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Nig Q J Hosp Med ; 22(2): 103-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23175907


BACKGROUND: Electrolytes and acid-base disorders are common challenges seen in the intensive care unit (ICU) resulting in difficulty in weaning patients off the ventilator, prolonged admission periods, preventable cardiac arrhythmias and cardiac arrest. These require prompt lab results most of which are done serially, ideally a point of care test (POCT), as most central hospital lab result's turnaround time (TAT) sometimes might not meet up with the urgency of clinical decision making in the ICU. OBJECTIVE: To determine the incidence of electrolytes and acid-base abnormalities using i-Stat portable analysers in the ICU of the Lagos University Teaching Hospital (LUTH). METHOD: The i-STAT Portable Clinical Analyzer, a POCT system consisting of a hand-held analyzer and single-use cartridges that measure different panels of analytes in 65-100 microl of blood using an EC8+ cartridge type analyzer for sodium, potassium, chloride, urea, glucose, pH, blood gases [TCO2, pO2, pCO2]) and heamatocrit was used. RESULTS: Over 66.78% of the patients had multiple electrolytes and acid-base abnormalities. Azotemia in 20%, hypoglycaemia in 13.33%, and hyperglycaemia in 53.33% of patients. CONCLUSION: it is concluded from this study that electrolyte and acid base abnormalities is not uncommon in the intensive care unit of LUTH and the i-STAT Portable Clinical Analyzer was helpful in facilitating early diagnosis and treatment.

Desequilíbrio Ácido-Base/sangue , Desequilíbrio Ácido-Base/diagnóstico , Estado Terminal , Sistemas Automatizados de Assistência Junto ao Leito , Equilíbrio Hidroeletrolítico , Desequilíbrio Hidroeletrolítico/diagnóstico , Adulto , Feminino , Hospitais de Ensino , Humanos , Incidência , Masculino , Monitorização Fisiológica/instrumentação , Desequilíbrio Hidroeletrolítico/sangue
Arab J Urol ; 10(4): 394-400, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26558056


OBJECTIVES: To assess the value of percentage free prostate-specific antigen (%fPSA) in the detection of prostate cancer among Nigerian men with an intermediate total PSA level (4-10 ng/mL), and to show if the optimum threshold for biopsy is different from Caucasian values when the widely used (six-core, digitally directed) prostate biopsy protocol in Nigerians is applied. PATIENTS AND METHODS: The study included 105 patients aged >50 years, with a palpably benign prostate gland and intermediate levels of total PSA (4-10 ng/mL). These patients had a free PSA assay and a transrectal digitally directed six-core biopsy of the prostate. The %fPSA was calculated and the optimum threshold value for detecting prostate cancer was determined. RESULTS: The mean (SD) age of the patients was 64.4 (6.6) years and their mean (SD) total PSA level was 6.6 (1.7) ng/mL. Of these men 14 (13.3%) had cancer of the prostate detected by the prostate biopsy. The %fPSA level related directly to sensitivity values but inversely to the specificity and the positive predictive values. The best threshold of %fPSA for detecting cancer in these men was <40%, with a sensitivity of 100%, specificity of 93.4% and a positive predictive value of 70% (P < 0.05). CONCLUSIONS: In evaluating Nigerian patients with a palpably benign prostate gland and within the intermediate total PSA range, when digitally directed biopsy protocol is adopted, a %fPSA threshold of <40% will detect significant percentage of those with prostate cancer, with a minimal number of unnecessary biopsies. This value differs from that reported in western studies in which transrectal ultrasonography-directed biopsy was used.

West Afr J Med ; 30(3): 188-92, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22120484


BACKGROUND: Cystatin C has been recognized as a good marker of kidney function but reference ranges have not been determined in Nigerian children. OBJECTIVE: To determine the reference range of serum cystatin C in Nigerian children with no overt signs of kidney disease and to determine and compare the relationship of serum cystatin C and serum creatinine with demographic and anthropometric variables. METHODS: Fifty-nine children aged two years to 16 years with no evidence of overt kidney disease were recruited from the Paediatric Clinics of the Lagos University Teaching Hospital. Serum cystatin C levels were measured using ELISA method while serum creatinine was measured by a rate-blanked and compensated Jaffe method using a Roche/Hitachi 902 auto-analyser. Both were measured using the same serum sample. RESULTS: The mean (±1.96SD) serum cystatin C level was 0.73 (0.41-1.04) mg/L and was similar among male and female children (P=0.640) and between children younger than five years and those five years and older (P=0.596). Unlike cystatin C, serum creatinine was higher among children five years or older. In contrast to serum creatinine, serum cystatin showed no significant correlation with age (r=0.153, P=0.246), weight (r=0.062, P=0.641) and length (r=0.067, P=0.612). CONCLUSION: Serum cystatin C reference range in Nigerian children is similar to that reported for children in other regions of the world and appears to be independent of gender, weight, height, body mass index and age after two years.

Biomarcadores/sangue , Creatinina/sangue , Cistatina C/sangue , Adolescente , Distribuição por Idade , Antropometria , Criança , Pré-Escolar , Estudos de Coortes , Demografia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Nigéria , Valores de Referência , Distribuição por Sexo