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2.
J Safety Res ; 79: 199-210, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34848002

RESUMO

INTRODUCTION: With prevalent and increased attention to driver inattention (DI) behavior, this research provides a comprehensive investigation of the influence of built environment and roadway characteristics on the DI-related vehicle crash frequency per year. Specifically, a comparative analysis between DI-related crash frequency in rural road segments and urban road segments is conducted. METHOD: Utilizing DI-related crash data collected from North Carolina for the period 2013-2017, three types of models: (1) Poisson/negative binomial (NB) model, (2) Poisson hurdle (HP) model/negative binomial hurdle (HNB) model, and (3) random intercepts Poisson hurdle (RIHP) model/random intercepts negative binomial hurdle (RIHNB) model, are applied to handle excessive zeros and unobserved heterogeneity in the dataset. RESULTS: The results show that RIHP and RIHNB models distinctly outperform other models in terms of goodness-of-fit. The presence of commercial areas is found to increase the probability and frequency of DI-related crashes in both rural and urban regions. Roadway characteristics (such as non-freeways, segments with multiple lanes, and traffic signals) are positively associated with increased DI-related crash counts, whereas state-secondary routes and speed limits (higher than 35 mph) are associated with decreased DI-related crash counts in rural and urban regions. Besides, horizontal curved and longitudinal bottomed segments and segments with double yellow lines/no passing zones are likely to have fewer DI-related crashes in urban areas. Medians in rural road segments are found to be effective to reduce DI-related crashes. Practical Applications: These findings provide a valuable understanding of the DI-related crash frequency for transportation agencies to propose effective countermeasures and safety treatments (e.g., dispatching more police enforcement or surveillance cameras in commercial areas, and setting more medians in rural roads) to mitigate the negative consequences of DI behavior.

3.
Environ Technol ; : 1-28, 2021 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-34739353

RESUMO

AbstractChromium (Cr) pollution is the primary pollution problem of the soil in tannery. However, the effect of tanning chemicals on Cr migration in soil has not been clearly elucidated. Column leaching tests were designed in this study to reveal the transport and transformation of Cr from basic chromium sulfate (BCS) into soil and the effects of lime on Cr migration and transformation. The results showed that BCS was mainly leached out in the state of Cr(Ⅵ) after entering the soil, and the Cr concentration in leachate decreased with the increase of the bulking thickness of the BCS. Compared with the soil absent of lime, the concentration of total Cr in the leachate from soil with lime decreased by 8.80-88.1%. The proportions of Cr in the residual fraction were generally increased in the soil with lime, whereas other fractions were decreased. The presence of lime can reduce the migration and toxicity of BCS in soil to a certain extent. The analysis of soil bacterial community showed that the relative abundance of Proteobacteria increased significantly with the exposure to BCS and the Burkholderiaceae was the dominant bacteria family in the BCS contaminated soil. Understanding the mobility of BCS and lime and the bacterial community in BCS contaminated soil is conducive to the risk assessment of the tannery site.

4.
Thromb J ; 19(1): 85, 2021 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-34772417

RESUMO

AIM: The present study aimed to explore these characteristics, particularly thin-cap fibroatheroma (TCFA), in relation to residual syntax score (rSS) in patients who presented with acute MI. METHODS AND OUTCOMES: A total of 434 consecutive patients with MI aged ≥18 years who had STEMI underwent primary PCI. Notably, compared with other subgroups, the presence of TCFA in culprit lesions and a higher level of rSS, were significantly associated with MACE. When rSS was divided into three groups, high rSS levels were associated with a higher incidence of MACE, in the subgroups of without TCFA (P = 0.005), plaque erosion (P = 0.045), macrophage infiltration (P = 0.026), and calcification (P = 0.002). AUC of ROC curve was 0.794 and 0.816, whereas the AUC of the survival ROC was 0.798 and 0.846. CONCLUSION: The results of this study could be used in clinical practice to support risk stratification. TRIAL REGISTRATION: This study was registered at ClinicalTrials.gov as NCT03593928 .

5.
J Nematol ; 532021.
Artigo em Inglês | MEDLINE | ID: mdl-34820628

RESUMO

Spodoptera litura is a notorious leaf feeding insect pest in the Asia-Pacific region and leads to a significant economic loss in vegetable and field crop production. Entomopathogenic nematodes (EPNs), lethal parasites of insects, are used as biocontrol agents. Yunnan Province in China is a well-known region due to its rich biodiversity. In the present study, a survey of EPNs using the Galleria-baiting technique was conducted in 2017 and 2018 throughout the entire Yunnan province. In total, 789 soil samples were collected from 232 sites, of which 75 samples were positive for EPNs. Phylogenetic analyses of ITS, D2D3 expansion region of the 28S rRNA gene, as well as mitochondrial cytochrome c oxidase subunit I (COI), were performed to identify isolated nematode species and evaluate their genetic diversity. In total, 13, 3, and 58 identified populations belong to Steinernema, Heterorhabditis, and Oscheius, respectively. The phylogenetic relationships of EPN species in the three genera were analyzed with the Neighbor-Joining method. The virulence of the trapped isolates in the genera of Steinernema, Heterorhabditis, and Oscheius against S. litura was evaluated. Ten new indigenous isolates from Steinernema and Heterorhabditis showed prominent virulence to S. litura within 48 hr which is equivalent to that of commercial EPNs populations. The present study provides background information on indigenous EPN resources for S. litura control in Asia-Pacific region.

6.
J Innate Immun ; : 1-14, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34823251

RESUMO

Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is constitutively produced by endothelial cells and plays a vital role in maintaining vascular homeostasis. Chronic periodontitis is an inflammatory disease characterized by bleeding of periodontal tissues that support the tooth. In this study, we aimed to determine the role of PAI-1 produced by endothelial cells in response to infections caused by the primary periodontal pathogen Porphyromonas gingivalis. We demonstrated that P. gingivalis infection resulted in significantly reduced PAI-1 levels in human endothelial cells. This reduction in PAI-1 levels could be attributed to the proteolysis of PAI-1 by P. gingivalis proteinases, especially lysine-specific gingipain-K (Kgp). We demonstrated the roles of these degradative enzymes in the endothelial cells using a Kgp-specific inhibitor and P. gingivalis gingipain-null mutants, in which the lack of the proteinases resulted in the absence of PAI-1 degradation. The degradation of PAI-1 by P. gingivalis induced a delayed wound healing response in endothelial cell layers via the low-density lipoprotein receptor-related protein. Our results collectively suggested that the proteolysis of PAI-1 in endothelial cells by gingipains of P. gingivalis might lead to the deregulation of endothelial homeostasis, thereby contributing to the permeabilization and dysfunction of the vascular endothelial barrier.

7.
Nat Commun ; 12(1): 6878, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34824249

RESUMO

Defect engineering is a strategy that is attracting widespread attention for the possibility of modifying battery active materials in order to improve the cycling stability of the electrodes. However, accurate investigation and quantification of the effect of the defects on the electrochemical energy storage performance of the cell are not trivial tasks. Herein, we report the quantification of vanadium-defective clusters (i.e., up to 5.7%) in the V2O3 lattice via neutron and X-ray powder diffraction measurements, positron annihilation lifetime spectroscopy, and synchrotron-based X-ray analysis. When the vanadium-defective V2O3 is employed as cathode active material in an aqueous Zn coin cell configuration, capacity retention of about 81% after 30,000 cycles at 5 A g-1 is achieved. Density functional theory calculations indicate that the vanadium-defective clusters can provide favorable sites for reversible Zn-ion storage. Moreover, the vanadium-defective clusters allow the storage of Zn ions in V2O3, which reduces the electrostatic interaction between the host material and the multivalent ions.

8.
J Phys Chem Lett ; : 11543-11554, 2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34806392

RESUMO

Electrocatalysis is recognized as a significant process for energy conversion. In fact, numerous factors, including the variable electronic structure of electrocatalysts, rich intermediates, and mutable active phases, have important but complex influences on the catalytic process. In addition, the support of electrocatalysts is considered as one of key factors that correlate to the final catalytic performance. In this Perspective, some recent advances regarding the support effects in electrocatalysis are briefly summarized. Synchrotron radiation-based characterizations are introduced to reveal the support-induced modulation in electrocatalysts. Recent in situ/operando studies are emphasized for better understanding of the real interaction between catalysts and support, together with visualizing the dynamic catalytic process. Some perspectives are proposed that may accelerate more attention being given to the support's optimization for future practical applications.

9.
Environ Sci Technol ; 55(22): 15323-15332, 2021 11 16.
Artigo em Inglês | MEDLINE | ID: mdl-34729979

RESUMO

Promoting sustainable food consumption is critical to meet the United Nation's Sustainable Development Goals. The existing research using average diets and the individual one-day diet recall data to obtain insights into food carbon footprints (CFs) may neglect the diverse food purchasing patterns in different households (HHs). In this paper, we analyzed detailed grocery shopping records of 57,578 U.S. HHs to evaluate the associated food CFs. The cradle-to-farm-gate CFs of 83 food items were calculated using a process-based life cycle assessment model adapted to the U.S. condition. Using the CF of a healthy and sustainable diet as the benchmark, we quantified the CF reduction potentials for each HH. Our results suggest three key strategies to reduce HH food CFs: (1) lowering the over-purchasing in small (one- or two-person) HHs can achieve two-thirds of the recognized carbon emission reduction potentials; (2) reducing the intake of snacks, ready-made food, and drinks leads to as much as, if not more, carbon emission reduction than changing diets; and (3) more attention needs to be paid to reduce the carbon intensity of food items with large purchased volume.


Assuntos
Pegada de Carbono , Alimentos , Dieta , Humanos
10.
Genet Mol Biol ; 44(4): e20200463, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34807222

RESUMO

Pain is a significant problem worldwide that affects the quality of life of patients. Dezocine is a non-addictive analgesic drug with kappa-opioid antagonist activity and has been successfully used to alleviate of postoperative pain. In addition, dezocine has an analgesic effect similar to that of morphine, alleviating moderate to severe pain. Rap guanine nucleotide exchange factor 3 (RAPGEF3) is a guanine nucleotide exchange factor for GTPases Rap1 and Rap2, which could enhance the activity of Rap1 to promote cell adhesion and axon regeneration, as well as promote neurite extension by interacting with nerve growth factors. Here, we first observed that overexpression of RAPGEF3 increased cell viability, as shown by a CCK-8 assay, and recovered brain function in rats. The expression of inflammation-related factors at the mRNA level was detected using qPCR, and the concentration of these factors in a cultured cell medium and rat serum samples were decreased as shown by ELISA after RAPGEF3 overexpression. Through western blotting, we further found that pro-inflammatory proteins were decreased, and these effects might be mediated by inhibition of the Ras/p-38 MAPK signaling pathway. Taken together, we speculated that RAPGEF3overexpression enhances the therapeutic effect of dezocine on neuropathic pain by inhibiting the inflammatory response through inhibition of the Ras/p-38 MAPK signaling pathway.

11.
Nat Commun ; 12(1): 6566, 2021 11 12.
Artigo em Inglês | MEDLINE | ID: mdl-34772935

RESUMO

As sequencing depth of chromatin studies continually grows deeper for sensitive profiling of regulatory elements or chromatin spatial structures, aligning and preprocessing of these sequencing data have become the bottleneck for analysis. Here we present Chromap, an ultrafast method for aligning and preprocessing high throughput chromatin profiles. Chromap is comparable to BWA-MEM and Bowtie2 in alignment accuracy and is over 10 times faster than traditional workflows on bulk ChIP-seq/Hi-C profiles and than 10x Genomics' CellRanger v2.0.0 pipeline on single-cell ATAC-seq profiles.

12.
Front Endocrinol (Lausanne) ; 12: 722674, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34721291

RESUMO

Objectives: The CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) contributes to islet ß-cell function and insulin secretion by inhibiting the activation of CDK5. The current studies on the relationship between CDKAL1 polymorphisms rs7756992 A>G and rs7754840 C>G and the risk of gestational diabetes mellitus (GDM) have drawn contradictory conclusions. Materials and Methods: A meta-analysis with a fixed- or random-effects model was conducted to estimate the correlation between studied CDKAL1 polymorphisms and GDM risk with the summary odds ratio (OR) and 95% confidence interval (CI). In addition, trial sequential analysis (TSA) and false-positive report probability (FPRP) analysis were performed to confirm the study findings. Results: A total of 13,306 subjects were included in the present study. Meta-analysis results showed that the variant heterozygous and homozygous genotypes of the two polymorphisms were associated with increased GDM risk in comparison with the wild-type AA genotype (AG vs. AA: OR = 1.23, 95% CI = 1.08, 1.41, p = 0.002; GG vs. AA: OR = 1.47, 95% CI = 1.05, 2.05, p = 0.024 for rs7756992; and CG vs. GG: OR = 1.36, 95% CI = 1.13, 1.65, p = 0.002; CC vs. GG: OR = 1.76, 95% CI = 1.37, 2.26, p < 0.001 for rs7754840). The TSA confirmed a significant association between rs7754840 and the susceptibility to GDM because the cumulative Z-curve crossed both the conventional cutoff value and the TSA boundaries under the heterozygote and homozygote models. Conclusions: This study supported the finding that rs7756992 and rs7754840 are associated with susceptibility to GDM. However, further functional studies are warranted to clarify the mechanism.

13.
Mil Med Res ; 8(1): 57, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34724985

RESUMO

BACKGROUND: Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whether mitochondrial DNA (mtDNA) variants, which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production, are associated with COVID-19 risk. METHODS: A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls (n = 615) and COVID-19 patients (n = 536). COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography scanning. The exclusion criteria for the healthy controls were any history of disease in the month preceding the study assessment. MtDNA variants defining mtDNA haplogroups were identified by PCR-RFLPs and HVS-I sequencing and determined based on mtDNA phylogenetic analysis using Mitomap Phylogeny. Student's t-test was used for continuous variables, and Pearson's chi-squared test or Fisher's exact test was used for categorical variables. To assess the independent effect of each mtDNA variant defining mtDNA haplogroups, multivariate logistic regression analyses were performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) with adjustments for possible confounding factors of age, sex, smoking and diseases (including cardiopulmonary diseases, diabetes, obesity and hypertension) as determined through clinical and radiographic examinations. RESULTS: Multivariate logistic regression analyses revealed that the most common investigated mtDNA variations (> 10% in the control population) at C5178a (in NADH dehydrogenase subunit 2 gene, ND2) and A249d (in the displacement loop region, D-loop)/T6392C (in cytochrome c oxidase I gene, CO1)/G10310A (in ND3) were associated with a reduced risk of severe COVID-19 (OR = 0.590, 95% CI 0.428-0.814, P = 0.001; and OR = 0.654, 95% CI 0.457-0.936, P = 0.020, respectively), while A4833G (ND2), A4715G (ND2), T3394C (ND1) and G5417A (ND2)/C16257a (D-loop)/C16261T (D-loop) were related to an increased risk of severe COVID-19 (OR = 2.336, 95% CI 1.179-4.608, P = 0.015; OR = 2.033, 95% CI 1.242-3.322, P = 0.005; OR = 3.040, 95% CI 1.522-6.061, P = 0.002; and OR = 2.890, 95% CI 1.199-6.993, P = 0.018, respectively). CONCLUSIONS: This is the first study to explore the association of mtDNA variants with individual's risk of developing severe COVID-19. Based on the case-control study, we concluded that the common mtDNA variants at C5178a and A249d/T6392C/G10310A might contribute to an individual's resistance to developing severe COVID-19, whereas A4833G, A4715G, T3394C and G5417A/C16257a/C16261T might increase an individual's risk of developing severe COVID-19.

14.
Adv Mater ; : e2108809, 2021 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-34784438

RESUMO

Endogenous heterojunction of 2D MXenes with unique structure shows inspiring potential in energy applications, which is impeded by complex synthesis method and finite MAX materials. Herein, an in situ hydrothermal strategy is implemented to successfully synthesize unique endogenous hetero-MXenes of amorphous MoS2 coupling with fluoride-free Mo2 CTx directly from Mo2 Ga2 C MAX. The distinctive morphology and heterojunction structure caused by the introduction of MoS2 endow the hetero-MXenes with extraordinary structural stability and optimized Li+ storage mechanism with improved charge transport and lithium ion adsorption capabilities. As a result, hetero-Mo2 C exhibits excellent electrochemical performance with a high discharge specific capacity of 1242 mAh g-1 at 0.1 A g-1 and long cycle stability of 683.9 mAh g-1 after 1200 cycling. This work provides new insights into rational design of novel MXenes heterojunctions, practically important for the development of MXenes and their applications in high-performance energy storage systems. This article is protected by copyright. All rights reserved.

15.
Neurosci Res ; 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34740726

RESUMO

Patients with TLE are prone to tolerance to antiepileptic drugs. Based on the perspective of molecular targets for drug resistance, it is necessary to explore effective drug resistant genes and signaling pathways for the treatment of TLE. We performed gene expression profiles in hippocampus of patients with drug-resistant TLE and identified ROCK2 as one of the 20 most significantly increased genes in hippocampus. In vitro and in vivo experiments were performed to identify the potential role of ROCK2 in epileptogenesis. In addition, the activity of Stat3 pathway was tested in rat hippocampal tissues and primary cultured astrocytes. The expression levels of ROCK2 in the hippocampus of TLE patients were significantly increased compared with the control group, which was due to the hypomethylation of ROCK2 promoter. Fasudil, a specific Rho-kinase inhibitor, alleviated epileptic seizures in the pilocarpine rat model of TLE. Furthermore, ROCK2 activated the Stat3 pathway in pilocarpine-treated epilepsy rats, and the spearman correlation method confirmed that ROCK2 is associated with Stat3 activation in TLE patients. In addition, ROCK2 was predominantly expressed in astrocytes during epileptogenesis, and induced epileptogenesis by activating astrocyte cell cycle progression via Stat3 pathway. The overexpressed ROCK2 plays an important role in the pathogenesis of drug-resistant epilepsy. ROCK2 accelerates astrocytes cell cycle progression via the activation of Stat3 pathway likely provides the key to explaining the process of epileptogenesis.

16.
J Hazard Mater ; 424(Pt C): 127562, 2021 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-34736200

RESUMO

Triclosan (TCS), a newly identified environmental endocrine disruptor (EED) in household products, has been reported to have toxic effects on animals and humans. The effects of TCS exposure on individual social behaviors and the potential underlying mechanisms are still unknown. This study investigated the behavioral effects of 42-day exposure to TCS (0, 50, 100 mg/kg) in drinking water using the open field test (OFT), social dominance test (SDT), social interaction test (SIT), and novel object recognition task (NOR). Using 16S rRNA sequencing analysis and transmission electron microscopy (TEM), we observed the effects of TCS exposure on the gut microbiota and ultrastructure of hippocampal neurons and synapses. Behavioral results showed that chronic TCS exposure reduced the social dominance of male and female mice. TCS exposure also reduced social interaction in male mice and impaired memory formation in female mice. Analysis of the gut microbiota showed that TCS exposure increased the relative abundance of the Proteobacteria and Actinobacteria phyla in female mice. Ultrastructural analysis revealed that TCS exposure induced ultrastructural damage to hippocampal neurons and synapses. These findings suggest that TCS exposure may affect social behaviors, which may be caused by altered gut microbiota and impaired plasticity of hippocampal neurons and synapses.

17.
Animals (Basel) ; 11(11)2021 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-34827741

RESUMO

This study aimed to investigate the protective value of Eucommia ulmoides extract (EUE) on chicks under cold stress. A total of 21 compounds were identified in EUE using mass spectrometry (LC-MS). Ninety chicks were divided into a control group (CS) fed a basal diet and an experimental group supplemented with EUE, exposed to 10 ± 1 °C for 8 h per day. Results showed, compared with the CS group, the body weights (BW) (p < 0.01) and average daily gains ADG (p < 0.05) of the EUE group were increased throughout the study period. Chicks fed EUE had higher AFI (0-7 d, p < 0.001) and lower feed-to-gain ratios (F/G) (0-15 d, p < 0.001). EUE increased the activities of superoxide dismutase (SOD) (15 d, p < 0.05) and glutathione peroxidase (GSH-Px) (7 d, p < 0.05), whereas it decreased malondialdehyde (MDA) (15 d, p < 0.01). The contents of IgA (7 d, p < 0.05), IgG (7 d; 15 d, p < 0.01), and IgM (15 d, p < 0. 001) were higher in the EUE group. Dietary EUE could also reduce chick organ damage. Overall, EUE as a natural feed additive can improve the growth performance, antioxidant capacity, and immune level, and reduce the organ damage of cold-stressed chicks.

18.
Clin Res Hepatol Gastroenterol ; : 101819, 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34619365

RESUMO

BACKGROUND: Different sized microspheres may affect the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT), but related data are lacking. Therefore, the current study aimed to investigate the treatment response, survival and safety of DEB-TACE using different sized microspheres in HCC patients with or without PVTT. METHODS: Totally 90 HCC patients underwent DEB-TACE treatment were retrospectively enrolled (30 cases with PVTT and 60 cases without PVTT). According to the sizes of microspheres, patients were divided into 100-300µm, 300-500µm and 500-700µm groups, respectively. RESULTS: Disease control rate (DCR) was highest in 300-500µm group (81.3%), followed by 500-700µm group (50.0%), then the lowest in 100-300µm group (12.5%) (P=0.004); while objective response rate (ORR) was similar among three groups (P=0.177) in patients with PVTT. Furthermore, overall survival (OS) (P=0.513) and adverse events (all P>0.05) were similar among three groups in patients with PVTT. Besides, in patients without PVTT: ORR (P=0.694), DCR (P=0.591), OS (P=0.816) were of no difference among three groups; but the fever incidence was highest in 300-500µm group (65.0%), second high in 500-700µm group (50.0%), then lowest in 100-300µm group (25.0%) (P=0.008), except for this, no difference of other adverse events among three groups was found (all P>0.05). CONCLUSION: DEB-TACE using 300-500µm microspheres (versus 100-300µm or 500-700µm microspheres) exhibits best treatment response without additional adverse events, indicating it might be the optimal choice for HCC patients with PVTT.

19.
Kaohsiung J Med Sci ; 2021 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-34622526

RESUMO

MiR-490-3p is regarded as a tumor suppressor in many cancers, but whether miR-490-3p is involved in the development of bladder cancer remains unknown. BALB/c nude mice (male, 15-20 g) were used to investigate the role of MiR-490-3p in bladder cancer. The relationship between miR-490-3p and PCBP2 involved in bladder cancer regulation were determined. Cell viability, proliferation, and cell cycle were estimated by cell counting kit-8 (CCK-8) assay, 5-bromo-2'-deoxyuridine (BrdU) detection, and flow cytometry analysis, respectively. In animal experiments, lentivirus was transfected into bladder cancer cells to overexpress miR-490-3p, which were then injected into mice and the change of tumor volume was assessed. Principal findings: The expression of MiR-490-3p was decreased in bladder cancer cells. Overexpression of miR-490-3p inhibited bladder cancer cell viability and proliferation. Moreover, overexpression of miR-490-3p caused cell cycle arrest in bladder cancer cells. The inhibitory effect of miR-490-3p on bladder cancer cells growth could be counteracted by enhancing PCBP2 expression. In vivo, bladder cancer growth in mice was blocked by miR-490-3p upregulation. MiR-490-3p suppressed bladder cancer growth and bladder cancer cell proliferation by down-regulating PCBP2 expression.

20.
Psychol Res Behav Manag ; 14: 1543-1554, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34629911

RESUMO

Purpose: WeChat is China' biggest social media platform. In addition to instant messaging, it has a great many useful functions that can help Chinese citizens adapt to an increasingly digitized society. This study aimed to examine the effect of WeChat use on the subjective well-being (SWB) of Chinese older adults living alone, and how the effect could occur. Participants and Methods: A total of 415 Chinese older adults living alone participated in the survey. Participants filled out questionnaires (scales) measuring their SWB, proficiency in WeChat use, social activity levels and self-esteem respectively. Mean scores of SWB were used to determine the difference in SWB between the users and non-users, and correlation test was performed to find out the association between proficiency in WeChat use and SWB among the users. Results: The mean score of WeChat users was 34.68 (SD = 7.301), significantly higher than that of the non-users, which was 32.73 (SD = 7.168) (t = 2.741, p = 0.006). Among the users, the more proficient in WeChat use one was, the higher their SWB score (r = 0.458, p < 0.01). The results combined to demonstrate that WeChat use has a positive effect on the SWB of Chinese older adults living alone. The findings also showed that the increase in SWB was obtained through the mediation of intergenerational support and social activities. Conclusion: This study suggests that WeChat use by Chinese older adults living alone could increase their intergenerational support and social activities; the increased intergenerational support and social activities then enhance the SWB of Chinese older adults living alone.

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