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1.
Artigo em Inglês | MEDLINE | ID: mdl-33802103

RESUMO

Mobility restrictions have been a heated topic during the global pandemic of coronavirus disease 2019 (COVID-19). However, multiple recent findings have verified its importance in blocking virus spread. Evidence on the association between mobility, cases imported from abroad and local medical resource supplies is limited. To reveal the association, this study quantified the importance of inter- and intra-country mobility in containing virus spread and avoiding hospitalizations during early stages of COVID-19 outbreaks in India, Japan, and China. We calculated the time-varying reproductive number (Rt) and duration from illness onset to diagnosis confirmation (Doc), to represent conditions of virus spread and hospital bed shortages, respectively. Results showed that inter-country mobility fluctuation could explain 80%, 35%, and 12% of the variance in imported cases and could prevent 20 million, 5 million, and 40 million imported cases in India, Japan and China, respectively. The critical time for screening and monitoring of imported cases is 2 weeks at minimum and 4 weeks at maximum, according to the time when the Pearson's Rs between Rt and imported cases reaches a peak (>0.8). We also found that if local transmission is initiated, a 1% increase in intra-country mobility would result in 1430 (±501), 109 (±181), and 10 (±1) additional bed shortages, as estimated using the Doc in India, Japan, and China, respectively. Our findings provide vital reference for governments to tailor their pre-vaccination policies regarding mobility, especially during future epidemic waves of COVID-19 or similar severe epidemic outbreaks.


Assuntos
China/epidemiologia , Surtos de Doenças , Humanos , Índia/epidemiologia , Japão/epidemiologia
2.
Zhongguo Yi Liao Qi Xie Za Zhi ; 45(2): 176-182, 2021 Apr 08.
Artigo em Chinês | MEDLINE | ID: mdl-33825378

RESUMO

The methods of monitoring the thermal ablation of tumor are compared and analyzed in recent years. The principle method results and insufficient of ultrasound elastography and quantitative ultrasound imaging are discussed. The results show that ultrasonic tissue signature has great development space in the field of real-time monitoring of thermal ablation, but there are still some problems such as insufficient monitoring accuracy difficulty in whole-course monitoring and insufficient in vivo experiments, so it is impossible to realize clinical application. It is necessary to further study the monitoring method which can realize accurate and real-time detection of ablation zone and transition zone and can be easily combined with the existing ultrasonic equipment.


Assuntos
Ablação por Cateter , Técnicas de Imagem por Elasticidade , Hipertermia Induzida , Neoplasias , Humanos , Fígado/diagnóstico por imagem , Fígado/cirurgia , Neoplasias/diagnóstico por imagem , Neoplasias/cirurgia , Ultrassonografia
3.
Chem Commun (Camb) ; 2021 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-33876175

RESUMO

Herein, an ultramild block polymerization strategy was employed to precisely control the exposure of structural terminations in the skeleton of covalent triazine-based frameworks (CTFs). The generated structural terminations with cyano (-CN) and hydroxy (-OH) groups (STCHs) could serve as not only the optimal adsorption sites for enriching targets, but also π-conjugated electron donor-acceptor dyads to accelerate the charge transfer. With spatial separation of charge localization sites, STCH-CTF exhibited a photoactivity of 2.5-4 times higher than that of pristine CTFs in the simultaneous oxidation of bisphenol A (BPA) and the reduction of hexavalent chromium (Cr(vi)).

4.
Sci Total Environ ; 781: 146573, 2021 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-33798876

RESUMO

Organic waste, the predominant component of global solid waste, has never been higher, resulting in increased landfilling, incineration, and open dumping that releases greenhouse gases and toxins that contribute to global warming and environmental pollution. The need to create and adopt sustainable closed-loop systems for waste reduction and valorization is critical. Using organic waste as a feedstock, gasification and pyrolysis systems can produce biooil, syngas, and thermal energy, while reducing waste mass by as much as 85-95% through conversion into biochar, a valuable byproduct with myriad uses from soil conditioning to bioremediation and carbon sequestration. Here, we present a novel case study detailing the circular economy of gasification biochar in Singapore's Gardens by the Bay. Biochar produced from horticultural waste within the Gardens was tested as a partial peat moss substitute in growing lettuce, pak choi, and pansy, and found to be a viable substitute for peat moss. At low percentages of 20-30% gasification biochar, fresh weight yields for lettuce and pak choi were comparable to or exceeded those of plants grown in pure peat moss. The biochar was also analyzed as a potential additive to concrete, with a 2% biochar mortar compound found to be of suitable strength for non-structural functions, such as sidewalks, ditches, and other civil applications. These results demonstrate the global potential of circular economies based on local biochar creation and on-site use through the valorization of horticultural waste via gasification, generating clean, renewable heat or electricity, and producing a carbon-neutral to -negative byproduct in the form of biochar. They also indicate the potential of scaled-up pyrolysis or gasification systems for a circular economy in waste management.

5.
J Environ Manage ; 286: 112163, 2021 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-33618320

RESUMO

Bioconversion of organic waste by the black soldier fly (BSF) larva yields a by-product commonly known as 'frass'. Although BSF larval frass has often been marketed as a biofertilizer, few studies have evaluated this claim. In this study, BSF larvae reared on a pure okara diet achieved an 85% waste reduction in the fresh weight of the okara. Subsequently, the frass was mixed with soil at concentrations of 10, 20, and 30% (vol/vol), and used to cultivate lettuce plants. At 10% concentration, the lettuce plants had biomasses comparable to those of the controls. Higher frass concentrations stunted the growth of the lettuce, likely because of the low C:N ratio of larval frass resulting from the rapid mineralization of nutrients. Larval frass was also found to be able to provide sufficient nutrients for lettuce growth as fertilizer application was only necessary after the first growth cycle, suggesting its suitability as a soil amendment. Analyses of the microbial community of all the growing media showed that the growth medium treatments with BSF larval frass tended to have a lower number of microbial species than the controls. Inherently higher micronutrient levels present in the frass resulted in the growth of lettuce plants. More importantly, the microbial analysis revealed that common foodborne pathogens were absent in the BSF larval frass and elemental analysis also indicated no heavy metal pollutants present. Overall, BSF larval frass was found to be a suitable soil amendment and more in-depth studies could facilitate its sensible use in agriculture.


Assuntos
Dípteros , Solo , Animais , Fertilizantes , Larva , Nutrientes
6.
Chin J Traumatol ; 24(2): 63-68, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33612396

RESUMO

Throughout the past 2020, the pandemic COVID-19 has caused a big global shock, meanwhile it brought a great impact on the public health network. Trauma emergency system faced a giant challenge and how to manage trauma under the pandemic of COVID-19 was widely discussed. However, the trauma treatment of special population (geriatric patients and patients taking anticoagulant drugs) has received inadequate attention. Due to the high mortality following severe traumatic hemorrhage, hemostasis and trauma-induced coagulopathy are the important concerns in trauma treatment. Sepsis is another topic should not be ignored when we talking about trauma. COVID-19 itself is a special kind of sepsis, and it may even be called as serious systemic infection syndrome. Sepsis has been become a serious problem waiting to be solved urgently no matter in the fields of trauma, or in intensive care and infection, etc. This article reviewed the research progress in areas including trauma emergency care, trauma bleeding and coagulation, geriatric trauma and basic research of trauma within 2020.

7.
Artigo em Inglês | MEDLINE | ID: mdl-33629485

RESUMO

BACKGROUND: Symptomatic knee osteoarthritis (SKOA) is a chronic, disabling condition, requiring long-term pain management; over 800,000 SKOA patients in the USA use opioids chronically. We aim to characterize the societal economic burden of opioid use in this population. METHODS: We used the Osteoarthritis Policy Model, a validated computer simulation of SKOA, to estimate the opioid-related lifetime and annual cost generated by the USA SKOA population. We included direct medical, lost productivity, criminal justice, and diversion costs. We modeled the SKOA cohort with mean (SD) age 54 (14) years and Western Ontario and McMaster University pain score 29 (17) (0-100, 100-worst). We estimated annual costs of strong ($1,381) and weak ($671) opioid regimens using Medicare fee schedules, Red Book, the Federal Supply Schedule, and published literature. The annual lost productivity and criminal justice costs of opioid use disorder (OUD), obtained from published literature, were $11,387 and $4,264, per-person. The 2015-2016 Medicare Current Beneficiary Survey provided OUD prevalence. We conducted sensitivity analyses to examine the robustness of our estimates to uncertainty in input parameters. RESULTS: Assuming 5.1% prevalence of chronic strong opioid use, the total lifetime opioid-related cost generated by the USA SKOA population was estimated at $14.0 billion, of which only $7.45 billion (53%) were direct medical costs. CONCLUSIONS: Lost productivity, diversion, and criminal justice costs comprise about half of opioid-related costs generated by the USA SKOA population. Reducing chronic opioid use may lead to a meaningful reduction in societal costs that can be used for other public health causes.

8.
Bioresour Technol ; 327: 124809, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33578356

RESUMO

This review is focused on the sustainable management of harvested water hyacinth (WH) via thermochemical conversion to carbonaceous materials (CMs), biofuels, and chemicals for energy and environmental applications. One of the major challenges in thermochemical conversion is to guarantee the phytoremediation performance of biochar and the energy conversion efficiency in biowaste-to-energy processes. Thus, a circular sustainable approach is proposed to improve the biochar and energy production. The co-conversion process can enhance the syngas, heat, and energy productions with high-quality products. The produced biochar should be economically feasible and comparable to available commercial carbon products. The removal and control of heavy and transition metals are essential for the safe implementation and management of WH biochar. CMs derived from biochar are of interest in wastewater treatment, air purification, and construction. It is important to control the size, shape, and chemical compositions of the CM particles for higher-value products like catalyst, adsorbent or conductor.


Assuntos
Eichhornia , Biodegradação Ambiental , Biocombustíveis , Carbono , Carvão Vegetal , Temperatura Alta
9.
Artigo em Inglês | MEDLINE | ID: mdl-33546495

RESUMO

Habitat destruction and declining ecosystem service levels caused by urban expansion have led to increased ecological risks in cities, and ecological network optimization has become the main way to resolve this contradiction. Here, we used landscape patterns, meteorological and hydrological data as data sources, applied the complex network theory, landscape ecology, and spatial analysis technology, a quantitative analysis of the current state of landscape pattern characteristics in the central district of Harbin was conducted. The minimum cumulative resistance was used to extract the ecological network of the study area. Optimized the ecological network by edge-adding of the complex network theory, compared the optimizing effects of different edge-adding strategies by using robustness analysis, and put forward an effective way to optimize the ecological network of the study area. The results demonstrate that: The ecological patches of Daowai, Xiangfang, Nangang, and other old districts in the study area are small in size, fewer in number, strongly fragmented, with a single external morphology, and high internal porosity. While the ecological patches in the new districts of Songbei, Hulan, and Acheng have a relatively good foundation. And ecological network connectivity in the study area is generally poor, the ecological corridors are relatively sparse and scattered, the connections between various ecological sources of the corridors are not close. Comparing different edge-adding strategies of complex network theory, the low-degree-first strategy has the most outstanding performance in the robustness test. The low-degree-first strategy was used to optimize the ecological network of the study area, 43 ecological corridors are added. After the optimization, the large and the small ecological corridors are evenly distributed to form a complete network, the optimized ecological network will be significantly more connected, resilient, and resistant to interference, the ecological flow transmission will be more efficient.

10.
Food Chem ; 348: 129091, 2021 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-33508603

RESUMO

Phospholipids are critical for milk digestion and infant development. But the profile of phospholipid molecular species in human milk and its dynamic changes during the lactation period have never been reported. The present study elucidated precise qualitative and quantitative analysis of 258 phospholipid molecular species in 486 human milk samples. Phosphatidylcholine is the most abundant class, followed by phosphatidylserine, phosphatidylethanolamine and sphingomyelin as the second abundant class in different lactation period. The plasmalogens declined along the lactation period, and the polyunsaturated-phospholipids decreased after 10-15 days. The decrease of phosphatidylcholines and phosphatidylglycerols, and the increase of lysophosphatidylethanolamines and lysophosphatidylcholines are critical changes from 0 to 5 days to 10-15 days; increase of phosphatidylinositols, phosphatidylserines, lysophosphatidylethanolamines and lysophosphatidylcholines is the key changes from 10-15 days to 40-45 days; the decrease of most phospholipid molecular species is the characteristic change from 40-45 days to 200-240 days; and the phospholipid profile achieved stability after 200 days.


Assuntos
Lactação , Lipidômica , Leite Humano/química , Mães , Fosfolipídeos/análise , Animais , China , Feminino , Humanos , Lactente
11.
J Biosci Bioeng ; 131(4): 356-363, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33388257

RESUMO

In this study, 5-methoxy-2-mercaptobenzimidazole (5-M-2-MB) was confirmed as an efficient tyrosinase inhibitor by methods of enzyme kinetic, fluorescence quenching, ANS-binding, thermodynamics, energy transfer, and molecular docking in combination. The results proved that 5-M-2-MB significantly inhibited the tyrosinase (IC50 = 60 ± 2 nM) in a reversible and competitive way with the Ki value of 80 ± 1 nM. It quenched the intrinsic fluorescence of tyrosinase through a static mechanism, and caused conformational change of the enzyme by increasing the hydrophobic region. Moreover, this compound could bind to tyrosinase and form 5-M-2-MB-tyrosinase complex by hydrogen bond and hydrophobic interaction. The interactions were generated between 5-M-2-MB and specific amino acid residues (Trp-358, Thr-308, Glu-356, and Asp-357) located on the A chain of tyrosinase. Therefore, this study would offer a theoretical foundation for developing the new tyrosinase inhibitor.

12.
Artigo em Inglês | MEDLINE | ID: mdl-33400480

RESUMO

Three-dimensional perovskite AMX3 has great potential in photoelectric applications, but the poor stability is a major problem that restricts its practical application. The emergence of lower dimensional perovskite solves this problem. Here, we have synthesized a group of novel low-dimensional perovskites with diverse structures. Different amino acids were incorporated in the perovskite cage. The formulas of the compounds are (A')mPbIm+2 (A' = COOH(CH2)nNH2, n = 1, 3, 5, 7, 9). These families of materials demonstrate structure-related stability, tunable bandgap, and different photoluminescence. Single-crystal X-ray diffraction indicated that the five materials employ different structure types varying from edge-sharing structures to face- and corner-sharing Pb/I structures by adjusting the number of C atoms in organic cations, and the level of [PbI6]4- octahedral distortion was also identified. The film prepared using these materials with longer carbon chains (n = 5, 7, 9) showed better stability, and they did not decompose within one year at 75% RH, 40 °C. The bifunctional organic ions containing carboxyl groups as spacer cations will form additional hydrogen bonding between perovskite layers, resulting in higher stability of the material. The band gaps of these materials vary from 2.19 to 2.6 eV depending on the octahedral connection mode and [PbI6]4- octahedral distortion level, density functional theory calculations (DFT) are consistent with our experimental trends and suggest that the face-sharing structure has the maximum band gap due to its flatter electron band structure. Bright green fluorescence was observed in (COOH(CH2)7NH3)2PbI4 and (COOH(CH2)9NH3)2PbI4 when excited by 365 nm UV light. A thorough comprehension of the structure-property relationships is of great significance for further practical applications of perovskites.

13.
Annu Rev Food Sci Technol ; 12: 407-432, 2021 03 25.
Artigo em Inglês | MEDLINE | ID: mdl-33441013

RESUMO

Chitosan is a biodegradable, biocompatible, and nontoxic aminopolysaccharide. This review summarizes and discusses the structural modifications, including substitution, grafting copolymerization, cross-linking, and hydrolysis, utilized to improve the physicochemical properties and enhance the bioactivity and functionality of chitosan and related materials. This manuscript also reviews the current progress and potential of chitosan and its derivatives in body-weight management and antihyperlipidemic, antihyperglycemic, antihypertensive, antimicrobial antioxidant, anti-inflammatory, and immunostimulatory activities as well as their ability to interact with gut microbiota. In addition, the potential of chitosan and its derivatives as functional ingredients in food systems, such as film and coating materials, and delivery systems is discussed. This manuscript aims to provide up-to-date information to stimulate future discussion and research to promote the value-added utilization of chitosan in improving the safety, quality, nutritional value and health benefits, and sustainability of our food system while reducing the environmental hazards.

14.
Biomed Pharmacother ; 135: 111194, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33395608

RESUMO

The increasing incidence of gout poses a very challenging management problem. However, the currently available drugs often have various toxic side effects. As a traditional edible and medicinal macrofungus, Sanghuangporus vaninii presents high medical research value. Therefore, to improve fermentation efficiency and identify novel anti-gout drugs, we optimized the culture medium of S. vaninii with lignin and further investigated its anti-gout effects. The results indicated that 0.06 g/L of lignin was most favorable for S. vaninii growth. In the hyperuricemia cell model, we found that S. vaninii could significantly induce the downregulation of xanthine oxidoreductase and the upregulation of hypoxanthine-guanine phosphoribosyltransferase. Furthermore, following oral administration of the extracts, the serum uric acid levels of mice with hyperuricemia were effectively reduced. In a gouty arthritis rat model, S. vaninii also achieved strong suppression of synovial swelling, indicating its anti-inflammatory activity. In addition, the antioxidant assays suggested that S. vaninii shows a strong free radical scavenging capacity and can effectively alleviate cellular oxidative stress. This activity further enhances its anti-inflammatory activity and reduces the incidence of comorbidities. In summary, our results provide the basis for the utilization of S. vaninii to develop anti-gout drugs.

15.
Blood ; 2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-33512466

RESUMO

OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell-specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here, we show by ChIP-seq that OBF1 extensively colocalizes with OCT1 and OCT2. We found that these factors also often colocalize with transcription factors of the ETS family. Furthermore, we showed that OBF1, OCT2 and OCT1 bind widely to the promoters or enhancers of genes involved in GC formation in mouse and human GC B cells. shRNA knockdown experiments demonstrated that OCT1, OCT2 and OBF1 regulate each other and are essential for proliferation of GC-derived lymphoma cell lines. OBF1 downregulation disrupts the GC transcriptional program: genes involved in GC maintenance -such as BCL6- are downregulated, while genes related to exit from the GC program -such as IRF4- are upregulated. Ectopic expression of BCL6 does not restore the proliferation of GC-derived lymphoma cells depleted of OBF1 unless IRF4 is also depleted, indicating that OBF1 controls an essential regulatory node in GC differentiation.

16.
Sci Total Environ ; 760: 144027, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33321411

RESUMO

The exploration of low-cost, high-performance and stable catalytic materials for sulfate radical-based advanced oxidation processes (SR-AOPs) is of great importance. This study presents Fe3O4-wrapped SBA-15 mesoporous silica catalyst (Fe3O4@SBA-15) for persulfate (PS) activation. The Fe3O4@SBA-15 with an Fe3O4 to SBA-15 weight ratio of 3:1 exhibited an impressive carbamazepine (CBZ) removal efficiency of ~100% after 30 min of SR-AOP at an initial pH of 3.0, a temperature of 25 °C, an initial PS concentration of 300 mg L-1 and a catalyst concentration of 0.50 g L-1. The primary oxidizing species produced in the system were identified as SO4- and HO by electron paramagnetic resonance spectra and radical quenching experiments. Benefiting from the synergetic effects of improved Fe3O4 dispersion and enhanced adsorption of CBZ and PS by SBA-15, the as-obtained heterogeneous Fe3O4@SBA-15 catalysts offer large numbers of active sites for free radical generation and high surface concentrations of CBZ and PS for SR-AOPs, as verified by physicochemical characterization and Langmuir-Hinshelwood model analysis. In addition, the activity of Fe3O4@SBA-15 was maintained throughout six successive cycling tests. Various inorganic anions, including Cl-, NO3-, HCO3-, and CO32-, as well as organic material in natural water, exert a negative impact on the Fe3O4@SBA-15 catalyzed SR-AOPs and deserve special attention.


Assuntos
Poluentes Químicos da Água , Carbamazepina , Oxirredução , Dióxido de Silício , Água , Poluentes Químicos da Água/análise
17.
Ultrasonics ; 110: 106287, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33091652

RESUMO

In this paper, we proposed ultrasound homodyned K (HK) imaging based on the noise-assisted correlation algorithm (NCA) for monitoring microwave ablation of porcine liver ex vivo. The NCA-based HK (αNCA and kNCA) imaging was compared with NCA-based Nakagami (mNCA) imaging and NCA-based cumulative echo decorrelation (CEDNCA) imaging. Backscattered ultrasound radiofrequency signals of porcine liver ex vivo during and after the heating of microwave ablation were collected (n = 15), which were processed for constructing B-mode imaging, NCA-based HK imaging, NCA-based Nakagami imaging, and NCA-based CED imaging. To quantitatively evaluate the final coagulation zone, the polynomial approximation (PAX) technique was applied. The accuracy of detecting coagulation area with αNCA, kNCA, mNCA, and CEDNCA parametric imaging was evaluated by comparing the PAX imaging with the gross pathology. The receiver operating characteristic (ROC) curve was used to further evaluate the performance of the three quantitative ultrasound imaging methods for detecting the coagulation zone. Experimental results showed that the average accuracies of αNCA, kNCA, mNCA, and CEDNCA parametric imaging combined with PAX imaging were 89.6%, 83.25%, 89.23%, and 91.6%, respectively. The average areas under the ROC curve (AUROCs) of αNCA, kNCA, mNCA, and CEDNCA parametric imaging were 0.83, 0.77, 0.83, and 0.86, respectively. The proposed NCA-based HK imaging may be used as a new method for monitoring microwave ablation.


Assuntos
Técnicas de Ablação , Fígado/diagnóstico por imagem , Fígado/cirurgia , Micro-Ondas/uso terapêutico , Ultrassonografia/métodos , Algoritmos , Animais , Processamento de Imagem Assistida por Computador , Técnicas In Vitro , Suínos
18.
Mater Sci Eng C Mater Biol Appl ; 118: 111441, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33255034

RESUMO

The success of artificial vascular graft in the host to obtain functional tissue regeneration and remodeling is a great challenge in the field of small diameter tissue engineering blood vessels. In our previous work, poly(ε-caprolactone) (PCL)/fibrin vascular grafts were fabricated by electrospinning. It was proved that the PCL/fibrin vascular graft was a suitable small diameter tissue engineering vascular scaffold with good biomechanical properties and cell compatibility. Here we mainly examined the performance of PCL/fibrin vascular graft in vivo. The graft showed randomly arranged nanofiber structure, excellent mechanical strength, higher compliance and degradation properties. At 9 months after implantation in the rat abdominal aorta, the graft induced the regeneration of neoarteries, and promoted ECM deposition and rapid endothelialization. More importantly, the PCL/fibrin vascular graft showed more microvessels density and fewer calcification areas at 3 months, which was beneficial to improve cell infiltration and proliferation. Moreover, the ratio of M2/M1macrophage in PCL/fibrin graft had a higher expression level and the secretion amount of pro-inflammatory cytokines started to increase, and then decreased to similar to the native artery. Thus, the electrospun PCL/fibrin tubular vascular graft had great potential to become a new type of artificial blood vessel scaffold that can be implanted in vivo for long term.

19.
Int J Biol Macromol ; 168: 496-506, 2021 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-33321137

RESUMO

The bioactivities of sulfated polysaccharides have shown to be associated with the gut microbiota, but the underlying mechanisms remain unclear. In this study, the effect of sulfated polysaccharides from pacific abalone (AGSP) on the human gut microbiota was analyzed via an in vitro fermentation model. The results revealed that AGSP altered the overall structure of the gut microbiota and increased relative abundances of some Bacteroidales members, implying that intestinal Bacteroidales can play important roles in the bioactivities of AGSP. To elucidate the underlying mechanisms, some species from the Bacteroides and Parabacteroides within Bacteroidales were isolated, and their characteristics on AGSP utilization were analyzed. It showed that AGSP utilization by intestinal Bacteroidales was species-dependent, and some species that liberated AGSP breakdown products promoted the growth of others unable to live in AGSP, forming an AGSP utilization network. The in vitro cell model showed that AGSP oligosaccharides had better anti-inflammatory activity and weaker cytotoxicity, implying that microbial degradation of AGSP can influence its reaction with host cells. These results indicated that the interaction between polysaccharides and gut microbes can together determine the beneficial effects of polysaccharides on the host health.


Assuntos
Anti-Inflamatórios/farmacologia , Bactérias/classificação , Bacteroidetes/metabolismo , Polissacarídeos/farmacologia , Adulto , Anti-Inflamatórios/química , Bactérias/efeitos dos fármacos , Bactérias/genética , Bactérias/isolamento & purificação , DNA Bacteriano/genética , Fezes/microbiologia , Feminino , Fermentação , Microbioma Gastrointestinal/efeitos dos fármacos , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Polissacarídeos/química , Análise de Sequência de DNA , Especificidade da Espécie , Sulfatos/química , Adulto Jovem
20.
Chin J Traumatol ; 24(1): 1-4, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33323318

RESUMO

The year 2020 is an extremely unusual year. The world lost more than one million lives due to the attack of COVID-19. Economic production has been greatly reduced, and daily activities are largely restricted. Luckily the work of Chinese Journal of Traumatology (CJTEE) has not been adversely affected. 2020 is a harvest year for the journal, which (1) was included in the high-quality academic journals by China Association for Science and Technology; (2) cover of each issue is newly designed; (3) submission increased by about 60% with more countries and regions covered; (4) usage in the ScienceDirect database exceeded a million; (5) the CiteScore rises to more than 2.0 the first time. This study reviewed the articles published in the year 2020 by CJTEE.


Assuntos
Publicações Periódicas como Assunto , Ciência/organização & administração , Sociedades Científicas/organização & administração , Tecnologia/organização & administração , Traumatologia/organização & administração , Ferimentos e Lesões , China , Humanos , Fatores de Tempo , Ferimentos e Lesões/etiologia
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