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1.
Pain Res Manag ; 2021: 9460695, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34804268

RESUMO

Acupuncture has been widely used as an alternative and complementary therapy for migraine. With the development of neuroimaging techniques, the central mechanism of acupuncture for migraine has gained increasing attention. This review aimed to analyze the study design and main findings of neuroimaging studies of acupuncture for migraine to provide the reference for future research. The original studies were collected and screened in three English databases (PubMed, Embase, and Cochrane Library) and four Chinese databases (Chinese National Knowledge Infrastructure, Chinese Biomedical Literature database, the Chongqing VIP database, and Wanfang database). As a result, a total of 28 articles were included. Functional magnetic resonance imaging was the most used neuroimaging technique to explore the cerebral activities of acupuncture for migraine. This review manifested that acupuncture could elicit cerebral responses on patients with migraine, different from sham acupuncture. The results indicated that the pain systems, including the medial pain pathway, lateral pain pathway, and descending pain modulatory system, participated in the modulation of the cerebral activities of migraine by acupuncture.

2.
Nat Commun ; 12(1): 6417, 2021 11 05.
Artigo em Inglês | MEDLINE | ID: mdl-34741027

RESUMO

To understand how RNA dynamics is regulated and connected to its function, we investigate the folding, conformational dynamics and robustness of Xrn1 resistance of a set of flaviviral xrRNAs using SAXS, smFRET and in vitro enzymatic assays. Flaviviral xrRNAs form discrete ring-like 3D structures, in which the length of a conserved long-range pseudoknot (PK2) ranges from 2 bp to 7 bp. We find that xrRNAs' folding, conformational dynamics and Xrn1 resistance are strongly correlated and highly Mg2+-dependent, furthermore, the Mg2+-dependence is modulated by PK2 length variations. xrRNAs with long PK2 require less Mg2+ to stabilize their folding, exhibit reduced conformational dynamics and strong Xrn1 resistance even at low Mg2+, and tolerate mutations at key tertiary motifs at high Mg2+, which generally are destructive to xrRNAs with short PK2. These results demonstrate an unusual regulatory mechanism of RNA dynamics providing insights into the functions and future biomedical applications of xrRNAs.

3.
Front Neurosci ; 15: 730322, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34616275

RESUMO

Objectives: This study was conducted in order to investigate the study design and main outcomes of acupuncture neuroimaging studies on low back pain (LBP). Methods: Neuroimaging studies of acupuncture on LBP were collected from three English databases such as PubMed and four Chinese databases such as China National Knowledge Infrastructure (CNKI) from inception to December 31, 2020. Study selection, data extraction, and assessment of risk of bias were performed independently by two investigators. The quality of studies was appraised with the Cochrane's risk of bias tools. Information on basic information, methodology, and brain imaging data were extracted. Results: The literature search returned 310 potentially eligible studies and 19 articles met inclusion criteria; 78.9% of studies chose manual acupuncture as the intervention, 89.5% of studies evaluated functional changes elicited by acupuncture, and 68.4% of studies used resting-state fMRI as imaging condition. The most frequently reported acupuncture-induced brain alterations of LBP patients were in the prefrontal cortex, insula, cerebellum, primary somatosensory cortex, and anterior cingulate cortex. There was a significant correlation between improved clinical outcomes and changes in the brain. Conclusions: The results suggested that improving abnormal structure and functional activities in the brain of the LBP patient is an important mechanism of acupuncture treatment for LBP. The brain regions involved in acupuncture analgesia for LBP were mainly located in the pain matrix, default mode network (DMN), salience network (SN), and descending pain modulatory system (DPMS). However, it was difficult to draw a generalized conclusion due to the heterogeneity of study designs. Further well-designed multimodal neuroimaging studies investigating the mechanism of acupuncture on LBP are warranted.

4.
Chemosphere ; 285: 131560, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34710966

RESUMO

The treatment of solid wastes and wastewater for sustainable development has been a hot topic. This work proposes a novel process of "waste treating waste" using magnetic copper smelter slag (CSS) as heterogeneous catalyst. The effect of process variables and water matrix was studied on catalytic performance. Under conditions of CSS 10 g/L, H2O2 100 mM, pH 4.4, and temperature 25 °C, tetracycline can be effectively degraded within 30 min. The apparent rate constant is comparable to or higher than previous reports, and the activation energy is 37 kJ/mol. The broad operation pH, slight effect of water matrix, and magnetic property of CSS are favorable for potential application. CSS was characterized by N2 adsorption-desorption isotherm, SEM-EDS, XRD, XPS, ICP and zeta potential. The dominant components of CSS are fayalite and magnetite, and the major metals of Fe and Cu provide active sites for H2O2 activation. Hydroxyl radical generated by H2O2 activation is dominant oxidative specie for tetracycline degradation. The plausible mechanism of tetracycline degradation in the solution and on catalyst surface is proposed.


Assuntos
Cobre , Poluentes Químicos da Água , Catálise , Peróxido de Hidrogênio , Cinética , Fenômenos Magnéticos , Tetraciclina , Poluentes Químicos da Água/análise
5.
Chem Sci ; 12(38): 12776-12784, 2021 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-34703564

RESUMO

RNA-guided Streptococcus pyogenes Cas9 (SpCas9) is a sequence-specific DNA endonuclease that works as one of the most powerful genetic editing tools. However, how Cas9 locates its target among huge amounts of dsDNAs remains elusive. Here, combining biochemical and single-molecule fluorescence assays, we revealed that Cas9 uses both three-dimensional and one-dimensional diffusion to find its target with high efficiency. We further observed surprising apparent asymmetric target search regions flanking PAM sites on dsDNA under physiological salt conditions, which accelerates the target search efficiency of Cas9 by ∼10-fold. Illustrated by a cryo-EM structure of the Cas9/sgRNA/dsDNA dimer, non-specific interactions between DNA ∼8 bp downstream of the PAM site and lysines within residues 1151-1156 of Cas9, especially lys1153, are the key elements to mediate the one-dimensional diffusion of Cas9 and cause asymmetric target search regions flanking the PAM. Disrupting these non-specific interactions, such as mutating these lysines to alanines, diminishes the contribution of one-dimensional diffusion and reduces the target search rate by several times. In addition, low ionic concentrations or mutations on PAM recognition residues that modulate interactions between Cas9 and dsDNA alter apparent asymmetric target search behaviors. Together, our results reveal a unique searching mechanism of Cas9 under physiological salt conditions, and provide important guidance for both in vitro and in vivo applications of Cas9.

6.
Hum Brain Mapp ; 42(18): 5985-5999, 2021 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-34533251

RESUMO

The aberrant static functional connectivity of brain network has been widely investigated in patients with functional constipation (FCon). However, the dynamics of brain functional connectivity in FCon patients remained unknown. This study aimed to detect the brain dynamics of functional connectivity states and network topological organizations of FCon patients and investigate the correlations of the aberrant brain dynamics with symptom severity. Eighty-three FCon patients and 80 healthy subjects (HS) were included in data analysis. The spatial group independent component analysis, sliding-window approach, k-means clustering, and graph-theoretic analysis were applied to investigate the dynamic temporal properties and coupling patterns of functional connectivity states, as well as the time-variation of network topological organizations in FCon patients. Four reoccurring functional connectivity states were identified in k-means clustering analysis. Compared to HS, FCon patients manifested the lower occurrence rate and mean dwell time in the state with a complex connection between default mode network and cognitive control network, as well as the aberrant anterior insula-cortical coupling patterns in this state, which were significantly correlated with the symptom severity. The graph-theoretic analysis demonstrated that FCon patients had higher sample entropy at the nodal efficiency of anterior insula than HS. The current findings provided dynamic perspectives for understanding the brain connectome of FCon and laid the foundation for the potential treatment of FCon based on brain connectomics.

7.
Water Sci Technol ; 84(5): 1146-1158, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34534112

RESUMO

A novel copper doped graphitic carbon nitride (Cu-C3N4) was successfully synthesized and used as an effective Fenton-like catalyst. Cu-C3N4 was characterized by scanning electron microscopy, surface area analyzer, Fourier transform infrared spectroscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy. Effect of process parameters including catalyst dosage, hydrogen peroxide (H2O2) concentration, solution pH, and initial methylene blue (MB) concentration was investigated to evaluate catalytic performance. The pseudo first-order kinetic model was used to describe the catalytic process. The enhancement of MB degradation is observed assisted by ultrasound. MB degradation of 96% is obtained within 30 min in Cu-C3N4/H2O2/ultrasound system, and the corresponding rate constant is 0.099 min-1. Effective MB degradation is obtained over a broad pH range (3.3-9.9). The catalytic mechanism is examined by ultraviolet-visible spectra, quenching test, and electron spin resonance determination. The dominant mechanism of MB degradation is ascribed to the ultrasonic H2O2 activation by Cu-C3N4 for hydroxyl radical generation. Cu-C3N4 has good reusability and is effective to degrade rhodamine B and acid orange 7. This work not only contributes to the field of wastewater treatment, but also provides insights into the synthesis of Fenton-like catalysts. The results manifest that Cu-C3N4 is a promising Fenton-like catalyst for dye degradation in the field of environmental pollution remediation.


Assuntos
Corantes , Peróxido de Hidrogênio , Cobre , Grafite , Compostos de Nitrogênio
8.
Trials ; 22(1): 536, 2021 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-34391451

RESUMO

BACKGROUND: Acupuncture is effective for reducing the symptoms of neck pain (NP). However, the underlying mechanisms are not fully elucidated. Based on evaluating the efficacy of two acupuncture prescriptions for treating NP, this study aims to investigate the potential central mechanism of acupuncture treatment for NP by functional magnetic resonance imaging (fMRI). METHODS: This is a randomized controlled trial; 86 patients will be randomly assigned into two acupuncture treatment groups at a ratio of 1:1. The whole study period includes 2 weeks baseline, 2 weeks treatments, and 12 weeks follow-up (4 and 12 weeks after treatment). The pain severity, the neck disability index, the cervical range of motion, and the pressure pain threshold, etc., will be used to evaluate the clinical efficacy of two acupuncture prescriptions for NP treatment. The MRI scans will be performed to detect cerebral activity changes of 20 patients in each group. The clinical data and MRI data will be analyzed, respectively. Pearson correlation coefficient will be used to evaluate the association between changes of cerebral activity features and improvement of clinical symptoms. DISCUSSION: The results will provide further evidence for the clinical application of acupuncture in the treatment of NP. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2000040930 . Registered on 16 December 2020.


Assuntos
Terapia por Acupuntura , Cervicalgia , Terapia por Acupuntura/efeitos adversos , Humanos , Imageamento por Ressonância Magnética , Cervicalgia/diagnóstico por imagem , Cervicalgia/terapia , Manejo da Dor , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
9.
BMJ Open ; 11(8): e045090, 2021 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-34429304

RESUMO

INTRODUCTION: Previous reviews have suggested that the effectiveness of acupuncture for inflammatory bowel disease (IBD) has not well been demonstrated due to the limited randomised controlled trials (RCTs). In recent years, the growing research on acupuncture for IBD make it possible to conduct a further systematic review and synthesise more sufficient clinical data to evaluate the effectiveness and safety of acupuncture for IBD. METHODS AND ANALYSIS: Nine electronic databases without language restriction will be retrieved from inception to March 2021, including the Cochrane Library, MEDLINE, EMBASE, Ovid, the Allied and Complementary Medicine Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing Chinese Science and Technology Periodical Database and Wanfang Database. The RCTs on acupuncture for IBD will be included. The data screening, data extraction and the assessment of risk bias will be performed respectively by two reviewers. The quality of evidence will be evaluated by using the Grading of recommendation Assessment, Development and Evaluation application. The meta-analysis will be performed if heterogeneity analysis conducted on the RevMan software (V.5.3) is insignificant. The primary outcome was symptoms alleviation after acupuncture treatment or even in the follow-up. ETHICS AND DISSEMINATION: Ethical approval will not be needed because data of this review are not involved in patient's information and privacy. The results will be published and diffused in a peer-reviewed journal or relative conferences. TRIAL REGISTRATION NUMBER: CRD42020157903.


Assuntos
Terapia por Acupuntura , Doenças Inflamatórias Intestinais , China , Humanos , Doenças Inflamatórias Intestinais/terapia , Metanálise como Assunto , Revisões Sistemáticas como Assunto
10.
Zhen Ci Yan Jiu ; 46(6): 510-4, 2021 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-34190456

RESUMO

The network analysis method based on brain connectomics is an important entry point to explore the working mechanism of brain and is also the current trend of researches on acupuncture stimulation-induced changes of neuroimages. We, in the present review, summarized the common network analysis methods for exploring the underlying mechanisms of brain network-mediated regulatory effects of acupuncture interventions. Moreover, combining the current research development and our team's previous research findings, we extracted the characteristics of targeting, conditionity and dynamic of regulatory effects of acupuncture-activated brain network, and put forward our prospects about the future research from the aspects of new scanning modes (for instance, multimodal data acquisition of magnetic resonance, electroencephalogram, near infrared spectrum, etc.), network analysis (such as Granger causality analysis, complex network measures, whole-brain connectivity dynamics tracking, high-order resting-state functional connectivity analysis, etc.) and experimental research paradigms (for example, introduce of transcranial magnetic stimulation induced transient changes of brain functional activity, machine learning approach, etc.).


Assuntos
Terapia por Acupuntura , Conectoma , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico , Imageamento por Ressonância Magnética , Estimulação Magnética Transcraniana
11.
Trials ; 22(1): 399, 2021 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-34127059

RESUMO

BACKGROUND: As it has been recorded in ancient Chinese classics, Yanglingquan (GB34) and Dannangxue (EX-LE6) are two important acupoints that can regulate the function of the gallbladder. Acupuncture at these two acupoints is considered particularly effective for gallbladder disease treatment, especially for alleviating gallbladder stone disease (GSD) symptoms that can be aggravated after intaking high-fat food. However, the superior effect between the two acupoints still needs to be further explored, as well as the underlying central mechanism has never been investigated to date. METHODS AND DESIGN: Ninety participants diagnosed with GSD will be randomly divided into group A (acupuncture at GB34), group B (acupuncture at EX-LE6), and group C (acupuncture at non-acupoint) in a ratio of 1:1:1. All of them will receive a 30-min acupuncture treatment with fatty-food cues being presented before and after acupuncture. During the task, participants will be scanned by MRI and required to rate their desire for high-/low-fat food with an 11-point Likert scale. Additionally, the participants' pain/discomfort sensation will be evaluated using the Numeric Rating Scale (NRS) at four timepoints, including before the 1st task fMRI scan, before and after acupuncture, and after the 2nd task fMRI scan. For both behavior and fMRI data, the ANOVA analysis will be conducted among three groups to testify the immediate effect of GB34 and EX-LE6. The post hoc t-test will be employed to further explore the superiority between acupuncture with GB34 and EX-LE6. Furthermore, correlation analyses will be conducted to investigate a possible correlation between neural changes and clinical data. DISCUSSION: In comparison to the non-acupoint, the results will firstly explore the superior effect between acupuncture with GB34 and EX-LE6 on GSD patients by observing their behavioral and neural response change to fatty-food cue, and then to investigate the underlying central mechanism. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2000034368 . Registered on 3 July 2020.


Assuntos
Pontos de Acupuntura , Terapia por Acupuntura , Terapia por Acupuntura/efeitos adversos , Vesícula Biliar/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Ensaios Clínicos Controlados Aleatórios como Assunto
12.
Chemosphere ; 272: 129883, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33581565

RESUMO

Hydrogen peroxide activation by pyrite for degradation of recalcitrant contaminants receives increasing attention. The improvement of catalytic efficiency of natural pyrite is still a challenging issue. This work provides a novel strategy of enhancing catalytic efficiency via pre-reaction between pyrite and hydrogen peroxide. Effects of process factors including pre-reaction time, hydrogen peroxide, solution pH and initial dye concentration were examined. Natural pyrite with low purity was characterized by Raman, scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Reaction kinetic verifies tremendous improvement of the reaction rate through pre-reaction. Enhanced dye degradation is ascribed to hydroxyl radical production promoted by self-regulation of pH, Fe2+ releasing and Fe2+/Fe3+ cycle. The plausible mechanism was proposed based on multiple determinations. Dye degradation in different water matrix was efficiently obtained, as well as multicomponent dyes. Additionally, broad operation pH and good reusing performance make the developed process highly attractive for application. This work provides a solid step-forward of pyrite/hydrogen peroxide Fenton process for treatment of recalcitrant contaminants in wastewater.


Assuntos
Águas Residuárias , Poluentes Químicos da Água , Catálise , Corantes , Peróxido de Hidrogênio , Ferro , Cinética , Oxirredução , Sulfetos
13.
J Air Waste Manag Assoc ; : 1-9, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-33433266

RESUMO

Recycling of waste printed circuit boards (PCBs) receives increasing attention due to abundant metallic resources and significant environmental threats. This work proposes a process for copper recovery from PCBs by froth flotation and oxidation leaching. Copper grade is improved from 38.70% to 68.34% with the recovery of 88.76% by froth flotation, and froth flotation is significantly influenced by copper liberation and particles dispersion of PCB powders. Process variables of oxidation leaching are examined by response surface methodology (RSM). A reliable mathematical model is obtained to predict the response as a function of independent variables and their interactions. Oxidation leaching is remarkably influenced by experimental variables, and the interactions between sulfuric acid and hydrogen peroxide are significant. Optimum conditions are achieved as sulfuric acid 1.0 mol/L, hydrogen peroxide 17%, temperature 50°C, and time 234 minutes, and the maximum leaching ratio of Cu is up to 99.94%, indicating that oxidation leaching is an effective method for Cu recovery from PCBs.Implications: Recycling of waste printed circuit boards (PCBs) receives increasing attention due to abundant metallic resources and significant environmental threats. This work proposes a novel process for copper recovery from PCBs by froth flotation and oxidation leaching. Froth flotation is efficient to enrich copper in metal fractions. Process variables of oxidation leaching are examined by response surface methodology (RSM). A reliable mathematical model is obtained to predict the response as a function of independent variables and their interactions. The froth flotation-oxidation leaching process is practicable and effective for copper recovery from waste printed circuit boards. This study significantly contributes to recycling metal resources from waste PCBs. We believe that this work will attract a broad readership and lead others to follow our approach.

14.
BMJ Open ; 11(1): e041931, 2021 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-33455934

RESUMO

INTRODUCTION: Biliary colic (BC) is a severe pain associated with nausea and vomiting, which is the most common symptom among the gallstone population. This protocol proposes a methodology for conducting a systematic review and meta-analysis that aims to assess the benefits and safety of acupuncture in patients with BC. METHODS AND ANALYSIS: Clinical trials will be identified through nine databases from inception to December 2020, using Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Allied and Complementary Medicine Database (AMED), CINAHL, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), VIP Database and Wanfang Database. Search words will be used for the BC and acupuncture. The analysis would include randomised, controlled, clinical trials of adults with BC that were published in either Chinese or English. The primary outcome is to measure pain relief. Two or three reviewers should be in charge of study selection, data extraction and evaluating the risk of bias. RevMan software (V.5.4) will be used to perform the assessment of the risk of bias and data synthesis. ETHICS AND DISSEMINATION: Ethics approval will not be required for this review, as it will only involve the collection of literature previously published. The results of this meta-analysis will be disseminated in a peer-reviewed journal or relevant conference, through publication. TRIAL REGISTRATION NUMBER: CRD42020167510.


Assuntos
Terapia por Acupuntura , Acupuntura , Cólica , Adulto , China , Cólica/terapia , Humanos , Metanálise como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto
15.
Brain Imaging Behav ; 15(1): 216-230, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32125619

RESUMO

Deqi is taken as an indispensable requirement to achieve acupuncture efficacy. This study aimed to explore the central influence of deqi on the efficacy of acupuncture for functional dyspepsia (FD). 70 FD patients were randomized to receive 20 sessions' acupuncture treatment with (n = 35) and without deqi (n = 35). In each group, 25 FD patients randomly selected underwent functional magnetic resonance imaging (fMRI) scans before and after treatment. After group re-division according to deqi response, changes of amygdala subregions-based resting-state functional connectivity (rsFC) were compared between the acupuncture with and without obvious deqi group. The clinical changes of the Nepean Dyspepsia Symptom Index (NDSI) measuring FD symptoms were also used to further assess the correlation with amygdala subregions rsFC in FD patients. The decrease in the NDSI scores (pre-pos) in the obvious deqi group was significantly greater than that in the acupuncture without obvious deqi group (p < 0.05). Compared to the without obvious deqi group, the obvious deqi group showed significantly decreased the left basolateral amygdala (BLA) rsFC with bilateral insular (INS), putamen and middle/posterior cingulate cortex (MCC/PCC), right pallidum and hippocampus (HIPP) after treatment. The changed NDSI scores(pre-post) of all 41 FD patients was significantly positively correlated with their Fisher's transformed z value of the left BLA rsFC with left INS (r = 0.376, FDR corrected p = 0.015), and rsFC with right HIPP (r = 0.394, FDR corrected p = 0.015). The changed NDSI scores(pre-post) of the obvious deqi group was significantly negatively correlated with their Fisher's transformed z value of the right centromedial amygdala (CMA) rsFC with left medial prefrontal cortex (mPFC) (r = -0.463, p = 0.035). The results tested the hypothesis that the advantage of deqi on efficacy is related to affecting the BLA and CMA rsFC. It suggested that deqi might influence the abnormal rsFC within the salience network (SN), and participate in the adaptive modulation of disrupted relationship between the SN and default mode network (DMN).


Assuntos
Terapia por Acupuntura , Complexo Nuclear Basolateral da Amígdala , Dispepsia , Tonsila do Cerebelo/diagnóstico por imagem , Dispepsia/diagnóstico por imagem , Dispepsia/terapia , Humanos , Imageamento por Ressonância Magnética
16.
J Headache Pain ; 21(1): 141, 2020 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-33287704

RESUMO

OBJECTIVES: To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS). METHODS: Seventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed. RESULTS: Compared with HS, MwoA patients showed decreased volume in the bilateral superior and inferior colliculus, periaqueductal gray matter (PAG), locus ceruleus, median raphe nuclei (MRN) and dorsal pons medulla junction. MwoA patients showed decreased Reho values in the middle occipital gyrus and inferior occipital gyrus, and increased Reho values in the MRN. Only a region in the MRN showed both structural and functional alteration in MwoA patients. Pearson correlation analysis showed that there was no association between volume or Reho values of the MRN and headache frequency, headache intensity, disease duration, self-rating anxiety scale or self-rating depression scale in MwoA patients. Resting state functional connectivity (FC) with the MRN as the seed showed that MwoA patients had increased FC between the MRN and PAG. CONCLUSIONS: MRN are involved in the pathophysiology of migraine during the interictal period. This study may help to better understand the migraine symptoms. TRIAL REGISTRATION: NCT01152632 . Registered 27 June 2010.


Assuntos
Enxaqueca sem Aura , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico , Humanos , Imageamento por Ressonância Magnética , Enxaqueca sem Aura/diagnóstico por imagem , Substância Cinzenta Periaquedutal , Núcleos da Rafe
17.
J Tradit Chin Med ; 40(6): 1041-1051, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33258357

RESUMO

OBJECTIVE: To explore how baseline resting-state cerebral function predicts clinical outcomes of acupuncture treatment for migraine. METHODS: One hundred migraine patients and 46 healthy subjects were recruited. Patients were randomized into the acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected at baseline and after 1 month of longitudinal acupuncture treatments. Fractional amplitude of low-frequency fluctuations (fALFF) calculations were applied to explore the associations between baseline fALFF and changes in clinical variables in the acupuncture treatment group and the waiting list group. RESULTS: Compared with healthy subjects, migraine patients had lower fALFF in the left rostral ventromedial medulla, right thalamus, left amygdala, and right angular gyrus. Regression analyses revealed that baseline fALFF values in the left middle frontal gyrus, left superior temporal gyrus, and middle temporal gyrus were positively associated with headache intensity changes in the acupuncture treatment group, while baseline fALFF values in the bilateral lingual gyrus and cuneus were negatively associated with headache intensity changes in this group. CONCLUSION: The baseline fALFF values of brain regions associated with cognitive pain modulation, but not migraine severity, may predict future headache intensity improvement levels in migraine patients receiving acupuncture treatment.


Assuntos
Terapia por Acupuntura , Encéfalo/diagnóstico por imagem , Cefaleia/terapia , Transtornos de Enxaqueca/terapia , Adulto , Feminino , Cefaleia/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Transtornos de Enxaqueca/diagnóstico por imagem , Resultado do Tratamento , Adulto Jovem
18.
Medicine (Baltimore) ; 99(48): e23292, 2020 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-33235086

RESUMO

BACKGROUND: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders (FGIDs) and significantly influences patients' quality of life. Many studies have found that patients with FD show significant functional abnormalities in multiple brain regions. However, these functional cerebral abnormalities are not fully consistent. This protocol aims to qualitatively and quantitatively assess and synthesize the functional cerebral abnormalities found in FD. METHODS: A systematic search will be conducted in 4 electronic databases (Medline, Web of Science, EMBASE, and the Cochrane Library) from inception to June 30, 2019, with the language restricted to English. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Quality assessment will be performed with a custom 11-point checklist. The functional changes in brain regions and the correlations between these altered brain regions and clinical variables in patients with FD will be evaluated through qualitative review. If data are available, an Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) will be used to synthesize the brain functional alterations and clinical variables in patients with FD. RESULTS: This review and meta-analysis will qualitatively and quantitatively assess and synthesize functional cerebral abnormalities consistently found in FD. CONCLUSION: This may assist in mapping functional brain abnormalities to characterize imaging-based neural markers of FD and improve our knowledge of the pathogenesis of FD. PROSPERO REGISTRATION NUMBER: CRD42019134983 (https://www.crd.york.ac.uk/prospero/).


Assuntos
Encéfalo/fisiopatologia , Dispepsia/fisiopatologia , Neuroimagem/métodos , Adulto , Idoso , Encéfalo/anatomia & histologia , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico/métodos , Dispepsia/complicações , Feminino , Neuroimagem Funcional/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Pesquisa Qualitativa , Qualidade de Vida
19.
Front Psychiatry ; 11: 583619, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33192729

RESUMO

Previous studies had illustrated the significant neural pathological changes in patients with psychogenic erectile dysfunction (pED), while few works focused on the neural underpinning of the psychosocial status in patients with pED. This study aimed to investigate the associations among the altered cerebral activity patterns, impaired erectile function, and the disrupted psychosocial status in patients with pED. Thirty-two patients with pED and 28 healthy controls (HCs) were included. The amplitude of low-frequency fluctuations (ALFF), region-of-interest-based functional connectivity (FC), as well as Pearson correlation analyses and mediation analyses between neuroimaging outcomes and clinical outcomes were performed. Compared to HCs, patients with pED manifested lower erectile function, disrupted psychosocial status, as well as decreased ALFF in the left dorsolateral prefrontal cortex (dlPFC) and reduced FC between the left dlPFC and left angular gyrus, and left posterior cingulate cortex (PCC) and precuneus, which belonged to the default mode network (DMN). Moreover, both the ALFF of the left dlPFC and FC between the left dlPFC and left PCC and precuneus were significantly correlated with the sexual function and psychosocial status in patients with pED. The disrupted psychosocial status mediated the influence of atypical FC between dlPFC and DMN on decreased erectile function. This study widened our understanding of the important role of psychosocial disorders in pathological neural changes in patients with pED.

20.
Neural Plast ; 2020: 8871712, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32908491

RESUMO

The effects of acupuncture facilitating neural plasticity for treating diseases have been identified by clinical and experimental studies. In the last two decades, the application of neuroimaging techniques in acupuncture research provided visualized evidence for acupuncture promoting neuroplasticity. Recently, the integration of machine learning (ML) and neuroimaging techniques becomes a focus in neuroscience and brings a new and promising approach to understand the facilitation of acupuncture on neuroplasticity at the individual level. This review is aimed at providing an overview of this rapidly growing field by introducing the commonly used ML algorithms in neuroimaging studies briefly and analyzing the characteristics of the acupuncture studies based on ML and neuroimaging, so as to provide references for future research.


Assuntos
Terapia por Acupuntura , Mapeamento Encefálico/métodos , Encéfalo/fisiologia , Aprendizado de Máquina , Neuroimagem , Plasticidade Neuronal , Encéfalo/diagnóstico por imagem , Humanos , Processamento de Imagem Assistida por Computador
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