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1.
Chemosphere ; 287(Pt 1): 131971, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34438208

RESUMO

In this study, combined electrooxidation and electrocoagulation (EO-EC) reactor using RuO2-IrO2/Ti and Al electrodes has been built for treatment of Cu-EDTA wastewater. Effects of current density, electrolyte, NaCl concentration, pH and initial concentration on EO-EC performance were investigated. In this study, Cu-EDTA removal efficiency increased with a higher current density. The electrolyte type exerted a significant role in EO-EC process, compared with Na2SO4 and NaNO3, NaCl was a superior supporting electrolyte because the oxidation of Cl- into Cl2 provided additional highly reactive oxidant ClO- for Cu-EDTA oxidation or mineralization. In neutral or alkaline solution, EO-EC reactor performed better than when it was acid. At the condition of current density 10.29 mA cm-2, C0(NaCl) 1 g L-1, C0(Cu) 50 mg L-1 and pH 7, the Cu and COD removal efficiency reached 99.85% and 85.01%, respectively within 60 min. The possible mechanism of Cu-EDTA removal was proposed based on SEM, EDS, XRD, FTIR and XPS analysis of the products. Cu-EDTA chelates were degraded or mineralized by direct charge transfer, chemisorbed M(·OH) and active chorine species produced on anode surface, in which degradation intermediates and mineralization products of Cu-EDTA were generated. Meanwhile, residual degradation intermediates and mineralization products were removed by electrocoagulation. In this study, EO-EC process has been proved to be an effective way for the treatment of Cu-EDTA contaminated wastewater.


Assuntos
Águas Residuárias , Poluentes Químicos da Água , Ácido Edético , Eletrocoagulação , Eletrodos , Oxirredução , Eliminação de Resíduos Líquidos , Poluentes Químicos da Água/análise
2.
J Oncol ; 2021: 3603030, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34603446

RESUMO

Previous studies have indicated the important role of block of proliferation 1 (BOP1) in the progression of several malignant tumors; no comprehensive pan-cancer analysis of BOP1 has been performed. Here, we aim to systematically identify the expression, prognostic value, and potential immunological functions of BOP1 in 33 malignancies. We obtained the gene expression data and clinical information from multiple public databases to assess the expression level and prognostic value of BOP1 in 33 cancers. We also analyzed the relationship between BOP1 expression and DNA methylation, tumor microenvironment (TME), microsatellite instability (MSI), tumor mutational burden (TMB), and immune checkpoints. Moreover, we conducted gene set enrichment analysis (GSEA) to investigate the biological function and signal transduction pathways of BOP1 in different types of tumors. Finally, we validated the expression of BOP1 in lung cancer cell line and detected the influence of BOP1 on lung cancer cell migration and the expression of epithelial-mesenchymal transition- (EMT-) related genes. Collectively, our findings elucidated that BOP1 has the potential to be a promising molecular prognostic biomarker for predicting poor survival in various malignant tumors, as well as a cancer-promoting gene involved in tumorigenesis and tumor immunity.

3.
Risk Manag Healthc Policy ; 14: 4177-4183, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34675712

RESUMO

Objective: In order to fight against coronavirus disease 2019 (COVID-19) better and to share our experience as a reference for clinical laboratory departments. Methods: This was a retrospective study conducted in the clinical laboratory department of Chengdu Women's and Children's Central Hospital in Chengdu, China, from April 2020 to January 2021. The number of nucleic acid and antibody testing specimens of suspected COVID-19 cases was analyzed. The key points of suspected-case sample processing and detection in the clinical laboratory department were summarized. The laboratory was directly involved in the sample processing and testing of suspected cases, the release of reports, and the transfer of specimens to the fever clinic. Results: The number of COVID-19 nucleic acid test specimens in our laboratory ranged from 102 to 2170 per day, and the number of antibody test specimens ranged from 24 to 391 per day. There were four main considerations in the treatment and detection of suspected-case specimens in the clinical laboratory: biosafety management in clinical laboratory departments, measures to ensure the health of the staff, the eight time points for processing suspected-case samples (turn-around time), and key points for the detection of suspected case specimens. Conclusion: The laboratory developed a protective process for COVID-19 antibody and nucleic acid detection during the pandemic. At present, the detection of COVID-19 antibodies and nucleic acids in the clinical laboratory department is orderly, and there have been no cases of laboratory infection.

4.
Biosci Trends ; 15(4): 257-261, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34261848

RESUMO

In Japan, the Law Concerning the Prevention of Infectious Diseases and Medical Care for Patients with Infectious Diseases (the "Infectious Diseases Control Law") classifies infectious diseases as category I-V infectious diseases, pandemic influenza, and designated infectious diseases based on their infectivity, severity, and impact on public health. COVID-19 was designated as a designated infectious disease as of February 1, 2020 and then classified under pandemic influenza as of February 13, 2021. According to national reports from sentinel surveillance, some infectious diseases transmitted by droplets, contact, or orally declined during the COVID-19 epidemic in Japan. As of week 22 (June 6, 2021), there were 704 cumulative cases of seasonal influenza, 8,144 cumulative cases of chickenpox, 356 cumulative cases of mycoplasma pneumonia, and 45 cumulative cases of rotavirus gastroenteritis; these numbers were significantly lower than those last year, with 563,487 cumulative cases of seasonal influenza, 31,785 cumulative cases of chickenpox, 3,518 cumulative cases of mycoplasma pneumonia, and 250 cumulative cases of rotavirus gastroenteritis. Similarly, many infectious diseases transmitted by droplets or contact declined in other countries and areas during the COVID-19 pandemic. One can reasonably assume that various measures adopted to control the transmission of COVID-19 have played a role in reducing the spread of other infectious diseases, and especially those transmitted by droplets or contact. Extensive and thorough implementation of personal protective measures and behavioral changes may serve as a valuable reference when identifying ways to reduce the spread of infectious diseases transmitted by droplets or contact in the future.


Assuntos
COVID-19/prevenção & controle , Controle de Doenças Transmissíveis , Doenças Transmissíveis/epidemiologia , COVID-19/epidemiologia , Doenças Transmissíveis/transmissão , Transmissão de Doença Infecciosa , Humanos , Japão/epidemiologia , Pandemias
5.
Glob Health Med ; 3(3): 125-128, 2021 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-34250286

RESUMO

Respiratory disease deaths associated with seasonal influenza are estimated to be 290,000 to 650,000 per year globally. In Japan, seasonal influenza affects more than 10 million people per year, and especially children, the elderly, and patients with underlying medical conditions, and seasonal influenza can cause severe illness. As SARS-CoV-2 continues to spread, the combined risk of concurrent influenza epidemics and the COVID-19 pandemic are a concern. When the status of influenza virus infections during the 2020-2021 flu season was compared to the 2011 to 2020 flu seasons, data indicated the absence of seasonal influenza outbreaks in Japan during the COVID-19 pandemic. The number of flu patients was roughly estimated to be 14,000 nationwide from September 2020 to March 2021, which marks the first sharp decrease since national influenza surveillance started in 1987 in conjunction with National Epidemiological Surveillance of Infectious Diseases (NESID). Moreover, approximately 500 sentinel sites (designated medical facilities) nationwide reported only 112 patients with severe influenza who required hospitalization. Since prevention and control measures amidst the COVID-19 pandemic have become the "new normal", one can reasonably assume that the absence of a seasonal influenza outbreak is related to prevention and control measures implemented in response to the COVID-19 pandemic. Basic infection prevention measures were thoroughly implemented, such as wearing masks, handwashing, and avoiding confined spaces, crowded places, and close-contact settings. More importantly, the behavioral changes adopted to constrain COVID-19 during three declared states of emergency reduced population density and contact with people, including closing schools, asking restaurants to reduce their business hours, teleworking, curbing the flow of people during vacation week, etc. These behavioral changes will serve as a valuable reference to reduce the spread of seasonal influenza in the future.

7.
Biosci Trends ; 15(1): 1-8, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33518668

RESUMO

The first case of COVID-19 in Japan was reported on 16 January 2020. The total number of the infected has reached 313,844 and the number of deaths has reached 4,379 as of 16 January 2021. This article reviews the characteristics of and responses to the three waves of COVID-19 in Japan during 2020-2021 in order to provide a reference for the next step in epidemic prevention and control. The Japanese Government declared a state of emergency on 7 April 2020, which suppressed the increase in the number of the infected by curtailing economic activity. The first wave peaked at 701 new cases a day and it decreased to 21 new cases on May 25 when the state of emergency was lifted. However, the number of the infected increased again due to the resumption of economic activity, with a peak of 1,762 new cases a day during the second wave. Although the situation was worse than that during the first wave, the government succeeded in limiting the increase without declaring a state of emergency again, and that may be attributed to a decrease in crowd activities and an increase in the number of inspections. During the third wave, the number of the infected continued to exceed the peak during previous waves for two months. Major factors for this rise include the government's implementation of further policies to encourage certain activities, relaxed immigration restrictions, and people not reducing their level of activity. An even more serious problem is the bed usage for patients with COVID-19; bed usage exceeds 50% not only in major cities but also in various areas. On 7 January 2021, 5,953 new cases were reported a day; this greatly exceeded the previous peak, and the state of emergency was declared again. Although Japan has been preparing its medical system since the first wave, maintaining that system has imposed a large economic burden on medical facilities, hence stronger measures and additional support are urgently needed to combat COVID-19 in the coming few months.


Assuntos
COVID-19 , Surtos de Doenças/estatística & dados numéricos , Ocupação de Leitos/estatística & dados numéricos , Humanos , Japão/epidemiologia
8.
J Colloid Interface Sci ; 581(Pt A): 195-204, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32771731

RESUMO

Compared with the transition metal induced homogeneous catalytic system, the heterogeneous catalytic system based on transition metal-doped metal organic frameworks (MOFs) were stable for the efficient utilization of transition metal and avoiding the metal leaching. The aim of this work is to synthesize Co-doped MIL-53(Al) by one-step solvent thermal method and use it to activate peroxymonosulfate (PMS) to remove tetracycline (TC) in water. The successful synthesis of Co-MIL-53(Al) samples was demonstrated by XDR, SEM and FTIR characterizations. The 25% Co-MIL-53(Al)/PMS system showed the optimal TC removal effect compared to the PMS alone and MIL-53(Al)/PMS system. The catalytic performances of Co-MIL-53(Al)/PMS system in conditions of different pH, co-existing substances and water bodies were investigated. Quenching experiment and electron paramagnetic resonance (EPR) showed that the degradation mechanism by Co-MIL-53(Al) activation PMS was mainly attributed to sulfate radical (SO4•-) and singlet oxygen (1O2) non-radical. The degradation intermediates of TC were also identified and the possible degradation pathways were proposed. Co-MIL-53(Al) showed good activity after four cycles. These findings demonstrated that Co-MIL-53(Al) can be a promising heterogeneous catalyst for activating PMS to degrade TC.


Assuntos
Cobalto , Água , Dietilamida do Ácido Lisérgico/análogos & derivados , Peróxidos , Tetraciclina
9.
Biomed Res Int ; 2020: 3650935, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33354565

RESUMO

Ischemic stroke (IS) greatly threatens human health resulting in high mortality and substantial loss of function. Recent studies have shown that the outcome of IS has sex specific, but its mechanism is still unclear. This study is aimed at identifying the sexually dimorphic to peripheral immune response in IS progression, predicting potential prognostic biomarkers that can lead to sex-specific outcome, and revealing potential treatment targets. Gene expression dataset GSE37587, including 68 peripheral whole blood samples which were collected within 24 hours from known onset of symptom and again at 24-48 hours after onset (20 women and 14 men), was downloaded from the Gene Expression Omnibus (GEO) datasets. First, using Bioconductor R package, two kinds of differentially expressed genes (DEGs) (nonsex-specific- and sex-specific-DEGs) were screened by follow-up (24-48 hours) vs. baseline (24 hours). 30 nonsex-specific DEGs (1 upregulated and 29 downregulated), 79 female-specific DEGs (25 upregulated and 54 downregulated), and none of male-specific DEGs were obtained finally. Second, bioinformatics analysis of female-specific DEGs was performed. Gene Ontology (GO) functional annotation analysis shows that DEGs were mainly enriched in translational initiation, cytosolic ribosome, and structural constituent of ribosome. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis shows that the top 6 enrichment pathways are ribosome, nuclear factor--kappa B (NF-kappa B) signaling pathway, apoptosis, mineral absorption, nonalcoholic fatty liver disease, and pertussis. Three functional modules were clustered in the protein-protein interaction (PPI) network of DEGs. The top 10 key genes of the PPI network constructed were selected, including RPS14, RPS15A, RPS24, FAU, RPL27, RPL31, RPL34, RPL35A, RSL24D1, and EEF1B2. Sex difference of ribosome in stroke-induced peripheral immunosuppression may be the potential mechanism of sex disparities in outcome after IS, and women are more likely to have stroke-induced immunosuppression. RPS14, RPS15A, RPS24, FAU, RPL27, RPL31, RPL34, RPL35A, RSL24D1, and EEF1B2 may be novel prognostic biomarkers and potential therapeutic targets for IS.


Assuntos
Imunossupressão , Ribossomos/química , Fatores Sexuais , Acidente Vascular Cerebral/metabolismo , Adulto , Idoso , Apoptose , Biomarcadores/metabolismo , Biologia Computacional , Citosol/metabolismo , Feminino , Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Redes Reguladoras de Genes , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Prognóstico , Mapeamento de Interação de Proteínas , Mapas de Interação de Proteínas/genética , Ribossomos/metabolismo , Transdução de Sinais
10.
Glob Health Med ; 2(1): 3-8, 2020 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-33330767

RESUMO

Because of the high mortality, recurrence, and rate of disability of stroke, a stroke prevention and treatment system was instituted in Shanghai in 2012; this system includes 11 municipal hospitals, 25 district hospitals, and 240 community health centers. Community health centers focus on early screening in the community, health management of high-risk individuals, and secondary prevention and rehabilitation of stroke patients. Residents' health profiles are utilized by community health centers to proactively identify the population at higher risk. District hospitals are responsible for screening for vascular lesions in high-risk individuals, including carotid artery and intracranial artery screening, and standardized treatment of stroke patients. Municipal hospitals concentrate on complex and emergency care for acute onset stroke. The system specifies care for all stages of stroke management. The development of the system has improved the capacity of and quality of care for stroke patients. The rate at which patients undergo intravenous thrombolysis and the percentage of patients with a door-to-needle time of less than 60 minutes have increased significantly. However, the primary and secondary prevention of stroke is insufficient, the stroke rehabilitation system is incomplete, and the quality of care in primary healthcare facilities is limited. An evaluation system and payment mechanisms are needed to incentivize healthcare personnel to fulfill their responsibilities and to ensure the system's operation.

11.
Glob Health Med ; 2(2): 56-59, 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-33330777

RESUMO

In the face of COVID-19, the scientific community has rapidly come together to address this outbreak in an open and collaborative manner to support the global response to this outbreak by rapidly sharing and highlighting research data and relevant findings. COVID-19 research is being published at a furious pace. Over 6,000 articles have been published as of 20 April 2020, and at least 15 online resource centers/websites for COVID-19 have been created by publishers to enable fast and free access to the latest research, evidence, and data available. Moreover, many evidence-based guidelines for COVID-19 have been issued based on academic articles and summaries of the experiences of frontline medical personnel. Various academic medical associations are also actively sharing information and providing technical support. As an example, 93 guides/proposals/responses to COVID-19 have been issued so far by 50 medical associations in Japan. However, few publications and national situation reports have provided information on the number of infected healthcare workers (HCWs). More publications and national situation reports are urgently needed to provide scientific information to devise specific infection prevention and control measures in order to protect HCWs from infection.

12.
Ann Transl Med ; 8(17): 1056, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33145275

RESUMO

Background: Instead of the complete lockdown, since the outbreak of coronavirus disease 2019 (COVID-19), Japan has been trying to control the infection by self-restraint request policy. It seems that the number of infected people has subsided, however, the increasing human activities again in the resumption of economy may lead to the second wave of infections. Here, we analyzed the major factors behind the success control of the first outbreak in Japan and the potential risk of the second wave. Methods: Employing a localized stochastic transition model, we analyze the real data and the results of simulation in Tokyo from March 1 to July 31. In the model, population is divided into three compartments: susceptible, infected, and removed; and area into three zones: crowded, mid and uncrowded. Different zones have different infection probabilities characterized by the number of people gathered there. The flow of the infection simulation in one day consists of three steps: (I) intercity movement of population, (II) isolating infected people, and (III) zone shifting following group behavioral patterns. Results: The major cause for the success of controlling the first outbreak in Tokyo is demonstrated through our simulation to be the early request of self-restraint as well as the early detection of infected people. Meanwhile, the observation that the increasing human activities again in the resumption of economy will lead to the second wave of infections is also found in the simulation with an extended period. Based on the analysis of intercity movement and behavioral pattern on Tokyo where normally about 2.9 million people come from the surrounding cities to the central area by using the public railway system every day, results showed that turning the workstyle of 55% of working people ranging in age from 20 to 64 years old into teleworking (remote work) may control the spread of infection without significant economic damage. Meanwhile, to keep about 75% of the normal activity level and to advocate the shift to telework are indispensable because a sudden resumption of activity from the lockdown sate can rapidly spread infection. Conclusions: As a new normal in face of COVID-19 for Tokyo and other cities that with a high population density, shifting the workstyle of 55% of working people to teleworking and to reduce 25% time staying in the high infection risk area could be an effective measure to control the spread of infection while maintaining a certain level of economic activity.

13.
Biosci Trends ; 14(5): 314-317, 2020 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-33100291

RESUMO

Fifth Generation (5G) mobile communications technology became available in Japan as of the end of March 2020. The Ministry of Internal Affairs and Communications (MIC) is proceeding with a plan to use 5G for a doctor-to-doctor remote diagnosis system. This remote diagnosis offers patients the benefit of receiving advanced medical care without having to travel long distances. The provision of a remote diagnosis will provide elderly patients in rural areas with an earlier diagnosis without burdening patients in Japan where the aging population and the uneven distribution of doctors are increasing. However, the system will increase the burden on specialists by expanding the doctor's catchment area. As a solution to that problem, deep learning-based artificial intelligence (AI) is expected to reduce the burden on doctors. In order to realize 5G- and AI-based real-time diagnostic support, diagnostic imaging using AI and an AI model that provides instructions are required. This is because ultrasonography and endoscopy, which can be used for remote diagnosis, do not acquire data on fixed areas like a CT or MRI scan. The AI model needs to instruct the doctor at the patient's home in order to collect appropriate information in accordance with the patient's symptoms and status. In order to build an interactive AI model, the interactions between doctors who are making a remote diagnosis should be recorded as training data and a 5G-based remote diagnosis system should be created. A remote diagnostic support system incorporating 5G and interactive diagnostic imaging incorporating AI will result in a system that places less of a burden on patients and doctors.


Assuntos
Telefone Celular , Aprendizado Profundo , Troca de Informação em Saúde/tendências , Encaminhamento e Consulta/tendências , Telemedicina/métodos , Diagnóstico Precoce , Endoscopia , Humanos , Japão , Telemedicina/instrumentação , Telemedicina/tendências , Ultrassonografia , Carga de Trabalho
14.
Bioresour Technol ; 317: 123980, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32795881

RESUMO

To reduce environmental pollution and waste of biomass from Ginkgo biloba leaf residues (GBLRs), we developed a cost-effective enzyme system to hydrolyze GBLRs into available reducing sugars (RS). Biomass characteristics of GBLRs were investigated, which indicated that the acid hydrolyzed fraction was 49.43% of the dry weight of GBLRs. The fraction could be effectively converted into RS by an enzyme cocktail with high polygalacturonase activity without traditionally intricate pretreatment. The strain A32 isolated from the ancient ginkgo soil was used for the production of the enzyme cocktail, and a response surface methodology was used to optimize the enzymatic production. The enzyme cocktail released 87.2% of RS from GBLRs at 35 â„ƒ for 72 h with 1% (m/v) of loading, and the RS concentration arrived 8.95 ± 0.39 mg/ml with 9% of GBLRs loading. The cost-effective system of self-prepared enzyme cocktail is promising for facilitating GBLRs' bio-based industry.


Assuntos
Ginkgo biloba , Árvores , Biomassa , Análise Custo-Benefício , Extratos Vegetais , Folhas de Planta
15.
J Colloid Interface Sci ; 580: 470-479, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32711198

RESUMO

Herein, Mn-doped MIL-53(Fe) were fabricated via one-pot solvothermal method and used for peroxymonosulfate (PMS) activation towards tetracycline (TC) degradation from aqueous solution. The characterizations of SEM, FTIR and XRD were utilized to reveal the morphology and structure of the materials. The results showed that Mn-MIL-53(Fe)-0.3 displayed the optimal catalytic performance, the removal efficiency of TC could reach 93.2%. Moreover, the catalytic activity of Mn-MIL-53(Fe) towards TC under different initial pH values, co-existing anions (Cl-,CO32- and SO42-) and humic acid (HA) were investigated. The results of thermodynamic experiment suggested that the catalytic process was endothermic. In addition, integrated with capture experiments results and the characterization results of electron paramagnetic resonance (EPR), which revealed that SO4·- and HO- were the reactive radicals involving in the reaction. More importantly, the possible activation mechanism was discussed in detail based on the X-ray photoelectron spectroscopy results. The active species were generated by the active sites of Fe(II) and Mn(II) on Mn-MIL-53(Fe) effectively activated PMS. Furthermore, the degradation intermediates and possible degradation pathway were investigated by LC-MS. Finally, the catalyst also showed good performance in actual wastewater and demonstrated good recyclability. The Mn-MIL-53(Fe)/PMS system exhibited a promising application prospect for antibiotic-containing waste water treatment.


Assuntos
Sulfatos , Tetraciclina , Antibacterianos , Dietilamida do Ácido Lisérgico/análogos & derivados
17.
Drug Discov Ther ; 14(3): 151-152, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32669524

RESUMO

Community-acquired pneumonia (CAP) is the third leading contributor to lost disability-adjusted life years worldwide, and this is especially true in the elderly population. In order to reduce the burden of disease, effective management of CAP is crucial to public health in terms of maintaining and promoting the health of the elderly and involves safe drug use, vaccinations, early treatment in the ICU, and health education. Since the long-term mortality of CAP is particularly high in the elderly, biomarkers and a predictive diagnostic model of CAP should be developed in future research.


Assuntos
Antibacterianos/administração & dosagem , Infecções Comunitárias Adquiridas/prevenção & controle , Gerenciamento Clínico , Vacinas Pneumocócicas/administração & dosagem , Pneumonia/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Atenção , Infecções Comunitárias Adquiridas/tratamento farmacológico , Infecções Comunitárias Adquiridas/epidemiologia , Humanos , Educação de Pacientes como Assunto/métodos , Pneumonia/tratamento farmacológico , Pneumonia/epidemiologia
18.
Intractable Rare Dis Res ; 9(2): 64-70, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32494552

RESUMO

Extrahepatic portosystemic shunt belongs to a family of rare vascular abnormalities. The clinical importance and manifestations of this vascular abnormality range from asymptomatic cases to liver or metabolic dysfunctions of various degrees. Congenital extrahepatic portosystemic shunt, also termed as Abernethy malformation, is a very rare congenital vascular malformation in which splenomesenteric blood drains into a systemic vein, bypassing the liver through a complete or partial extrahepatic shunt. So far, limited cases of congenital extrahepatic portosystemic shunt have been reported. In this review, incidence, mechanisms, complications, diagnoses and treatments of congenital extrahepatic portosystemic shunt are described.

19.
Bull Environ Contam Toxicol ; 105(1): 1, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32561950

RESUMO

In the original publication of the article, there was an error in the abstract section. The incorrect sentence "the dominant microbes in the DEHP-contaminated soil were Sphingomonas and Bacillus, which belonged to the Acidobacteria and Proteobacteriav, respectively" should be revised to "the dominant microbes in the DEHP-contaminated soil were belonged to the Acidobacteria and Proteobacteria, respectively." This has been corrected with this erratum.

20.
Biosci Trends ; 14(4): 304-309, 2020 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-32507777

RESUMO

C-reactive protein (CRP)- and albumin (Alb)-based scoring systems are available for predicting the prognosis of patients with diverse forms of gastrointestinal cancer, but their utility for patients with intrahepatic cholangiocarcinoma (ICC) is still unclear. This study aimed to elucidate whether a high CRP/Alb ratio is associated with the surgical outcome of ICC patients. Patients who underwent initial and curative resection for ICC were included in this study, and were divided into the High and Low CRP/Alb groups based on their preoperative CRP and Alb values. The surgical outcomes were compared between the two groups. The median CRP/Alb ratio amongst 88 patients was 0.033 (range, 0.019-3.636); 44 patients with CRP/Alb > 0.033 were allocated to the High CRP/Alb group and 44 patients were allocated to the Low CRP/Alb group. The operative data did not differ between the two groups, while the tumor status was more advanced in the High CRP/Alb group. The median overall survival was 2.4 years (95% CI, 1.4-3.3) and 8.9 years (3.8-NA) in the High and Low CRP/Alb groups, respectively (P < 0.001), and recurrence-free survival was 0.5 years (95% CI, 0.3-0.7) and 7.7 years (1.3-NA), respectively (P < 0.001). In a multivariate analysis, the independent factors for overall survival were High CRP/Alb (P = 0.017) and multiple nodules (P = 0.008). Taken together, the survival of ICC patients in the High CRP/Alb group was reduced compared to that of patients in the Low CRP/Alb group due to the advanced stage of the tumor as well as malnutrition.


Assuntos
Neoplasias dos Ductos Biliares/diagnóstico , Biomarcadores Tumorais/sangue , Colangiocarcinoma/diagnóstico , Recidiva Local de Neoplasia/epidemiologia , Receptores Imunológicos/sangue , Albumina Sérica Humana/análise , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias dos Ductos Biliares/sangue , Neoplasias dos Ductos Biliares/mortalidade , Neoplasias dos Ductos Biliares/cirurgia , Ductos Biliares Intra-Hepáticos/patologia , Ductos Biliares Intra-Hepáticos/cirurgia , Colangiocarcinoma/sangue , Colangiocarcinoma/mortalidade , Colangiocarcinoma/cirurgia , Intervalo Livre de Doença , Feminino , Hepatectomia , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/prevenção & controle , Estadiamento de Neoplasias , Período Pré-Operatório , Prognóstico , Estudos Retrospectivos , Medição de Risco/métodos , Adulto Jovem
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