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1.
Front Mol Biosci ; 8: 745286, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34722633

RESUMO

CAR-T cell therapy is the most advanced way to treat therapy resistant hematologic cancers, in particular B cell lymphomas and leukemias, with high efficiency. Donor T cells equipped ex vivo with chimeric receptor recognize target tumor cells and kill them using lytic granules. CAR-T cells that recognize CD19 marker of B cells (CD19 CAR-T) are considered the gold standard of CAR-T therapy and are approved by FDA. But in some cases, CD19 CAR-T cell therapy fails due to immune suppressive microenvironment. It is shown that tumor cells upregulate expression of PD-L1 surface molecule that binds and increases level and signal provided by PD-1 receptor on the surface of therapeutic CAR-T cells. Induction of this negative signaling results in functional impairment of cytotoxic program in CAR-T cells. Multiple attempts were made to block PD-1 signaling by reducing binding or surface level of PD-1 in CAR-T cells by various means. In this study we co-expressed CD19-CAR with PD-1-specific VHH domain of anti-PD-1 nanobody to block PD-1/PD-L1 signaling in CD19 CAR-T cells. Unexpectedly, despite increased activation of CAR-T cells with low level of PD-1, these T cells had reduced survival and diminished cytotoxicity. Functional impairment caused by disrupted PD-1 signaling was accompanied by faster maturation and upregulation of exhaustion marker TIGIT in CAR-T cells. We conclude that PD-1 in addition to its direct negative effect on CAR-induced signaling is required for attenuation of strong stimulation leading to cell death and functional exhaustion. These observations suggest that PD-1 downregulation should not be considered as the way to improve the quality of therapeutic CAR-T cells.

2.
Acta Naturae ; 13(3): 15-23, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34707894

RESUMO

Antitumor therapy, including adoptive immunotherapy, inevitably faces powerful counteraction from advanced cancer. If hematological malignancies are currently amenable to therapy with CAR-T lymphocytes (T-cells modified by the chimeric antigen receptor), solid tumors, unfortunately, show a significantly higher degree of resistance to this type of therapy. As recent studies show, the leading role in the escape of solid tumors from the cytotoxic activity of immune cells belongs to the tumor microenvironment (TME). TME consists of several types of cells, including neutrophils, the most numerous cells of the immune system. Recent studies show that the development of the tumor and its ability to metastasize directly affect the extracellular traps of neutrophils (neutrophil extracellular traps, NETs) formed as a result of the response to tumor stimuli. In addition, the nuclear DNA of neutrophils - the main component of NETs - erects a spatial barrier to the interaction of CAR-T with tumor cells. Previous studies have demonstrated the promising potential of deoxyribonuclease I (DNase I) in the destruction of NETs. In this regard, the use of eukaryotic deoxyribonuclease I (DNase I) is promising in the effort to increase the efficiency of CAR-T by reducing the NETs influence in TME. We will examine the role of NETs in TME and the various approaches in the effort to reduce the effect of NETs on a tumor.

3.
Bull Exp Biol Med ; 167(4): 446-451, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31493253

RESUMO

A system for detection of malignantly transformed cells, including follicular lymphoma Bcells, was developed and experimentally validated. The system is based on the use of bacteriophages carrying exposed ligands for pathogenic B-cell receptors. The efficiency of binding to target cells is several times higher than in systems with chemically synthesized biotinylated peptides. The new method is proposed as a noninvasive diagnostic test for mapping B-cell lymphoma and for determining the specificity of B-cell receptors and high-throughput combinatorial selection of various repertories of B cells.


Assuntos
Linfócitos B/metabolismo , Técnicas de Visualização da Superfície Celular/métodos , Bacteriófagos/metabolismo , Linhagem Celular , Ensaio de Imunoadsorção Enzimática , Citometria de Fluxo , Humanos , Linfoma Folicular/imunologia , Linfoma Folicular/metabolismo , Modelos Biológicos
4.
Rev Sci Instrum ; 90(3): 033302, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30927810

RESUMO

The operation modes of a self-magnetically insulated ion diode were studied. The plasma formation at the anode surface was found to be accompanied by an electron leakage current due to the bipolar high voltage pulse. The emitting anode surface and ion beam density distribution were investigated at the ion diode output area. The characteristics of the electron leakage current are presented depending on the ion diode operation mode. The area of the emitting anode surface was approximately 25%-30% of the total anode area. The electron leakage current reaches up to 6.5 kA in the ion diode.

5.
Kardiologiia ; 59(2): 56-60, 2019 Mar 07.
Artigo em Russo | MEDLINE | ID: mdl-30853022

RESUMO

AIM: to assess clinical efficacy and expediency (appropriateness) of simultaneous single stage combined coronary stenting and closure of atrial septal defect. MATERIALS AND METHODS: Of total number of patients who underwent endovascular correction of atrial septal defect (ASD) (n=91), in 6 (6.6 %) the procedure of endovascular repair of secondary ASD was combined with performed at same session oronary stenting. Mean age of these patients was 63±6.4 years. Mean diameter of ASD according to transesophageal echocardiography was 13.7±3.1 мм (from 10 to 17 mm). Two patients had dysplasia of atrial septum with pronounced aneurysmal protrusion in the right atrial cavity. Estimate of coronary arteries (CA) involvement SYNTAX score was 14.5±4.9. RESULTS: At initial stage we performed coronary stenting, then ASD closure with occluder. Technical success of combined endovascular procedures was 100 %. Six ASD occluders were implanted in 6 patients. Mean occluder diameter was 21±7,3 mm. Immediately after occluder implantation complete defect closure was achieved in 5 cases, in one case small residual shunt was observed. CA stenting procedure, in one patient after successful recanalization of chronic CA occlusion, in all cases was fulfilled without complications. At control examination after 13.5±1.5 months complete closure of defects was preserved. In all cases significant reduction of right heart chambers occurred. According to echocardiography right atrial volume decreased from 48.6±5.6 to 32.6±3.3 cm3, right ventricular volume - from 45.2±5.1 to 33.4±3.8 cm3, systolic pulmonary pressure fell from 49.7±8.6 to 32.6±6.9 mm Hg. According to control coronary angiography good effect of endovascular procedures was preserved. Tolerance to exercise rose from 68.5±11.8 до 85.3±12.4 W. CONCLUSION: Same time CA stenting and endovascular ASD closure appears to be safe and effective procedure. The strategy used was not associated with additive risk for a patient and shortened duration of hospital stay.


Assuntos
Comunicação Interatrial , Intervenção Coronária Percutânea , Idoso , Cateterismo Cardíaco , Ecocardiografia , Ecocardiografia Transesofagiana , Humanos , Pessoa de Meia-Idade , Resultado do Tratamento
6.
Acta Naturae ; 11(4): 33-41, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31993233

RESUMO

In this article, we present a comprehensive, updated, and elucidative review of the current knowledge on the function played by tumor-derived vesicles (TDVs) in the crosstalk between tumor and immune cells. Characterization of the structure, biogenesis, and the major functions of TDVs is reported. The review focuses on particular ways of suppression or activation of CD4+/CD8+ T cells by tumor-derived vesicles. Tumor-derived vesicles play an important role in the suppression of antitumor immunity. During the last 15 years, vesicle research has elucidated and improved our knowledge about the role of the vesicles in intercellular communication. Nevertheless, there are still blinds spots concerning vesicle heterogeneity and isolation methods, their uptake by target cells, and the role of mRNA in T-cell transformation or suppression. Along with the substantial progress in understanding of the role of tumor-derived vesicles in intercellular communication, novel antitumor therapy strategies based on vesicle inhibition in a tumor microenvironment are likely to appear very soon.

7.
Adv Gerontol ; 31(3): 362-367, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30584875

RESUMO

Essential hypertension (EG) is an age-associated disease. Often EG of elderly patients haven't good way of treatment. Thus, the search of new target molecules for EG therapy is an actual goal of gerontology and molecular medicine. It was shown, that during EG concentrations of GDF11 «youth protein¼ decreased in 3,3 times and GDF15, JAM-A/1, CCL11 «aging proteins¼ increased in 1,4-2,4 times. EG patients have abnormal microcirculation processes. It was shown as decreasing in 1,3 and 1,7 times of hemodynamic HI1 and H1-H3 indexes. EG patients have negative correlation of GDF15 concentration with arterial pressure. EG patients have no correlation of JAM-A/1 concentration with arterial pressure. Normal is positive correlation with GDF15, JAM-A/1 concentration with arterial pressure. GDF15 blood level during EG have positive correlation with HI1-HI3 and negative correlation with NEUR_HI2 and MAYER_HI3 indexes. It can show on pathogenesis mechanisms of endothelial and smooth muscles function of vessels tissues. We suppose, that the regulation of GDF11, GDF15, JAM-A/1, CCL11 «youth and aging proteins¼ can be target object of EG therapy.


Assuntos
Envelhecimento/fisiologia , Hipertensão Essencial/etiologia , Proteínas/fisiologia , Idoso , Pressão Arterial , Fator 15 de Diferenciação de Crescimento , Hemodinâmica , Humanos
8.
Acta Naturae ; 10(2): 16-23, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30116611

RESUMO

Chimeric antigen receptor-modified T-cell therapy (CAR-T therapy) is one of the fastest developing areas of immuno-oncology. Over the past decade, it has revolutionized the cell therapy modality and expedited its pace of development, from optimization of the structure of chimeric antigen receptors and animal model experiments to successful clinical application. The initial designs of the CAR configuration focused on increasing T-cell activation, cytotoxicity, and persistence. However, the first attempts to treat patients with CAR T cells have demonstrated the need for increased safety and controlled activation of genetically modified T cells. Herein, we summarize the different molecular approaches to engineering chimeric antigen receptors for reducing the potential clinical risks of T-cell therapy.

9.
Bull Exp Biol Med ; 165(3): 386-389, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30003423

RESUMO

Death receptor 5 (DR5) is a promising target for antitumor therapy due to its high expression on different tumor cells. Resistance of various tumor cells against TRAIL, a natural ligand for the death receptors, reduces its therapeutic potential and prompts the search for novel agonists at these receptors. Previous screening across the combinatorial peptide library yielded a peptide sequence KVVLTHR that specifically binds DR5. Incorporation of this sequence into TNFα resulted in binding DR5 with mutant protein TNFα-mut and appearance of cytotoxicity against lymphoma cells.


Assuntos
Apoptose/efeitos dos fármacos , Regulação Neoplásica da Expressão Gênica , Linfócitos/efeitos dos fármacos , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética , Fator de Necrose Tumoral alfa/genética , Sequência de Aminoácidos , Apoptose/genética , Sítios de Ligação , Linhagem Celular Tumoral , Clonagem Molecular , Escherichia coli/genética , Escherichia coli/metabolismo , Expressão Gênica , Vetores Genéticos/química , Vetores Genéticos/metabolismo , Humanos , Linfócitos/metabolismo , Linfócitos/patologia , Modelos Moleculares , Mutação , Ligação Proteica , Conformação Proteica em alfa-Hélice , Conformação Proteica em Folha beta , Domínios e Motivos de Interação entre Proteínas , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/antagonistas & inibidores , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/química , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/química , Receptores Tipo I de Fatores de Necrose Tumoral/genética , Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo , Proteínas Recombinantes/química , Proteínas Recombinantes/genética , Proteínas Recombinantes/metabolismo , Transdução de Sinais , Ligante Indutor de Apoptose Relacionado a TNF/química , Ligante Indutor de Apoptose Relacionado a TNF/genética , Ligante Indutor de Apoptose Relacionado a TNF/metabolismo , Ligante Indutor de Apoptose Relacionado a TNF/farmacologia , Fator de Necrose Tumoral alfa/química , Fator de Necrose Tumoral alfa/metabolismo , Fator de Necrose Tumoral alfa/farmacologia
10.
Bull Exp Biol Med ; 164(4): 473-477, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29511894

RESUMO

We studied the influence of the type and structure of polyethyleneimine on bioavailability and expression of plasmid DNA carrying IGF-1 gene. Polymers with different molecular weights (2.5, 10, 25, and 60 kDa) of linear and branching structure were studied. It was found that the time of polyplex circulation in the blood did not exceed 24 h and the maximum concentration of plasmid DNA was attained with complexes with a molecular weight of 60 kDa. Analysis of liver samples showed that administration of 60-kDa branched polyethyleneimine complex provides DNA protection from degradation for 4 h; in 24 h from the start of the experiment, its concentration was significantly higher than the concentration of other studied polyethyleneimines. The expression of plasmid IGF-1 DNA for this complex attained maximum in 4 h and was equal to 15.50 (7.98; 21.98) arb. units/ml. These results allow us to recommend using polyethyleneimines with branched structure and a molecular weight of 60 kDa for improving plasmid DNA protection and bioavailability.


Assuntos
Portadores de Fármacos/química , Fator de Crescimento Insulin-Like I/farmacocinética , Fígado/química , Plasmídeos/farmacocinética , Polietilenoimina/química , Animais , Animais não Endogâmicos , Disponibilidade Biológica , Expressão Gênica , Injeções Intravenosas , Fator de Crescimento Insulin-Like I/genética , Fígado/metabolismo , Masculino , Estrutura Molecular , Peso Molecular , Plasmídeos/sangue , Ratos , Relação Estrutura-Atividade , Transfecção , Transgenes
11.
Sci Rep ; 7(1): 15548, 2017 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-29138423

RESUMO

The 35-kDa Orange Carotenoid Protein (OCP) is responsible for photoprotection in cyanobacteria. It acts as a light intensity sensor and efficient quencher of phycobilisome excitation. Photoactivation triggers large-scale conformational rearrangements to convert OCP from the orange OCPO state to the red active signaling state, OCPR, as demonstrated by various structural methods. Such rearrangements imply a complete, yet reversible separation of structural domains and translocation of the carotenoid. Recently, dynamic crystallography of OCPO suggested the existence of photocycle intermediates with small-scale rearrangements that may trigger further transitions. In this study, we took advantage of single 7 ns laser pulses to study carotenoid absorption transients in OCP on the time-scale from 100 ns to 10 s, which allowed us to detect a red intermediate state preceding the red signaling state, OCPR. In addition, time-resolved fluorescence spectroscopy and the assignment of carotenoid-induced quenching of different tryptophan residues derived thereof revealed a novel orange intermediate state, which appears during the relaxation of photoactivated OCPR to OCPO. Our results show asynchronous changes between the carotenoid- and protein-associated kinetic components in a refined mechanistic model of the OCP photocycle, but also introduce new kinetic signatures for future studies of OCP photoactivity and photoprotection.


Assuntos
Proteínas de Bactérias/química , Carotenoides/química , Ficobilissomas/química , Synechocystis/química , Proteínas de Bactérias/genética , Carotenoides/efeitos da radiação , Cristalografia por Raios X , Cinética , Lasers , Luz , Modelos Moleculares , Ficobilissomas/efeitos da radiação , Transdução de Sinais/efeitos da radiação , Espectrometria de Fluorescência , Synechocystis/genética
12.
Acta Naturae ; 9(3): 55-63, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29104776

RESUMO

This article offers a detailed review of the current approaches to anticancer therapy that target the death receptors of malignant cells. Here, we provide a comprehensive overview of the structure and function of death receptors and their ligands, describe the current and latest trends in the development of death receptor agonists, and perform their comparative analysis. In addition, we discuss the DR4 and DR5 agonistic antibodies that are being evaluated at various stages of clinical trials. Finally, we conclude by stating that death receptor agonists may be improved through increasing their stability, solubility, and elimination half-life, as well as by overcoming the resistance of tumor cells. What's more, effective application of these antibodies requires a more detailed study of their use in combination with other anticancer agents.

14.
Bull Exp Biol Med ; 163(3): 381-384, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28744632

RESUMO

Death receptors, in particular DR5, are highly attractive targets of antitumor therapy. The major limitation to application of natural death receptor ligands (TRAIL) is their non-specific cytotoxicity against normal cells. Since TRAIL can also bind decoy receptors (DcR) and prevent induction of apoptosis, the search for new DR-specific ligands is a topical issue. In the present study, we used combinatorial phage display peptide libraries to select a panel of DR5-binding amino acid sequences. A comparative analysis of the selected peptides enabled identification of the consensus sequence responsible for binding to DR5. Integration of this motif into polypeptide cytotoxic agents may provide targeted elimination of malignantly transformed cells.


Assuntos
Fragmentos Fc das Imunoglobulinas/química , Biblioteca de Peptídeos , Peptídeos/química , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/química , Proteínas Recombinantes de Fusão/química , Motivos de Aminoácidos , Animais , Sítios de Ligação , Expressão Gênica , Células HEK293 , Humanos , Fragmentos Fc das Imunoglobulinas/genética , Fragmentos Fc das Imunoglobulinas/imunologia , Separação Imunomagnética/métodos , Ligantes , Camundongos , Modelos Moleculares , Peptídeos/genética , Peptídeos/imunologia , Plasmídeos/química , Plasmídeos/metabolismo , Ligação Proteica , Estrutura Secundária de Proteína , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/imunologia , Proteínas Recombinantes de Fusão/genética , Proteínas Recombinantes de Fusão/imunologia , Transfecção
15.
Bull Exp Biol Med ; 163(2): 218-221, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28726199

RESUMO

A catalytic antibody A17 and its mutants highly efficiently interact with organophosphorus pesticide paraoxon. In this work, we studied the protective properties of antibody A17-K47 in paraoxon poisoning using a mouse model. The optimal paraoxon dose simulating the acute toxic effect of organophosphorus compounds was 550 µg/kg. The pharmacokinetic parameters of A17-K47 antibody were t1/2distr =7.2±1.4 min, t1/2el =330±20 min. The antibody did not cause toxic effects when administered at a ten-fold calculated therapeutic dose (610 mg/kg). The drug did not reduce mortality from acute paraoxon poisoning; however, the absence of drug toxicity opens up prospects for its use in symptomatic treatment of chronic paraoxon poisoning.


Assuntos
Anticorpos Catalíticos/metabolismo , Antídotos/metabolismo , Compostos Organofosforados/metabolismo , Compostos Organofosforados/toxicidade , Paraoxon/metabolismo , Paraoxon/toxicidade , Animais , Feminino , Masculino , Camundongos , Camundongos Endogâmicos BALB C
16.
Bull Exp Biol Med ; 162(6): 777-780, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28429225

RESUMO

Elimination of B cells producing autoantibodies to neuroantigens is considered as beneficial in the treatment of multiple sclerosis. Myelin oligodendrocyte glycoprotein (MOG) is a significant autoantigen in multiple sclerosis. It was shown that MOG-like peptoid AMogP3 can bind autoantibodies produced by pathological lymphocytes. We propose a structure of an innovative drug for targeted elimination of the pool of autoreactive B cells responsible for multiple sclerosis pathogenesis; this compound is a complex of peptoid AMogP3 with Fc fragment of human immunoglobulin. The obtained Fc-PEG-AMogP3 conjugate effectively interact with autoreactive antibodies, which attests to their high therapeutic potential.


Assuntos
Autoanticorpos/química , Autoantígenos/química , Imunoconjugados/química , Fragmentos Fc das Imunoglobulinas/química , Cadeias Pesadas de Imunoglobulinas/química , Glicoproteína Mielina-Oligodendrócito/química , Peptoides/química , Autoanticorpos/metabolismo , Autoantígenos/imunologia , Linfócitos B/imunologia , Linfócitos B/patologia , Reagentes para Ligações Cruzadas/química , Humanos , Imunoconjugados/metabolismo , Fragmentos Fc das Imunoglobulinas/metabolismo , Cadeias Pesadas de Imunoglobulinas/metabolismo , Terapia de Alvo Molecular , Esclerose Múltipla/imunologia , Esclerose Múltipla/patologia , Esclerose Múltipla/terapia , Glicoproteína Mielina-Oligodendrócito/imunologia , Fragmentos de Peptídeos/química , Fragmentos de Peptídeos/imunologia , Peptoides/imunologia , Polietilenoglicóis/química , Ligação Proteica , Soluções , Succinimidas/química
17.
Mikrobiologiia ; 86(1): 47-53, 2017.
Artigo em Russo | MEDLINE | ID: mdl-30207142

RESUMO

Microbial biofilms are a basic form of existence of bacteria in the environment, as well as in the animal and plant organisms. The patterns of biofilm formation depending on cultivation conditions is presently insufficiently studied. This paper presents experimental results on the effect of carbon sources on biofilm formation and movement on the swarming type in a phytopathogenic bacterium Pectobacterium carotovorum. A polyol inositol was shown to cause a significant activation of these processes.


Assuntos
Biofilmes/crescimento & desenvolvimento , Carbono/metabolismo , Inositol/metabolismo , Pectobacterium carotovorum/fisiologia
18.
Khirurgiia (Mosk) ; (10): 16-20, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27804930

RESUMO

AIM: To estimate an efficacy of endoscopic treatment of benign cicatricial esophageal strictures using ionized argon plasma. MATERIAL AND METHODS: It is presented treatment of 35 patients with post-ambustial and 17 patients with peptic strictures of the esophagus. Their age ranged from 17 to 73 years. Esophageal stenosis achieved 0.1-1.0 cm. Local, tubular and prolonged stenoses were observed in 18 (51.5%), 3 (8.6%) and 14 (39.9%) patients respectively. Peptic stenoses were local in 100% of cases and localized in lower esophagus before cardia. RESULTS: Endoscopic techique resulted good and satisfactory outcomes in 53.8% and 27% of cases within short terms. The best results were obtained in case of local post-ambustial and peptic ulcers. At the end of treatment inflammation and mitotic activity were decreased in mucosa and submucosa of the narrowed segment. Also thickness of the epithelium and stratification of tissue layers were normal. Connective tissue volume was moderately decreased in subepithelial area.


Assuntos
Coagulação com Plasma de Argônio , Queimaduras Químicas/complicações , Estenose Esofágica , Esofagoscopia , Refluxo Gastroesofágico/complicações , Adulto , Coagulação com Plasma de Argônio/instrumentação , Coagulação com Plasma de Argônio/métodos , Biópsia , Estenose Esofágica/diagnóstico , Estenose Esofágica/etiologia , Estenose Esofágica/cirurgia , Esofagoscopia/instrumentação , Esofagoscopia/métodos , Esôfago/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde
19.
Bull Exp Biol Med ; 161(1): 72-4, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-27270939

RESUMO

Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.


Assuntos
Receptor gp130 de Citocina/metabolismo , Fibronectinas/farmacologia , Receptor gp130 de Citocina/química , Fibronectinas/química , Células HEK293 , Humanos , Multimerização Proteica/efeitos dos fármacos , Fator de Transcrição STAT3/metabolismo , Transdução de Sinais/efeitos dos fármacos
20.
Patol Fiziol Eksp Ter ; 60(4): 47-51, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-29244922

RESUMO

The observation was conducted on 41 female subjects age 32 to 69 with compensated cardio-vascular diseases. 23 of the subjects had an increased body mass index (BMI). It was established that the older the females the less of the irisin muscle hormone is found in the blood. In the subjects with a higher BMI the level of irisin in the blood is also higher. Direct correlations were found between the level of irisin and the level of female sex hormones - estrogen and progesterone. Under the effect of kinesitherapy exercises the level of irisin in females with normal BMI increases; whereas in the females with a higher BMI it generally stays the same or is decreased. The characteristics of irisin's response to the kinesitherapy exercises depends on its original level, the intensity of physical exercise and the subject's physique.


Assuntos
Índice de Massa Corporal , Doenças Cardiovasculares , Estrogênios/sangue , Terapia por Exercício , Fibronectinas/sangue , Progesterona/sangue , Adulto , Idoso , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/terapia , Feminino , Humanos , Pessoa de Meia-Idade
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