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1.
J Basic Clin Physiol Pharmacol ; 33(1): 103-107, 2022 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-34995022

RESUMO

OBJECTIVES: The use of Hydroxychloroquine (HCQ) prophylaxis has been recommended by the National task force constituted by the Indian Council of Medical Research (ICMR) for the prevention of corona virus disease 2019 (COVID-19) among healthcare workers (HCWs). However, this recommendation was based essentially on the preclinical data and limited clinical experience. The aim of this study was to evaluate the efficacy and safety of HCQ as a pre-exposure prophylaxis for COVID-19 infection among Indian HCWs. METHODS: A cross-sectional study was conducted among HCWs of a tertiary care hospital in north India. The HCQ prophylaxis was initiated among 996 HCWs and they were followed up to 8 weeks for conversion to COVID-19 positive status and any adverse drug reaction (ADR). RESULTS: About 10.3% of the study participants were tested positive for COVID-19 which was comparable to the positivity rate among HCWs not taking HCQ prophylaxis (9.7%). CONCLUSIONS: HCQ was well tolerated at a weekly dose of 400 mg for 8 weeks but provided no additional benefit in prevention of COVID-19 among HCWs.


Assuntos
COVID-19 , Hidroxicloroquina/administração & dosagem , Profilaxia Pré-Exposição , COVID-19/tratamento farmacológico , COVID-19/prevenção & controle , Estudos Transversais , Pessoal de Saúde , Humanos , Índia , Centros de Atenção Terciária , Falha de Tratamento
2.
Plants (Basel) ; 9(12)2020 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-33321878

RESUMO

Upland cotton (Gossypium hirsutum L.) growth and development during the pre-and post-flowering stages are susceptible to high temperature and drought. We report the field-based characterization of multiple morpho-physiological and reproductive stress resilience traits in 11 interspecific chromosome substitution (CS) lines isogenic to each other and the inbred G. hirsutum line TM-1. Significant genetic variability was detected (p < 0.001) in multiple traits in CS lines carrying chromosomes and chromosome segments from CS-B (G. barbadense) and CS-T (G. tomentosum). Line CS-T15sh had a positive effect on photosynthesis (13%), stomatal conductance (33%), and transpiration (24%), and a canopy 6.8 °C cooler than TM-1. The average pollen germination was approximately 8% greater among the CS-B than CS-T lines. Based on the stress response index, three CS lines are identified as heat- and drought-tolerant (CS-T07, CS-B15sh, and CS-B18). The three lines demonstrated enhanced photosynthesis (14%), stomatal conductance (29%), transpiration (13%), and pollen germination (23.6%) compared to TM-1 under field conditions, i.e., traits that would expectedly enhance performance in stressful environments. The generated phenotypic data and stress-tolerance indices on novel CS lines, along with phenotypic methods, would help in developing new cultivars with improved resilience to the effects of global warming.

3.
Data Brief ; 24: 103888, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31193349

RESUMO

A field experiment has been conducted in Cotton-Wheat cropping system for three cropping cycles, wherein we evaluated a total of five treatments (Control, Sub-soiling at 1.0 m, Sub-soiling at 1.5 m, Cross sub-soiling at 1.0 m and Cross sub-soiling at 1.5 m) in complete randomized block design to find out the effect of sub-soiling on the physical properties of soil and root parameters of cotton in Indian Punjab, where heavy machinery usage in farm operations is causing soil compaction leading to ill effects. Data elucidated that any level of sub-soiling not only improved soil physical properties by reduction in bulk density but also enhanced steady state infiltration rate as compared to control. Data also revealed that root length, fresh root weight plant-1 and dry root weight plant-1 of cotton exhibited significant differences in sub-soiled plots versus control for initial two years of experimentation but trivial differences existed thereafter. Consequently, both cotton and wheat crop resulted in higher yield owing to above mentioned reasons. The field data set is made publicly available to enable critical or extended analysis.

4.
Forensic Sci Int ; 290: 258-278, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30099346

RESUMO

A study was undertaken wherein different fingermark developers were evaluated for the recovery of fingermarks from brass cartridge cases, besides the evaluation of factors such as firing effects and surface characterization of the cases. The latent fingermarks on α-brass plates, fired and unfired cartridge cases were deposited and aged for 1-14days before development with different developers. In order to mimic the fired cartridge case conditions, the brass plates were heated and examined at room temperature (RT), at 63 and at 200°C. The sequential treatment with cyanoacrylate, gun blue and fluorescent dye has been found to be the best among other developers for the recovery of latent fingermarks on brass surfaces including fired and unfired cartridge cases. Cartridge cases and other brass surfaces were also analyzed by surface characterization methods, including X-ray diffraction, scanning electronic microscopy, energy dispersive X-ray spectroscopy and metallographic examination. The tested surfaces correspond to α-phase brass Cu0.7Zn0.3 composition and have shown different surface morphologies (such as grain structure) and different levels of oxidation, even for cartridge cases obtained from the same batch. Due to this, the effectiveness of a given reagent for a specific brass surface is uncertain. Therefore, the application of the entire tested sequence of developers is strongly recommended. Further, the effects of firing on fingermarks on cartridge cases were examined, and the results indicated that the blowback of hot gases through the looseness between cartridge case and chamber wall of the firearm is the main cause responsible for deterioration of fingermarks during firing. Despite the recognized damage caused to fingermarks by the firing effects, good quality fingermarks were recovered from fired cartridge cases in which full fingermarks were intentionally deposited prior to firing. This indicates that the handling of the cartridges before and during the loading of the gun may have a strong influence on the quantity and quality of fingermarks, and that the firing itself is not the main responsible factor for the absence or low quality of fingermarks, as frequently reported in fired cartridge cases studies.


Assuntos
Dermatoglifia , Armas de Fogo , Cobre , Cianoacrilatos , Corantes Fluorescentes , Humanos , Microscopia Eletrônica de Varredura , Espectrometria por Raios X , Volatilização , Difração de Raios X , Zinco
5.
J Environ Biol ; 36(4): 891-5, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26364466

RESUMO

Field experiments were conducted during 2012 and 2013 to determine the effect of select defoliants i.e dropp ultra and ethrel, their optimal dose and suitable time of application on earliness and seed cotton yield in 3 American cotton cultivars. MRC7361BGII (3055.2 kg ha(-1)) and MRC7017BGII (2913.0 kg ha(-1)) resulted in significantly improved seed cotton yield as compared to F1 861 (2346.0 kg ha(-1)). Dropp ultra? @ 200 ml ha(-1) revealed highest yield (3018.7 kg ha(-1)) followed by ethrel @ 2000 ppm (2820.1 kg ha(-1)) and control (2730.0 kg ha(-1)) , while statistically least yield (2516.9 kg ha(-1)) was observed with higher dose of dropp ultra @ 225 ml ha(-1). Defoliants applied 150 days after sowing (DAS) resulted in significantly better yield (2853.3 kg ha(-1)) as compared to the early application at 140 DAS (2689.5 kg ha(-1) owing to improvement in open bolls and boll weight. Pooled data indicated that dropp ultra @ 200 ml ha(-1) has potential to promote crop earliness, better boll opening and their retention by keeping vegetative and reproductive growth in harmony to enhance seed cotton yield.


Assuntos
Fibra de Algodão/estatística & dados numéricos , Desfolhantes Químicos/administração & dosagem , Gossypium/efeitos dos fármacos , Biomassa , Gossypium/crescimento & desenvolvimento , Compostos Organofosforados/administração & dosagem , Reguladores de Crescimento de Plantas/farmacologia
6.
J Environ Biol ; 36(4): 993-8, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26364480

RESUMO

Field experiments were conducted during Kharif 2012 and 2013 to evaluate the efficacy of different herbicides for weed management in cotton. Highest seed cotton yield (3537.3 kg ha(-1)) was recorded in weed free plots followed by pendimethalin @1.0 kg a.i ha(-1) as Pre.em.+quizalofopethyl @50 g a.i ha(-1) post-em at 2-4 weed leaf stage + one hoeing (3318.9 kg ha") owing to improved number of bolls per plant and boll weight. Statistically least yield was recorded underweedy check (1435.4 kg ha(-1)). Application of pyrithiobac sodium could not express any visible toxic effect on crop indicating its selectivity for cotton, although none of the tested new chemicals i.e., pyrithiobac sodium@ 62.5g a.i ha(-1) and quizalofopethyl @50g a.i ha(-1) when applied alone could not outperform the existing recommended chemicals for weed management. Yield losses to the extent of 6.2-59.4% were recorded due to weed competition. Weed control efficiency (WCE) was highest under weed free check (86.8%) followed by pendimethalin @1.0 kg a.i ha(-1) as Pre. em.+quizalofopethyl @50g a.i ha(-1), at 2-4 weed leaf stage + one hoeing (73.7%), whereas minimum values were for weedy check (24.7%). Though net returns (r94660 ha(-1)) were highest for weed free check but higher B:C ratio (2:11) was observed for pendimethalin @1.0 kg a.i ha(-1) as Pre em.+quizalofopethyl @50 g a.i ha(-1) post-em at 2-4 weed leaf stage+one hoeing. Therefore, for reasons such as labor shortage besides their timely availability, using these herbicides in combination with cultural practices could be the practical solution foreconomically efficient and effective weed management.


Assuntos
Gossypium/crescimento & desenvolvimento , Herbicidas , Controle de Plantas Daninhas , Toxinas de Bacillus thuringiensis , Proteínas de Bactérias/genética , Biomassa , Endotoxinas/genética , Gossypium/genética , Proteínas Hemolisinas/genética , Índia , Plantas Geneticamente Modificadas/crescimento & desenvolvimento
7.
J Environ Biol ; 35(5): 839-42, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25204056

RESUMO

Field experiments comprising three Btcotton hybrids in main, two plant geometries in sub and three nutrient levels in sub sub plots of Split Plot design replicated thrice were conducted at PAU, Regional Research Station, Faridkot during Kharif 2010 and 2011. MRC7361 recorded significantly the highest SCY (3121.6 kg ha(-1)) followed by Bioseed 6488 (2649.5 kg ha(-1)) and RCH134 (2107.4 kg ha(-1)). Statistically improved bolls per plant and boll weight primarily helped MRC7361 in achieving the highest yield. Owing to better fertilizer use efficiency (5.47) and water productivity (649.3 gm(-3)), highest net returns of < or = 101047 ha(-1) were observed with MRC7361 as compared to Bioseed 6488 (< or = 83343 ha(-1)) and RCH134 (< or = 63014 ha(-1)). Bolls per plant and benefit cost ratio was significantly enhanced under wider geometry of 67.5 x 90 cm. Application of 225 kg N, 45 kg P ha(-1) produced significantly higher SCY (2825.9 kg ha(-1)) owing to improved sympods and bolls per plant than 150 kg N, 30 kg P ha(-1) (2374.9 kg ha(-1)) and 187.5 kg N, 37.5 kg P ha(-1) (2677.6 kg ha(-1)). As a result of this, statistically highest net returns of < or = 89552 ha(-1) were obtained with application of 225 kg N, 45 kg Pha(-1). Water productivity improved significantly with each successive increase in the level of nutrients. Contrarily, fertilizer use efficiency exhibited reverse trend with statistically highest value (5.08) for the lowest level of nutrients.


Assuntos
Produtos Agrícolas/economia , Gossypium/crescimento & desenvolvimento , Toxinas de Bacillus thuringiensis , Proteínas de Bactérias/genética , Biomassa , Quimera , Produtos Agrícolas/crescimento & desenvolvimento , Endotoxinas/genética , Gossypium/genética , Proteínas Hemolisinas/genética , Plantas Geneticamente Modificadas
8.
J Biomed Mater Res A ; 102(1): 254-74, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23468256

RESUMO

Bioactive glass and glass-ceramics are used in bone repair applications and are being developed for tissue engineering applications. Bioactive glasses/Bioglass are very attractive materials for producing scaffolds devoted to bone regeneration due to their versatile properties, which can be properly designed depending on their composition. An important feature of bioactive glasses, which enables them to work for applications in bone tissue engineering, is their ability to enhance revascularization, osteoblast adhesion, enzyme activity and differentiation of mesenchymal stem cells as well as osteoprogenitor cells. An extensive amount of research work has been carried out to develop silicate, borate/borosilicate bioactive glasses and phosphate glasses. Along with this, some metallic glasses have also been investigated for biomedical and technological applications in tissue engineering. Many trace elements have also been incorporated in the glass network to obtain the desired properties, which have beneficial effects on bone remodeling and/or associated angiogenesis. The motivation of this review is to provide an overview of the general requirements, composition, structure-property relationship with hydroxyapatite formation and future perspectives of bioglasses.Attention has also been given to developments of metallic glasses and doped bioglasses along with the techniques used for their fabrication.


Assuntos
Apatitas/química , Substitutos Ósseos/química , Cerâmica/química , Engenharia Tecidual/métodos , Oligoelementos/química , Animais , Humanos
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