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1.
Microb Pathog ; 142: 104067, 2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-32061915

RESUMO

Helicobater pylori (H. pylori) is the most important bacteria known to be associated with various gastroduodenal diseases. virB11 gene is a structural gene of tfs3a genes cluster in the plasticity region of H. pylori. In this study, the structure and biology of virB11 gene were analyzed and elucidated with bioinformatics analysis. After cloning, expression and purification, VirB11 protein was generated for the cytotoxicity to GES-1 cells and the anti-VirB11 protein antibody production for localization and interaction proteins analysis. The results showed that VirB11 protein is a hydrophilic protein, mainly locates in cell membrane. IL-8 productions from GES-1 cells co-culture with VirB11 protein were increased gradually with time (p < 0.001). The interaction proteins of VirB11 protein were F0F1 ATP synthase subunit alpha, ATP synthase subunit beta and isocitrate dehydrogenase. We demonstrate that VirB11 protein possesses cytotoxicity and potentially plays important roles in ATP metabolism to provide energy in the course of H. pylori infection.

2.
Nanoscale ; 11(27): 12915-12923, 2019 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-31250863

RESUMO

SnO2 has a high theoretical capacity of 1493 mA h g-1 as an anode material for Li-ion batteries, but its full reversibility is difficult to achieve upon cycling due to the sluggish kinetics. We for the first time demonstrate a fully reversible SnO2 anode for Li-ion batteries enabled by self-doping and partial amorphization by anchoring its nanoparticles on a graphene/single walled carbon nanotube hybrid framework. The uniquely structured nanocomposite containing 74% SnO2 exhibits high reversible capacities together with good rate and cycling capabilities. For instance, the composite anode retains an overall capacity of 1215 mA h g-1 (1425 mA h g-1 for SnO2) after 200 cycles at 0.1 A g-1, which is very close to its theoretical capacity. Moreover, an overall capacity of 947 mA h g-1 (1062 mA h g-1 for SnO2) can be delivered at a higher rate (1 A g-1) with 98% capacity retention over 350 cycles. This exceptional performance can be attributed to the formation of highly dispersed metallic Sn in the Li2O matrix during cycling, which is caused by the unique two-step lithiation mechanism of the self-doped and partially amorphous SnO2 nanoparticles. A similar strategy can also be applied to develop other high-performance electrodes with conversion reactions.

3.
Adv Mater ; 31(24): e1901372, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31026108

RESUMO

Aluminum is regarded as a promising alternative for graphite anode in next-generation lithium-ion batteries, but its application is hindered by the simultaneous presence of aluminum oxide and the huge volume changes. Herein, hydrogenation-induced self-assembly of robust Al nanocrystals with high purity that are uniformly anchored on graphene is demonstrated. The strong molecular interaction between Al and graphene can not only thermodynamically facilitate the homogenous distribution of Al on graphene but also effectively alleviate the volume changes and preserve the structural integrity of the electrode. More importantly, density functional theory calculations reveal that the absence of oxidation can lower the energy barrier for Li diffusion inside the Al matrix to less than 1/6 of that in an Al matrix with only one monolayer coverage of oxygen. These unique structural features enable the aluminum/graphene nanosheets (Al@GNs) electrode to realize a high reversible capacity of 1219 mAh g-1 and an excellent cycling stability with capacity of 766 mAh g-1 after 1000 cycles at the 3 A g-1 rate. Furthermore, a full cell, comprising an Al@GNs anode and LiFePO4 cathode, exhibits remarkable capacity retention of 96.4% after 100 cycles at the 0.5 A g-1 rate.

4.
Nanoscale ; 11(7): 3208-3215, 2019 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-30702117

RESUMO

Developing sodium ion battery (SIB) anode materials of a low-cost and high-capacity nature for future large-scale applications still involves challenges. Herein, we have reported gallium sulfide (Ga2S3) as a novel SIB anode material for the first time. Ga2S3 nanorods have been synthesized via the facile hydrothermal preparation of a GaOOH precursor with subsequent H2S annealing. Mixed with graphene upon electrode preparation, this Ga2S3 electrode maintains a reversible specific capacity of 476 mA h g-1 after 100 cycles at a current density of 0.4 A g-1, with a coulombic efficiency of over 99%. Ex situ XRD analysis and theoretical calculations are employed to comprehensively elucidate the detailed sodium ion storage mechanism of Ga2S3, which is composed of initial Na+ intercalation, a subsequent multi-step conversion reaction between S and Na+, and an eventual alloying reaction between Ga and Na+ with the end product of Na7Ga13. Further kinetics analysis has demonstrated that the conversion reaction is the rate-limiting step due to a multi-step reaction with the intermediate phase of GaS. Moreover, the appearance of liquid metal Ga, as confirmed via TEM observations and theoretical calculations, can serve as a self-healing agent that repairs cracks in the electrode. Our findings shed light on the further design of Ga-based materials, and they also can be extended to solid-state-battery systems.

5.
Chin J Integr Med ; 2019 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-30623343

RESUMO

The development of Chinese medicine and Western medicine andrology is based on different social background and academic systems, either Chinese medicine or Western medicine andrology has their limitations, therefore, integration of Chinese and Western medicine (ICWM) andrology is in a great need. After more than 30 years of development, andrology has made great achievements in the construction of specialized academic association, holding academic conferences and publication of academic monographs, and the research progress on this field is mainly in the combination of disease and syndrome, microdifferentiation of symptoms and signs and basic research development. However, the comprehensive theoretic system of ICWM andrology has not yet established, and the related studies are still on the primary stage. In the future studies, great efforts still need to be made to expand the methods for the investigation of ICWM, and make innovations in the field of andrology.

6.
Zhonghua Nan Ke Xue ; 25(2): 168-171, 2019 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32216206

RESUMO

Spermatogenesis is a complex and precise process of differentiation of germ cells, which involves three stages: mitosis of spermatogonia, meiosis of spermatocytes and formation of spermatozoa. The process is controlled by many factors, including regulation of cyclins in spermatogenic cells, which plays a pivotal role. Cyclins form heterologous dimer compounds with protein kinase activity by binding to cyclin-dependent kinases, then phosphorylate multiple proteins and promote the orderly conduct of each phase of the cell cycle. In recent years, cyclins A, B, D and E have been found to play important roles in the regulation of spermatogenesis. This article presents an overview on the roles of these four cyclins in regulating the progression of spermatogenesis.


Assuntos
Ciclinas/metabolismo , Espermatócitos/citologia , Espermatogênese , Espermatogônias/citologia , Humanos , Masculino , Meiose , Mitose
7.
ACS Nano ; 12(12): 12741-12750, 2018 Dec 26.
Artigo em Inglês | MEDLINE | ID: mdl-30485062

RESUMO

Magnesium sulfide (MgS), representative of alkaline-earth metal chalcogenides (AEMCs), is a potential conversion/alloy-type electrode material for lithium ion batteries (LIBs), by virtue of its low potential, high theoretical capacity, and abundant magnesium resource. However, the limited capacity utilization and inferior rate performance still hinder its practical application, and the progress is rather slow due to the challenging fabrication technique for MgS. Herein, we report a series of controlled-size hollow MgS nanocrystals (NCs) homogeneously distributed on graphene (MgS@G), fabricated through a metal hydride framework (MHF) strategy, and its application as advanced electrode material for LIBs. The hollow structure of MgS NCs is mainly attributed to the Kirkendall effect and the escape of hydrogen atoms from metal hydride during sulfuration. The as-synthesized MgS@G demonstrates robust nanoarchitecture and admirable interactions, which ensure a spatially confined lithiation/delithiation process, optimize the dynamics of two-steps conversion/alloying reactions, and induce a synergetic pseudocapacitive storage contribution. As a result, a representative MgS@G composite delivers a largely enhanced capacity of >1208 mAh g-1 at a current density of 100 mA g-1 and a long-term cycle stability at a high current density of 5 A g-1 with a capacity of 838 mAh g-1 over 3000 cycles, indicating well-sustained structural integrity. This work presents an effective route toward the development of high-performance magnesium-based material for energy storage.

8.
ACS Nano ; 12(8): 8177-8186, 2018 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-30063322

RESUMO

Metal hydrides have attracted great intentions as anodes for lithium-ion batteries (LIBs) due to their extraordinary theoretical capacity. It is an unsolved challenge, however, to achieve high capacity with stable cyclability, owing to their insulating property and large volume expansion upon lithium storage. Here, we introduce self-initiated polymerization to realize molecular-scale functionality of metal hydrides with conductive polymer, that is, polythiophene (PTh), on graphene, leading to the formation of MgH2@PTh core-shell nanoparticles on graphene. The nanoscale characteristics of MgH2 not only relieve the induced stress upon volume changes but also allow fast diffusivity and high reactivity for Li-ion transport. More importantly, the conformal coating of ultrathin PTh membrane can effectively suppress the detrimental reactions between MgH2 and electrolyte, provide enhanced performance with facile electron and Li+ transport, and preserve its structural integrity, attributed to the strong molecular interaction between PTh and MgH2 as well as its various products during electrochemical reactions. With this structure, a high reversible specific capacity of 1311 mAh g-1 at 100 mA g-1, excellent rate performance of 1025 mAh g-1 at 2000 mA g-1, and a capacity retention of 84.5% at 2000 mA g-1 after 500 cycles are observed for MgH2@PTh nanoparticles as anode for LIBs.

9.
Biol Pharm Bull ; 41(9): 1401-1405, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-29984732

RESUMO

The present study aims to investigate the roles of steroidogenic acute regulatory protein (StAR) in Yangjing Capsule (YC) induced anti-apoptotic effects on Leydig cells and the related mechanism. Leydig tumor cells (MLTC-1) were cultured and treated with YC, and immunofluorescence assay was performed to examine the expression of StAR; furthermore, luciferase reporter assay was conducted to evaluate the impact of YC on StAR promoter; next, MLTC-1 cells were treated with StAR small interfering RNA (siRNA), and flow cytometry was carried out to examine the effect of StAR siRNA on the apoptosis of the cells; furthermore, quantitative (q)RT-PCR and Western blot methods was used to determine the expression of StAR and apoptosis related molecules Bcl-2, Bax and Caspase-3 on both mRNA and protein levels in different groups; finally the secretion of testosterone in different groups was examined by radioimmunoassay. We observed that the YC can increase the expression of StAR in a dose-dependent manner, and YC can activate the promoter of StAR; moreover, transfection of StAR siRNA can block YC induced anti-apoptotic effects and increased production of testosterone. In conclusion, our results suggested that YC might suppress the apoptosis of MLTC-1 cells and enhance the production of testosterone through regulating the expression of StAR.


Assuntos
Apoptose/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Células Intersticiais do Testículo/efeitos dos fármacos , Células Intersticiais do Testículo/metabolismo , Fosfoproteínas/biossíntese , Testosterona/biossíntese , Animais , Apoptose/fisiologia , Cápsulas , Linhagem Celular Tumoral , Relação Dose-Resposta a Droga , Expressão Gênica , Masculino , Camundongos , Fosfoproteínas/agonistas
10.
Adv Mater ; 30(30): e1802011, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29888482

RESUMO

The rational design of an efficient and inexpensive electrocatalyst based on earth-abundant 3d transition metals (TMs) for the hydrogen evolution reaction still remains a significant challenge in the renewable energy area. Herein, a novel and effective approach is developed for synthesizing ultrafine Co nanoparticles encapsulated in nitrogen-doped carbon nanotubes (N-CNTs) grafted onto both sides of reduced graphene oxide (rGO) (Co@N-CNTs@rGO) by direct annealing of GO-wrapped core-shell bimetallic zeolite imidazolate frameworks. Benefiting from the uniform distribution of Co nanoparticles, the in-situ-formed highly graphitic N-CNTs@rGO, the large surface area, and the abundant porosity, the as-fabricated Co@N-CNTs@rGO composites exhibit excellent electrocatalytic hydrogen evolution reaction (HER) activity. As demonstrated in electrochemical measurements, the composites can achieve 10 mA cm-2 at low overpotential with only 108 and 87 mV in 1 m KOH and 0.5 m H2 SO4 , respectively, much better than most of the reported Co-based electrocatalysts over a wide pH range. More importantly, the synthetic strategy is versatile and can be extended to prepare other binary or even ternary TMs@N-CNTs@rGO (e.g., Co-Fe@N-CNTs@rGO and Co-Ni-Cu@N-CNTs@rGO). The strategy developed here may open a new avenue toward the development of nonprecious high-performance HER catalysts.

11.
ACS Nano ; 12(5): 5011-5020, 2018 05 22.
Artigo em Inglês | MEDLINE | ID: mdl-29694023

RESUMO

The realization of high-performance anode materials with high capacity at fast lithiation kinetics and excellent cycle stability remains a significant but critical challenge for high-power applications such as electric vehicles. Two-dimensional nanostructures have attracted considerable research interest in electrochemical energy storage devices owing to their intriguing surface effect and significantly decreased ion-diffusion pathway. Here we describe rationally designed metastable CoSeO3·H2O nanosheets synthesized by a facile hydrothermal method for use as a Li ion battery anode. This crystalline nanosheet can be steadily converted into amorphous phase at the beginning of the first Li+ discharge cycling, leading to ultrahigh reversible capacities of 1100 and 515 mAh g-1 after 1000 cycles at a high rate of 3 and 10 A g-1, respectively. The as-obtained amorphous structure experiences an isotropic stress, which can significantly reduce the risk of fracture during electrochemical cycling. Our study offers a precious opportunity to reveal the ultrafast lithiation kinetics associated with the rapid amorphization mechanism in layered cobalt selenide nanosheets.

12.
ACS Nano ; 12(4): 3816-3824, 2018 04 24.
Artigo em Inglês | MEDLINE | ID: mdl-29608285

RESUMO

MgH2 nanoparticles (NPs) uniformly anchored on graphene (GR) are fabricated based on a bottom-up self-assembly strategy as anode materials for lithium-ion batteries (LIBs). Monodisperse MgH2 NPs with an average particle size of ∼13.8 nm are self-assembled on the flexible GR, forming interleaved MgH2/GR (GMH) composite architectures. Such nanoarchitecture could effectively constrain the aggregation of active materials, buffer the strain of volume changes, and facilitate the electron/lithium ion transfer of the whole electrode, leading to a significant enhancement of the lithium storage capacity of the GMH composite. Furthermore, the performances of GMH composite as anode materials for LIBs are enabled largely through robust interfacial interactions with poly(methyl methacrylate) (PMMA) binder, which plays multifunctional roles in forming a favorable solid-electrolyte interphase (SEI) film, alleviating the volume expansion and detachment of active materials, and maintaining the structural integrity of the whole electrode. As a result, these synergistic effects endow the obtained GMH composite with a significantly enhanced reversible capacity and cyclability as well as a good rate capability. The GMH composite with 50 wt % MgH2 delivers a high reversible capacity of 946 mA h g-1 at 100 mA g -1 after 100 cycles and a capacity of 395 mAh g-1 at a high current density of 2000 mA g-1 after 1000 cycles.

13.
ACS Nano ; 12(3): 2968-2979, 2018 03 27.
Artigo em Inglês | MEDLINE | ID: mdl-29470054

RESUMO

Two-dimensional (2D) hydroxide nanosheets can exhibit exceptional electrochemical performance owing to their shortened ion diffusion distances, abundant active sites, and various valence states. Herein, we report ZnCo1.5(OH)4.5Cl0.5·0.45H2O nanosheets (thickness ∼30 nm) which crystallize in a layered structure and exhibit a high specific capacitance of 3946.5 F g-1 at 3 A g-1 for an electrochemical pseudocapacitor. ZnCo1.5(OH)4.5Cl0.5·0.45H2O was synthesized by a homogeneous precipitation method and spontaneously crystallized into 2D nanosheets in well-defined hexagonal morphology with crystal structure revealed by synchrotron X-ray powder diffraction data analysis. In situ growth of ZnCo1.5(OH)4.5Cl0.5·0.45H2O nanosheet arrays on conductive Ni foam substrate was successfully realized. Asymmetric supercapacitors based on ZnCo1.5(OH)4.5Cl0.5·0.45H2O nanosheets @Ni foam// PVA, KOH//reduced graphene oxide exhibits a high energy density of 114.8 Wh kg-1 at an average power density of 643.8 W kg-1, which surpasses most of the reported all-solid-state supercapacitors based on carbonaceous materials, transition metal oxides/hydroxides, and MXenes. Furthermore, a supercapacitor constructed from ZnCo1.5(OH)4.5Cl0.5·0.45H2O nanosheets@PET substrate shows excellent flexibility and mechanical stability. This study provides layered bimetallic hydroxide nanosheets as promising electroactive materials for flexible, solid-state energy storage devices, presenting the best reported performance to date.

14.
Adv Sci (Weinh) ; 4(9): 1600257, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28932654

RESUMO

A facile hydrogenation-induced self-assembly strategy to synthesize lithium hydride (LiH) nanosheets with a thickness of 2 nm that are uniformly distributed on graphene is reported and designed. Taking advantage of LiH nanosheets with high reactivity and a homogeneous distribution on graphene support as a nanoreactor, the confined chemical synthesis of oxygen-free lithiated composites is effectively and efficiently realized.

15.
Small ; 13(44)2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28722318

RESUMO

Fe2 O3 is regarded as a promising anode material for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) due to its high specific capacity. The large volume change during discharge and charge processes, however, induces significant cracking of the Fe2 O3 anodes, leading to rapid fading of the capacity. Herein, a novel peapod-like nanostructured material, consisting of Fe2 O3 nanoparticles homogeneously encapsulated in the hollow interior of N-doped porous carbon nanofibers, as a high-performance anode material is reported. The distinctive structure not only provides enough voids to accommodate the volume expansion of the pea-like Fe2 O3 nanoparticles but also offers a continuous conducting framework for electron transport and accessible nanoporous channels for fast diffusion and transport of Li/Na-ions. As a consequence, this peapod-like structure exhibits a stable discharge capacity of 1434 mAh g-1 (at 100 mA g-1 ) and 806 mAh g-1 (at 200 mA g-1 ) over 100 cycles as anode materials for LIBs and SIBs, respectively. More importantly, a stable capacity of 958 mAh g-1 after 1000 cycles and 396 mAh g-1 after 1500 cycles can be achieved for LIBs and SIBs, respectively, at a large current density of 2000 mA g-1 . This study provides a promising strategy for developing long-cycle-life LIBs and SIBs.

16.
Biosci Trends ; 11(1): 95-104, 2017 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-28154340

RESUMO

As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression of POU3F1 still remains unknown. The objective of this study is to determine whether the transcription factor POU3F1 is up-regulated by YC extract through the PI3K/AKT signaling pathway to regulate SSCs survival and proliferation. Cultured GC-1 spermatogonial (spg) cells were treated with 0.01, 0.1, and 1 mg/mL YC extract for 48 h. Cell viability was analyzed using MTT assay, while POU3F1 expression was quantitatively detected using real time-polymerase chain reaction and Western blot analysis. POU3F1, GDNF family receptor alpha1 (GFRα1) short interfering ribonucleic acid (siRNA), and LY294002 (PI3K inhibitor) were applied as blockers to explore the underlying pathway. After 48 h treatment with YC extract, GC-1 spg cells proliferated and POU3F1 expression was significantly increased in a dose-dependent manner. POU3F1 siRNA partially blocked those effects of YC extract. Both GFRα1 siRNA and LY294002, as upstream blockers, reduced POU3F1 expression induced by YC extract. The conclusion is that YC extract promotes proliferation of GC-1 spg cells via up-regulation of POU3F1. The potential mechanism is that YC extract triggers the activation of the PI3K/AKT pathway and then up-regulates POU3F1 expression.


Assuntos
Medicamentos de Ervas Chinesas/farmacologia , Fator 6 de Transcrição de Octâmero/metabolismo , Transdução de Sinais/efeitos dos fármacos , Espermatogônias/citologia , Espermatogônias/metabolismo , Regulação para Cima/efeitos dos fármacos , Animais , Cápsulas , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Técnicas de Silenciamento de Genes , Fator Neurotrófico Derivado de Linhagem de Célula Glial/metabolismo , Masculino , Camundongos , Fosfatidilinositol 3-Quinases/metabolismo , Fosforilação/efeitos dos fármacos , Inibidores de Proteínas Quinases/farmacologia , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Espermatogônias/efeitos dos fármacos
17.
ACS Appl Mater Interfaces ; 9(4): 3544-3553, 2017 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-28060478

RESUMO

A unique 3D graphene-single walled carbon nanotube (G-SWNT) aerogel anchored with SnO2 nanoparticles (SnO2@G-SWCNT) is fabricated by the hydrothermal self-assembly process. The influences of mass ratio of SWCNT to graphene on structure and electrochemical properties of SnO2@G-SWCNT are investigated systematically. The SnO2@G-SWCNT composites show excellent electrochemical performance in Li-ion batteries; for instance, at a current density of 100 mA g-1, a specific capacity of 758 mAh g-1 was obtained for the SnO2@G-SWCNT with 50% SWCNT in G-SWCNT and the Coulombic efficiency is close to 100% after 200 cycles; even at current density of 1 A g-1, it can still maintain a stable specific capacity of 537 mAh g-1 after 300 cycles. It is believed that the 3D G-SWNT architecture provides a flexible conductive matrix for loading the SnO2, facilitating the electronic and ionic transportation and mitigating the volume variation of the SnO2 during lithiation/delithiation. This work also provides a facile and reasonable strategy to solve the pulverization and agglomeration problem of other transition metal oxides as electrode materials.

18.
Zhonghua Nan Ke Xue ; 23(2): 164-168, 2017 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-29658256

RESUMO

Objective: To study the safety and efficacy of Bushen Daozhuo Granules (BDG) in the treatment of type Ⅲ prostatitis. METHODS: This multicenter randomized controlled clinical trial included 478 patients with type Ⅲ prostatitis, 290 in the trial group and 188 as controls, the former treated with BDG at 200 ml bid and the latter with tamsulosin hydrochloride sustainedrelease capsules at 0.2 mg qd, both for 4 weeks. Before treatment, after 4 weeks of medication, and at 4 weeks after drug withdrawal, we obtained the NIH Chronic Prostatitis Symptom Index (NIHCPSI) scores and compared the safety and effectiveness rate between the two groups of patients. RESULTS: Compared with the baseline, the NIHCPSI score was markedly decreased in the control group after 4 weeks of medication (21.42 ± 4.02 vs 15.67 ± 3.65, P < 0.05) but showed no statistically significant difference from that at 4 weeks after drug withdrawal (19.03 ± 3.86) (P>0.05), while the NIHCPSI score in the trial group was remarkably lower than the baseline both after 4 weeks of medication and at 4 weeks after drug withdrawal (10.92 ± 2.06 and 12.91 ± 2.64 vs 21.58 ± 3.67, P < 0.05). The trial group exhibited both a higher rate of total effectiveness and safety than the control (P < 0.05). CONCLUSIONS: BDG is safe and effective for the treatment of type Ⅲ prostatitis.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Prostatite/tratamento farmacológico , Agentes Urológicos/uso terapêutico , Cápsulas , Doença Crônica , Preparações de Ação Retardada , Medicamentos de Ervas Chinesas/efeitos adversos , Humanos , Masculino , Prostatite/patologia , Sulfonamidas/efeitos adversos , Sulfonamidas/uso terapêutico , Tansulosina , Resultado do Tratamento , Agentes Urológicos/efeitos adversos
19.
ACS Appl Mater Interfaces ; 8(33): 21334-42, 2016 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-27471909

RESUMO

As a novel class of soft matter, two-dimensional (2D) atomic nanosheet-like crystals have attracted much attention for energy storage devices due to the fact that nearly all of the atoms can be exposed to the electrolyte and involved in redox reactions. Herein, atomically thin γ-FeOOH nanosheets with a thickness of ∼1.5 nm are synthesized in a high yield, and the band and electronic structures of the γ-FeOOH nanosheet are revealed using density-functional theory calculations for the first time. The rationally designed γ-FeOOH@rGO composites with a heterostacking structure are used as an anode material for lithium-ion batteries (LIBs). A high reversible capacity over 850 mAh g(-1) after 100 cycles at 200 mA g(-1) is obtained with excellent rate capability. The remarkable performance is attributed to the ultrathin nature of γ-FeOOH nanosheets and 2D heterostacking structure, which provide the minimized Li(+) diffusion length and buffer zone for volume change. Further investigation on the Li storage electrochemical mechanism of γ-FeOOH@rGO indicates that the charge-discharge processes include both conversion reaction and capacitive behavior. This synergistic effect of conversion reaction and capacitive behavior originating from 2D heterostacking structure casts new light on the development of high-energy anode materials.

20.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 36(10): 1261-1264, 2016 10.
Artigo em Chinês | MEDLINE | ID: mdl-30641017

RESUMO

'Essence and blood from the same source', as one of basic theories of Chinese medi- cine (CM), is important for syndrome typing and clinical medication. Vascular endothelial growth factor (VEGF) can be produced and secreted in Leydig cells and Sertoli cells, which can not only promote the formation of new blood vessels, but also regulate synthesis of testosterone and the proliferation and dif- ferentiation of germ cells. The roles of VEGF in the spermatogenesis reveal scientific connotations of 'essence and blood from the same source', and it plays an important role in guiding clinical practice of CM.


Assuntos
Medicina Tradicional Chinesa , Espermatogênese , Fator A de Crescimento do Endotélio Vascular , Humanos , Células Intersticiais do Testículo , Masculino , Células de Sertoli , Testosterona , Fator A de Crescimento do Endotélio Vascular/metabolismo
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