metabolite classes common to both extracts such as flavonoids, steroids and saponins. In particular, in the aqueous leaf extract phenols, condensed tannins and alkaloids were observed. Eradication results using the aqueous leaf extract showed an inhibition of the microbial biofilm mass, moreover the biofilms were more sensitive to the bark extract, which presented a greater inhibition number and an action similar to standard drugs. It is important to highlight the leaf extract showed significant eradication at the lowest concentrations for mature yeast biofilms, thus demonstrating its potential to modify microbial resistance susceptibility. Bacterial and fungal biofilm eradication results using the Ziziphus joazeiro aqueous extracts presented a biofilm inhibition effect for both, moreover the results support the ethnopharmacological knowledge surrounding the use of Ziziphus joazeiro stems in the community. In comparison, the bark extract presented a more effective treatment than the leaf extract against biofilms, presenting inhibition levels similar to the used standard drugs.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31300127

RESUMO

The oil presented the α-Terpinene as the major compound with 54.09% presence. Antibacterial activity demonstrated significant MIC against Staphylococcus aureus (256 µg/mL) and moderate against Pseudomonas aeruginosa (512 µg/mL). The modulating effect of antibiotics was significant against P. aeruginosa potentiating the effect of all the antibiotics tested. The IC50 observed for CT LM 23 was clinically relevant (19.3 µg/mL), similar to that obtained for CA INCQS 40006 (25.2 µg/mL). The combined effect with fluconazole also showed significant results, 0.1 and 22.7 µg/mL, for CT LM 23 and CA INCQS 40006, respectively. For CA LM 77 the IC50 was 101.9 µg/mL and for CT INCQS 40042 a value of 53.3 µg/mL. Regarding the modulation, both were considered of clinical relevance, 3.3 and 6.4 µg/mL. OEDA has low antioxidant activity (>1024 µg/mL). Therefore, the popular use against infections was corroborated by this work.

3.
Chem Biodivers ; 2019 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-31348574

RESUMO

The aim of this study was to investigate the antibacterial activity of red propolis and resin and their association with standard antibiotics to evaluate possible differences of activity. We also submitted red propolis and the resin to a HPLC analysis to confirm the botanical origin. The extracts were tested against P. aeruginosa and S. aureus alone and in association with gentamicin and imipenem. The HPLC analysis identified seven compounds with six of them present in both substances. The lowest MIC values obtained in this study were observed against S. aureus. In general, MIC values showed to be lower for red propolis against all species tested in comparison to resin. Despite the synergistic behavior to be similar for both substances, we observed that inhibitory concentrations of drugs were lower when associated with red propolis in comparison to resin.

4.
Cad. Bras. Ter. Ocup ; 27(2): 426-437, abr.-jun. 2019. tab, graf
Artigo em Português | LILACS-Express | ID: biblio-1011677

RESUMO

Resumo Introdução As lesões traumáticas de membro superior frequentemente levam ao afastamento do trabalho. Assegurar a manutenção do papel ocupacional de trabalhador compõe os objetivos do terapeuta ocupacional que atua na área de saúde do trabalhador, por meio de ações de prevenção e reabilitação. Nesse sentido, é importante conhecer os fatores que influenciam no retorno ao trabalho. Objetivo Documentar evidências sobre as barreiras e facilitadores para o retorno ao trabalho de pessoas que sofreram traumas agudos em membros superiores. Método Estudo de revisão bibliográfica pelo método de revisão integrativa. A busca foi realizada nas bases de dados da Biblioteca Virtual em Saúde (BVS), Scielo, Lilacs, Periódicos Capes e Pubmed. Foram pesquisados artigos publicados no período entre 2005 e 2015, escritos em português, inglês ou espanhol. Resultados A amostra final é composta de 13 artigos. Após a análise qualitativa, os resultados foram agrupados em quatro categorias temáticas para a verificação das barreiras e facilitadores correspondentes: Paciente, Lesão, Reabilitação e Trabalho. A gravidade da lesão, tempo de hospitalização, número de procedimentos cirúrgicos, inserção em programa de reabilitação, reabilitação voltada ao trabalho, suporte sócio familiar e no local de trabalho foram os principais elementos identificados. Conclusão O programa de reabilitação deve ser integrado e multidisciplinar com ações voltadas ao manejo da dor, recuperação funcional e preparo para o retorno ao trabalho. O suporte sócio familiar e no ambiente de trabalho sempre que possível devem ser considerados dentro do programa de reabilitação profissional para garantir o retorno ao trabalho.


Abstract Introduction Traumatic upper limb injuries often lead to work disability. Ensuring the maintenance of the worker occupational role is a goal for occupational therapists in occupational health, using prevention and rehabilitation techniques. Therefore, it is important to know the factors that influence return to work. Objective To document evidence of barriers and facilitators elements of return to work after acute upper limb trauma. Method A review study using the integrative review approach. The search included Biblioteca Virtual em Saúde (BVS), Scielo, Lilacs, Periódicos Capes and Pubmed databases. Articles that mentioned a return to work and upper limb trauma in their abstract, published between 2005 and 2015 and written in Portuguese, English or Spanish, were also used. Results The final sample consists of 13 articles, after qualitative analysis the results were grouped into four categories: Patient, Injury, Rehabilitation, and Work. Injury severity, hospitalization time, number of surgical procedures, insertion in a rehabilitation program, work-related rehabilitation, family and workplace support were the main elements identified. Conclusion The rehabilitation program should be integrated and multidisciplinary with actions aimed at pain management, functional recovery, and preparation for a return to work. Support family member and whenever possible work environment should be considered within the vocational rehabilitation program to ensure the return to work.

5.
Chem Phys Lipids ; 219: 23-27, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30710506

RESUMO

The bioprospection of zootherapeutic products can be a source of new drugs and to the creation of new strategies of natural resources conservation and management of endangered species. This fact is supported by ethnobiological studies indicating that the usage of zootherapeutic products can be replaced by the use of natural products isolated from plants and domestic animals. The emergence of antibiotic-resistant bacteria has increased the need for research for new active principles. Ethnoveterinary studies in Brazil have shown that Sus scrofa domesticus fat is used for diseases associated with bacterial pathogens. The objective of this study was to identify the chemical composition and to evaluate the antibacterial activity of the fixed oil of Sus scrofa domesticus (OFSC) when used alone or associated with antibiotics. In the analysis of the oil composition, there were 4 constituents identified, with oleic acid being the major constituent. The OFSC did not present antibacterial activity when tested alone; however, it showed synergism in the modulating activity when associated with antibiotics Amikacin and Amoxicillin.

6.
J Ethnopharmacol ; 233: 87-93, 2019 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-30592980

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Northeast Brazilian ethnoveterinary studies associated with the medicinal use of zootherapies have shown that ruminants' body fat such as sheep (Ovis aries), goats (Capra hircus) and cows (Bos taurus) are used in diseases affecting domestic animals. AIM OF THE STUDY: The objective of this study was to evaluate the antibacterial activity of the fixed oils from these ruminants in isolation and in association with antibiotics. RESULTS: Ovis aries (OFOA), Capra hircus (OFCH) and Bos taurus (OFBT) fixed oils were extracted using a Soxhlet apparatus with hexane as the solvent. Through the use of gas chromatography coupled to mass spectrometry (GC-MS) the methyl esters from the ruminants' fixed oils were obtained and the fatty acids present in these oils were indirectly determined. The OFOA, OFCH and OFBT antibacterial and antibiotic modifying activities against standard and multi-resistant bacterial strains were carried out using the broth microdilution test. The fixed oils from these species did not present antibacterial activity when tested in isolation, obtaining Minimal Inhibitory Concentration (MICs) values ≥ 1024 µg/mL. However, when associated with antibiotics, OFBT and OFCH showed a synergistic activity for the Amicacin, Amoxicillin, Norfloxacin and Oxytetracycline antibiotics. CONCLUSION: The OFOA promoted a synergistic action for the same antibiotics with the exception of Norfloxacin.


Assuntos
Tecido Adiposo/química , Antibacterianos/farmacologia , Ácidos Graxos/farmacologia , Óleos/farmacologia , Animais , Antibacterianos/química , Bactérias/efeitos dos fármacos , Bactérias/crescimento & desenvolvimento , Bovinos , Ácidos Graxos/análise , Feminino , Cabras , Masculino , Testes de Sensibilidade Microbiana , Óleos/química , Ovinos
7.
Microb Pathog ; 124: 163-169, 2018 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-30142465

RESUMO

In the Northeast of Brazil, ethnoveterinary studies have shown that the body fat from Gallus gallus domesticus and Meleagris gallopavo are used for diseases that affect domestic animals. The objective of this study was to identify the chemical composition and to evaluate the antibacterial activity of the Gallus gallus domesticus (OFGG) and Meleagris gallopavo (OFMG) fixed oils in isolation and in association with antibiotics. The OFGG and OFMG from the poultry's body fat were extracted using hexane as a solvent in Soxhlet. Their composition was indirectly determined using fatty acid methyl esters. The OFGG and OFMG antibacterial and modulatory activities against standard and multi-resistant bacterial strains were performed through the broth microdilution test. In the OFGG chemical composition, 4 constituents were identified. The saturated fatty acid (AGS) and unsaturated fatty acid (AGI) percentages were 35.1% and 64.91% respectively, with linoleic acid being the major component. In the OFMG, 3 constituents were identified. The AGS percentage was 27.71% and 72.29% for AGI, with oleic acid as the most abundant component. The oils did not present antibacterial activity when tested in isolation, presenting Minimum Inhibitory Concentrations (MICs) > 512 µg/mL. However, when associated with antibiotics the OFGG showed synergistic activity with the antibiotics Amikacin, Amoxicillin, Norfloxacin and Oxytetracycline, while the OFMG promoted a synergistic action with the antibiotics Amikacin, Amoxicillin and Norfloxacin.

8.
Biomed Pharmacother ; 97: 1575-1585, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29793320

RESUMO

Mimosa tenuiflora (Willd.) Poiret, popularly known in Brazil as "jurema-preta" is widely used against bronchitis, fever, headache and inflammation. Its antioxidant, anti-inflammatory and antinociceptive potential has already been reported. To assess the orofacial antinociceptive effect of M. tenuiflora, ethanolic extracts of M. tenuiflora (leaves, twigs, barks and roots) were submitted to in vitro tests of antioxidant activity. The extract with the highest antioxidant potential was partitioned and subjected to preliminary chemical prospecting, GC-MS, measurement of phenolic content and cytotoxicity tests of the fraction with the highest antioxidant activity. The nontoxic fraction with the highest antioxidant activity (FATEM) was subjected to tests of acute and chronic orofacial nociception and locomotor activity. The possible mechanisms of neuromodulation were also assessed. The EtOAc fraction, obtained from the ethanolic extract of M. tenuiflora barks, was the one with the highest antioxidant potential and nontoxic (FATEM), and Benzyloxyamine was the major constituent (34.27%). FATEM did not alter the locomotor system of mice and reduced significantly the orofacial nociceptive behavior induced by formalin, glutamate, capsaicin, cinnamaldehyde or acidic saline compared to the control group. FATEM also inhibited formalin- or mustard oil-induced temporomandibular nociception. In addition, it also reduced mustard oil-induced orofacial muscle nociception. However, FATEM did not alter hypertonic saline-induced corneal nociception. Neuropathic nociception was reversed by treatment with FATEM. The antinociceptive effect of FATEM was inhibited by naloxone, L-NAME and glibenclamide. FATEM has pharmacological potential for the treatment of acute and neuropathic orofacial pain and this effect is modulated by the opioid system, nitric oxide and ATP-sensitive potassium channels. These results lead us to studies of isolation and characterization of bioactive principles.


Assuntos
Analgésicos/uso terapêutico , Dor Facial/tratamento farmacológico , Mimosa/química , Nociceptividade , Extratos Vegetais/uso terapêutico , Acroleína/análogos & derivados , Analgésicos/farmacologia , Animais , Antioxidantes/metabolismo , Capsaicina , Cercopithecus aethiops , Fracionamento Químico , Etanol , Dor Facial/patologia , Ácido Glutâmico , Glibureto/farmacologia , Glibureto/uso terapêutico , Camundongos , Atividade Motora/efeitos dos fármacos , NG-Nitroarginina Metil Éster/farmacologia , NG-Nitroarginina Metil Éster/uso terapêutico , Naloxona/farmacologia , Naloxona/uso terapêutico , Nociceptividade/efeitos dos fármacos , Fenóis/análise , Extratos Vegetais/farmacologia , Ratos Wistar , Articulação Temporomandibular/efeitos dos fármacos , Articulação Temporomandibular/patologia , Células Vero
9.
Int J Paleopathol ; 18: 47-51, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28888392

RESUMO

In 2005, an adult male was excavated in the cloister of the former Convent of the Holy Spirit, in the Franciscan Province of Holy Mary of Arrábida, Lisbon district. From the anterior part of the sacrum, a darker organic agglomeration was collected and studied for intestinal parasites. Samples were rehydrated with Lycopodium tablets in a Na3PO4 5% solution for 72h, followed by the swirl technique. Organic material was concentrated at 2500rpm. At least 20 slides of each sample were examined using a light/polarized microscope. A control sample from outside the pelvis revealed no biological remains. A sample collected inside the pelvic girdle was positive for pollen grains, other plant remains and Toxocara eggs, perhaps T. cati (2766 eggs/gram sediment). This finding, although exciting, cannot be explained in a simple way because humans are not definitive hosts for Toxocara species. Ingestion of feces-contaminated food or water, geophagy, or true infection are hypotheses considered in this study, which demonstrates the difficulty of interpreting the presence of animal parasites in human remains. This is the first time Toxocara eggs are found associated with human remains.

10.
Acta Trop ; 176: 380-384, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28935551

RESUMO

Neglected diseases are those that are prevalent in developing countries, even with a rich biodiversity. These diseases still persist because of the lack of scientific studies, government negligence or failures of the public health system. This study aims to identify the composition of extracts and fractions from Psidium brownianum and Psidium guajava through LC-MS, to evaluate its in vitro anti-parasitic and cytotoxic activity against Trypanosoma cruzi, Leishmania brasiliensis and L. infantum epismastigote and promastigote forms, as well as mammalian cells. The results showed the presence of chemical constituents in the two Psidium species as quercetin, myricetin and gallic acid derivatives. The P. brownianum extract and fractions showed low toxicity at all tested concentrations and all samples were effective at the concentration of 1000µg/mL against the parasites, with the extract being the most efficient against the L. infantum promastigote form. The ethanolic extract, and the flavonoid and tannic fractions, from P. guajava showed low toxicity for the fibroblasts. All samples showed effectiveness at the highest concentration tested and the extract was more effective against the promastigote forms tested. The results showed that the species Psidium brownianum and Psidium guajava demonstrated an anti-parasitic activity against the T. cruzi, L. brasiliensis and L. infantum parasite cell lines indicating these species as an alternative therapy given their efficacy in the in vitro assays performed, opening the possibility for new biological studies to further this knowledge through in vivo assays.


Assuntos
Leishmania braziliensis/efeitos dos fármacos , Leishmania infantum/efeitos dos fármacos , Extratos Vegetais/análise , Extratos Vegetais/farmacologia , Psidium , Trypanosoma cruzi/efeitos dos fármacos , Animais , Produtos Biológicos/análise , Produtos Biológicos/farmacologia , Cromatografia Líquida , Citotoxinas/farmacologia , Fibroblastos/efeitos dos fármacos , Flavonoides/farmacologia , Ácido Gálico/análogos & derivados , Ácido Gálico/farmacologia , Espectrometria de Massas , Folhas de Planta , Quercetina/análogos & derivados , Quercetina/farmacologia
11.
Food Res Int ; 101: 54-60, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28941697

RESUMO

This study evaluated the influence of spouted bed drying temperature and maltodextrin dextrose equivalent on the probiotic microbial survival during drying and storage period and on physicochemical properties of fermented probiotic orange juice in powder. Probiotic orange juice was spouted bed dried at 60, 70, 80 and 90°C using maltodextrin with a different dextrose equivalent (10, 20, 30 and 39). After drying, the microbial was higher when lower drying temperatures were applied. During the storage, the highest drying temperatures (80 and 90°C) negatively affected the microorganism survival. On the other hand, at the lowest drying temperature (60°C), the product presented higher Aw, what negatively affected the microbial survival during storage. The temperature of 70°C was the best to preserve the microbial viability during storage. Physicochemical parameters were improved when temperature increased and dextrose equivalent decreased.

12.
Food Chem Toxicol ; 107(Pt B): 572-580, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28359875

RESUMO

The aim of this study was to investigate the effect of the dry and rainy season on the antibacterial activity and chemical composition of the Brazilian red propolis. The samples were collected in rainy (RP-PER) and dry (RP-PED) seasons and analyzed by HPLC-DAD. The extracts were tested alone and in association with antibiotics against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The HPLC analysis identified luteolin and quercetin as the main compounds. Seasonal variation was observed according to concentrations of the compounds. The MIC values against E. coli ranged from 128 µg/mL to 512 µg/mL (EC 06 and EC ATCC). The red propolis showed MIC values of 512 µg/mL against both strains of P. aeruginosa used in our study (PA03 and PA24) and against strains of Gram-positive bacteria S. aureus the MICs ranged from 64 µg/mL to ≥1024 µg/mL (SA10). A synergistic effect was observed when we combined the RP-PED with gentamicin against all the strains tested. When we combined the RP-PED with Imipenem, we only observed synergistic effect against P. aeruginosa. According to our synergistic activity results, the utilization of red propolis collected in the drier periods can be used as an adjuvant against multiresistant bacterial infections.


Assuntos
Antibacterianos/farmacologia , Compostos Fitoquímicos/farmacologia , Própole/química , Antibacterianos/química , Brasil , Escherichia coli/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Compostos Fitoquímicos/química , Pseudomonas aeruginosa/efeitos dos fármacos , Estações do Ano , Staphylococcus aureus/efeitos dos fármacos
13.
Semina cienc. biol. saude ; 38(1): 99-104, jan./jun 2017. tab
Artigo em Inglês | LILACS | ID: biblio-905802

RESUMO

Free radicals are responsible for causing many chronic and degenerative diseases. Antioxidants are substances capable of scavenging free radicals and preventing cell damage. In this context, antioxidant activity of alcoholic extracts from leaves of Anacardium occidentale and Myracrodruon urundeuva was evaluated by 2,2-diphenyl-1-picrylhydrazyl DPPH and 2,2'-azinobis-(3-ethyl-benzothiazolin6-sulfonic acid) ABTS methods. Phenolic content and phytochemical analysis were performed for each species. Results showed that both species exhibited free radical scavenging activity. These results are directly related to high phenolic content found in the extracts. M. urundeuva showed antioxidant activity similar to butylhydroxytoluene (BHT) and could be considered a promising plant source of natural antioxidant.


Os radicais livres são responsáveis por causar muitas doenças crônicas e degenerativas. Os antioxidantes são substâncias capazes de eliminar radicais livres e impedi-los de causar danos celulares. Neste contexto, a atividade antioxidante dos extratos alcoólicos das folhas de Anacardium occidentale e Myracrodruon urundeuva foi avaliada pelos métodos de 2,2- difenil-1-picrilhidrazil (DPPH) e 2,2'-azinobis-(3-etil-benzothiazolin-6-sulfónico ácido) (ABTS). O conteúdo fenólico e análise fitoquímica dos extratos também foram avaliados. As duas espécies exibiram atividade sequestradora de radicais livres. Estes resultados estão relacionados com alto teor de compostos fenólicos encontrados nos extratos. M. urundeuva mostrou atividade antioxidante semelhante ao butilhidroxitolueno (BHT), se tornando uma fonte promissora de antioxidante natural.


Assuntos
Compostos Fenólicos , Anacardium , Antioxidantes/análise , Radicais Livres
14.
Temas psicol. (Online) ; 24(4): 1311-1327, dez. 2016. tab
Artigo em Português | LILACS-Express | ID: biblio-846306

RESUMO

O estabelecimento de laços com a família, amigos ou mesmo professores é crucial para o desenvolvimento dos adolescentes e jovens adultos. Uma individuação bem-sucedida na adolescência implica qualidade de relação. O presente estudo tem como objetivo analisar as diferenças na percepção do suporte social e processo de individuação em função da configuração familiar, bem como analisar o poder preditor da configuração familiar, do gênero, da idade e da percepção do suporte social dos jovens no processo de individuação. A amostra foi constituída por 827 jovens a frequentarem o ensino secundário e universitário, com idades entre os 13 e os 25 anos. A coleta de dados foi realizada no Norte de Portugal, mediante questionários de auto-relato: Social Support Appraisals (SSA) e Munich Individuation Test of Adolescence (MITA). Os resultados mostraram que jovens de famílias intactas apresentavam uma individuação mais bem-sucedida comparativamente com jovens de famílias divorciadas, e ainda evidenciaram o poder preditor da percepção do suporte da família no desenvolvimento da individuação. Neste sentido, verificou-se a importância da configuração e do suporte familiar para uma individuação bem-sucedida.


The establishment of bonds with family, friends or teachers is crucial to the development of adolescents and young adults. A successful individuation in adolescence involves the quality of relationships. This study aims to analyze the differences in the perception of social support and individuation process according to the family setting and to analyze the predictive power of family structure, gender, age and perceived social support of young people in the process of individuation. The sample consisted of 827 young people to attend secondary school and university, aged between 13 and 25 years. The data collection was carried in northern Portugal, through self-report questionnaires: Social Support Appraisals (SSA) and Munich Individuation Test of Adolescence (MITA). The results showed that young peole of intact families had a more successful individuation compared to young people from divorced families, and showed the predictive power of family support perception in the development of individuation. In this sense, this study showed the importance of setting and family support to a successful individuation.


El establecimiento de vínculos con la familia, amigos o profesores es crucial para el desarrollo de los adolescentes y adultos jóvenes. El éxito del proceso de individuación en la adolescencia implica calidad en las relaciones. Este estudio tiene como objetivo analizar las diferencias en la percepción de apoyo social y el proceso de individuación de acuerdo con el entorno familiar y analizar la capacidad de predicción de la estructura familiar, el género, la edad y el apoyo social percibido de los jóvenes en el proceso de individuación. La muestra consistió en 827 jóvenes que asisten a la escuela secundaria y la universidad, con edades comprendidas entre 13 y 25 años. La recolección de datos se realizó en el norte de Portugal, a través de cuestionarios de autoinforme: Social Support Appraisals (SSA) e Munich Individuation Test of Adolescence (MITA). Los resultados mostraron que los jóvenes de familias intactas tenían una mejor individuación en comparación con los jóvenes de familias divorciadas, y mostraron el poder predictivo de la percepción de apoyo familiar en el desarrollo de la individuación. En este sentido, este estudio demostró la importancia del entorno y del apoyo familiar en el éxito del proceso de individuación de los jóvenes.

15.
Temas psicol. (Online) ; 24(4): 1311-1327, dez. 2016. ilus, tab
Artigo em Português | Index Psicologia - Periódicos técnico-científicos | ID: psi-70000

RESUMO

O estabelecimento de laços com a família, amigos ou mesmo professores é crucial para o desenvolvimento dos adolescentes e jovens adultos. Uma individuação bem-sucedida na adolescência implica qualidade de relação. O presente estudo tem como objetivo analisar as diferenças na percepção do suporte social e processo de individuação em função da configuração familiar, bem como analisar o poder preditor da configuração familiar, do gênero, da idade e da percepção do suporte social dos jovens no processo de individuação. A amostra foi constituída por 827 jovens a frequentarem o ensino secundário e universitário, com idades entre os 13 e os 25 anos. A coleta de dados foi realizada no Norte de Portugal, mediante questionários de auto-relato: Social Support Appraisals (SSA) e Munich Individuation Test of Adolescence (MITA). Os resultados mostraram que jovens de famílias intactas apresentavam uma individuação mais bem-sucedida comparativamente com jovens de famílias divorciadas, e ainda evidenciaram o poder preditor da percepção do suporte da família no desenvolvimento da individuação. Neste sentido, verificou-se a importância da configuração e do suporte familiar para uma individuação bem-sucedida.(AU)


The establishment of bonds with family, friends or teachers is crucial to the development of adolescents and young adults. A successful individuation in adolescence involves the quality of relationships. This study aims to analyze the differences in the perception of social support and individuation process according to the family setting and to analyze the predictive power of family structure, gender, age and perceived social support of young people in the process of individuation. The sample consisted of 827 young people to attend secondary school and university, aged between 13 and 25 years. The data collection was carried in northern Portugal, through self-report questionnaires: Social Support Appraisals (SSA) and Munich Individuation Test of Adolescence (MITA). The results showed that young peole of intact families had a more successful individuation compared to young people from divorced families, and showed the predictive power of family support perception in the development of individuation. In this sense, this study showed the importance of setting and family support to a successful individuation.(AU)


El establecimiento de vínculos con la familia, amigos o profesores es crucial para el desarrollo de los adolescentes y adultos jóvenes. El éxito del proceso de individuación en la adolescencia implica calidad en las relaciones. Este estudio tiene como objetivo analizar las diferencias en la percepción de apoyo social y el proceso de individuación de acuerdo con el entorno familiar y analizar la capacidad de predicción de la estructura familiar, el género, la edad y el apoyo social percibido de los jóvenes en el proceso de individuación. La muestra consistió en 827 jóvenes que asisten a la escuela secundaria y la universidad, con edades comprendidas entre 13 y 25 años. La recolección de datos se realizó en el norte de Portugal, a través de cuestionarios de autoinforme: Social Support Appraisals (SSA) e Munich Individuation Test of Adolescence (MITA). Los resultados mostraron que los jóvenes de familias intactas tenían una mejor individuación en comparación con los jóvenes de familias divorciadas, y mostraron el poder predictivo de la percepción de apoyo familiar en el desarrollo de la individuación. En este sentido, este estudio demostró la importancia del entorno y del apoyo familiar en el éxito del proceso de individuación de los jóvenes.(AU)


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Divórcio , Família , Percepção , Individuação
16.
Ultrason Sonochem ; 31: 237-49, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26964946

RESUMO

The present study has evaluated the effects of power ultrasound pre-treatment on air-drying and bioactive compounds of cashew apple bagasse. The sonication induced the disruption of cashew bagasse parenchyma, which resulted in lower resistance to water diffusion, less hysteresis, and increased rehydration rate. The processing did not affect the lignocellulose fibers or the sclerenchyma cells. For sonicated samples, water activity reached values below 0.4, after 2h of drying, which is appropriate to prevent bacterial and fungi growth. The sorption isotherms of cashew apple bagasse presented sigmoid-shape for all samples and followed the type II according to BET classification. Sonicated cashew apple bagasse showed higher antioxidant activity, higher total phenolic compounds (TPC) and higher vitamin C content when compared to the non-sonicated sample. The increase in TPC and vitamin C contributed to the product antioxidant activity. A slight reduction on Vitamin C bioaccessibility was observed, but the TPC bioaccessibility has increased. Sonication reduced the quality loss of conventional drying treatments improving the quality of the dried product.


Assuntos
Antioxidantes/química , Celulose/química , Ultrassom , Técnicas In Vitro
17.
Rev. psicol. organ. trab ; 15(4): 419-430, dez. 2015. tab
Artigo em Português | LILACS-Express | ID: lil-772541

RESUMO

Este estudo pretende contribuir para a compreensão do conflito entre trabalho e família em motoristas profissionais que trabalham com transporte de passageiros e da influência que outras variáveis possam ter nesse âmbito. Foi analisada especificamente a relação entre o conflito trabalho-família e as variáveis sociodemográficas (idade), do contexto familiar (número e idade dos filhos) e do contexto profissional (duração da jornada de trabalho, satisfação com o trabalho, suporte social dos supervisores e suporte social dos colegas de trabalho). Os dados foram recolhidos por meio de questionário, tendo participado 154 trabalhadores de uma empresa de transportes de passageiros do norte de Portugal. Todos os participantes eram do sexo masculino, e a maioria deles tinha idade entre 40 e 59 anos, eram casados e tinham filhos. Os resultados revelaram que os motoristas apresentam valores médios relativamente reduzidos de conflito trabalho-família e indicaram que a idade dos filhos, o número de horas trabalhadas semanalmente e a percepção de suporte dos supervisores constituíram preditores significativos do conflito trabalho-família.


This study aims to contribute to the understanding of work-family conflict among professional drivers, and the influence that other variables may have in that context. We analyzed the relationship between work-family conflict and socio-demographic variables (age), family context (number of children and their ages), and professional context (number of working hours, job satisfaction, and perception of supervisor and co-worker social support) in particular. Data were collected through a questionnaire administered to 154 male workers of a passenger transport company in the north of Portugal. The majority of the participants were aged 40-50, were married, and had children. Data showed that the drivers reported relatively low mean levels of work-family conflict. Results also showed that the age of their children, weekly hours worked, and the perception of supervisor support were significant predictors of work-family conflict.


Este estudio pretende contribuir a la comprensión del conflicto entre trabajo y familia en conductores profesionales que trabajan con el transporte de pasajeros, y de la influencia que otras variables puedan tener en ese contexto. Específicamente, se analizó la relación entre el conflicto trabajo-familia y las variables sociodemográficas (edad), el contexto familiar (número de hijos y su edad), así como el contexto profesional (duración de la jornada de trabajo, satisfacción laboral, apoyo social de los supervisores y soporte social de los compañeros de trabajo). Los datos se recogieron mediante un cuestionario aplicado a 154 trabajadores hombres de una empresa de transporte de pasajeros del norte de Portugal. La mayoría de los participantes tenía entre 40 y 59 años, estaban casados y tenían hijos. Los resultados muestran que los conductores tienen valores medios relativamente bajos de conflicto trabajo-familia. Los resultados también indicaron que la edad de los hijos, el número de horas trabajadas semanalmente y la percepción de apoyo de los supervisores constituyeron predictores significativos del conflicto trabajo-familia.

18.
J Food Sci Technol ; 52(9): 5961-7, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26345014

RESUMO

Oligosaccharides can be synthesized using the sugars present in the fruit juices through the dextransucrase acceptor reaction. In the present work, the effect of reducing sugar and sucrose concentration on oligosaccharide formation in lemon juice was evaluated through response surface methodology. The oligosaccharide formation in lemon juice was favored at high concentrations of sucrose (75 g/L) and reducing sugar (75 g/L). At this synthesis conditions, an oligosaccharide concentration of 94.81 g/L was obtained with a conversion of 63.21% of the initial sugars into the target product. Oligosaccharides with degree of polymerization up to 11 were obtained. The lemon juice was dehydrated in spouted bed using maltodextrin as drying adjuvant. The powder obtained at 60°C with 20 % maltodextrin presented low moisture (2.24 %), low water activity (Aw = 0.18) and the lowest reconstitution time (~46 s). The results showed that lemon juice is suitable for oligosaccharides enzyme synthesis and can be dehydrated in spouted bed.

19.
Rev. cienc. salud (Bogotá) ; 13(3): 345-354, set.-dic. 2015. ilus, tab
Artigo em Português | LILACS-Express | ID: lil-780609

RESUMO

Introdução: Combinações múltiplas de drogas estão sendo utilizadas no combate à disseminação de bactérias patogênicas resistentes a antibióticos. No entanto, a utilização incorreta desses antibióticos fez com que algumas bactérias sejam selecionadas, deixando apenas as resistentes aos agentes antimicrobianos, com o consequente surgimento de resistência aos antibióticos. Objetivos: Nesse contexto, avaliaram-se as atividades microbiológicas dos antibióticos claritromicina, gentamicina, ciprofloxacino e imipenem, além de comparar as atividades da associação entre esses fármacos, frente às cepas bacterianas de Escherichia coli e Staphylococcus aureus. Materiais e Métodos: A Concentração Inibitória Mínima (CIM) foi realizada pelo método de microdiluição em caldo para cada uma das amostras selecionadas. Posteriormente, com base nos valores das cims, foi avaliado o efeito antimicrobiano da combinação das drogas pelo método de modulação. Resultados: A associação demonstrou efeitos sinérgicos frente às linhagens testadas, sugerindo-se que a associação dos antibióticos testados aumenta o seu potencial antimicrobiano. Conclusão: Nesse sentido, o uso de antibióticos em combinação pode ser realizado mediante investigações posteriores que comprovem a segurança de seu uso.


Introducción: Actualmente, se está utilizando la combinación de múltiples drogas en la lucha contra la propagación de bacterias patógenas resistentes a los antibióticos. Sin embargo, el uso inadecuado de estos antibióticos ha causado que algunas bacterias se seleccionen, con la consiguiente aparición de resistencia a los antibióticos. Objetivo: Se evaluó la actividad microbiológica de los antibióticos claritromicina, gentamicina, ciprofloxacino e imipenem, y se comparó la actividad sinérgica de estos fármacos, frente a las cepas bacterianas de Escherichia coli y Staphylococcus aureus. Materiales y Métodos: Se determinó la Concentración Mínima Inhibitoria (CMI) por el método de microdilución en caldo para cada una de las muestras seleccionadas y se evaluó el efecto antimicrobiano de la combinación de fármacos por el método de modulación. Resultados: La combinación mostró efectos sinérgicos frente a las cepas ensayadas, lo que sugiere que la asociación de los antibióticos ensayados aumenta su potencial antimicrobiano. Conclusión: Se puede utilizar antibióticos en combinación; sin embargo, se requiere realizar investigaciones adicionales que demuestren ser seguros para su utilización.


Introduction: Combining multiple drugs is an strategy used to combat the dissemination of pathogenic and drug resistant bacteria. However, the misuse of these drugs against bacteria have caused the selection of more resistant specimens called multidrug-resistant bacteria. Objective: In this work we evaluated the antibiotic activity of claritromicin, gentamicin, ciprofloxacin and imipenen, alone or associating one by one, against strains of Escherichia coli and Staphylococcus aureus. Material and methods: The minimal inhibitory concentration (mic) was performed using the microdilution assay. Based in the mic values, the antibiotic effect of the drugs alone and in association were determined. Results: The association between the drugs demonstrated the synergism against the bacterial strains. Conclusion: The use of the combined antibiotic-therapy can be positively performed, but additional studies have to be conducted first for proving that its use is safe.

20.
Artigo em Inglês | MEDLINE | ID: mdl-26257815

RESUMO

Dengue represents a serious social and economic public health problem; then trying to contribute to improve its control, the objective of this research was to develop phytoterapics for dengue treatment using natural resources from Caatinga biome. Galactomannans isolated from Adenanthera pavonina L., Caesalpinia ferrea Mart., and Dimorphandra gardneriana Tull were chemically sulfated in order to evaluate the antioxidant, and antiviral activities and the role in the inhibition of virus DENV-2 in Vero cells. A positive correlation between the degree of sulfation, antioxidant and antiviral activities was observed. The sulfated galactomannans showed binding to the virus surface, indicating that they interact with DENV-2. The sulfated galactomannans from C. ferrea showed 96% inhibition of replication of DENV-2 followed by D. gardneriana (94%) and A. pavonina (77%) at 25 µg/mL and all sulfated galactomannans also showed antioxidant activity. This work is the first report of the antioxidant and antiviral effects of sulfated galactomannans against DENV-2. The results are very promising and suggest that these sulfated galactomannans from plants of Caatinga biome act in the early step of viral infection. Thus, sulfated galactomannans may act as an entry inhibitor of DENV-2.

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