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1.
ACS Appl Mater Interfaces ; 13(37): 44096-44107, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34499466

RESUMO

Mitochondria are the "power plant" of the cell, providing a constant source of energy, and are involved in a variety of intracellular signaling pathways. Among these pathways, Ca2+ homeostasis is closely related to the normal function of mitochondria. By destroying the Ca2+ steady state of mitochondria and disrupting their multiple cellular activities, tumor cell killing can be achieved. In addition, the presence of an intracellular oxidative stress state triggers the closure of cellular calcium channels, which leads to intracellular Ca2+ retention and enrichment. We designed a targeted and tumor microenvironment (TME)-responsive CaO2-based nanosystem that can selectively target cancer cells for pH-controlled degradation and drug release, alter cellular physiological mechanisms by disrupting Ca2+ homeostasis in an artificial manner, and introduce mitochondrial Ca2+ excess-mediated apoptosis. Meanwhile, the production of Ca(OH)2 will raise the pH of the microenvironment and subsequently promote the oxidation process of glutathione by H2O2 released from CaO2 degradation, achieving the goal of remodeling TME. Moreover, calcium overload of tumor cells and calcification of tissues can both inhibit tumor growth and act as a contrast agent for computed tomography imaging.

2.
Chem Pharm Bull (Tokyo) ; 69(8): 760-767, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34334519

RESUMO

Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that the daldinin A derivatives showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound with three carbon atoms on the alkyl side exhibited the best effect.


Assuntos
Descoberta de Drogas , Células Endoteliais/efeitos dos fármacos , Compostos Heterocíclicos com 3 Anéis/farmacologia , Hiperglicemia/tratamento farmacológico , Ascomicetos/química , Morte Celular/efeitos dos fármacos , Células Endoteliais/metabolismo , Compostos Heterocíclicos com 3 Anéis/síntese química , Compostos Heterocíclicos com 3 Anéis/química , Humanos , Hiperglicemia/metabolismo , Estrutura Molecular
3.
Chem Commun (Camb) ; 57(60): 7362-7365, 2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34196343

RESUMO

A facile strategy was introduced for room-temperature controllable synthesis of hierarchically flower-like hollow COFs (FHF-COFs). Furthermore, the universality for synthesis of the HFH-COFs was validated by altering the building units. Inspired by the unique morphology, extremely large surface area and good chemical stability, HFH-COFs could serve as an attractive adsorption probe by loading with gold nanoparticles and be applied to enrichment of brain natriuretic peptide from human serum. This work opens up a whole new approach for controllable synthesis of the HFH-COFs at room temperature and expands the application of COFs as a promising enrichment probe for complex biological samples.


Assuntos
Estruturas Metalorgânicas/química , Peptídeo Natriurético Encefálico/isolamento & purificação , Adsorção , Ouro/química , Humanos , Limite de Detecção , Nanopartículas Metálicas/química , Estruturas Metalorgânicas/síntese química , Peptídeo Natriurético Encefálico/sangue , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
4.
Ying Yong Sheng Tai Xue Bao ; 32(6): 2129-2137, 2021 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-34212619

RESUMO

The long-term series of geographic data and remote sensing data contain noise and perio-dic fluctuation. We used the improved complete ensemble empirical mode decomposition with adaptive noise (ICEEMDAN) to decompose the data of the normalized difference vegetation index (NDVI), precipitation, and temperature from 1982 to 2015 on per-pixels in the Loess Pla-teau to obtain residuals. Using the residual with less noise and periodic fluctuations, we examined the changes of NDVI and the relationship between NDVI and climatic factors. The results showed that the spatial change trend of NDVI was mainly increasing from 1982 to 2015 in the Loess Plateau. The significance of the change trend of residual NDVI (95.9%) was greater than the original NDVI (72.3%), with spatial variations. Temperature and precipitation could largely explain the changes in vegetation coverage. The proportions of areas with extremely significant positive and negative correlations between temperature and NDVI on the Loess Plateau were 83.7% and 13.9%, respectively, while that between precipitation and NDVI were 54.4% and 37.2%, respectively. There were obvious spatial variations in the responses of vegetation to climate change on the Loess Plateau. Different climatic factors had different effects on different types of vegetation. In general, temperature had stronger correlation with different vegetation than precipitation. Therefore, temperature was the main driving factor for the changes of vegetation cover in the Loess Plateau.


Assuntos
Mudança Climática , Ecossistema , China , Temperatura
5.
Front Psychol ; 12: 634581, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34122225

RESUMO

This study had two aims: to test the effect and the effect size of specific problematic Internet use (SPIU) [online shopping, online pornography, social network site (SNS) usage, and Internet gaming] on generalized problematic Internet use (GPIU) and to reveal the gender differences in GPIU and SPIU for students from the elementary school level to the university level. In total, 5,215 Chinese students (2,303 males, mean age = 16.20 years, range = 10-23 years) from four types of schools (elementary school, junior high school, senior high school, and university) provided self-report data on demographic variables (gender and educational levels), online shopping, online pornography, SNS usage, Internet gaming, and GPIU. After calculations had been controlled for demographic variables, the results indicated that (i) online shopping, online pornography, SNS usage, and Internet gaming positively predicted GPIU-and Internet gaming was the most critical predictor of GPIU-and that (ii) gender differences were revealed in Internet gaming and GPIU in all educational levels, except at senior high school where the gender differences in GPIU were not significant. Significant gender differences were found for online shopping and online pornography for all educational levels above elementary school. These results provided further understanding of the association between GPIU and SPIU and gender differences in PIU, which suggested that gender differences across different educational levels should be considered in interventions of PIU.

6.
ACS Nano ; 2021 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-34160201

RESUMO

Strict conditions such as hypoxia, overexpression of glutathione (GSH), and high concentration of hydrogen peroxide (H2O2) in the tumor microenvironment (TME) limit the therapeutic effects of reactive oxygen species (ROS) for photodynamic therapy (PDT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT). Here we fabricated a biocatalytic Janus nanocomposite (denoted as UPFB) for ultrasound (US) driven SDT and 808 nm near-infrared (NIR) light mediated PDT by combining core-shell-shell upconversion nanoparticles (UCNPs, NaYF4:20%Yb,1%Tm@NaYF4:10%Yb@NaNdF4) and a ferric zirconium porphyrin metal organic framework [PCN-224(Fe)]. Our design not only substantially overcomes the inefficient PDT effect arising from the inadequate Förster resonance energy transfer (FRET) process from UCNPs (donor) to MOFs (acceptor) with only NIR laser irradiation, but also promotes the ROS generation via GSH depletion and oxygen supply contributed by Fe3+ ions coordinated in UPFB as a catalase-like nanozyme. Additionally, the converted Fe2+ from the foregoing process can achieve CDT performance under acidic conditions, such as lysosomes. Meanwhile, UPFB linked with biotin exhibits a good targeting ability to rapidly accumulate in the tumor region, verified by fluorescence imaging and T2-weighted magnetic resonance imaging (MRI). In a word, it is believed that the synthesis and antitumor detection of UPFB heterostructures render them suitable for application in cancer therapeutics.

7.
Adv Mater ; 33(30): e2101223, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34145652

RESUMO

Recently, enzyme dynamic therapy (EDT) has drawn much attention as a new type of dynamic therapy. However, the selection of suitable nanocarriers to deliver chloroperoxidase (CPO) and enhancement of the level of hydrogen peroxide (H2 O2 ) in the tumor microenvironment (TME) are critical factors for improving the efficiency of EDT. In this study, a rapidly decomposing nanocomposite is designed using tetra-sulfide-bond-incorporating dendritic mesoporous organosilica (DMOS) as a nanocarrier, followed by loading CPO and sodium-hyaluronate-modified calcium peroxide nanoparticles (CaO2 -HA NPs). The nanocomposite can effectively generate singlet oxygen (1 O2 ) for tumor therapy without any exogenous stimulus via trimodal-enhanced EDT, including DMOS-induced depletion of glutathione (GSH), H2 O2 compensation from CaO2 -HA NPs in mildly acidic TME, and oxidative stress caused by overloading of Ca2+ . As tetra-sulfide bonds are sensitive to GSH, DMOS can generate hydrogen sulfide (H2 S) gas as a new kind of H2 S gas nanoreactor. Additionally, the overloading of Ca2+ can cause tumor calcification to accelerate in vivo tumor necrosis and promote computed tomography imaging efficacy. Therefore, a novel H2 S gas, EDT, and Ca2+ -interference combined therapy strategy is developed.

8.
Nanoscale ; 13(25): 11128-11137, 2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34132712

RESUMO

The natural biomaterial sarcosine as an electron transport layer (ETL) to modify ITO or ITO/ZnO was successfully introduced into inverted organic solar cells (OSCs) with PM6:BTP-BO-4Cl as the active layer. The introduction of sarcosine on the surface of ITO or ITO/ZnO resulted in lower work function (WF) and higher surface energy. The active layers processed on the surfaces of ITO or ITO/ZnO presented a more optimized morphology and a more ordered molecular arrangement after their modification with sarcosine. The introduction of sarcosine as an ETL promoted charge transport and collection in the OSCs. Therefore, the power conversion efficiency (PCE) of the OSCs increased to 13.53% from 3.86% by modifying ITO with sarcosine. The PCE of the OSCs with ZnO as ETLs improved to 16.45% from 14.85% by modifying ZnO with sarcosine. The improved PCEs benefited from the simultaneously improved short-circuit current density (JSC), fill factor (FF), and open-circuit voltage (VOC). Therefore, this work demonstrates that sarcosine has great potential as an ETL to improve the performance of OSCs.

10.
Front Neural Circuits ; 15: 675365, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33994957

RESUMO

Objective: This study explored whether acupuncture affects the maintenance of long-term potentiation (LTP)-like plasticity induced by transcranial magnetic stimulation (TMS) and the acquisition of motor skills following repetitive sequential visual isometric pinch task (SVIPT) training. Methods: Thirty-six participants were recruited. The changes in the aftereffects induced by intermittent theta-burst stimulation (iTBS) and followed acupuncture were tested by the amplitude motor evoked potential (MEP) at pre-and-post-iTBS for 30 min and at acupuncture-in and -off for 30 min. Secondly, the effects of acupuncture on SVIPT movement in inducing error rate and learning skill index were tested. Results: Following one session of iTBS, the MEP amplitude was increased and maintained at a high level for 30 min. The facilitation of MEP was gradually decreased to the baseline level during acupuncture-in and did not return to a high level after needle extraction. The SVIPT-acupuncture group had a lower learning skill index than those in the SVIPT group, indicating that acupuncture intervention after SVIPT training may restrain the acquisition ability of one's learning skills. Conclusion: Acupuncture could reverse the LTP-like plasticity of the contralateral motor cortex induced by iTBS. Subsequent acupuncture may negatively affect the efficacy of the acquisition of learned skills in repetitive exercise training.

11.
Analyst ; 146(9): 2991-2997, 2021 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-33949450

RESUMO

A spherical thiol-functionalized covalent organic framework (COF-SH) was designed via a facile thiol-yne click reaction of a alkynyl-terminated COF and pentaerythritol tetra(3-mercaptopropionate). The COF-SH was explored as a new adsorbent for the selective enrichment of Hg2+. The as-prepared COF-SH exhibited a uniform mesoporous structure, a high abundance of binding sites, and good chemical stability, which endow it with great performance for the adsorption of Hg2+ and its corresponding maximum adsorption capacity was up to 617.3 mg g-1. Furthermore, the adsorption behavior of Hg2+ on the COF-SH wasin good agreement with the Langmuir and pseudo-second-order models. The influences of adsorbent dosage, pH, selectivity, and reusability of the COF-SH on Hg2+ adsorption were also investigated. Besides this, the COF-SH showed high selectivity towards Hg2+ even in the presence of a high concentration of K+, Na+, Ca2+, Mg2+ and Zn2+ metal ions. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), the corresponding limit of detection (LOD) of Hg2+ was determined at very low concentrations of 80 pg mL-1 (equal to 396 amoL µL-1). In addition, the COF-SH was successfully applied to rapidly enrich and sensitively detect Hg2+ in industrial sewage, with recoveries in the range of 101.8-103.4%, demonstrating the promising potential of COF-SH as an effective adsorbent for use in environmental sample pretreatment.

12.
Oxid Med Cell Longev ; 2021: 1470380, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33854690

RESUMO

Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA). Alterations in SUA homeostasis have been linked to a number of diseases, and hyperuricemia is the major etiologic factor of gout and has been correlated with metabolic syndrome, cardiovascular disease, diabetes, hypertension, and renal disease. Oxidative stress is usually defined as an imbalance between free radicals and antioxidants in our body and is considered to be one of the main causes of cell damage and the development of disease. Studies have demonstrated that hyperuricemia is closely related to the generation of reactive oxygen species (ROS). In the human body, xanthine oxidoreductase (XOR) catalyzes the oxidative hydroxylation of hypoxanthine to xanthine to uric acid, with the accompanying production of ROS. Therefore, XOR is considered a drug target for the treatment of hyperuricemia and gout. In this review, we discuss the mechanisms of uric acid transport and the development of hyperuricemia, emphasizing the role of oxidative stress in the occurrence and development of hyperuricemia. We also summarize recent advances and new discoveries in XOR inhibitors.


Assuntos
Xantina Desidrogenase/antagonistas & inibidores , Humanos , Hiperuricemia , Estresse Oxidativo
13.
Reproduction ; 162(1): 11-20, 2021 05 27.
Artigo em Inglês | MEDLINE | ID: mdl-33929340

RESUMO

Urocortins (UCNs), belonging to corticotropin-releasing hormone (CRH) family, exert their function via CRH receptor type 1 (CRHR1) and 2 (CRHR2). Our previous studies have demonstrated that CRH acts on CRHR1 to potentiate prostaglandins (PGs) output induced by inflammatory stimuli in myometrial cells. In the present study, we sought to investigate the effects of UCNs on prostaglandin (PG) output via CRHR2 in cultured human uterine smooth muscle cells (HUSMCs) from pregnant women at term. We found that UCN and UCN 3 treatment promoted PGE2 and PGF2α secretion in a dose-dependent manner. In contrast, UCN2 dose-dependently inhibited PGE2 and PGF2α secretion. Their effects were reversed by CRHR2 antagonist and CRHR2 siRNA. Mechanically, we showed that UCN and UCN3 suppressed cAMP production and led to Gi activation while UCN2 stimulated cAMP production and activated Gs signaling. Further, UCN and UCN3 but not UCN2 activated NF-κB and MAPK signaling pathways through Gi signaling. UCN and UCN3 stimulation of PGs secretion were dependent on Gi/adenylyl cyclase (AC)/cAMP, NF-κB and MAPK signaling pathways. UCN2 suppression of PGs output was through Gs/AC/cAMP signaling pathways. Our data suggest that UCN, UCN2 and UCN3 can finely regulate PGs secretion via CRHR2, which facilitates the functional status of the uterus during pregnancy.

14.
Artigo em Inglês | MEDLINE | ID: mdl-33794375

RESUMO

Harmine is a beta-carboline and harmala alkaloid with extensive bioactivities. However, its toxicity, especially in neural system, is not systematically assessed and the toxic mechanism is not yet clear. Using Caenorhabditis elegans (C. elegans) as a model system, we found that harmine exhibited dosage dependent (0, 5, 10, 20, 40, 80, 160, and 320 µmol/L) toxic effect, such as growth inhibition, egg laying defects, shortened life span and increased mortality. Although harmine did not result in obvious structural alterations in neurite or death of neurons, it did show direct acetylcholinesterase inhibition activity. Further, we found that harmine treatment decreased worm pharyngeal pump rate and lowered the content of nitric oxide (NO) in worm body, implying foraging disorders, which is an indicator of acetylcholinergic neuron activity inhibition. Besides, network pharmacology and molecular docking reveals that acetylcholinesterase is one of the major neural toxicity targets as well. Above all, harmine can directly inhibit the activity of acetylcholinesterase, leading to excessive accumulation of acetylcholine, which may be one of the harmine neurotoxicity mechanisms.


Assuntos
Caenorhabditis elegans/efeitos dos fármacos , Inibidores da Colinesterase/toxicidade , Harmina/toxicidade , Neurônios/efeitos dos fármacos , Neurotoxinas/toxicidade , Animais
15.
Nat Commun ; 12(1): 1751, 2021 03 19.
Artigo em Inglês | MEDLINE | ID: mdl-33741915

RESUMO

Malignant Pleural Mesothelioma (MPM) is typically diagnosed 20-50 years after exposure to asbestos and evolves along an unknown evolutionary trajectory. To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomic intratumour heterogeneity varies widely across the cohort. Phylogenetic tree topology ranges from linear to highly branched, reflecting a steep gradient of genomic instability. Using transfer learning, we detect repeated evolution, resolving 5 clusters that are prognostic, with temporally ordered clonal drivers. BAP1/-3p21 and FBXW7/-chr4 events are always early clonal. In contrast, NF2/-22q events, leading to Hippo pathway inactivation are predominantly late clonal, positively selected, and when subclonal, exhibit parallel evolution indicating an evolutionary constraint. Very late somatic alteration of NF2/22q occurred in one patient 12 years after surgery. Clonal architecture and evolutionary clusters dictate MPM inflammation and immune evasion. These results reveal potentially drugable evolutionary bottlenecking in MPM, and an impact of clonal architecture on shaping the immune landscape, with potential to dictate the clinical response to immune checkpoint inhibition.


Assuntos
Deleção Cromossômica , Neoplasias Pulmonares/genética , Mesotelioma/genética , Mutação , Neoplasias Pleurais/genética , Proteínas Supressoras de Tumor/genética , Células Clonais/metabolismo , Células Clonais/patologia , Análise por Conglomerados , Estudos de Coortes , Humanos , Estimativa de Kaplan-Meier , Prognóstico , Microambiente Tumoral/genética , Proteínas Supressoras de Tumor/classificação , Sequenciamento Completo do Exoma/métodos
16.
Transl Psychiatry ; 11(1): 97, 2021 02 04.
Artigo em Inglês | MEDLINE | ID: mdl-33542178

RESUMO

The associated factors of suicide attempts in patients with major depressive disorder (MDD) comorbid with anxiety remains unclear. To the best of our knowledge, this is the first study with a large sample size that examines the risk factors of suicide attempts in first-episode drug-naïve (FEND) MDD patients comorbid with anxiety and includes clinical correlates, metabolic parameters, and thyroid hormone levels. A total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the symptoms of patients. Metabolic parameters and thyroid hormone levels were measured. The prevalence of suicide attempts in MDD patients comorbid anxiety symptoms was 24.28%, which was 9.51 times higher than that in MDD patients without anxiety symptoms (3.25%). Compared to non-attempters, MDD patients with anxiety symptoms who attempted suicide scored higher on HAMD and HAMA, and had higher systolic blood pressure, higher levels of thyroid stimulating hormone (TSH), and thyroid peroxidases antibody (TPOAb), which were also correlated with suicide attempts in MDD patients comorbid anxiety symptoms. The combination of HAMA score, HAMD score, and TSH could differentiate suicide attempters from non-suicide attempters. Further, the age of onset, illness duration, BMI, TSH, and TPOAb were associated with the times of suicide attempts in MDD patients comorbid anxiety symptoms. Our results demonstrate high prevalence of suicide attempts in MDD patients comorbid anxiety symptoms. Several clinical correlates, metabolic parameters, and thyroid hormones function contribute to the suicide attempts in MDD patients comorbid anxiety symptoms.


Assuntos
Transtorno Depressivo Maior , Preparações Farmacêuticas , Ansiedade , Estudos Transversais , Transtorno Depressivo Maior/epidemiologia , Humanos , Tentativa de Suicídio , Hormônios Tireóideos
17.
Org Biomol Chem ; 19(9): 2023-2029, 2021 03 11.
Artigo em Inglês | MEDLINE | ID: mdl-33594399

RESUMO

An efficient silver-catalyzed method of decarboxylative radical allylation of α,α-difluoroarylacetic acids to build CF2-allyl bonds has been developed. Using allylsulfone as an allyl donor, α,α-difluorine substituted arylacetic acids bearing various functional groups are successfully allylated to access a series of 3-(α,α-difluorobenzyl)-1-propylene compounds in moderate to excellent yields in aqueous CH3CN solution under the mild conditions. Experimental studies disclosed that the α-fluorine substitution of arylacetic acid has a great influence on free radical activity and reactivity.

18.
Analyst ; 146(5): 1543-1547, 2021 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-33565552

RESUMO

4-Mercaptobenzoic acid (MBA) is introduced as a matrix for laser desorption/ionization time-of-flight mass spectrometry (MS) analysis of metals, exhibiting matrix-interference-free background, greatly enhanced MS signal intensity, and excellent reproducibility. The developed method was successfully extended for the rapid screening and sensitive determination of ultratrace metals in fine particulate matter (PM2.5).

19.
Ecotoxicol Environ Saf ; 210: 111865, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33418154

RESUMO

Cd contamination in rice grains has become a topic of great concern because of the high health risks associated with the long-term consumption of Cd-contaminated rice. Identification of Cd sources in rice grains by scientific methods is important for controlling heavy metal pollution and protecting human health. Here, the Cd concentrations and Cd isotopic compositions of rice plants (root, stem, leaf, and grain) and topsoil, and possible pollution sources (agricultural fertilizers, industrial dust, and automobile exhaust) were analyzed using an instrument of inductively coupled plasma mass spectrometry (ICP-MS) and multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). The results showed variations in the Cd isotopes of different components of rice plants and the fractionation coefficient of rice grains relative to topsoil (Δ114/110Cdrice grains-topsoil = 0.25‰). The contributions of pollution sources to rice grains were realized by combining the Cd isotopic composition with an isotopic mixing model (Isosource). The analysis showed that all three possible pollution sources contributed to the Cd in the rice grains in the field, the average Cd contribution of industrial dust, agricultural fertilizers and automobile exhaust was 87%, 9%, and 4%, respectively. Our study provides a feasible method for the identification of pollution sources of Cd in rice grains at the field scale and demonstrates that Cd isotopic composition is one of the powerful tools to trace the pollution sources of Cd in crops.


Assuntos
Cádmio/análise , Grão Comestível/química , Oryza , Poluentes do Solo/análise , Cádmio/química , Fracionamento Químico , Poeira , Monitoramento Ambiental , Fertilizantes , Humanos , Indústrias , Isótopos/análise , Emissões de Veículos
20.
Int J Cardiovasc Imaging ; 37(4): 1311-1319, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33392873

RESUMO

To investigate whether 2D strain and 3D echocardiography could early identify the impaired right ventricular (RV) function after anthracycline exposure. Sixty-one patients with diffuse large B-cell lymphoma treated with anthracycline were studied. Echocardiography was conducted at baseline, after the third cycle of the chemotherapy, after the completion of the chemotherapy, and follow-up at 10 months after the initiation of chemotherapy. RV global longitudinal strain (RV GLS) and RV free wall longitudinal strain (RV FWLS) were calculated using speckle tracking echocardiography. RV ejection fraction (RVEF) was analyzed by 3D echocardiography. RV systolic dysfunction was defined by ≥ 2 RV parameters below the threshold value, and cardiotoxicity was defined as a reduction in left ventricular EF > 10 to < 53%. After the third cycle of chemotherapy, only RV GLS was significantly decreased, while after the completion of the chemotherapy, RV GLS, RV FWLS, and RVEF were all significantly decreased compared with baseline measurements. At the end of follow-up, 9 patients (14.8%) were diagnosed with RV systolic dysfunction, and 16 patients (26.2%) had at least 1 abnormal RV function parameter. The proportion of RV systolic dysfunction was significantly higher in patients with cardiotoxicity than in patients without cardiotoxicity, yielding an odds ratio of 5.143. A percentage decrease in RV FWLS and RVEF were independent predictors of RV systolic dysfunction. Two-dimensional strain and 3D echocardiography are valuable methods for evaluating anthracycline-related impairment of RV function in DLBCL patients receiving chemotherapy. RV FWLS and RVEF are reliable predictors of RV systolic dysfunction.


Assuntos
Antibióticos Antineoplásicos/efeitos adversos , Doxorrubicina/efeitos adversos , Ecocardiografia Tridimensional , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Volume Sistólico/efeitos dos fármacos , Disfunção Ventricular Direita/induzido quimicamente , Disfunção Ventricular Direita/diagnóstico por imagem , Função Ventricular Direita/efeitos dos fármacos , Adulto , Cardiotoxicidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Disfunção Ventricular Direita/fisiopatologia
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