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1.
Sci Rep ; 9(1): 19046, 2019 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-31836761

RESUMO

Growing evidence has suggested a possible relationship between dietary calcium intake and metabolic syndrome (MetS) risk. However, the findings of these observational studies are inconclusive, and the dose-response association between calcium intake and risk of MetS remains to be determined. Here, we identified relevant studies by searching PubMed and Web of Science databases up to December 2018, and selected observational studies reporting relative risk (RR) with 95% confidence interval (CI) for MetS based on calcium intake and estimated the summary RRs using random-effects models. Eight cross-sectional and two prospective cohort studies totaling 63,017 participants with 14,906 MetS cases were identified. A significantly reduced risk of MetS was associated with the highest levels of dietary calcium intake (RR: 0.89; 95% CI: 0.80-0.99; I2 = 75.3%), with stronger association and less heterogeneity among women (RR: 0.74, 95% CI: 0.66-0.83; I2 = 0.0%) than among men (RR: 1.06, 95% CI: 0.82-1.37; I2 = 72.6%). Our dose-response analysis revealed that for each 300 mg/day increase in calcium intake, the risk of MetS decreased by 7% (RR: 0.93; 95% CI: 0.87-0.99; I2 = 77.7%). In conclusion, our findings suggest that dietary calcium intake may be inversely associated with the risk of MetS. These findings may have important public health implications with respect to preventing the disease. Further studies, in particular longitudinal cohort studies and randomized clinical trials, will be necessary to determine whether calcium supplementation is effective to prevent MetS.

2.
Wei Sheng Yan Jiu ; 48(5): 728-732, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31601312

RESUMO

OBJECTIVE: To assess the situations of dietary microelements intakes among elderly people in different areas of Zhejiang Province, and analyze the food sources of microelements. METHODS: Data were obtained from the 2010-2012 Chinese National Nutrition and Health Survey in Zhejiang Province. 832 elderly people( 434 male, 398 female, age was( 68. 02±6. 68) years) were from large cities, small-medium cities and rural counties. The 24-hour dietary recall method for 3 consecutive days was used to collect food intake information to analyze dietary intakes among elderly people of Fe, Mn, Cu, Zn, Se and their sources in different areas. RESULTS: The elderly people'intakes of Mn was 4. 86( 3. 44, 6. 45) mg/d, Cu was 1. 69( 1. 13, 2. 27) mg/d, and Se was36. 85( 21. 32, 54. 21) µg/d, those were generally low. The intake of Zn was 10. 15( 7. 94, 12. 62) mg/d in males, was low as well. Intakes of Mn, Cu, Se were significantly different in different areas, small-medium cities had highest intakes of Mn( 5. 87 mg/d)and Cu( 1. 88 mg/d), large cities had a highest intake of Se( 45. 47 µg/d). The food sources of microelements were slightly variant. Rural counties had less fungi and algae sources of Fe and Mn than large cities and small-medium cities. The Cu from vegetables were higher than dried legumes and the Se from poultry and poultry products were higher than eggs in rural counties. The Zn from fish, shellfish and mollusk were higher than dried legumes in large cities. CONCLUSION: The insufficient status of microelements intakes among elderly people in Zhejiang Province was serious, and there were differences among elderly people from different areas in intakes and food sources of microelements.


Assuntos
Dieta/estatística & dados numéricos , Nutrientes/análise , Estado Nutricional , Oligoelementos/análise , Idoso , Animais , Cidades , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Verduras
3.
Wei Sheng Yan Jiu ; 48(5): 817-821, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31601327

RESUMO

OBJECTIVE: To compare the disease burden of diet-related chronic diseases in China between 1990 and 2016. METHODS: Based on the Global Burden of Disease 2016, we extracted the absolute number of deaths and disability-adjusted life years( DALYs) of diet-related chronic diseases and the corresponding age-standardized rates in China in 1990 and 2016. Subgroup analyses were conducted in various gender, dietary risk factors and categories of diseases. RESULTS: In 2016, the total number and rate of diet-related NCDs deaths was 2493 thousand and 182. 4/100000. The corresponding number and rate of DALYs was 54995 thousand person-year and 4023. 0/100000. Compared with those in 1990, the rates of death and DALYs in 2016 increased by19. 5% and 9. 3%, respectively. Both death rate and DALYs rate increased with the age. Death rate( 214. 6/100000) and DALYs rate( 4961. 1/100000) in males were 1. 4-fold and 1. 6-fold as that in females( 148. 2/100000 and 3028. 2/100000, respectively). High intake in sodium, low intake in whole grains and low intake in fruits were the three leading dietary risk factors and cardiovascular diseases accounted for 88. 1% DALYs in all chronic diseases. CONCLUSION: The burden of diet-related chronic diseases in China is severe and it continues increasing over years.


Assuntos
Doença Crônica/epidemiologia , Dieta , China/epidemiologia , Feminino , Humanos , Masculino , Anos de Vida Ajustados por Qualidade de Vida , Fatores de Risco
4.
Wei Sheng Yan Jiu ; 47(1): 37-40, 2018 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-29903221

RESUMO

OBJECTIVE: To analyze the dietary energy and pattern of the elderly in different economic area of Zhejiang Province. METHODS: Data was from Chinese National Nutrition and Health Survey from 2010 to 2012 in Zhejiang Province. The 24 h dietary recall method for 3 consecutive days was used in dietary survey and weighing method was used for condiment intake. RESULTS: There were 793 elderly( age≥60 years) attended in the survey. The intake of beans and nuts, fish and shrimps, eggs, cereals and vegetables respectively were 30. 26, 54. 07, 20. 56, 300. 27 and 277. 78 g. The livestock and poultry meat( 92. 69 g), salt( 9. 14 g), and cooking oil( 33. 60 g) intake was higher than that recommended. Dietary pattern of the urban was better than that of the rural areas. The proportion of energy providing in protein and fat was 14. 17% and 34. 46%, respectively. The proportion of protein from grain and animal food was 31. 51% and 37. 48%. The proportion of fat from plant food was 66. 44%. CONCLUSION: The major problems areirregular diet, imbalanced diet, and unreasonable food sources of protein in Zhejiang province. Because the level of each localities economic development is different, each region's dietary problems are different. We need to research in different areas to analyze specific issues of nutrition interventions, and improving the elders' life quality.


Assuntos
Dieta , Inquéritos Nutricionais , Características de Residência , Idoso , Animais , Ingestão de Energia , Comportamento Alimentar , Humanos , Pessoa de Meia-Idade , Estado Nutricional , Inquéritos e Questionários , Verduras
5.
Nutrients ; 9(5)2017 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-28513555

RESUMO

OBJECTIVE: Our study aimed to investigate the nutritional vitamin D status of school children aged 9-15 years and white-collar workers in Zhejiang province, and evaluate the efficacy of low-dose-oral vitamin D supplementation in both populations. METHODS: We conducted a prospective controlled trial during March 2014 to November 2015, comparing the efficacy of vitamin D supplements (400 IU/day) with non-intervention for 18 months in school children aged 9-15 years. Meanwhile, a before-after study was conducted among white-collar workers for 1 year. Serum 25(OH)D concentration was measured at baseline and after vitamin D supplementation, respectively. RESULTS: At the baseline, 95% of school children and 84% of adult participants had vitamin D deficiency (<20 ng/mL). In school children, no difference was observed between the intervention and control groups with regard to anthropometric data. Serum 25(OH)D concentrations of the school children intervention group, school children control group and white-collar workers were 12.77 ± 3.01 ng/mL, 14.17 ± 3.59 ng/mL and 16.58 ± 3.66 ng/mL at baseline and increased to 17.34 ± 3.78 ng/mL, 18.04 ± 4.01 ng/mL and 17.75 ± 5.36 ng/mL after vitamin D supplementation, respectively. Although, after adjusting for potential confounders, the 400 IU oral vitamin D supplementation increased serum 25(OH)D concentration in school children (ß = 0.81, p = 0.0426) as well as in white-collar workers (p = 0.0839), the prevalence of vitamin D deficiency was still very high among school children (79.23% in intervention group and 72.38% in control group) and white-collar workers (76.00%). CONCLUSIONS: High prevalence of vitamin D deficiency was common in these two study populations. Daily doses of 400 IU oral vitamin D supplementation was not able to adequately increase serum 25(OH)D concentrations. A suitable recommendation regarding the level of vitamin D supplementation is required for this Chinese population.


Assuntos
Suplementos Nutricionais , Vitamina D/análogos & derivados , Vitamina D/administração & dosagem , Adolescente , Adulto , Criança , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vitamina D/sangue , Vitaminas/administração & dosagem , Adulto Jovem
6.
Br J Nutr ; 116(5): 853-63, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27385039

RESUMO

Animal studies have suggested that Mn might be associated with some components of the metabolic syndrome (MetS). A few epidemiological studies have assessed dietary Mn intake and its association with the risk of the MetS and its components among Chinese adults. In this study, we assessed daily dietary Mn intake and its relationship with MetS risk among Chinese adults in Zhejiang Province using data from the 5th Chinese National Nutrition and Health Survey (2010-2012). A total of 2111 adults were included. Dietary Mn intake was assessed using 3-d 24-h dietary recalls; health-related data were obtained by questionnaire surveys, physical examinations and laboratory assessments. The mean intake of Mn was 6·07 (sd 2·94) mg/d for men (n 998) and 5·13 (sd 2·65) mg/d for women (n 1113). Rice (>42 %) was the main food source of Mn. The prevalence of the MetS was 28·0 % (590/2111). Higher Mn intake was associated with a decreased risk of the MetS in men (Q4 v. Q1 OR 0·62; 95 % CI 0·42, 0·92; P trend=0·043) but an increased risk in women (Q4 v. Q1 OR 1·56; 95 % CI 1·02, 2·45; P trend=0·078). In addition, Mn intake was inversely associated with abdominal obesity (P trend=0·016) and hypertriacylglycerolaemia (P trend=0·029) in men, but positively associated with low HDL-cholesterol in both men (P trend=0·003) and women (P trend<0·001). Our results suggest that higher Mn intakes may be protective against the MetS in men. The inverse association between Mn intake and the MetS in women might be due to the increased risk for low HDL-cholesterol.


Assuntos
Inquéritos sobre Dietas , Manganês/administração & dosagem , Síndrome Metabólica/etiologia , Adulto , Idoso , China , Feminino , Análise de Alimentos , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
7.
Zhonghua Yu Fang Yi Xue Za Zhi ; 49(5): 424-8, 2015 May.
Artigo em Chinês | MEDLINE | ID: mdl-26081706

RESUMO

OBJECTIVE: To explore the association between socioeconomic status (SES) and blood pressure control in diagnosed hypertension patients. METHODS: The database of Zhejiang provincial survey on metabolic syndrome which implemented in 2010 in which prior hypoertensive patients were brought into this sutdy. Descriptive statistics were applied to test the distributive differences of relevant factors (age, sex, marital status, hypertension duration, BMI, education level, per capita household yearly income, smoking, alcohol drinking, fruit and vegetable intake) between patients with optimally-controlled blood pressure and those without. The SES of diagnosed hypertension patients was measured separately by two common indicators: education level and the per capita household yearly income. Univariate and multivariate logistic regression models were used to differentiate the association between those two SES indicators and blood pressure control, and the trend of the association was also tested. RESULTS: Totally, 2 394 hypertension patients were diagnosed and identified. Of the patients analysed, the overall mean was (61.53 ± 10.64) years, and 55.7% (1 334 cases) had ≤ 5 years' disease duration. 1 090 achieved optimal blood pressure control, which accounted for a proportion of 45.5%. 1 676 had elementary school education and below, accounting for 70.1%. The patients with per capita household yearly income of < 5 000 Yuan and 5 000-14 999 Yuan groups were 401 (29.4%) and 690 (50.5%) respectively. 416 (17.4%) were smokers and 541 (22.6%) were alcohol drinkers. Based on the statistical tests, we found that the distributions of age, marital status, hypertension duration, body mass index, smoking and alcohol drinking were different between two groups (t or χ² values were 4.57, 5.44, 6.40, 6.21, 5.99, 3.98, respectively, all P values were < 0.05). Optical blood pressure control in higer education level group was significantly better than that of in lower education level (χ² = 12.65, P < 0.001), and there was no statistical significance association between per capita household yearly income and optimal blood pressure control (χ² = 2.78, P = 0.249). Multivariate logistic regression models revealed that, of those two SES indicators, a positive association was shown between education level and optimal blood pressure control: compared with patients in the category of 'elementary school and below, those of 'junior high school and above observed an OR of 1.40 (95% CI: 1.09-1.81). And in further trend χ² test, we identified a trend of such association (χ² trend = 12.74, P = 0.002). However, no significant association has been recognized between per capita household yearly income and optimal blood pressure control: compared with patients in the category of < 5 000 Yuan group, those of 5 000-14 999 Yuan and ≥ 15 000 Yuan groups had OR of 0.93 (95% CI: 0.72-1.20) and 1.04 (95% CI: 0.83-1.31) respectively. CONCLUSION: Among all diagnosed hypertension patients, those with lower education level have poorer blood pressure control and should be labelled as the key population for intense health education and standardized management to improve their blood pressure control status.


Assuntos
Comportamento Alimentar , Hipertensão , Classe Social , Resultado do Tratamento , Consumo de Bebidas Alcoólicas , Pressão Sanguínea , Índice de Massa Corporal , Demografia , Educação , Frutas , Humanos , Renda , Modelos Logísticos , Síndrome Metabólica , Fumar , Verduras
8.
Zhonghua Liu Xing Bing Xue Za Zhi ; 36(2): 105-9, 2015 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-25907715

RESUMO

OBJECTIVE: To understand the prevalence of dyslipidemia among non-overweight adults and related factors in Zhejiang province. METHODS: A total of 10 868 non-overweight adults (aged ≥18 years and BMI<24.0 kg/m²) included in a population-based cross-sectional survey on metabolic syndrome in Zhejiang province in 2010 were selected to conduct questionnaire survey, health examination and blood fat detection. RESULTS: The overall prevalence of dyslipidemia in this population was 41.38%. The prevalence was significantly higher in males (43.19%) than in females (39.84%) (χ² = 12.53, P < 0.001). The prevalence of dyslipidemia significantly decreased in males (trend χ² = 47.61, P < 0.001) but increased in females (trend χ² = 3.88, P < 0.05) with age. There was no significant difference in the prevalence between urban area (41.21%) and rural area (41.49%) (χ² = 0.08, P = 0.774). Multiple logistic regression analysis showed that sex, family history of chronic diseases, smoking, alcohol use, high meat and egg diet, cooking with animal oil, physical activity, central obesity and BMI were factors related to prevalence of dyslipidemia. CONCLUSION: The prevalence of dyslipidemia was high among the non-overweight adults in Zhejiang, and family history, smoking, high-fat diet, physical inactivity, central obesity seemed to be the major risk factors.


Assuntos
Dislipidemias/epidemiologia , Adulto , Consumo de Bebidas Alcoólicas , China/epidemiologia , Doença Crônica , Estudos Transversais , Dieta , Feminino , Humanos , Lipídeos , Masculino , Síndrome Metabólica , Obesidade Abdominal , Prevalência , Fatores de Risco , Fumar , Inquéritos e Questionários
9.
Zhonghua Liu Xing Bing Xue Za Zhi ; 35(9): 985-9, 2014 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-25492136

RESUMO

OBJECTIVE: To investigate the joint association of adiposity, physical activity, sedentary leisure time and job intensity on diabetes and impaired glycoregulation. METHODS: Data was from the 2010 Zhejiang survey and 17 437 adults ( ≥18 years) were examined. Logistic regression was used in this cross-sectional study. RESULTS: Under the same level of sedentary leisure time, adiposity anticipants showed an OR of 2.52-2.75 times for people with diabetes than those with normal or underweight BMI, and anticipants with highest WC having an OR of 2.09-3.71 times than those with the lowest WC. With the same level of physical activity, those adiposity anticipants had an OR of 2.19-5.98 times for diabetes than those with normal or underweight BMI, and anticipants with the highest WC had an OR of 3.10-6.25 times than those with the lowest WC. Anticipants who had no physical activity but with adiposity. BMI had an OR of 3.21 times than those with normal or underweight BMI, but there was no significant difference between diabetes and BMI in those that practising physical activities. Within the 3 levels of physical activity, participants that practising no physical activity, had an OR of 1.68-4.23 times for diabetes than those who were physically active when WC was used as a measure for adiposity. CONCLUSION: Controlling weight and waist seemed more important than improving physical activity or reducing sedentary leisure time in the prevention program on diabetes. WC was better measure on the risks for adiposity-related diabetes than BMI, especially when physical activity was under consideration.

10.
Int J Epidemiol ; 43(6): 1835-45, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25135908

RESUMO

BACKGROUND: In many Western populations, blood pressure varies moderately with season and outdoor temperature. Relatively little is known about effects of seasonal changes in blood pressure on the detection and control of hypertension in general populations, especially in low- and middle-income countries. METHODS: We analysed cross-sectional data of 57 375 (42% men) participants aged 30-79 (mean 52.3) years who were enrolled during 2004-08, as part of the China Kadoorie Biobank, from a rural county in the south-east costal Zhejiang Province. Analyses related daily mean outdoor temperature, obtained from local Meteorological Bureau, to mean systolic (SBP) and diastolic blood pressure (DBP), rate of newly detected hypertension and, among those with self-reported physician-diagnosed hypertension, rate of adequate blood pressure control, using multiple linear and logistic regression models. RESULTS: The overall mean blood pressure was 135.9 mmHg for SBP and 80.5 mmHg for DBP. Daily outdoor temperature ranged between -2.9 and 33.7°C, with July being the hottest month (mean 29.4°C) and January the coldest (mean 4.0°C). Comparing January (the coldest month) with July (the warmest), the differences in the adjusted SBP/DBP were 19.2/7.7 mmHg. Each 10°C lower ambient temperature was associated with 6.9/2.9 mmHg higher SBP/DBP,14.1% higher prevalence of newly detected hypertension and, among those with pre-diagnosed hypertension, 13.0% lower hypertension control rate. CONCLUSION: In rural China, lower outdoor temperature is strongly associated with higher mean blood pressure and hypertension prevalence as well as poorer hypertension control, and should be considered when conducting population-based hypertension surveys and providing treatment for hypertensive patients.


Assuntos
Hipertensão/epidemiologia , População Rural/estatística & dados numéricos , Estações do Ano , Temperatura Ambiente , Adulto , Idoso , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/fisiologia , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Prevalência , Resultado do Tratamento
11.
J Epidemiol ; 24(5): 361-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24910131

RESUMO

BACKGROUND: Whether cigarette smoking and alcohol consumption are associated with the risk of metabolic syndrome (MetS) remains controversial. This study investigated the associations of cigarette smoking and alcohol consumption with MetS in a male population in China. METHODS: We conducted a cross-sectional study. A questionnaire was used to collect data on cigarette smoking, alcohol consumption, MetS status, and other related information from 8169 men aged 19-97 years. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between smoking and alcohol consumption and the risk of MetS. RESULTS: The prevalence of MetS was 15.2% in the study population. Proportions of current smokers and drinkers were 48.2% and 46.5%, respectively. Adjusted OR of MetS was 1.34 (95% CI, 1.01-1.79) among smokers who smoked ≥40 cigarettes/day compared with nonsmokers and 1.22 (95% CI 1.03-1.46) for those who consumed 0.1-99 grams of alcohol/day compared with nondrinkers. Adjusted OR was 2.32 (95% CI 1.45-3.73) among ex-drinkers who never smoked, 1.98 (95% CI 1.35-2.91) among ex-drinkers who were current smokers, and 1.34 (95% CI 1.08-1.68) among current drinkers who never smoked compared with those who neither smoked nor drank. There was a significant interaction between smoking and drinking alcohol on MetS (P for interaction is 0.001). CONCLUSIONS: Our study indicated that smoking and drinking is associated with higher prevalence of MetS. Interactions between smoking and drinking on the risk of MetS in men in China may also exist. Our findings need to be confirmed in future case-control or cohort studies.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Síndrome Metabólica/epidemiologia , Fumar/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
12.
Zhonghua Liu Xing Bing Xue Za Zhi ; 35(3): 246-9, 2014 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-24831619

RESUMO

OBJECTIVE: Using multilevel analysis model to analyze the regional-cluster and risk factors of blood pressure among adult residents in Zhejiang province. METHODS: Totally, 17 437 residents were studied through a multi-stage cluster random sampling method from 60 streets/townships. Risk factors on SBP and DBP were analyzed through a two-level regression model, respectively. RESULTS: The average blood pressure in males appeared as: SBP (125.14±17.90) mmHg, DBP (80.02±10.07) mmHg, compared with SBP (123.36±20.20) mmHg, DBP (77.42±10.09) mmHg in females. The average blood pressure in urban areas were SBP (126.29 ± 19.46) mmHg, DBP (79.64±10.20) mmHg, compared with SBP (122.82±18.86) mmHg, DBP (77.99±10.08) mmHg in rural areas, with differences statistically significant (P < 0.001), between the two areas. Pearson correlation coefficients between SBP, SDP and age were 0.44 and 0.21(P < 0.001), respectively. 5.24% variation of the SBP and 4.96% variation of the DBP were attributed to the environmental factors. Factors as age, gender, hypertension in family history, taking medication for blood pressure, physical exercise, smoking, alcohol drinking, BMI, waist, FPG, TG and TC at the individual level. were associated with both SBP and SDP (P < 0.05). Family income seemed to be related to SBP. Education, reducing salt intake, intensity of occupation would affect on DBP. Influence of FPG and TC on SBP varied among streets/townships while relation between TC and DBP also varied. CONCLUSION: The distribution of blood pressure showed regional-cluster phenomenon. Strategies for different regions directed to prevent hypertension should consider the individual factors such as age, BMI, FPG, TG, TC, the regional factors and the sensitivity of different population to factors.


Assuntos
Pressão Sanguínea/fisiologia , Hipertensão/epidemiologia , Hipertensão/prevenção & controle , Adolescente , Viés , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multinível , Análise de Regressão , Fatores de Risco
13.
PLoS One ; 9(3): e87690, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24609110

RESUMO

To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated. This study found the sensitivities of all the two-step screening strategies with further Oral Glucose Tolerance Test (OGTT) at different Fasting Plasma Glucose (FPG) cut-off points from 5.0 to 7.0 (mmol/L) ranged from 0.66 to 0.91. For the FPG point of 5.0 mmol/L, 91 percent of undiagnosed cases were identified. The total cost of detecting one undiagnosed diabetes case ranged from 547.1 to 1294.5 CNY/case, and the strategy with FPG at cut-off point of 6.1 (mmol/L) resulted in the least cost. Considering both sensitivity and cost of screening diabetes, FPG cut-off point at 5.4 mmol/L was optimized for the two-step strategy. In conclusion, different optimal cut-off points of FPG for two-step strategy in screening of undiagnosed diabetes should be used for different screening purposes.


Assuntos
Diabetes Mellitus/diagnóstico , Adulto , Idoso , China , Estudos Transversais , Feminino , Teste de Tolerância a Glucose , Humanos , Masculino , Pessoa de Meia-Idade
14.
J Nucl Med ; 54(11): 1969-73, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24115527

RESUMO

UNLABELLED: Attentional impairments are seen in many clinical syndromes, including attention deficit hyperactivity disorder, schizophrenia, and Alzheimer disease. Understanding the mechanism of attention can be helpful for the diagnosis and treatment of these diseases. The aim of this study was to assess brain glucose metabolic changes in a rat model of attention. METHODS: Small-animal PET studies were performed at 4 stages. Statistical parametric mapping was used for image analysis. RESULTS: Increased (18)F-FDG uptake was found in the lateral hypothalamic area and left accumbens nucleus in the learning condition. Under the attentive condition, increased (18)F-FDG uptake was observed in the right retrosplenial cortex but (18)F-FDG uptake was decreased in the right medial geniculate nucleus. (18)F-FDG uptake change in the right retrosplenial cortex was negatively correlated with correct latency of behavior performance. CONCLUSION: (18)F-FDG small-animal PET imaging provided novel findings on attention-related glucose metabolic changes, which were significantly correlated with the behavior performance in this rat model.


Assuntos
Atenção/fisiologia , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons , Animais , Comportamento Animal/fisiologia , Transporte Biológico , Encéfalo/metabolismo , Fluordesoxiglucose F18/metabolismo , Aprendizagem/fisiologia , Masculino , Ratos , Ratos Sprague-Dawley , Tempo de Reação/fisiologia
15.
Zhonghua Liu Xing Bing Xue Za Zhi ; 34(4): 311-5, 2013 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-23937831

RESUMO

OBJECTIVE: To access the prevalence rates of pre-hypertensive patients at different stages and its associated risk factors among adults of Zhejiang province. METHODS: Study subjects were selected among local residents aged ≥ 18 years from 15 counties by multi stage stratified cluster random sampling method, from July to November, 2010. Each participant was required to complete questionnaire, physical examination and testing for overnight fasting blood specimen. RESULTS: 17 437 residents were surveyed including 8169 males and 9268 females. The overall prevalence of prehypertension was 34.39%. The prevalence of pre-hypertension appeared to be higher in males (38.57%) than in females (30.70%) (χ(2) = 119.36, P < 0.0001). The prevalence of pre-hypertension decreased with the increase of age in males who were above 25 year olds (χ(2) = 76.94, P < 0.0001) and in females who were above 45 year olds (χ(2) = 114.66, P < 0.0001). The prevalence of pre-hypertension appeared to be higher in the rural (35.60%) than in the urban (32.39%) areas (χ(2) = 18.69, P < 0.0001). Data from multivariable logistic regression showed that factors as being male, aged older than 35 years of age, with waist circumference as ≥ 85 cm for men and ≥ 80 cm for women, body mass index ≥ 25.0 kg/m(2) and triglyceride ≥ 1.7 mmol/L were risk factors of pre-hypertension while having had higher education was a protective factor. CONCLUSION: Pre-hypertension was prevalent among adults residents in Zhejiang province. Factors as overweight, obesity, dyslipidemia appeared to be major risk factors for pre-hypertension.


Assuntos
Pré-Hipertensão/epidemiologia , Adolescente , Adulto , Idoso , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco
16.
PLoS One ; 8(5): e62469, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23671599

RESUMO

The aim of this study was to investigate factors associated with prevalence, awareness, treatment and control of hypertension in southern China. A cross-sectional, population-based survey was conducted in 180 villages across 15 counties in southern China from July to November 2010. Totally, 17437 persons completed all of the questionnaires, measurement examination and blood specimen collection. Adjusted rate of hypertension was 22.59% (95%CI: 22.52%-22.66%), for men 23.36% (95%CI: 23.25%-23.47%) and for women 21.77% (95%CI: 21.68%-21.86%). Multivariate logistic regression showed that old age, education attainment, alcohol use, diabetes, obesity, high TC and high TG were associated with hypertension. Among the hypertensive individuals, 54.33% were aware of their hypertension, and 46.34% were currently taking antihypertensive medication, but only 18.26% had their blood pressure controlled. Among all the hypertensive subjects, awareness was more common in those who were female, living in the urban, old age, low education attainment, diabetes, overweight, obese, Low HDL-C. Among the subjects aware of their diagnosis of hypertension, medication treatment was more common in those living in the urban, old age, nonsmoker and diabetes. Among the individuals who receiving medication treatment, controlled hypertension were less common in those living in the urban, young age, low education attainment, overweight and obese. Despite high rate of hypertension, awareness, treatment and control of hypertension still need to be strengthened.


Assuntos
Grupo com Ancestrais do Continente Asiático , Conhecimentos, Atitudes e Prática em Saúde , Hipertensão/tratamento farmacológico , Hipertensão/etnologia , Adolescente , Adulto , Fatores Etários , Idoso , Consumo de Bebidas Alcoólicas/efeitos adversos , China/epidemiologia , Colesterol/sangue , Serviços de Saúde Comunitária , Estudos Transversais , Complicações do Diabetes/complicações , Escolaridade , Feminino , Humanos , Hipertensão/etiologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Obesidade/complicações , Prevalência , Fatores de Risco , Inquéritos e Questionários , Triglicerídeos/sangue , Adulto Jovem
17.
BMC Public Health ; 13: 355, 2013 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-23590682

RESUMO

BACKGROUND: Existing studies which regarding to the association between individual socioeconomic status (SES) and obesity are still scarce in developing countries. The major aim of this study is to estimate such association in an adult population which was drawn from an economically prosperous province of China. METHODS: Study population was determined by multilevel randomized sampling. Education and income were chosen as indicators of individual SES, general obesity and abdominal obesity were measured by body mass index (BMI) and waist circumference (WC). Descriptive statistical methods were used to depict overall and factor-specific distributions of general and abdominal obesity among 16,013 respondents. Two-step logistic regression models were fitted on gender basis. RESULTS: The age-and-sex adjusted rates of general overweight, general obesity, abdominal overweight and abdominal obesity in study population were 28.9% (95%CI: 27.9%-29.9%), 7.5% (95%CI: 7.0%-8.1%), 32.2% (95%CI: 31.2%-33.3%) and 12.3% (95%CI: 11.6%-13.1%), respectively. Based on model fitting results, a significant inverse association between education and obesity only existed in women, while in men, income rather than education was positively related to obesity. CONCLUSIONS: The atypical SES-obesity relationship we found reflected the on-going social economy transformation in affluent regions of China. High-income men and poorly-educated women were at higher risk of obesity in Zhejiang province, thus merit intense focuses.


Assuntos
Obesidade/epidemiologia , Classe Social , Adulto , Índice de Massa Corporal , China/epidemiologia , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Inquéritos Epidemiológicos , Humanos , Modelos Logísticos , Masculino , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Obesidade Abdominal/epidemiologia , Características de Residência , Fatores de Risco , Circunferência da Cintura
18.
Zhonghua Yu Fang Yi Xue Za Zhi ; 47(11): 1020-5, 2013 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-24507231

RESUMO

OBJECTIVE: To explore the association between dyslipidemia and different subtypes of hypertension among Zhejiang population. METHODS: From June to October in 2010, 19 113 local residents aged ≥ 18 years old were selected among 7571 families from fifteen counties in Zhejiang by four stage stratified-random sampling method. A self-designed questionnaire was adopted to collect information on demographic characteristics, physical activity and life style. At the same time, physical examinations including height, weight, blood pressure and blood lipids were carried out. RESULTS: A total of 19 113 participants completed the interviews, physical examinations and collected the blood samples.Excluding those who did not meet the criteria, 14 731 were finally enrolled in the study. The prevalence rates of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), systolic and diastolic hypertension (SDH) were 7.16% (1055/14 731, standardized rate:5.46%), 4.60% (677/14 731, standardized rate:4.41%), 7.09% (1045/14 731, standardized rate:5.75%), respectively. Among normal blood pressure group, subjects with normal TC, high TC and abnormal TC were separately 10 571 (88.43%), 1173 (9.81%) and 210 (1.76%); subjects with normal HDL-C and low HDL-C were separately 6885 (57.60%) and 5069 (42.40%); subjects with normal TG, high TG, abnormal TG were separately 9952 (79.91%), 1213 (10.15%) and 1189(9.95%).In ISH group, subjects with normal TC, high TC and abnormal TC were separately 826 (78.29%), 188 (17.82%) and 41 (3.89%); subjects with normal HDL-C and low HDL-C were separately 666(63.13%) and 389 (36.87%); subjects with normal TG, high TG and abnormal TG were separately 737 (69.86%), 150 (14.22%) and 168 (15.92%). Multi factor analysis showed that high TG and abnormal TG were associated with ISH (OR (95%CI):1.43 (1.16-1.76), 1.65 (1.34-2.03) respectively). Among IDH group, subjects with normal TC, high TC, abnormal TC were separately 556(82.13%), 99(14.62%) and 22 (3.25%); subjects with normal HDL-C, low HDL-C were separately 335 (49.48%) and 342 (50.52%); subjects with normal TG, high TG, and abnormal TG separately were 402 (59.38%), 107 (15.81%) and 168 (24.82%). The multi factor analysis showed that high TG and abnormal TG could increase the risk of IDH (OR(95%CI):1.57 (1.24-1.98), 2.18 (1.76-2.70) respectively). Among SDH group, subjects with normal TC, high TC and abnormal TC were 817 (78.18%), 193 (18.47%) and 35 (3.35%); subjects with normal HDL-C and abnormal HDL-C were separately 599 (57.32%) and 446 (42.68%); subjects with normal TG, high TG, abnormal TG were separately 675 (64.59%), 164 (15.69%) and 206 (19.71%). The multi factor analysis showed that high TC, high TG and abnormal TG were also associated with the increased risk of SDH (OR (95%CI):1.38 (1.14-1.67), 1.43(1.18-1.75), 1.73 (1.43-2.10) respectively). CONCLUSION: Dyslipidemia is an important factor of different subtypes of hypertension among Zhejiang population, especially triglycerides. Dyslipidemia screening should be strengthened to reduce the risk of cardiovascular diseases.


Assuntos
Dislipidemias/epidemiologia , Hipertensão/epidemiologia , Lipídeos/sangue , Adulto , Idoso , China/epidemiologia , Feminino , Humanos , Hipertensão/sangue , Hipertensão/classificação , Masculino , Pessoa de Meia-Idade , Fatores de Risco
19.
Zhonghua Liu Xing Bing Xue Za Zhi ; 26(2): 101-5, 2005 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-15921609

RESUMO

OBJECTIVE: To study the socio-demographic characteristics, acquired immune deficiency syndrome (AIDS) related behaviors of male clients of female sex workers and their determinants. METHODS: Contacting subjects through 5 ways including volunteers of female sex workers (FSWs), sexually transmitted disease (STD) clinics, long-distance bus stations, long-distance cargo station while adopting methods as snowballing, employing an anonymous questionnaire. Data was analyzed by logistic regression analysis. RESULTS: (1) The majority of clients were 25-45 years old, married and of junior high school or above educational levels; (2) Among male clients of FSWs, numbers of having had commercial sexual intercourse was between 1 to 240, averaged 24 in the previous year. It significantly related to their occupation and the experience of their friends or colleagues who ever visited female sex workers; (3) 27.98% of them used condom every time during commercial sexual intercourse, which significantly related to the score of knowledge on AIDS, concourse of sex intercourse and inhabitation; (4) 28.36% of them had ever contracted STD, which significantly related to the frequency of commercial sexual intercourse in the previous year, risk awareness of being infected with human immunodeficiency virus, and frequency of condom use during commercial sexual intercourse. CONCLUSION: The proportion of always using condom was low among male clients of FSWs, and had had STDs. And it's necessary for active and specific intervention programs to them.


Assuntos
Síndrome de Imunodeficiência Adquirida/prevenção & controle , Preservativos , Trabalho Sexual , Sexo sem Proteção/estatística & dados numéricos , Adulto , China , Humanos , Masculino , Pessoa de Meia-Idade , Assunção de Riscos , Comportamento Sexual
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