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1.
Front Cardiovasc Med ; 9: 854107, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35694656

RESUMO

Background: Patients with diabetes are a high-risk group for coronary in-stent restenosis (ISR), so it would be valuable to identify biomarkers to predict their prognosis. The plasma big endothelin-1 (big ET-1) level is closely related to cardiovascular adverse events; however, for patients with ISR and diabetes who undergo percutaneous coronary intervention (PCI), whether big ET-1 is independently correlated with prognosis is still uncertain. Methods: Patients with drug-eluting stent (DES) restenosis who underwent successful re-PCI from January 2017 to December 2018 at the Chinese Academy of Medical Sciences Fuwai Hospital were enrolled and followed up for 3 years. The patients were divided into the tertiles of baseline big ET-1. The primary end points were major adverse cardiovascular events (MACEs): cardiac death, non-fatal myocardial infarction (MI), target lesion revascularization (TLR), and stroke. A Cox multivariate proportional hazard model and the C-statistic were used to evaluate the potential predictive value of big ET-1 beyond traditional and angiographic risk factors. Results: A total of 1,574 patients with ISR were included in this study, of whom 795 were diabetic. In patients with ISR and diabetes, after an average follow-up of 2.96 ± 0.56 years, with the first tertile of big ET-1 as a reference, the hazard ratio [HR] (95% CI) of MACEs after adjustment for traditional and angiographic risk factors was 1.24 (0.51-3.05) for the second tertile and 2.60 (1.16-5.81) for the third. Big ET-1 improved the predictive value for MACEs over traditional risk factors (C-statistic: 0.64 vs. 0.60, p = 0.03). Big ET-1 was not significantly associated with the risk of MACEs in patients without diabetes. Conclusion: Increased plasma big ET-1 was associated with a higher risk of adverse cardiovascular prognosis independent of traditional and angiographic risk factors, and therefore, it might be used as a predictive biomarker, in patients with ISR and diabetes.

2.
J Asian Nat Prod Res ; : 1-7, 2022 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-35672871

RESUMO

Two undescribed stilbenoid diglycosides, dendrosonside A and dendrosonside B (1 and 2), were isolated from the stems of Dendrobium 'Sonia'. Their structures were elucidated based on 1 D/2D NMR and HRESIMS. The glycosyls contained in the two isolates were determined as D-glucose by acid hydrolysis and GC-MS analyses. In addition, 1 and 2 were further tested for the inhibition of nitric oxide production.

3.
Artigo em Inglês | MEDLINE | ID: mdl-35682077

RESUMO

Soil pollution in coal mining areas is a serious environmental problem in China and elsewhere. In this study, surface and vertical profile soil samples were collected from a coal mine area in Dazhu, Southwestern China. Microscopic observation, concentrations, chemical speciation, statistical analysis, spatial distribution, and risk assessment were used to assess heavy metal pollution. The results show that the weathering of coal-bearing sandstone and mining activities substantially contributed to soil pollution. The concentrations of Fe, Ni, Cu, Zn, Mn, Cd, Hg, and Pb exceeded their background values. Cd caused the most intense pollution and was associated with heavily-extremely contaminated soils. The residual fraction was dominant for most metals, except Cd and Mn, for which the reducible fraction was dominant (Cd: 55.17%; Mn: 81.16%). Zn, Ni, Cd, and Cu presented similar distribution patterns, and Hg and As also shared similar distribution characteristics. Factor 1 represented anthropogenic and lithologic sources, which were affected by mining activities; Factor 2 represented anthropogenic sources, e.g., fertilizers and traffic pollution; and Factor 3 represented the contribution of metals from soil-forming parent material. More than half of the study area had high pollution risk and was not suitable for vegetable cultivation.


Assuntos
Minas de Carvão , Mercúrio , Metais Pesados , Poluentes do Solo , Cádmio/análise , China , Carvão Mineral/análise , Monitoramento Ambiental/métodos , Poluição Ambiental/análise , Mercúrio/análise , Metais Pesados/análise , Medição de Risco , Solo , Poluentes do Solo/análise
4.
Chem Sci ; 13(17): 4788-4793, 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35655881

RESUMO

Plasmonic molecules are discrete assemblies of similar/dissimilar nanomaterials (atomic equivalents) with efficient inter-unit coupling toward electromagnetic hybridization. Albeit fundamentally and technologically very important, these structures are rare due to the lack of a general way to manipulate the structure, composition, and coupling of the nanoassemblies. While DNA nanotechnology offers a precious chance to build such structures, the weak coupling of DNA-bonded materials and the very limited material building blocks are two obstacles. This work aims to remove the bottlenecking barriers on the road to dimeric (and possibly more complicated) plasmonic molecules. After solving key synthetic issues, DNA-guided, solvo-driven Ag ion soldering is utilized to build a whole set (10 combinations of 4 metals) of homo/heterodimeric plasmonic nanomolecules with prescribed compositions. Importantly, strong in-solution electric-dipole coupling mediated by a sub-1.5 nm interparticle dielectric gap is achieved for materials with strong (Au, Ag) or damped (Pt, Pd) plasmonic responses. The involvement of Pt/Pd materials is of great value for plasmon-mediated catalysis. The broken dimeric symmetry is desirable for Fano-like resonance and photonic nanodiode devices, as well as lightening-up of plasmon dark states. The generality and reliability of the method would allow excitonic, nonlinear-optical, and magnetic units to be involved toward correspondingly enhanced functions.

5.
Biochem Biophys Rep ; 31: 101286, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35655951

RESUMO

Background: High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. The progression from initial infection to cervical cancer has been linked to properties of the viral sequences. However, the distribution of HPV16 variants among Chinese women has not been extensively addressed and the role of HPV16 variants in the risk of cervical carcinogenesis remains poorly understood. Methods: HPV16 positive cervical exfoliated cell samples were collected from 249 women living in Beijing, China. PCR products from two fragments of E6-E7 and LCR of HPV16 in these samples were sequenced and analyzed. Results: Lineage A was found in the subjects, including A1, A2, A3 and A4 sublineages. Based on the HPV16 reference sequences, 26 nucleotide mutations of A4 sublineage and 39 nucleotide mutations of A1-3 sublineages were found in the E6, E7 and LCR of HPV16 isolates. Point mutations T843C, A7287C and A7872G of A4 sublineage were significantly associated with high-grade cervical lesions. The high-frequency sites in HPV16 LCR located at regions that can bind to multiple transcription factors. Conclusions: This study contributes to the identification of unique variants in the E6, E7 and LCR of HPV16 isolates infected in Chinese women. Mutations of T843C, A7287C and A7872G in A4 sublineages were significantly associated with high-grade cervical lesions, suggesting that mutations in the E7 and LCR region have potential effects on viral replication and progression of cervical cancer.

6.
Chemosphere ; 303(Pt 2): 135012, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35660389

RESUMO

In comparison with the thermal hazard of polymers, noxious smoke and gas produced by the combustion of polymers make the environment self-purification a huge challenge. As a new type of a highly effective flame retardant, black phosphorus (BP) can effectively decrease the thermal hazard of polymers, but its performances in smoke suppression and toxicity reduction are unsatisfactory. In this article, a method of covalently grafting diazotized BP with a ferrocene oligomer was applied to promote the smoke suppression and toxicity reduction efficiency of BP. In our work, the BP-NH nanomaterials with a mass of amino groups on the surface were acquired by diazotizing the BP. Then, the BP-Fe was obtained by covalently grafting the ferrocene chloride salt and nitrogen-containing heterocycles on the surface of BP. The smoke production rate (SPR) and total smoke production (TSP) values of the epoxy resin (EP) decreased by 49.8% and 52.5% with the addition of 2 wt% BP-Fe, respectively. In comparison with previous studies, this work was far more effective than the previous work in smoke suppression and flame retardant. The release of toxic gases (CO and HCN) and volatile organic compounds in the EP was also effectively inhibited at the same time. In addition, the storage modulus and tensile strength of nanocomposites increased by 35.1% and 27.2% with the addition of 1 wt% BP-Fe. This work also provides a new idea on how to simultaneously strengthen the toxic smoke suppression, mechanical properties, and flame retardant of polymer materials.

7.
J Geriatr Cardiol ; 19(5): 367-376, 2022 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-35722036

RESUMO

BACKGROUND: Three-vessel disease (TVD) with a SYNergy between PCI with TAXus and cardiac surgery (SYNTAX) score of ≥ 23 is one of the most severe types of coronary artery disease. We aimed to take advantage of machine learning to help in decision-making and prognostic evaluation in such patients. METHODS: We analyzed 3786 patients who had TVD with a SYNTAX score of ≥ 23, had no history of previous revascularization, and underwent either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) after enrollment. The patients were randomly assigned to a training group and testing group. The C4.5 decision tree algorithm was applied in the training group, and all-cause death after a median follow-up of 6.6 years was regarded as the class label. RESULTS: The decision tree algorithm selected age and left ventricular end-diastolic diameter (LVEDD) as splitting features and divided the patients into three subgroups: subgroup 1 (age of ≤ 67 years and LVEDD of ≤ 53 mm), subgroup 2 (age of ≤ 67 years and LVEDD of > 53 mm), and subgroup 3 (age of > 67 years). PCI conferred a patient survival benefit over CABG in subgroup 2. There was no significant difference in the risk of all-cause death between PCI and CABG in subgroup 1 and subgroup 3 in both the training data and testing data. Among the total study population, the multivariable analysis revealed significant differences in the risk of all-cause death among patients in three subgroups. CONCLUSIONS: The combination of age and LVEDD identified by machine learning can contribute to decision-making and risk assessment of death in patients with severe TVD. The present results suggest that PCI is a better choice for young patients with severe TVD characterized by left ventricular dilation.

8.
Front Cardiovasc Med ; 9: 879834, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35722116

RESUMO

Aims: To explore the effects of age and sex on the outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients with the three-vessel disease (TVD). Methods and Results: The study is a subanalysis of data from a prospective cohort of 8,943 patients with angiographically confirmed TVD at Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China. The primary end point was major adverse cardiac and cerebrovascular events (MACCEs), a composite of all-cause death, myocardial infarction, and stroke. In total, 2,819 patients with NSTE-ACS who received CABG (43.6%) or PCI (56.4%) were included, among whom 32.7% were of 65-74 years, 7.2% were ≥75 years, and 22.6% were women. The median follow-up duration was 6.8 years. The superiority of CABG relative to PCI in terms of MACCE was decreased with age (adjusted hazard ratio [HR] [95% confidence interval (CI)]: <65 years: 0.662 [0.495-0.885], p = 0.005; 65-74 years: 0.700 [0.512-0.956], p = 0.025; ≥75 years: 0.884 [0.529-1.479], p = 0.640) and was only seen in men (adjusted HR [95% CI]: men: 0.668 [0.526-0.848], p = 0.001; women: 0.713 [0.505-1.006], p = 0.054). Significant treatment-by-sex and treatment-by-age interactions were observed in patients ≥ 75 years and women, respectively, (p interaction with sex = 0.001; p interaction with age = 0.002). Conclusion: Coronary artery bypass grafting is favorable for most NSTE-ACS patients with TVD. The preponderance of CABG over PCI disappeared in patients ≥ 75 years and women. PCI is superior in women ≥ 75 years.

9.
Hum Mol Genet ; 2022 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-35717579

RESUMO

Although multiple common susceptibility loci for lung cancer (LC) have been identified by genome-wide association studies (GWAS), they can explain only a small portion of heritability. The etiological contribution of rare deleterious variants (RDVs) to LC risk is not fully characterized and may account for part of the missing heritability. Here, we sequenced the whole exomes of 2777 participants from the Environment and Genetics in Lung cancer Etiology (EAGLE) study, a homogenous population including 1461 LC cases and 1316 controls. In single variant analyses, we identified a new RDV, rs77187983 (EHBP1, Odds Ratio [OR] = 3.13, 95% confidence interval [CI] = 1.34-7.30, P = 0.008) and replicated two previously reported RDVs, rs11571833 (BRCA2, OR = 2.18; 95% CI = 1.25-3.81, P = 0.006) and rs752672077 (MPZL2, OR = 3.70, 95% CI = 1.04-13.15, P = 0.044). In gene-based analyses, we confirmed BRCA2 (P = 0.007) and ATM (P = 0.014) associations with LC risk and identified TRIB3 (P = 0.009), involved in maintaining genome stability and DNA repair, as a new candidate susceptibility gene. Furthermore, cases were enriched with RDVs in homologous recombination repair (carrier frequency [CF] = 22.9% vs. 19.5%, P = 0.017) and Fanconi anemia (CF = 12.5% vs. 10.2%, P = 0.036) pathways. Our results were not significant after multiple testing correction but were enriched in cases vs. controls from large scale public biobank resources, including TCGA, FinnGen, and UK Biobank. Our study identifies novel candidate genes and highlights the importance of RDVs in DNA repair related genes for LC susceptibility. These findings improve our understanding of LC heritability and may contribute to the development of risk stratification and prevention strategies.

11.
Artigo em Inglês | MEDLINE | ID: mdl-35646144

RESUMO

The constant dark induction (DD) causes lipid degeneration and nonalcoholic fatty liver disease (NAFLD) in zebrafish, which might be closely related to the imbalance of gut microbiota and require in-depth study. In this study, a total of 144 zebrafish were divided into four groups, including the control group, Yihe-Tang group, constant dark group, and constant dark + Yihe-Tang group, and were treated with constant darkness (except control and Yihe-Tang groups) for 21 days. The bodyweights of zebrafish were recorded after 8 d, 15 d, and 22 d. The sequencing analysis of gut microbiota, detection of liver histopathological changes, and comparison of lipid metabolism-related gene expression levels were performed on the 22nd day of the experiment. The results showed that the Yihe-Tang could inhibit the constant dark-induced increase in zebrafish weight and liver steatosis. As compared to the control group, the dark treatment could alter the composition of gut microbiota in zebrafish, increase the relative abundance of harmful bacteria, and decrease the Cetobacterium and Bacteroides to Firmicutes ratio in the intestines. The abundance of Proteobacteria in the constant dark + Yihe-Tang group was close to that in the control group and that of Fusobacteria and Cetobacterium increased, especially the Cetobacterium, which increased significantly. The constant dark treatment caused an abnormal expression of liver lipid-related genes, inhibited lipid metabolism, and promoted fat accumulation. However, the Yihe-Tang could restore these changes to the level of the control group. This study indicated that Yihe-Tang could restore the constant dark-induced liver lipid degeneration. We hypothesized that Cetobacterium could significantly inhibit steatosis.

12.
Front Endocrinol (Lausanne) ; 13: 852247, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35663308

RESUMO

Background: Hyperuricemia has recently been identified as a risk factor of cardiovascular diseases; however, prognostic value of hyperuricemia in patients with ST-segment elevation myocardial infarction (STEMI) remained unclear. Simultaneously, the mechanism of this possible relationship has not been clarified. At present, some views believe that hyperuricemia may be related to the inflammatory response. Our study aimed to investigate the association between hyperuricemia and long-term poor prognosis and inflammation in STEMI patients undergoing percutaneous coronary intervention (PCI). Methods: A total of 1,448 consecutive patients with STEMI were studied throughout 2013 at a single center. The primary endpoint was all-cause death at 2- and 5-year follow-up. Inflammatory biomarkers were collected on admission of those patients: high sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count. Results: Hyperuricemia was associated with higher 2- and 5-year all-cause death in STEME patients compared to normouricemia (5.5% vs. 1.4%, P <0.001; 8.0% vs 3.9%, P = 0.004; respectively). After multivariable adjustment, hyperuricemia was still an independent predictor of 2-year all-cause death (hazard ratio (HR) =4.332, 95% confidence interval (CI): 1.990-9.430, P <0.001) and 5-year all-cause death (HR =2.063, 95% CI: 1.186-3.590, P =0.010). However, there was no difference in hs-CRP, ESR, and WBC count on admission in STEMI patients with hyperuricemia compared to normouricemia (P >0.05). Conclusions: Hyperuricemia was associated with higher risks of 2- and 5-year all-cause deaths in patients with STEMI undergoing PCI. However, this study did not find a correlation between hyperuricemia and inflammatory responses in newly admitted STEMI patients.


Assuntos
Hiperuricemia , Intervenção Coronária Percutânea , Infarto do Miocárdio com Supradesnível do Segmento ST , Proteína C-Reativa/análise , Humanos , Hiperuricemia/complicações , Hiperuricemia/epidemiologia , Intervenção Coronária Percutânea/efeitos adversos , Infarto do Miocárdio com Supradesnível do Segmento ST/complicações , Infarto do Miocárdio com Supradesnível do Segmento ST/cirurgia , Resultado do Tratamento
13.
Br J Clin Pharmacol ; 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35508710

RESUMO

BACKGROUND: Toxicity is a major concern related to the clinical use of polymyxin B, and available safety data for renal transplant patients are limited. AIMS: We investigated the safety of polymyxin B and toxicity risk factors in renal transplant patients. METHODS: A prospective study was performed on a group of renal transplant patients who received intravenous polymyxin B between January 2018 and August 2021. Polymyxin B treatment was monitored to evaluate toxicity and risk factors. RESULTS: A total of 235 courses of polymyxin B were administered to 213 patients. Of these, 121 (51.5%) developed skin hyperpigmentation (SH), 149 (63.4%) developed neurotoxicity and 10 (5.5%) developed acute kidney injury of which 80% was reversible. Risk factors for developing SH included a high total dose by weight (odds ration [OR] 1.31, 95% confidence interval [CI] 1.08-1.60, P = .008) and the presence of neurotoxicity (OR 2.86, 95% CI 1.56-5.26, P = .001). Neurotoxicity manifested during the first 2 days of treatment. Neurotoxicity occurred most commonly in women (OR 3.84, 95% CI 1.82-8.10, P < .0001), and the presence of SH (OR 1.98, 95% CI 1.13-3.46, P = .016) was also an independent risk factor. CONCLUSIONS: Neurotoxicity and SH are the two major adverse effects of polymyxin B in renal transplant patients, which may limit its clinical use.

14.
Artigo em Inglês | MEDLINE | ID: mdl-35639326

RESUMO

In this study, we proposed an advanced oxidation process of pyrite (FeS2) and peroxymonosulfate (PMS) and prepared a modified polyaluminum chloride biochar (P-BC). The motivation is to use the combination of FeS2 + PMS + P-BC to improve waste activated sludge (WAS) dewaterability. The method to improve the sludge dewatering effect with the combination of FeS2 + PMS + P-BC is as follows: in the first step, pour 0.75 g/g TSS FeS2 and 0.6 g/g TSS PMS into the sludge, and stir for 15 min. Then, add P-BC and stir for 5 min; complete the entire WAS processing process. The vacuum filtration test was used to evaluate the dehydration effect. The water content (Wc) and specific resistance to filtration (SRF) of the raw sludge can be reduced from the original values of 92% and 2.36 × 1013 m/kg to 67% and 9.89 × 1011 m/kg, respectively. The results showed that the combination of FeS2 + PMS + P-BC can effectively improve the sludge dewatering effect through oxidation. A laser particle size analyzer is used to observe changes in sludge particle size. The median diameter of sludge particles increased from 55.37 to 64.56 µm. A zeta analyzer to is used observe changes in sludge zeta potential. The zeta potential of sludge particles increased from - 15.8 to 0.4 mV. In the analysis of extracellular polymeric substances (EPS) of sludge, it was found that protein (PN) and polysaccharide (PS) in EPS decreased significantly. To further analyze the phenomenon of PN and PS drop, excitation-emission-matrix spectra (3D-EEM) was used. To observe the changes of sludge functional group, X-ray photoelectron spectroscopy was used. It was found that FeS2 + PMS + P-BC can destroy the functional groups of sludge, such as O-H, C-C, and O═C-NH- related to proteins and polysaccharides.

15.
Artigo em Inglês | MEDLINE | ID: mdl-35523403

RESUMO

Oxidative stress has an important role in determining severe damage to the liver, including steatosis. Curcumin (CUR) is a natural polyphenol compound with antioxidant potential but its mechanism is still unclear. In this study, 2% ethanol (ETH) was used to establish a liver injury model in Tg (fabp10: Ps Red) transgenic zebrafish with the fluorescent liver. Ethanol-treated zebrafish had an increased vacuole rate at 144 h post-fertilization (hpf), thus confirming the effectiveness of the proposed model in inducing liver damage. However, when ethanol was submitted to co-exposure with curcumin, fluorescence area and signal intensity, as well as vacuole rate, were similar to the levels found in the control group. RNA-seq results showed that ethanol and CUR affected the regulation of catalytic activity and phenylalanine metabolism, biosynthesis of amino acids, and arginine and proline metabolism signaling pathways. QRT-PCR analysis also showed that treatment with CUR led to the downregulation of genes involved in the Nrf2-Keap1 signaling pathway and altered the expression pattern of genes related to glutathione metabolism (gsr, gpx1a, gstp1, gsto1, and idh1a). CUR also induced an increase in GSH content and recovered decreased GSH caused by ethanol exposure. The findings discussed herein indicate that CUR can promote glutathione synthesis, which aided in the recovery from ethanol-induced liver damage in zebrafish larvae.


Assuntos
Curcumina , Animais , Antioxidantes/metabolismo , Antioxidantes/farmacologia , Curcumina/química , Etanol/metabolismo , Etanol/toxicidade , Glutationa/metabolismo , Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo , Fígado/metabolismo , Fator 2 Relacionado a NF-E2/metabolismo , Estresse Oxidativo , Peixe-Zebra/metabolismo
16.
Artigo em Inglês | MEDLINE | ID: mdl-35524474

RESUMO

Muscular dysplasia is the key factor in influencing surgical outcomes in patients with cleft lip/palate. In this research, we attempted to evaluate a new acellular dermal matrix (ADM) as a substitute for reconstruction of the orbicularis oris muscle with growth factors such as Insulin-Like Growth Factor I (IGF-I), vascular endothelial growth factor (VEGF) in a rabbit model. 30 male New Zealand Rabbits (2-3 m, 1700-2000 g) were divided into four groups as follows; a group in which the orbicularis oris muscle of the upper lip was implanted with ADM, a group in which the orbicularis oris muscle of the upper lip was implanted with ADM + IGF-I + VEGF, a group in which the upper lip was operated without implantation of an ADM scaffold, and a normal upper lip for comparison. Macroscopic observation, histological evaluation, and immunohistochemistry were employed to evaluate levels of the muscle regeneration, vascularization, and inflammation at 1, 2, 4, 6, and 12 weeks after the operation. All wounds healed well without infection, immune rejection and so on. Histological evaluation showed that ADM was totally degraded and replaced by connective tissue. The area in which the ADM scaffold was coated with growth factors show a significant increase in the formation of new myofibers after injury, and the vascularization improved compared to the control group and the normal group. In regard to the degrees of inflammation, there were no notable differences among the groups. In conclusion, Our study indicated that ADM grafts combined with IGF-I and VEGF have potential advantages in alleviating muscular dysplasia in cleft lip treatment.

17.
Nanomaterials (Basel) ; 12(10)2022 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-35630998

RESUMO

Titanium dioxide is a mainstream photocatalyst, but it still confronts great obstacles of poor visible light absorption and rapid recombination rate of photogenerated carriers. Herein, we describe the design of a highly active visible-light photocatalytic system of graphited carbon layers anchored V2O5/TiO2 heterojunctions derived from Ti3C2 MXene, which demonstrates about 4.58 and 2.79 times higher degradation activity of MB under visible light (λ > 420 nm) than pure V2O5 and TiO2-carbon. Combined with the characterization results, the formed V2O5/TiO2 heterojunction promotes the separation of photogenerated carriers, while the graphitized carbon derived from MXene acts as an electronic reservoir to enhance the absorption of visible light. The ESR results show that superoxide radicals and hydroxyl radicals are the main active species in the reaction system. Therefore, we propose a possible mechanism model to provide a feasible idea for the subsequent design of high-efficiency photocatalysts for environmental treatment.

18.
Polymers (Basel) ; 14(10)2022 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-35631884

RESUMO

Poly (vinyl alcohol)/ß-cyclodextrin (PVA/CD) composite fibers are prepared by wet spinning followed by hot stretching. XRD results show that ß-CDs are in an amorphous state in fiber, and ß-CD can help maintain the fibrous crystal that exists in the composite fiber. The DSC results show that the total crystalline ratio of the composite fibers decreased with the increase of ß-CD. The as-prepared composite fibers were further crosslinked with glutaraldehyde (GA) to improve their usability. The crosslinked structure, together with amorphous ß-CD, contributes to the loading and sustained release of fragrance molecules that were studied. The fragrance retention ratio of PVA/CD/GA is 55.63% and 48.25% for cis-jasmone and citronella, even after 25 days. The inclusion complexes of ß-CD and fragrance molecules are confirmed by 2D-FTIR, which is responsible for the sustained release of fragrance. This study may contribute to the mass production of wearable long-term scented fabrics.

19.
Phytother Res ; 2022 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-35624528

RESUMO

Gypenoside XVII (GP-17), a tetracyclic triterpene saponin isolated from the functional food Gynostemma pentaphyllum, has been demonstrated protective effects against cerebrovascular and cardiovascular diseases on multiple disease models. In this study, we established a myocardial infarction (MI) model by ligating the left anterior descending coronary artery, and explored whether GP-17 prevent myocardial ischemia/reperfusion (I/R) injuries in mice. Compared with the I/R group, GP-17 significantly improved the cardiac function, reduced the MI, decreased myocardial pathology, activated superoxide dismutase and catalase, and reduced the content of lactate dehydrogenase, creatine kinase, malondialdehyde, and inflammatory factor. The proteomic analysis showed multiple differential proteins between the GP-17 and I/R groups enriched in endoplasmic reticulum and mitochondria. Western-Blot showed that GP-17 significantly decreased the expression of GRP78, ATF6, CHOP, and phosphorylation of PERK, indicating the inhibition of ERS. GP-17 inhibited the expression of ATG5, LC3A/B, and BAX, illustrating the suppression of autophagy and apoptosis. Moreover, both GP-17 and 4-PBA could improve the downregulated Mfn2, meaning that inhibition of ERS regulated the mitochondrial fusion fission balance, thus protected the function of mitochondria. In conclusion, we found that GP-17 prevented against myocardial I/R injury by inhibit ERS-induced cell apoptosis, autophagy, oxidative stress, and mitochondrial division.

20.
Mol Cell ; 82(10): 1781-1783, 2022 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-35594841

RESUMO

Caspases are often considered the final checkpoint for a pathogen to save its replicative niche from collapsing after cell death signaling has been initiated in response to infection. Two recent works (Li et al., 2021; Peng et al., 2022) found that pathogens inhibit host cell death by inactivating multiple caspases with a novel posttranslational modification.


Assuntos
Caspases , Interações Hospedeiro-Patógeno , Caspases/genética , Caspases/metabolismo , Morte Celular , Replicação do DNA
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