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1.
Front Neurol ; 11: 557415, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33343482

RESUMO

Introduction: Orofacial pain features may negatively influence a person's well-being and vice versa. Some aspects of well-being can be measured with axis II instruments that assess patients' psychosocial and behavioral status. The aim of this study was to investigate associations between pain features and psychosocial variables as indicators of well-being. Materials and Methods: Seven hundred ninety-nine anonymized datasets collected using the Web-based Interdisciplinary Symptom Evaluation (WISE) of patients reporting to the Interdisciplinary Orofacial Pain Unit, University of Zurich, between March 19, 2017 and May 19, 2019, were analyzed. Pain features including intensity, number of locations, impact, and duration were evaluated. Psychometric measures assessed pain-related catastrophizing and disability, illness perception, distress, anxiety, depression, injustice experience, dysmorphic concerns, and insomnia. Results: Most patients were between 30 and 59 years old (58.3%), female (69.8%), working (66.0%), and experienced pain for more than 6 months (68.5%). Pain intensities were higher in women than men and higher in disabled than working patients. Scores indicating elevated stress and depression were also observed in disabled patients. The sample prevalence rates of clinically relevant axis II instrument scores were as follows: Graded Chronic Pain Scale for the Head (GCPS-H), 27%; Patient Health Questionnaire 4 (PHQ4), 21%; PHQ9, 21%; Pain Catastrophizing Scale (PCS), 20%; General Anxiety Disorder 7 (GAD7), 15%; Insomnia Severity Index (ISI), 15%; Injustice Experience Questionnaire (IEQ), 14%; GCPS for the Body (GCPS-B), 13%; PHQ for Stress (PHQstr), 6%; and Dysmorphic Concern Questionnaire (DCQ), 2%. Noteworthy results of correlation analysis of the clinically relevant axis II scores and pain measures were as follows: the PHQstr had moderate associations (0.34-0.43) with the sum of pain intensity at rest and during function, number of pain locations, and typical pain intensity. The IEQ scores were moderately associated with typical pain intensity at 0.39. The DCQ scores were moderately associated with pain extension at 0.41. Conclusions: Moderate correlations of certain pain and well-being measures were found in patients reporting clinically relevant stress, injustice experience, and dysmorphic concern, all of which reflect impaired well-being. PHQ4 is suitable for routine distress screening in the clinical setting.

2.
Ther Umsch ; 77(3): 111-115, 2020 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-32669074

RESUMO

Aversive childhood stress and its implications für expert reports using the example of chronic pain Abstract. Insurance-medical questions regarding the consequences of severe aversive childhood stress arise in the context of psychiatric and psychosomatic expert reports. In psychiatric expert reports, the insurance-medical weighting of disorders of thinking, feeling and behaviour is in the foreground. In psychosomatic expert reports the assessment of limited performance with regard to functional body symptoms are considered to be most important. The majority of expert reports in the psychosomatic field concern people with chronic pain disorders. Pain disorders can develop insidiously over the years or be triggered by accidents. For expert reports of chronic pain conditions, guidelines have been developed by the corresponding specialist bodies in Switzerland. These have been available in German and French since 2019 (www.sappm.ch). The following overview focuses on expert reports of chronic pain disorders and is based on the Swiss guidelines mentioned above. The demanding nature of writing such expert reports is also recognized by specialists in other European countries.


Assuntos
Dor Crônica/diagnóstico , Criança , Doença Crônica , Europa (Continente) , Humanos , Suíça
3.
Ther Umsch ; 76(5): 261-266, 2019.
Artigo em Alemão | MEDLINE | ID: mdl-31577185

RESUMO

Temporomandibular disorders - a biopsychosocial perspective Abstract. Clinicians encountering patients complaining of jaw joint symptoms need to see and understand the patients' somatic complaint in the context of possible biographic, psychological and social burdens and to select the appropriate therapeutic options accordingly.


Assuntos
Transtornos da Articulação Temporomandibular , Humanos , Articulação Temporomandibular
4.
Front Neurol ; 10: 542, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31191436

RESUMO

Introduction: Orofacial pain and dysfunction include a broad range of disturbances among which pain and insomnia are some of the most common complaints. Sleep strengthens physiological and psychological resilience and is an absolute requirement for health. Insomnia is a common symptom or sleep disorder, yet data on its prevalence is sparse. Here we extracted data from the insomnia severity index which was part of the web-based interdisciplinary symptom evaluation (WISE) tool given to a large sample of patients seeking care at an orofacial pain unit for analyzing insomnia prevalence in this clinical population. Material and methods: Anonymized data were available from 952 patients who consulted the Orofacial Pain Unit at the Center of Dental Medicine, University of Zurich, Zurich, Switzerland between January 2017 and December 2018. Prevalence data for insomnia stratified by gender and 10 age groups (decades) were calculated. The distribution of four insomnia severity grades was determined, also stratified by age and gender. Results: 952 patients (290 men: 30.5%) with a mean age of 44.8 ± 17.4 years completed a WISE. Three hundred and fifty-two (37.0%) patients with a mean age of 45.8 ± 16.7 years positively responded to a screening question for insomnia and/or hypersomnia. Insomnia was severe in women from the 2nd to 8th decade, ranging from 4.3% (3rd decade) to 14.5% (6th decade), and moderately severe from the 2nd to 9th decade, ranging from 18.8% (6th decade) to 27.8% (2nd decade). In men, severe insomnia was present from the 3rd to 7th decade, ranging from 2.3% (7th decade) to 4.4% (4th decade) and moderately severe insomnia from the 3rd to 7th decade, ranging from 4.6% (7th decade) to 12.2% (5th decade). Conclusions: This is the first study reporting on insomnia in a large sample of patients seeking care at an orofacial pain unit. One in three patients reported some form of sleep disturbances, which for almost half of them was moderate to severe insomnia. The gender ratio was almost equal throughout adulthood, yet younger and older women were more frequently affected and experienced higher insomnia severity than men.

5.
J Headache Pain ; 17(1): 77, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27581159

RESUMO

BACKGROUND: Medical symptoms independent of body location burden individuals to varying degrees and may require care by more than one expert. Various paper and computer-based tools exist that aim to comprehensively capture data for optimal clinical management and research. METHODS: A web-based interdisciplinary symptom evaluation (WISE) was newly designed, constructed, and technically implemented. For worldwide applicability and to avoid copyright infringements, open source software tools and free validated questionnaires available in multiple languages were used. Highly secure data storage limits access strictly to those who use the tool for collecting, storing, and evaluating their data. Concept and implementation is illustrated by a WISE sample tailored for the requirements of a single center in Switzerland providing interdisciplinary care to orofacial pain and temporomandibular disorder patients. RESULTS: By combining a symptom- burden checklist with in-depth questionnaires serving as case-finding instruments, an algorithm was developed that assists in clarifying case complexity and need for targeted expert evaluation. This novel modular approach provides a personalized, response-tailored instrument for the time- and cost-effective collection of symptom-burden focused quantitative data. The tool includes body drawing options and instructional videos. It is applicable for biopsychosocial evaluation in a variety of clinical settings and offers direct feedback by a case report summary. CONCLUSIONS: In clinical practice, the new instrument assists in clarifying case complexity and referral need, based on symptom burden and response -tailored case finding. It provides single-case summary reports from a biopsychosocial perspective and includes graphical symptom maps. Secure, centrally stored data collection of anonymous data is possible. The tool enables personalized medicine, facilitates interprofessional education and collaboration, and allows for multicenter patient-reported outcomes research.


Assuntos
Dor Facial/diagnóstico , Avaliação de Sintomas/instrumentação , Transtornos da Articulação Temporomandibular/diagnóstico , Análise Custo-Benefício , Dor Facial/etiologia , Dor Facial/psicologia , Heurística , Humanos , Internet , Desenvolvimento de Programas , Avaliação de Programas e Projetos de Saúde , Pesquisa Qualitativa , Design de Software , Inquéritos e Questionários , Suíça , Transtornos da Articulação Temporomandibular/complicações , Transtornos da Articulação Temporomandibular/psicologia , Interface Usuário-Computador
6.
Biosens Bioelectron ; 20(3): 545-52, 2004 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-15494238

RESUMO

Peptidic spacers, 0.4 and 2 nm in length, were used to couple ferrocene moieties to streptavidin. The resulting conjugates were immobilised on electrode surfaces using biotin binding. The electron transfer through multilayers of the conjugates is strongly dependent on the length of the spacer between the protein and the attached ferrocene. A monolayer of the long-linker conjugate immobilised on interdigitated microelectrode arrays was found to electrochemically bridge the 2 microm wide non-conductive gap between the electrodes. The redox current through the layer is dependent on external parameters such as the applied voltage difference between the two electrode arrays or the temperature. The long-range electrochemical conductivity in combination with the biotin binding capability is a prerequisite for the application of the conjugates in future bio-electrochemical devices.


Assuntos
Técnicas Biossensoriais/métodos , Materiais Revestidos Biocompatíveis/química , Eletroquímica/métodos , Compostos Ferrosos/química , Microeletrodos , Estreptavidina/química , Adsorção , Técnicas Biossensoriais/instrumentação , Cristalização/métodos , Condutividade Elétrica , Eletroquímica/instrumentação , Teste de Materiais , Metalocenos , Oxirredução , Ligação Proteica , Temperatura
7.
Talanta ; 63(1): 159-65, 2004 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-18969414

RESUMO

By activating SiH bonds, poly(hydromethylsiloxane) can be covalently bound in a first step to various metal or polymer surfaces. In a second step, unreacted SiH bonds can be brought to react with organic compounds having adequate functional groups such as double or triple bonds, carbonyl or hydroxyl groups. This scheme is used to bind biorecognition groups to solids. The novel concept is demonstrated by attaching a newly synthesized biotin derivative to Au. It is shown that the immobilized biotin is capable of binding streptavidin.

8.
Biosens Bioelectron ; 19(3): 239-47, 2003 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-14611760

RESUMO

Conjugates of avidin with ferrocene and with microperoxidase 8 have been used as electrochemically active molecular building blocks. Assemblies of the conjugates with biotinylated glucose oxidase or lactate oxidase on gold electrodes were tested as enzyme sensors for glucose and lactate. The electrochemical detection is based either on ferrocene-mediated oxidation of the substrate in oxygen-free solution, or on microperoxidase-catalysed reduction of H2O2 which is enzymatically produced from the substrate and molecular oxygen. Glucose and lactate were detectable with both detection principles in concentrations down to 1 or 0.1 mM, respectively. The molecular architecture concept allows quick adaptation of the sensors to other analytes, and it provides a platform for arrays of sensors with different selectivity.


Assuntos
Avidina/química , Técnicas Biossensoriais/instrumentação , Compostos Ferrosos/química , Glucose Oxidase/química , Glucose/análise , Ácido Láctico/análise , Oxigenases de Função Mista/química , Peroxidases/química , Técnicas Biossensoriais/métodos , Materiais Revestidos Biocompatíveis/síntese química , Materiais Revestidos Biocompatíveis/química , Enzimas Imobilizadas/química , Desenho de Equipamento/métodos , Análise de Falha de Equipamento , Estudos de Viabilidade , Glucose/química , Ácido Láctico/química , Metalocenos , Microquímica/instrumentação , Microquímica/métodos , Oxirredução , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Coloração e Rotulagem/métodos
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