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1.
5.
Int J Dermatol ; 57(1): 104-109, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29231239

RESUMO

BACKGROUND: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. OBJECTIVE: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. METHODS: Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. RESULTS: A total of 100 women were included in this observational pilot study. Mean age was 48.44 years (range 18-80). Mean hair loss severity at baseline was Sinclair 2.79 (range 2-5). Mean hair shedding score at baseline was 4.82. Mean duration of diagnosis was 6.5 years (range 0.5-30). Mean reduction in hair loss severity score was 0.85 at 6 months and 1.3 at 12 months. Mean reduction in hair shedding score was 2.3 at 6 months and 2.6 at 12 months. Mean change in blood pressure was -4.52 mmHg systolic and -6.48 mmHg diastolic. Side effects were seen in eight women but were generally mild. No patients developed hyperkalemia or any other blood test abnormality. Six of these women continued treatment, and two women who developed urticaria discontinued treatment. LIMITATIONS: Prospective, uncontrolled, open-label observational study. DISCUSSION: Once daily capsules containing minoxidil 0.25 mg and spironolactone 25 mg appear to be safe and effective in the treatment of FPHL. Placebo-controlled studies to investigate this further are warranted.


Assuntos
Alopecia/tratamento farmacológico , Diuréticos/uso terapêutico , Minoxidil/uso terapêutico , Espironolactona/uso terapêutico , Vasodilatadores/uso terapêutico , Administração Oral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Diuréticos/administração & dosagem , Diuréticos/efeitos adversos , Combinação de Medicamentos , Feminino , Humanos , Pessoa de Meia-Idade , Minoxidil/administração & dosagem , Minoxidil/efeitos adversos , Projetos Piloto , Estudos Prospectivos , Índice de Gravidade de Doença , Espironolactona/administração & dosagem , Espironolactona/efeitos adversos , Urticária/induzido quimicamente , Vasodilatadores/administração & dosagem , Vasodilatadores/efeitos adversos , Adulto Jovem
6.
Methods Mol Biol ; 1453: 109-21, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27431251

RESUMO

Common human balding or hair loss is driven by follicle miniaturization. Miniaturization is thought to be caused by a reduction in dermal papilla size. The molecular mechanisms that regulate papilla size are poorly understood, and their elucidation would benefit from a tractable experimental model. We have found that dermal papilla cells from sheep spontaneously aggregate in culture to form papilla-like structures. Here, we describe methods for microdissecting dermal papillae from wool follicles, for initiating and maintaining cultures of ovine papilla cells, and for using these cells in an in vitro assay to measure the effect of bioactive molecules on aggregate size.


Assuntos
Derme/citologia , Folículo Piloso/citologia , Animais , Técnicas de Cultura de Células , Separação Celular , Células Cultivadas , Ovinos
7.
Wound Repair Regen ; 24(4): 679-85, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27067025

RESUMO

Hair follicle cells contribute to wound healing, skin circulation, and skin diseases including skin cancer, and hair transplantation is a useful technique to study the participation of hair follicle cells in skin homeostasis and wound healing. Although hair follicle transplantation is a well-established human hair-restoration procedure, follicular transplantation techniques in animals have a number of shortcomings and have not been well described or optimized. To facilitate the study of follicular stem and progenitor cells and their interaction with surrounding skin, we have established a new murine transplantation model, similar to follicular unit transplantation in humans. Vibrissae from GFP transgenic mice were harvested, flip-side microdissected, and implanted individually into needle hole incisions in the back skin of immune-deficient nude mice. Grafts were evaluated histologically and the growth of transplanted vibrissae was observed. Transplanted follicles cycled spontaneously and newly formed hair shafts emerged from the skin after 2 weeks. Ninety percent of grafted vibrissae produced a hair shaft at 6 weeks. After pluck-induced follicle cycling, growth rates were equivalent to ungrafted vibrissae. Transplanted vibrissae with GFP-positive cells were easily identified in histological sections. We established a follicular vibrissa transplantation method that recapitulates human follicular unit transplantation. This method has several advantages over current protocols for animal hair transplantation. The method requires no suturing and minimizes the damage to donor follicles and recipient skin. Vibrissae are easier to microdissect and transplant than pelage follicles and, once transplanted, are readily distinguished from host pelage hair. This facilitates measurement of hair growth. Flip-side hair follicle microdissection precisely separates donor follicular tissue from interfollicular tissue and donor cells remain confined to hair follicles. This makes it possible to differentiate migration of hair follicle cells from interfollicular epidermis in lineage tracing wound experiments using genetically labeled donor follicles.


Assuntos
Folículo Piloso/transplante , Transplante de Pele/métodos , Vibrissas/transplante , Cicatrização/fisiologia , Animais , Diferenciação Celular , Movimento Celular , Folículo Piloso/citologia , Folículo Piloso/crescimento & desenvolvimento , Masculino , Camundongos , Camundongos Nus , Camundongos Transgênicos , Microdissecção/métodos , Modelos Animais , Fenômenos Fisiológicos da Pele , Células-Tronco/fisiologia , Vibrissas/citologia , Vibrissas/crescimento & desenvolvimento
9.
Int J Trichology ; 6(3): 88-94, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25210331

RESUMO

The arrector pili muscle (APM) consists of a small band of smooth muscle that connects the hair follicle to the connective tissue of the basement membrane. The APM mediates thermoregulation by contracting to increase air-trapping, but was thought to be vestigial in humans. The APM attaches proximally to the hair follicle at the bulge, a known stem cell niche. Recent studies have been directed toward this muscle's possible role in maintaining the follicular integrity and stability. This review summarizes APM anatomy and physiology and then discusses the relationship between the follicular unit and the APM. The potential role of the APM in hair loss disorders is also described, and a model explaining APM changes in hair loss is proposed.

11.
Med J Aust ; 199(11): 811-2, 2013 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-24329675

RESUMO

OBJECTIVE: To test the popular assertion that bald men are more virile than their well thatched contemporaries DESIGN, PARTICIPANTS AND SETTING: Secondary analysis of data from a case-control study in a community setting between 1994 and 1997 among men below the age of 70 years, using in-person interviews and categorisation of baldness, with subsequent completion of a questionnaire by the participant. We analysed risk factors for baldness using unconditional logistic regression. MAIN OUTCOME MEASURES: Baldness; history of ejaculations between the ages of 20 and 49 years; total number of sexual partners. RESULTS: There was no significant association between baldness and the frequency of ejaculations, but bald men were significantly less likely to have had more than four female sexual partners. CONCLUSIONS: In the population studied, bald men appear to be no more virile than their well thatched contemporaries.


Assuntos
Alopecia/psicologia , Ejaculação , Comportamento Sexual/estatística & dados numéricos , Parceiros Sexuais/psicologia , Adulto , Idoso , Alopecia/diagnóstico , Alopecia/etiologia , Estudos de Casos e Controles , Feminino , Humanos , Entrevistas como Assunto , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
13.
Med J Aust ; 197(10): 565-8, 2012 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-23163687

RESUMO

OBJECTIVES: To report the burden and cost of non-melanoma skin cancer (NMSC) treatments in Australia and to project estimates of numbers and costs to 2015. DESIGN AND SETTING: Retrospective study of data obtained from Medicare Australia for NMSC treated by excision, curettage, laser or cryotherapy between 1 January 1997 and 31 December 2010, by year, sex, age group and state or territory. MAIN OUTCOME MEASURES: Total number, total Medicare Benefits Schedule (MBS) benefit and total cost in Australian dollars of NMSC treatments. RESULTS: The total number of NMSC treatments increased from 412 493 in 1997 to 767 347 in 2010, and we estimated that the number of treatments would increase to 938 991 (95% CI, 901 047-976 934) by 2015. The total MBS benefit for NMSC treatments in 2010 was $93.5 million, and we estimated that this will increase to $109.8 million (95% CI, $105.9-$113.7 million) by 2015, whereas the total cost with inflation (ie, cost which includes diagnosis, treatment and pathology) was $511.0 million in 2010, estimated to increase to $703.0 million (95% CI, $674.6-$731.4 million) by 2015. CONCLUSION: NMSC treatments increased by 86% between 1997 and 2010. We anticipate that the number and the total cost without inflation of NMSC treatments will increase by a further 22% between 2010 and 2015. NMSC will remain the most costly cancer and place an increasing burden on the Australian health care system.


Assuntos
Custos de Cuidados de Saúde , Neoplasias Cutâneas/economia , Austrália/epidemiologia , Humanos , Programas Nacionais de Saúde , Estudos Retrospectivos , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/terapia
14.
Australas J Dermatol ; 53(4): e91-2, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23157795

RESUMO

The occurrence of alopecia areata (AA) in a red-haired individual is considered to be rare. We report two cases of red-haired men who were afflicted with patch-type AA. Astonishingly, the hair regrowth was coloured black, in contrast to the surrounding red hair, an event which has been reported only once in the past after cyclophosphamide administration. This phenomenon raises some interesting questions regarding the significance of pigmentation and the melanocortin-1 receptor in AA pathogenesis.


Assuntos
Alopecia em Áreas/patologia , Cabelo/patologia , Pigmentação , Adulto , Alopecia em Áreas/tratamento farmacológico , Anti-Inflamatórios/uso terapêutico , Criança , Cabelo/crescimento & desenvolvimento , Humanos , Masculino
15.
J Photochem Photobiol B ; 114: 140-6, 2012 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-22727928

RESUMO

Several previous studies have reported luminescence emission from skin following exposure to UVA radiation in air. We show that UVA irradiation of biomaterials and polymers in oxygen, including bovine stratum corneum, followed by photon counting results in a complex emission due to a combination of photophysical processes together with photo-induced chemiluminescence (PICL). The photophysical processes include fluorescence, phosphorescence and charge-recombination luminescence. By irradiating materials in an inert atmosphere such as nitrogen and allowing photophysical light emission to fully decay before admitting oxygen, the weak photo-induced chemiluminescence generated via free radical reactions with oxygen can be separated and analysed. PICL emission from bovine stratum corneum is weaker than for wool keratin and bovine skin collagen, probably due to its higher water content, and the presence of the natural antioxidants ascorbate and tocopherol.


Assuntos
Pele/efeitos da radiação , Raios Ultravioleta , Animais , Antioxidantes/química , Antioxidantes/metabolismo , Ácido Ascórbico/química , Ácido Ascórbico/metabolismo , Bovinos , Medições Luminescentes , Oxigênio/química , Oxigênio/metabolismo , Vitamina E/química , Vitamina E/metabolismo
17.
Drug Discov Today ; 13(17-18): 791-7, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18617016

RESUMO

Male pattern baldness affects up to half of the male Caucasian population by middle age, and almost all Caucasian men by old age. Especially in younger men, this heritable form of hair loss can have significant psycho-social consequences. Although approved pharmacological agents exist to manage the condition, none of the currently available options are highly efficacious. New treatments under development, and acceleration in our understanding of the underlying molecular genetic aetiology of this condition provide increased hope for future targeted treatment strategies.


Assuntos
Alopecia/terapia , Adulto , Idoso , Alopecia/etiologia , Alopecia/genética , Alopecia/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade
19.
J Investig Dermatol Symp Proc ; 12(2): 2-5, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18004288

RESUMO

Shiny hair with a smooth texture and clean-cut ends or tapered tips is generally perceived to be healthy. Hair texture and shine relate to hair surface properties, whereas the integrity of hair ends relates to the hair cortex. Hair can be straight, wavy or curly, blonde, black, brown, red, gray white, and its natural variations are important to our identity. Manipulation of the normal structure of the hair shaft is epidemic and dictated by culture, fashion, and above all, celebrity. Although cosmetic procedures are intrinsically safe, there is potential for damage to the hair. Loss of lustre, frizz, split ends, and other hair problems are particularly prevalent among people who repeatedly alter the natural style of their hair or among people with hair that is intrinsically weak. This may be due to individual or racial variation or less commonly an inherited structural abnormality in hair fiber formation. Hair health is also affected by common afflictions of the scalp as well as age-related phenomena such as graying and androgenetic alopecia. Hair products that improve the structural integrity of hair fibers and increase tensile strength are available, as are products that increase hair volume, reduce frizz, improve hair manageability, and stimulate new hair growth.


Assuntos
Doenças do Cabelo/etiologia , Preparações para Cabelo/efeitos adversos , Cabelo , Ácidos Eicosanoicos/química , Feminino , Cabelo/anatomia & histologia , Cabelo/química , Cabelo/efeitos dos fármacos , Doenças do Cabelo/etnologia , Preparações para Cabelo/farmacologia , Humanos , Higiene
20.
J Investig Dermatol Symp Proc ; 10(3): 184-9, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16382660

RESUMO

Maryborough, in central Victoria has an approximate population of 8000 and census data is well matched for Australia overall. Australia has compulsory voting and registration on the electoral roll. To determine the age-related prevalence of balding among men and women in Maryborough we conducted a postal survey of 5000 men and women aged 20 or older, and 427 were invited to attend for examination. Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p<0.01). The prevalence of mid-frontal hair loss increases with age and affects 57% of women and 73.5% of men aged 80 and over.


Assuntos
Alopecia/epidemiologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Alopecia/classificação , Feminino , Cabelo/crescimento & desenvolvimento , Cor de Cabelo , Humanos , Masculino , Pessoa de Meia-Idade , Exame Físico , Prevalência , Análise de Regressão , Dermatoses do Couro Cabeludo/epidemiologia , Inquéritos e Questionários , Vitória/epidemiologia
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