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1.
Artigo em Russo | MEDLINE | ID: mdl-8017136

RESUMO

The examination of 99 children immunized with adsorbed DPT vaccine revealed that the intensity of immune response to the diphtheria and tetanus components of the preparation were linked with a number of genetic markers (respectively, HLA-A9, B35, etc.; HLA-A25, B8, etc.) and their combinations. The groups of children with high and low sensitivity include an elevated number of persons with the corresponding titers of antibodies of other specificity. The results obtained in this study should be considered in working out individual immunization schedules.


Assuntos
Anticorpos Antibacterianos/biossíntese , Clostridium tetani/imunologia , Corynebacterium diphtheriae/imunologia , Vacina contra Difteria, Tétano e Coqueluche/imunologia , Adsorção , Anticorpos Antibacterianos/sangue , Especificidade de Anticorpos/genética , Especificidade de Anticorpos/imunologia , Antígenos de Grupos Sanguíneos/genética , Antígenos de Grupos Sanguíneos/imunologia , Marcadores Genéticos/genética , Marcadores Genéticos/imunologia , Antígenos HLA-A/genética , Antígenos HLA-A/imunologia , Antígenos HLA-B/genética , Antígenos HLA-B/imunologia , Humanos , Lactente
3.
Ter Arkh ; 63(8): 84-8, 1991.
Artigo em Russo | MEDLINE | ID: mdl-1792627

RESUMO

As many as 96 patients with chronic glomerulonephritis (CGN) and 25 with lupus glomerulonephritis (LGN) were examined for chromosomal aberrations (CA) in peripheral blood lymphocytes in different clinical variants and morphological forms of CGN and LGN as well as for their dynamics under the influence of cytotoxic drugs. In patients with active CGN and LGN, chromosomal instability may develop. The treatment with cyclophosphamide in a dose of 2.0-2.5 mg/kg/day appreciably increases chromosomal instability the level of which rises progressively with the treatment period increase. The treatment with azathioprine in a dose of 1.5-2.0 mg/kg/day is not associated with a noticeable increment of the rate of CA. The studies of the level of CA can be used for estimating CGN and LGN activity. Chronic renal failure did not change the level of CA either in CGN or in LGN. In different morphological forms of glomerulonephritis, the rate of CA was determined by the clinical variant of the disease. In order to reduce potential complications provoked by the treatment with cytotoxic drugs, dynamic studies of the CA rate should be carried out in addition to the conventional tests.


Assuntos
Azatioprina/efeitos adversos , Aberrações Cromossômicas , Ciclofosfamida/efeitos adversos , Glomerulonefrite/genética , Nefrite Lúpica/genética , Adolescente , Adulto , Células Cultivadas/efeitos dos fármacos , Células Cultivadas/ultraestrutura , Feminino , Glomerulonefrite/sangue , Glomerulonefrite/tratamento farmacológico , Humanos , Falência Renal Crônica/sangue , Falência Renal Crônica/tratamento farmacológico , Falência Renal Crônica/genética , Nefrite Lúpica/sangue , Nefrite Lúpica/tratamento farmacológico , Linfócitos/efeitos dos fármacos , Linfócitos/ultraestrutura , Masculino , Pessoa de Meia-Idade , Fatores de Tempo
4.
Vrach Delo ; (9): 47-9, 1990 Sep.
Artigo em Russo | MEDLINE | ID: mdl-2284767

RESUMO

The levels of aberration of chromosomes in peripheral blood leucocytes were investigated in patients with chronic and lupoid glomerulonephritis considering the clinical variants and morphological forms of the disease. In chronic glomerulonephritis high levels of chromosome aberration were found in patients with nephrotic type; in lupoid glomerulonephritis the frequency of chromosome aberration was higher in patients with active glomerulonephritis. Chronic renal failure did not essentially change the level of chromosome aberration both in chronic and lupoid glomerulonephritis. In different morphological forms of glomerulonephritis the frequency of chromosome aberration was determined by the clinical variant of the disease.


Assuntos
Aberrações Cromossômicas/genética , Glomerulonefrite/genética , Nefrite Lúpica/genética , Adolescente , Adulto , Células Cultivadas/ultraestrutura , Doença Crônica , Feminino , Humanos , Linfócitos/ultraestrutura , Masculino , Pessoa de Meia-Idade
5.
Zh Mikrobiol Epidemiol Immunobiol ; (8): 66-70, 1990 Aug.
Artigo em Russo | MEDLINE | ID: mdl-2239007

RESUMO

The results of 5-year observations on the duration of immunity to measles virus in persons vaccinated and revaccinated against measles, as well as in persons having had this infection, are presented. The intensity of immunity was determined in the same persons with the use of the passive hemagglutination test. The study revealed differences in the formation, intensity and duration of postvaccinal immunity. A significant decrease in the concentration of antibodies over the period of 5 years was established in 50.0-52.3% of vaccines. Revaccination with live measles vaccine is an effective measure for enhancing immunity to measles virus in persons with initial antibody titers less than 1:10-1:20, but revaccination made in a single injection is not sufficient for the stable maintenance of measles morbidity at the sporadic level. Postinfectious immunity is characterized by stability and has no tendency towards decrease. Persons having had measles have no need in additional measures irrespective of the time elapsed after the disease.


Assuntos
Imunização Secundária , Vacina contra Sarampo/imunologia , Sarampo/imunologia , Anticorpos Antivirais/sangue , Formação de Anticorpos , Criança , Convalescença , Humanos , Sarampo/prevenção & controle , Vírus do Sarampo/imunologia , Fatores de Tempo , Ucrânia , População Urbana
8.
Lab Delo ; (8): 60-3, 1990.
Artigo em Russo | MEDLINE | ID: mdl-1705607

RESUMO

Anti-DNA antibody titers are elevated in the patients with purulent diseases of the lungs and antibodies to nDNA appear that are undetectable in normal subjects. These data correlate with the inflammatory process activity in the lungs, with the diameter of the decayed cavity, disease duration, and efficacy of therapy. Dynamic titration of antibodies to DNA (particularly nDNA) over the course of the disease appears to be an important prognostic test reflecting the stability of autoimmune impairments and the efficacy of the therapeutic scheme used in the treatment of patients with purulent diseases of the lungs.


Assuntos
Anticorpos Antinucleares/análise , Bronquiectasia/imunologia , Abscesso Pulmonar/imunologia , Doença Aguda , Adulto , Doença Crônica , Feminino , Humanos , Masculino
9.
Klin Med (Mosk) ; 67(9): 38-41, 1989 Sep.
Artigo em Russo | MEDLINE | ID: mdl-2586038

RESUMO

Follow-up of 114 patients with bronchiectasis has demonstrated that immunomodulation agents levamisole and splenin included in combined treatment augment their therapeutic effect and normalize the immune status of patients. This is manifested by normalization of the amount and functional activity to T-lymphocytes, the content of IgG, IgM and IgA and the autoimmune shifts. A favourable effect was encountered significantly more often than that in patient who were treated by the traditional methods without the use of the immunomodulation agents and in those who were given only levamisole and splenin together with anti-bacterial and hygienic therapy.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Bronquiectasia/tratamento farmacológico , Levamisol/administração & dosagem , Baço , Timopoietinas/administração & dosagem , Hormônios do Timo/administração & dosagem , Adolescente , Adulto , Antibacterianos/administração & dosagem , Bronquiectasia/imunologia , Avaliação de Medicamentos , Quimioterapia Combinada , Humanos , Pessoa de Meia-Idade , Sulfanilamidas/administração & dosagem
10.
Vrach Delo ; (8): 116-9, 1989 Aug.
Artigo em Russo | MEDLINE | ID: mdl-2588507

RESUMO

A study of the immunological status in 52 patients with acute and 20 patients with chronic abscesses of the lungs, 86 patients with viral hepatitis revealed disorders of the immunological reactivity of a quantitative character with monotypic immune response. In autoimmune disorders it is necessary to carry out immunocorrection. In chronic forms immunocorrection should be considered the main treatment method.


Assuntos
Hepatite A/imunologia , Hepatite B/imunologia , Abscesso Pulmonar/imunologia , Adulto , Anticorpos/análise , Formação de Anticorpos/imunologia , DNA/imunologia , Antígenos de Superfície da Hepatite B/análise , Humanos , Imunidade Celular/imunologia , Imunoglobulinas/análise , Pessoa de Meia-Idade
13.
Zh Mikrobiol Epidemiol Immunobiol ; (6): 38-43, 1989 Jun.
Artigo em Russo | MEDLINE | ID: mdl-2800792

RESUMO

The introduction of mass immunization against tetanus has resulted in the decrease of morbidity rate (5.2 times), the leveling of morbidity rate among the urban and rural population and among males and females, though no essential effect on the seasonal distribution of tetanus morbidity has been observed. Persons over 50 years of age (housewives and pensioners) have become the main groups of risk at the post-immunization period. Mass immunization against tetanus over a period of many years has ensured the existence of a sufficient immune stratum (89.9 +/- 3.0% to 100 +/- 3.0%) and a sufficient level of antitoxic immunity (means geom equal to 6.72-9.6 I.U./ml) among children. Among adults, the proportion of persons protected from tetanus decreases in older age groups from 82.1 +/- 1.3% in persons aged 31-40 years to 22.1 +/- 2.0% in persons over 60 years. The observed differences between the coverage of the population with immunization and the proportion of persons having protective titers of tetanus antibodies require constant control of the intensity of immunity and its correction with regard to its initial level, especially in persons of older age groups.


Assuntos
Toxoide Tetânico/uso terapêutico , Tétano/epidemiologia , Adolescente , Adulto , Fatores Etários , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Estações do Ano , Tétano/imunologia , Tétano/prevenção & controle , Fatores de Tempo , U.R.S.S.
16.
Artigo em Russo | MEDLINE | ID: mdl-3137742

RESUMO

Blood groups, including rhesus grouping, have been determined in 218 donors and HLA of loci A, B, C in 121 donors immunized with adsorbed tetanus toxoid (40 binding units). The presence of HLA Aw 32, B 8; HLA Bw 16, haplotypes A3 Bw 16 and A1, blank antigens of locus C is linked with the production of, respectively, high or low (less than or equal to 16 I.U./ml) antibody titers. The effectiveness of immunization is influenced by agglutinogen B, which is confirmed by its associations (in a complex with HLA Bw 16 or Bw 35) with low immune response.


Assuntos
Doadores de Sangue , Marcadores Genéticos , Imunização , Toxoide Tetânico/imunologia , Sistema ABO de Grupos Sanguíneos/genética , Sistema ABO de Grupos Sanguíneos/imunologia , Adsorção , Anticorpos Antibacterianos/análise , Clostridium tetani/imunologia , Antígenos HLA/genética , Antígenos HLA/imunologia , Humanos , Sistema do Grupo Sanguíneo Rh-Hr/genética , Sistema do Grupo Sanguíneo Rh-Hr/imunologia , Caracteres Sexuais
20.
Zh Mikrobiol Epidemiol Immunobiol ; (11): 107-12, 1986 Nov.
Artigo em Russo | MEDLINE | ID: mdl-3799109

RESUMO

Seven-year experience in the methodological guidance of the post-graduate specialization of medical graduates specializing in epidemiology has made it possible for the authors to come to the conclusion on the positive role of the on-the-job training of young specialists for a year after graduation, which is manifested by a shorter time necessary for their professional formation, the development of their capacity for making scientifically grounded, active solutions of practical problems. At the same time some defects, difficulties, and unsolved problems of on-the-job training have been revealed. The authors propose to organize internship also for this category of medical specialists and to carry out the specialization of all sanitary inspectors on the basis of "clinical" sanitary and epidemiological stations.


Assuntos
Educação Médica Continuada , Epidemiologia/educação , Capacitação em Serviço , Capacitação em Serviço/organização & administração , Internato e Residência , Medicina , Especialização , Ensino/métodos , Ucrânia
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