Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 52
Filtrar
1.
Carbohydr Polym ; 290: 119466, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35550749

RESUMO

With the increasing population of mosquitoes due to urbanisation, requirement for effective mosquito repellent gadgets is rising. To guarantee the security from mosquitoes, dire need is felt to build productive innovations. In the current work, a carbohydrate-based textile fibre was functionalised for imparting colour, mosquito repellency, antibacterial activity and UV protection using a novel polymeric dye. Mosquito repellent 4-amino N,N-diethyl-meta-toluamide (DEET-NH2) was diazotised and reacted with chitosan for the in-situ preparation of azo polymeric dye. The separately prepared polymeric dye was characterised using FTIR (Fourier Transform Infrared Spectroscopy) analysis. In-situ dyed fabric was thoroughly characterised and evaluated for colouration, mechanical and functional properties. The dyed cotton showed an outstanding mosquito repellency (100%) with good durability. Moreover, antibacterial activity (>78%) and UV protection (good to very good) were also displayed by the dyed cotton. An innovative technique to develop multifunctional carbohydrate-based fibre is developed.

2.
Artigo em Inglês | MEDLINE | ID: mdl-35490431

RESUMO

Collagen is the most important structural protein and also a main component of extra-cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by altering it's biosynthesis pathway through various signaling pathways, receptors and genes. Activity of cancer cells can also be regulated by other ECM components like metalloproteinases, hyaluronic acid, fibronectin and so on. Hypoxia is also one of the condition which leads to cancer progression by stimulating the expression of procollagen lysine as a collagen crosslinker, which increases the size of collagen fibres promoting cancer spread. The collagen content in cancerous cells leads to resistance in chemotherapy. So, to reduce this resistance, some of the collagen regulating therapies are introduced, which include inhibiting its biosynthesis, disturbing cancer cell signaling pathway, mediating ECM components and directly utilizing collagenase. This study is an effort to compile the strategies reported to control the collagen level and different collagen inhibitors reported so far. More research is needed in this area, growing understandings of collagen's structural features and its role in cancer progression will aid in the advancement of newer chemotherapies.

3.
Genes (Basel) ; 13(3)2022 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-35328060

RESUMO

Hypoxic ischemic injury to the fetal and neonatal brain is a leading cause of death and disability worldwide. Although animal and culture studies suggest that glutamate excitotoxicity is a primary contributor to neuronal death following hypoxia, the molecular mechanisms, and roles of various neural cells in the development of glutamate excitotoxicity in humans, is not fully understood. In this study, we developed a culture model of human fetal neural stem cell (FNSC)-derived astrocytes and examined their glutamate uptake in response to hypoxia. We isolated, established, and characterized cultures of FNSCs from aborted fetal brains and differentiated them into astrocytes, characterized by increased expression of the astrocyte markers glial fibrillary acidic protein (GFAP), excitatory amino acid transporter 1 (EAAT1) and EAAT2, and decreased expression of neural stem cell marker Nestin. Differentiated astrocytes were exposed to various oxygen concentrations mimicking normoxia (20% and 6%), moderate and severe hypoxia (2% and 0.2%, respectively). Interestingly, no change was observed in the expression of the glutamate transporter EAAT2 or glutamate uptake by astrocytes, even after exposure to severe hypoxia for 48 h. These results together suggest that human FNSC-derived astrocytes can maintain glutamate uptake after hypoxic injury and thus provide evidence for the possible neuroprotective role of astrocytes in hypoxic conditions.


Assuntos
Astrócitos , Ácido Glutâmico , Células-Tronco Neurais , Astrócitos/metabolismo , Hipóxia Celular , Células Cultivadas , Transportador 1 de Aminoácido Excitatório/genética , Transportador 1 de Aminoácido Excitatório/metabolismo , Ácido Glutâmico/metabolismo , Humanos , Células-Tronco Neurais/metabolismo
4.
Hosp Top ; : 1-15, 2022 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-35037828

RESUMO

This study evaluates global health diplomacy and governance by performing bibliometric analysis to investigate the current publication trends, authors and keywords-based clusters, research trends, author's productivity, and future research areas. The analysis results suggest that global health diplomacy has garnered attention only in developed countries and has been researched negligibly in developing countries. The research in this field increases after the onset of pandemics such as Swine Flu and COVID-19. Authors kickbush and lee are the most influential authors based on their h index. The identified future research areas are "International laws" and "Social Determinants of Health."

5.
Health Mark Q ; 39(1): 61-73, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34720067

RESUMO

This study considers Theory of Reasoned Action and Technology Acceptance Model frameworks to test the mediating role of attitude towards using E-health platforms. 224 medical practitioners' responses are collected in the online mode. The mediation analysis supports the full mediation role of attitude towards using the E-health platforms in the relationship between perceived usefulness and intentions to use with (indirect effect = .15, SE = 0.03, LLCI = 0.09, and ULCI = .22). E-health platform developers should take active measures to improve the attitude of medical practitioners towards using such platforms, to derive the best results of the added features.

6.
J Cardiovasc Electrophysiol ; 33(1): 32-39, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34741568

RESUMO

BACKGROUND: There is a high incidence of atrial fibrillation (AF) in patients with isolated rheumatic mitral regurgitation (MR). The histopathologic changes in the atria of patients with isolated rheumatic MR with and without AF are unknown. OBJECTIVES: We aimed to determine the histological findings in patients with isolated severe rheumatic MR with and without AF. METHODS: Patients with severe isolated rheumatic MR undergoing valve replacement surgeries underwent endocardial biopsies from right atrial appendage, left atrial appendage, right free wall, left free wall, left posterior wall, and mitral valve. Group I consisted of patients in sinus rhythm (SR), and Group II included patients with AF. We analyzed and compared these 10 histological features in the biopsies of patients in Groups I and II. RESULTS: Of the 25 patients, 12 were in Group I and 13 in Group II. In Group I, patients had severe myocyte hypertrophy (60% vs. 18%, p = .04) that was significantly more in the right atrium (22.7% vs. 11.4%, p = .059). Interstitial adipose tissue deposition was more common in Group I (30% vs. 25%, p = .06). Interstitial fibrosis was evenly distributed at all sites without significant difference between the two groups. Group II patients had a higher prevalence and severity of vacuolar degeneration (91% vs. 60%, p = .09). CONCLUSIONS: Patients with isolated severe rheumatic MR and AF have more vacuolar degeneration in the atrial tissue. Patients with SR have myocyte hypertrophy and interstitial adipose tissue deposition. Interstitial fibrosis is uniformly distributed in patients in SR and AF.


Assuntos
Fibrilação Atrial , Insuficiência da Valva Mitral , Cardiopatia Reumática , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/etiologia , Átrios do Coração , Humanos , Valva Mitral , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/cirurgia , Cardiopatia Reumática/complicações , Cardiopatia Reumática/diagnóstico por imagem , Cardiopatia Reumática/cirurgia
7.
Indian J Microbiol ; 61(4): 427-440, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34744198

RESUMO

Presently, fossil fuels are extensively employed as major sources of energy, and their uses are considered unsustainable due to emissions of obnoxious gases on the burning of fossil fuels, which can lead to severe environmental complications, including human health. To tackle these issues, various processes are developing to waste as a feed to generate eco-friendly fuels. The biological production of fuels is considered to be more beneficial than physicochemical methods due to their environmentally friendly nature, high rate of conversion at ambient physiological conditions, and less energy-intensive. Among various biofuels, hydrogen (H2) is considered as a wonderful due to high calorific value and generate water molecule as end product on the burning. The H2 production from biowaste is demonstrated, and agri-food waste can be potentially used as a feedstock due to their high biodegradability over lignocellulosic-based biomass. Still, the H2 production is uneconomical from biowaste in fuel competing market because of low yields and increased capital and operational expenses. Anaerobic digestion is widely used for waste management and the generation of value-added products. This article is highlighting the valorization of agri-food waste to biofuels in single (H2) and two-stage bioprocesses of H2 and CH4 production.

8.
Prog Mol Biol Transl Sci ; 184: 205-218, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34749974

RESUMO

Emergence of a captivating phenomenon aggregation induced emission (AIE) in the early years of 21st century attracted worldwide researchers. In the last two decades various novel AIE active biocompatible small molecules, macromolecules and polymers have been developed for diverse biomedical applications. Imaging of specific organelle such as mitochondria, ribosomes, nuclei and many others play important in the controlling and successful treatment of various diseases. Conventional luminescent probe molecules used in the imaging at cellular or subcellular level exhibit very weak emission on dispersion or on aggregation in aqueous media. AIE luminogens development is indispensable to overcome the notorious aggregation-caused quenching (ACQ) issue inherited by conventional fluorophores. In the present chapter we mostly highlighted over one decade development of various AIE active luminogens utilized for imaging of cell nucleus, nucleon and nucleic acids. The development of those AIE luminogens exhibits promising results in the early diagnosis of cancer diseases.


Assuntos
Corantes Fluorescentes , Neoplasias , Núcleo Celular , Humanos
9.
Health Mark Q ; 38(2-3): 188-204, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34632967

RESUMO

The current study is conceptualized to assess the perception of the general population towards health insurance providers and the policy features, to segment them based on their attitudes. The mixed-method design is used in this study. One fifty health insurance users response were analyzed. The data analysis technique includes focus group discussion, henry garret ranking method, factor analysis and cluster analysis. This study concludes that health insurance providers needs to devise insurance policies incorporating the features of home health, telemedicine and income protection features. The existing users should be offered customization option due to covid-19 to prevent customer switch.


Assuntos
COVID-19 , Comportamento do Consumidor , Humanos , Seguro Saúde , SARS-CoV-2
10.
Opt Express ; 29(15): 23056-23072, 2021 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-34614578

RESUMO

Recently, chiral structured illumination microscopy has been proposed to image fluorescent chiral domains at sub-wavelength resolution. Chiral structured illumination microscopy is based on the combination of structured illumination microscopy, fluorescence-detected circular dichroism, and optical chirality engineering. Since circular dichroism of natural chiral molecules is typically weak, the differential fluorescence is also weak and can be easily buried by the noise, hampering the fidelity of the reconstructed images. In this work, we systematically study the impact of the noise on the quality and resolution of chiral domain images obtained by chiral SIM. We analytically describe the signal-to-noise ratio of the reconstructed chiral SIM image in the Fourier domain and verify our theoretical calculations with numerical demonstrations. Accordingly, we discuss the feasibility of chiral SIM in different experimental scenarios and propose possible strategies to enhance the signal-to-noise ratio for samples with weak circular dichroism.

11.
Indian J Otolaryngol Head Neck Surg ; 73(4): 514-518, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34692464

RESUMO

Spontaneous perforation of the esophagus is an emergency that requires early diagnosis and management. It may be fatal and delay in treatment can cause an increase in morbidity and mortality. Despite of being very rare in infants, we have to be watchful whenever we encounter signs and symptoms related to it. Only 7 cases of spontaneous esophageal perforation in infants have been report in the literature to the best of our knowledge. Here we are reporting a rare case of spontaneous esophageal rupture in an infant.

12.
Opt Lett ; 46(18): 4546-4549, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34525041

RESUMO

We propose double structured illumination microscopy (SIM) method, which enables simultaneous imaging of achiral and chiral domains at sub-wavelength resolution. In double SIM, the illumination field is spatially structured both in the intensity and optical chirality so that moiré effects can be concurrently generated on the achiral and chiral fluorescent domains of a sample. This allows for down-modulating the high spatial frequency of both domains at the same time and thus provides sub-wavelength details after image reconstruction. We introduce the working principle of double SIM and theoretically demonstrate the feasibility of this method using different kinds of synthetic samples.

13.
Hosp Top ; : 1-8, 2021 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-34251990

RESUMO

Ayurveda as alternative medicine is widely popular across the globe. Moreover, after the onset of COVID-19, it has been looked at as a preferred option to boost immunity to prevent the infection of COVID-19. However, in developing countries, the misconceptions associated with Ayurveda lead to post-purchase embarrassment. This study proposes a model of perceived increased Availability of Ayurveda products in the market, with dependent variables such as brand influence, perceived immunity against COVID-19, post-product purchase embarrassment, and perceived safe and effective nature. The analysis is done by IBM AMOS v.22, the conceptualized hypothesis was also tested.

14.
Phys Rev E ; 103(5-1): 052105, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34134190

RESUMO

The theory developed in our previous papers [Phys. Rev. E 99, 030101(R) (2019)10.1103/PhysRevE.99.030101; Phys. Rev. E 103, 032611 (2021)10.1103/PhysRevE.103.032611] is applied in this paper to investigate the dependence of slowing down of dynamics of glass-forming liquids on the attractive and repulsive parts of intermolecular interactions. Through an extensive comparison of the behavior of a Lennard-Jones glass-forming liquid and that of its WCA reduction to a model with truncated pair potential without attractive tail, we demonstrate why the two systems exhibit very different dynamics despite having nearly identical pair correlation functions. In particular, we show that local structures characterized by the number of mobile and immobile particles around a central particle markedly differ in the two systems at densities and temperatures where their dynamics show large difference and nearly identical where dynamics nearly overlap. We also show how the parameter ψ(T) that measures the role of fluctuations embedded in the system on size of the cooperatively reorganizing cluster (CRC) and the crossover temperature T_{a} depend on the intermolecular interactions. These parameters stemming from the intermolecular interactions characterize the temperature and density dependence of structural relaxation time τ_{α}. The quantitative and qualitative agreements found with simulation results for the two systems suggest that our theory brings out the underlying features that determine the dynamics of glass-forming liquids.

15.
Phys Rev E ; 103(3-1): 032611, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33862818

RESUMO

In this paper, we develop a theory to calculate the structural relaxation time τ_{α} of fragile supercooled liquids. Using the information of the configurational entropy and structure, we calculate the number of dynamically free, metastable, and stable neighbors around a central particle. In supercooled liquids, the cooperatively reorganizing clusters (CRCs) in which the stable neighbors form "stable" nonchemical bonds with the central particle emerge. For an event of relaxation to take place, these bonds have to reorganize irreversibly; the energy involved in the processes is the effective activation energy of relaxation. The theory brings forth a temperature T_{a} and a temperature-dependent parameter ψ(T) which characterize slowing down of dynamics on cooling. It is shown that the value of ψ(T) is equal to 1 for T>T_{a}, indicating that the underlying microscopic mechanism of relaxation is dominated by the entropy-driven processes, while for T

16.
Environ Sci Pollut Res Int ; 28(27): 36680-36694, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33704640

RESUMO

Water pollution has become a worldwide threat as the natural water resources are shrinking day by day. Emergent actions are needed to conserve water stocks to fulfill the sustainable development goals. Herein, we have prepared activated carbon-doped magnetic nanocomposites (AC@CoFe2O4) with environment friendly approach and characterized for FTIR, XRD, SEM, EDS, BET surface area, and pHzpc. AC@CoFe2O4 nanocomposite was applied for the decolorization of toxic food dyes (rhodamine B and tartrazine) from wastewater. Effect of ultrasonic waves, pH, contact time, surfactants, temperature, and analysis of real wastewater systems were studied. Adsorption isotherm, kinetics, and thermodynamics of the experiment were calculated for the present removal process. The effect of ultrasonication shows that the maximum removal percentage for RhB was found to be 92% and for tartrazine, it was found to be 86% at 60 min. Ultrasound-assisted adsorption and degradation revealed good results because of the formation of highly active ·H and ·OH radicals in the liquid through the decomposition of water molecules by the formation of hot spots under ultrasonic waves. Highest decolorization of 69% was obtained for RhB with anionic surfactant SDS and climax decolorization of tartrazine was acquired in case of CTAB as 60.5%. Analysis of real wastewater samples shows that the decolorization of RhB was found to be ~ 91% from well-water and ~ 95% removal of tartrazine was observed from submersible water on AC@CoFe2O4 nanocomposites. The decolorization best fitted (R2 < 0.988) with Langmuir model and value of Langmuir climax decolorization efficiency (Q0) was found to be 142.68 and 435.72 mg/g for RhB and tartrazine, respectively. Kinetic analysis revealed that adsorption follows pseudo-second-order equation. The dye-loaded AC@CoFe2O4 nanocomposites were recycled by 0.1 M HCl or NaOH and regenerated AC@CoFe2O4 nanocomposites were used up to five rounds with better adsorption efficiency.


Assuntos
Nanocompostos , Poluentes Químicos da Água , Purificação da Água , Adsorção , Carvão Vegetal , Corantes , Concentração de Íons de Hidrogênio , Cinética , Fenômenos Magnéticos , Tensoativos , Águas Residuárias , Poluentes Químicos da Água/análise
17.
Hosp Top ; 99(2): 64-74, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33043859

RESUMO

BACKGROUND: Factors affecting job satisfaction of home health nurses are studied. METHODS: PSS-10, CBI and HHNJS are used to measure the perceived stress, burnout of home health nurses and Job Satisfaction. RESULTS: The significant predictors for Job satisfaction were Relationship with organization, Autonomy and control, Salary and Benefits as 82% of variation in job satisfaction was explained by these, (F change (3, 144) = 236.72, p < .001). CONCLUSION: Agencies should work upon improving the dimensions such as the "relationship with the organization", "Autonomy and control" and "Salary and Benefits" to increases the Job satisfaction of home health nurses.


Assuntos
Esgotamento Profissional/psicologia , Satisfação no Emprego , Enfermeiros de Saúde Comunitária/psicologia , Percepção , Atitude do Pessoal de Saúde , Esgotamento Profissional/epidemiologia , Distribuição de Qui-Quadrado , Estudos Transversais , Países em Desenvolvimento/estatística & dados numéricos , Humanos , Índia , Enfermeiros de Saúde Comunitária/estatística & dados numéricos , Análise de Regressão , Estresse Psicológico/epidemiologia , Estresse Psicológico/etiologia , Estresse Psicológico/psicologia , Local de Trabalho/psicologia , Local de Trabalho/normas
18.
Indian J Community Med ; 45(2): 168-171, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32905074

RESUMO

BACKGROUND: Hospitals are adopting electronic medical records (EMRs) in larger numbers; however, the barrier to derive its full utility is the low acceptance by physicians. AIMS AND OBJECTIVES: This study is done with an objective to identify the factors to overcome the barriers preventing the adoption of EMR by physicians. MATERIALS AND METHODS: This study is cross sectional in natures and a self-administered questionnaire is developed based on the Technology Acceptance Model. RESULTS: The four identified factors are positive attitude toward EMR, reliability, difficulty to use, and adaptability, these factors together, have explained 62.54 percent variance in the data set. CONCLUSION: The physician's acceptance for EMRs can be improved by focusing on the identified four factors, which are "positive attitude toward electronic medical records," reliability of electronic medical records," "difficulty level of use," and "adaptability of electronic medical records."

19.
J Indian Assoc Pediatr Surg ; 25(4): 248-250, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32939120

RESUMO

We, herein, present an extremely rare case of an esophageal atresia (EA) with distal tracheoesophageal fistula (TEF) with additional perforated membrane at the lower one-third of fistula. A neonate presented with difficulty in breathing and excessive frothing from the mouth. Radiograph with red rubber catheter in situ (obstruction at 10 cm from the gum margins) suggested EA with distal TEF. During thoracotomy, after ligation of fistula, a 6 Fr infant feeding tube was introduced into the distal esophagus which revealed obstruction at the lower one-third. An esophagotomy was performed; a membrane with opening at the center was identified. Following its excision, the esophageal end became dusky necessitating esophagostomy and feeding gastrostomy. A high index of suspicion for membranous obstruction at the lower one-third of fistula should be kept in mind while dealing with EA with distal TEF.

20.
Hosp Top ; 98(3): 108-117, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32633216

RESUMO

Introduction: Hospitals struggle to implement MEWS. This study aims to improve MEWS implementation in the studied hospital.Objective: Improve the implementation of MEWS with the help of HFMEA.Materials: HFMEA together with training is used to improve the implementation.Results: The pre-intervention RPN got reduced from 1558 to 516 in the post-implementation phase.Application: This demonstrates improvement in the implementation of MEWS with the help of HFMEA, this study design can be widely used.Conclusion: The HFMEA is an effective tool to use for the improvement of MEWS implementation by the hospital nurses.


Assuntos
Escore de Alerta Precoce , Melhoria de Qualidade/normas , Estudos Transversais , Análise do Modo e do Efeito de Falhas na Assistência à Saúde/métodos , Humanos , Melhoria de Qualidade/tendências
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...