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J Mater Sci Mater Med ; 24(5): 1261-9, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23430337

RESUMO

Angiogenesis is essential for tissue regeneration and repair. A growing body of evidence shows that the use of bioactive glasses (BG) in biomaterial-based tissue engineering (TE) strategies may improve angiogenesis and induce increased vascularization in TE constructs. This work investigated the effect of adding nano-sized BG particles (n-BG) on the angiogenic properties of bovine type I collagen/n-BG composites. Nano-sized (20-30 nm) BG particles of nominally 45S5 Bioglass® composition were used to prepare composite films, which were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The in vivo angiogenic response was evaluated using the quail chorioallantoic membrane (CAM) as an model of angiogenesis. At 24 h post-implantation, 10 wt% n-BG containing collagen films stimulated angiogenesis by increasing by 41 % the number of blood vessels branch points. In contrast, composite films containing 20 wt% n-BG were found to inhibit angiogenesis. This experimental study provides the first evidence that addition of a limited concentration of n-BG (10 wt%) to collagen films induces an early angiogenic response making selected collagen/n-BG composites attractive matrices for tissue engineering and regenerative medicine.


Assuntos
Cerâmica/farmacologia , Colágeno/química , Nanocompostos/química , Neovascularização Fisiológica/efeitos dos fármacos , Animais , Materiais Biocompatíveis/química , Materiais Biocompatíveis/farmacologia , Bovinos , Células Cultivadas , Cerâmica/química , Colágeno/farmacologia , Coturnix/embriologia , Embrião não Mamífero , Vidro/química , Teste de Materiais , Membranas Artificiais , Nanopartículas/química , Tamanho da Partícula , Engenharia Tecidual/instrumentação , Alicerces Teciduais/química
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