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1.
Int. braz. j. urol ; 45(3): 495-502, May-June 2019. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-1012326

RESUMO

ABSTRACT Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. Materials and Methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. Results: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8μmoL / L, 150.3 ± 45.3μmoL / L, 15.9 ± 7μmoL / L, 78.8 ± 7μmoL / L, 10.5 ± 3.5μmoL / L, 13.8 ± 5.8μmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5μmoL / L, 147.5 ± 50.1μmoL / L, 15.5 ± 8.7μmoL / L, 79.7 ± 9μmoL / L, 10.1 ± 4.5μmoL / L, 13.5 ± 7.2μmoL / L in patients with prostatitis and as 144.1 ± 21.2μmoL / L, 191 ± 32.3μmoL / L, 23.4 ± 10.1μmoL / L, 76.1 ± 98.3μmoL / L, 11.9 ± 4.1μmoL / L, 16.4 ± 6.9μmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). Conclusions: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.

2.
Int Braz J Urol ; 45(3): 495-502, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30676303

RESUMO

BACKGROUND: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. MATERIALS AND METHODS: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. RESULTS: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8µmoL / L, 150.3 ± 45.3µmoL / L, 15.9 ± 7µmoL / L, 78.8 ± 7µmoL / L, 10.5 ± 3.5µmoL / L, 13.8 ± 5.8µmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5µmoL / L, 147.5 ± 50.1µmoL / L, 15.5 ± 8.7µmoL / L, 79.7 ± 9µmoL / L, 10.1 ± 4.5µmoL / L, 13.5 ± 7.2µmoL / L in patients with prostatitis and as 144.1 ± 21.2µmoL / L, 191 ± 32.3µmoL / L, 23.4 ± 10.1µmoL / L, 76.1 ± 98.3µmoL / L, 11.9 ± 4.1µmoL / L, 16.4 ± 6.9µmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). CONCLUSIONS: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.


Assuntos
Dissulfetos/sangue , Neoplasias da Próstata/sangue , Prostatite/sangue , Compostos de Sulfidrila/sangue , Idoso , Análise de Variância , Biomarcadores Tumorais/sangue , Estudos de Casos e Controles , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/fisiologia , Neoplasias da Próstata/diagnóstico , Prostatite/diagnóstico , Valores de Referência , Reprodutibilidade dos Testes , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Estatísticas não Paramétricas
3.
Urol J ; 2018 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-30206925

RESUMO

PURPOSE:   The study aims to compare the effectiveness, safety and costs of two different anesthesia methods in PCNL (percutaneous nephrolithotomy) operations. MATERIAL-METHOD: In our study, data was retrospectively examined of 1657 patients who underwent PCNL due to renal calculi between 2009 and 2017. Patients were separated into two groups according to the type of anesthesia; as those implemented PCNL under general anesthesia (GA) (n=572) and those under spinal anesthesia(SA) (n=1085). Standard PCNL technique was used in both groups. Gender, age, operation duration, period of hospitalization, stone-free ratio, post-operative narcotic analgesic need and complications were compared between these two groups. RESULTS: A total of 1657 patients consisting of 1064 (64.2%) male patients and 593 (35.8%) female patients were included in the study. The average age of the all patients was 33.2±12.4 (range 16-74) years. The two groups were similar in terms of mean age, gender, stone size, stone location and body mass index. Mean operation time was significantly shorter in the SA group than in the GA group (81.8±33.9 minute vs. 118.2±-42.9 minute respectively, p<.001). Mean period of hospitalization was remarkable shorter in the SA group than in the GA group (30.0±9.9 hours vs. 38.4±11.2 hours respectively, p<.001). Post-operative narcotic analgesic need rate was significantly higher  in the GA group than in the SA group (33.4% vs. 10.9%, respectively, P<.001). Anesthesia cost was found significantly lower in the SA group than in the GA group (USD 21.3±2.8 vs. USD 83.6±9.5, respectively, p<.001). Significant difference was not observed between both groups in terms of stone-free ratio, amount of bleeding, fluoroscopy time, pre-operative and post-operative complications. CONCLUSION: Compared to those performed with GA, PCNL performed with SA is a safe, effective and low-cost method.

4.
Urolithiasis ; 2018 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-30078089

RESUMO

To show the efficacy of mirabegron for medical expulsive treatment, in patients had intramural located distal ureteral stone. A 80 patients had intramural ureteral stone were assessed retrospectively between April 2017 and January 2018. Mirabegron 50 mg/day + diclofenac 100 mg/day (group 1, n = 40), and only diclofenac 100 mg/day (group 2, n = 40) were administered to patients, consecutively. Age, gender, stone size, laterality, and severity of hydronephrosis were recorded. Spontaneous stone expulsion rates (SER), stone expulsion time, and the number of daily colic episodes were evaluated. In the group 1, one (2.5%) patient was excluded due to nasopharyngitis, and one (2.5%) patient was excluded due to 5 mmHg systolic blood pressure increase. In addition, four (10%) patients in group 1, and six (15%) patients in group 2, who did not attend follow-up examinations, were excluded from the study. There was not any statistically significant difference between the two groups in terms of age, gender, stone location, severity of hydronephrosis, stone size (p = 0.736, p = 0.310, p = 0.467, p = 0.801, p = 0.761, consecutively). Spontaneous expulsion ratios were calculated as 73.52% in group 1, and 47.05% in group 2 (p = 0.026). However, there was not any statistically significant difference in terms of stone expulsion time (p = 0.979). SER for patients had ≤ 6 mm stones was higher in group 1 (87.5 vs 52.49%, p = 0.031). In addition, group 2 patients had more pain episodes (1.02 ± 0.52 vs. 1.29 ± 0.57, p = 0.049). In the current study, mirabegron has been shown to be an efficient, safe and a new treatment modality, with lower side effect profile for the intramural located distal ureteral stones.

5.
Asian Pac J Cancer Prev ; 17(8): 3737-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27644609

RESUMO

BACKGROUND: The purpose of this study is to evaluate if there is a relation between platelet:lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) values and tumour histology and spread in bladder cancer cases. MATERIALS AND METHODS: Bladder cancer patients undergoing TUR-M operation, with histopathologically verified diagnosis, followed-up and treated at the Private Medical Park Gaziantep Hospital between 2010 and 2015, were included in the study. NLR and PLR values were calculated using complete blood count data obtained at the first presentation. RESULTS: A total of 99 patients were included in the study, 7 (7.1%) women and 92 men (92.9%). When NLR was used as the indicator of systemic inflammatory response (SIR), it was determined that 52 (52.5%) of the patients were SIR negative and 47 (47.5%) SIR positive. No significant relation could be detected between NLR and tumour grade and muscle invasion (p=0.948, p=0.480). When PLR was used as SIR indicator, it was determined that 71 (71.7%) of the patients were found as negative and 28 (28.3%) as positive. No significant relation could be detected between PLR and tumour grade and muscle invasion (p=0.651, p=0.494). CONCLUSIONS: In our study we did not detected a relation between tumour histological behavior and PLR and NLR in bladder cancer. However, NLR and PLR are easily calculated, accessible, inexpensive and simple-to-use laboratory data from whole blood counts.


Assuntos
Inflamação/patologia , Músculos/patologia , Neoplasias da Bexiga Urinária/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Contagem de Células Sanguíneas/métodos , Plaquetas/patologia , Feminino , Humanos , Contagem de Leucócitos/métodos , Contagem de Linfócitos/métodos , Linfócitos/patologia , Masculino , Pessoa de Meia-Idade , Neutrófilos/patologia , Contagem de Plaquetas/métodos , Prognóstico , Estudos Retrospectivos
6.
Urology ; 79(5): 1023-6, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22546378

RESUMO

OBJECTIVE: To demonstrate the effects of intravesical dexpanthenol use on bladder histology and lipid peroxidation in a chemical cystitis animal model. METHODS: Thirty-five New Zealand rabbits were divided into 3 groups. Cystitis was conducted with transurethral intravesical hydrochloric acid instillation on the subjects in groups I and II. Then, Group I subjects were transurethrally administered intravesical dexpanthenol therapy twice a week, Group II subjects were given only intravesical isotonic NaCl instillation, and Group III subjects were administered intravesical isotonic NaCl instillation without conducting chemical cystitis to create the same stress. Treatment schemes of all groups were arranged in the same manner. After 6-week therapy, the rabbits were sacrificed and histopathologic investigations were carried out to demonstrate changes in the urinary bladder. Serum and tissue malondialdehyde (MDA) values were examined to investigate the effect of dexpanthenol on lipid peroxidation. RESULTS: We observed that the basal membrane and mucosal integrity were maintained, inflammatory cells were suppressed, and MDA levels decreased in group I, which received dexpanthenol therapy. However, it was also observed that mucosal integrity was spoiled, numerous inflammatory cells were accumulated, and MDA levels were significantly increased in group II, which was administered isotonic NaCl. CONCLUSION: In light of our findings, intravesical dexpanthenol therapy could be a new therapeutic approach in the treatment of interstitial cystitis because of its low cost and acceptable side effects.


Assuntos
Cistite Intersticial/tratamento farmacológico , Cistite Intersticial/patologia , Malondialdeído/metabolismo , Ácido Pantotênico/análogos & derivados , Complexo Vitamínico B/uso terapêutico , Administração Intravesical , Animais , Cistite Intersticial/induzido quimicamente , Modelos Animais de Doenças , Feminino , Ácido Clorídrico , Peroxidação de Lipídeos/efeitos dos fármacos , Malondialdeído/sangue , Ácido Pantotênico/farmacologia , Ácido Pantotênico/uso terapêutico , Coelhos , Estatísticas não Paramétricas , Complexo Vitamínico B/farmacologia
7.
Urol Int ; 80(3): 283-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18480632

RESUMO

AIM: To develop a prediction model based on artificial neural networks (ANN) for the treatment selection in vesicoureteral reflux (VUR). METHODS: A total of 96 children with VUR (145 ureteric units (UU)) were treated at our institution during 2004-2006. An ANN based on quick propagation architecture was created with the commercially available software package. The patients' age and sex, the cause and grade of VUR, the affected ureter, the type of treatment (conservative, subureteric injection, or open surgery), existence of renal scar on DMSA, follow-up times and the number of injections were used as variables. These data were also transferred to a statistical software package and regression analysis was done. RESULTS: In all, 105 UU showed no reflux, 5 UU showed improvements in reflux grade (considered only in the conservative management group), and the remaining 35 UU showed persistence. In the training group (n = 99), ANN showed 98.5% sensitivity, 92.5% specificity, 97% positive predictive value, and 96% negative predictive value in predicting treatment outcome. CONCLUSIONS: We have demonstrated that ANN can accurately predict the resolution of VUR, and thus could be useful in daily clinical practice. This approach would allow urologists to aid in the decision-making process of VUR treatment.


Assuntos
Redes Neurais (Computação) , Refluxo Vesicoureteral/terapia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino
8.
Urology ; 69(4): 633-6, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17445639

RESUMO

OBJECTIVES: To evaluate the activity of the therapeutic agents (tamsulosin and/or tolterodine) used to accelerate the expulsion of stones and to reduce the probable complications during observation of the medical treatment of distal ureteral stones to allow spontaneous passage. METHODS: A total of 120 patients with distal ureteral stones were included in the study. Patients with stones less than 10 mm and allowing urinary flow were included in the study. The patients were studied in four randomly divided groups. Group 1 patients received tamsulosin 0.4 mg/day, group 2 patients received tamsulosin 0.4 mg/day plus tolterodine 2 mg (twice a day), group 3 patients received tolterodine 2 mg (twice a day), and group 4 patients did not receive any medical treatment (control group). RESULTS: Differences among the four groups in patient age and stone dimension were not statistically significant (P >0.05). The stone expulsion rates were greater (P <0.05) in groups 1 and 2 than in groups 3 and 4. A significant variation (P <0.05) regarding the time to stone expulsion was observed in groups 1 and 2. CONCLUSIONS: In our study, the use of tamsulosin for the expulsion of distal ureteral stones was effective; however, the use of tolterodine provided no additional advantages.


Assuntos
Antagonistas Adrenérgicos alfa/uso terapêutico , Compostos Benzidrílicos/uso terapêutico , Cresóis/uso terapêutico , Antagonistas Muscarínicos/uso terapêutico , Fenilpropanolamina/uso terapêutico , Sulfonamidas/uso terapêutico , Cálculos Ureterais/tratamento farmacológico , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tansulosina , Tartarato de Tolterodina
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