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1.
Georgian Med News ; (288): 77-81, 2019 Mar.
Artigo em Russo | MEDLINE | ID: mdl-31101781

RESUMO

The aim of this study was to investigate the efficacy and safety of the ombitasvir/ paritaprevir/ ritonavir and dasabuvir in patients with HCV, genotype-1b, in real clinical practice in Ukraine. The study included a total of 50 HCV infection genotype 1b patients receiving ombitasvir/ paritaprevir/ ritonavir and dasabuvir for 12 weeks. The patients were evaluated in respect of demographic, clinical and virological data, sustained virologic response (SVR) and adverse events. The mean age of patients was 52 years (40-60), 42% men, 20% treatment experienced, 42% with compensated cirrhosis. The SVR12 rate of all HCV genotype 1b patients was 96% (95%CI:86,3-99,5%). The most common adverse events were fatigue in 14 (28%) patients, diarrhea in 10 (20%) and headache in 12 (24%). In our study, the real world clinical practice data shows that ombitasvir/ paritaprevir/ ritonavir and dasabuvir for 12 weeks in HCV genotype 1b patients was well tolerated and resulted in 96% SVR12 regardless of previous treatment status and liver fibrosis stage.


Assuntos
Antivirais , Hepatite C Crônica , Adulto , Anilidas/uso terapêutico , Antivirais/uso terapêutico , Carbamatos/uso terapêutico , Quimioterapia Combinada , Feminino , Genótipo , Hepacivirus , Hepatite C Crônica/tratamento farmacológico , Humanos , Compostos Macrocíclicos/uso terapêutico , Masculino , Pessoa de Meia-Idade , Ribavirina , Ritonavir/uso terapêutico , Sulfonamidas/uso terapêutico , Resultado do Tratamento , Ucrânia , Uracila/análogos & derivados , Uracila/uso terapêutico
2.
Vestn Oftalmol ; 106(4): 3-5, 1990 Jul-Aug.
Artigo em Russo | MEDLINE | ID: mdl-2238319

RESUMO

The authors analyze the results of treatment of patients whose organ of vision was injured in accident. They point out a complex of measures promoting a relatively favorable optic and cosmetic outcome of injuries and discuss the shortcomings of ophthalmologic service. Various aspects of the problem are considered to develop practical recommendations on effective care of the injured patients.


Assuntos
Traumatismos Oculares/terapia , Acidentes Domésticos , Acidentes de Trabalho , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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