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1.
World J Clin Cases ; 9(26): 7937-7943, 2021 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-34621849

RESUMO

BACKGROUND: Adrenocortical carcinoma (ACC) is a rare and highly invasive endocrine malignant tumor with a poor prognosis. Although surgical resection is the main treatment for ACC, postoperative recurrence and metastasis have become the important factors of death. Transcatheter arterial chemoembolization (TACE) is an important option for the treatment of advanced ACC with liver metastasis. However, due to the small number of patients treated for ACC, the safety of the operation is not completely clear and needs to be further studied. CASE SUMMARY: A 47-year-old patient with ACC after surgery was admitted for reexamination by abdominal computerized tomography suggesting liver metastasis. Because the patient expressed reluctance to undergo surgery again, we treated her with TACE for the liver lesions. After treatment, symptoms of acute adrenal dysfunction such as decreased blood pressure, anorexia, and fatigue appeared, which were relieved after hydrocortisone treatment. To date, the patient's liver lesion is well controlled and no other metastases are observed. CONCLUSION: We report a rare case of acute adrenal hypofunction after TACE. Glucocorticoid supplementation can alleviate the symptoms.

2.
J Diabetes Res ; 2021: 5477941, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34621904

RESUMO

Objective: To systematically study the mechanism of cordyceps cicadae in the treatment of diabetic nephropathy (DN) with the method of network pharmacology and molecular docking analysis, so as to provide theoretical basis for the development of new drugs for the treatment of DN. Methods: TCMSP, Symmap, PubChem, PubMed, and CTD database were used to predict and screen the active components and therapeutic targets for DN. The network of active components and targets was drawn by Cytoscape 3.6.0, the protein-protein interaction (PPI) was analyzed by the STRING database, and the DAVID database was used for the enrichment analysis of intersection targets. Molecular docking studies were finished by Discovery Studio 3.5. Results: A total of 36 active compounds, including myriocin, guanosine, and inosine, and 378 potential targets of cordyceps cicadae were obtained. PPI network analysis showed that AKT1, MAPK8, and TP53 and other targets were related to both cordyceps cicadae and DN. GO and KEGG pathway analysis showed that these targets were mostly involved in R-HSA-450341, 157.14-3-3 cell cycle, and PDGF pathways. Docking studies suggested that myriocin can fit in the binding pocket of two target proteins (AKT1 and MAPK8). Conclusion: Active ingredients of cordyceps cicadae such as myriocin may act on DN through different targets such as AKT1, MAPK8, and TP53 and other targets, which can help to develop innovative drugs for effective treatment of DN.

3.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(5): 832-838, 2021 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-34622601

RESUMO

Objective: To study the distributional characteristics of allergens in children with allergic diseases in Shaanxi province. Methods: A total of 4 622 children diagnosed with allergic diseases in the Asthma Center, Department of Pediatrics, Xijing Hospital from March 2015 to February 2019 were selected. Serum allergen-specific immunoglobulin E (sIgE) of 19 common kinds of allergens were examined with enzyme-linked immunosorbent assay (ELISA). The children were divided into different groups according to sex, age and geographical regions, and the distributional characteristics of allergens of the different groups were compared. Results: The overall positive rate for the 19 allergens of the 4 622 children was 62.8%. The ranking of the positive rates for individual allergens from high to low were as follows: 24.2% for milk, 18.0% for mold mix, 16.7% for dog dander, 16.4% for house dust mite, 11.7% for cat dander, 10.7% for cashew, 10.6% for weed pollen, 8.8% for egg white, 7.8% for house dust, 7.7% for tree pollen, 5.6% for amaranth, 4.9% for mulberry tree, 3.6% for mango, 3.2% for beef, 2.8% for cockroach, 2.1% for crab, 1.5% for shrimp, 0.8% for pineapple, and 0.3% for shellfish. Analysis based on sex showed that the allergen positive rates in boys were higher than those in girls. Analysis by age difference showed that generally the positive rates for inhaled allergens increased along with the increase in patient age, while the positive rates for ingested allergens decreased along with the increase in patient age. Analysis by geographical regions showed that the positive rate of house dust mite in the patients from the southern part of Shaanxi, the positive rate of weed pollen in the patients from the northern part of Shaanxi and the positive rates of milk and egg white in the patients from the central part of Shaanxi were higher than those in other areas. The cluster analysis and correlation analysis showed that the 19 allergens could be roughly divided into 4 categories. There were moderate correlations among tree pollen, mulberry tree and amaranth. There were moderate correlations among mulberry tree, mango and amaranth. There was moderate correlation between shrimp and crab, and there were mild or weak correlations among most of the other allergens. Conclusion: Among the 4 622 children with allergic diseases in Shaanxi Province who were treated in the Asthma Center, Department of Pediatrics, Xijing Hospital, male patients showed higher sensitivity to allergens. The positive rates of inhaled allergens increased, while the positive rates of ingested allergens decreased with increase in patient age. There were regional differences in the distribution of allergens. Some allergens were correlated with each other, which may be related to cross-reaction.


Assuntos
Asma , Hipersensibilidade , Alérgenos , Animais , Asma/epidemiologia , Gatos , Bovinos , Criança , Cães , Poeira , Humanos , Imunoglobulina E , Masculino
4.
Front Chem ; 9: 733350, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34616713

RESUMO

Seven new clerodane diterpenoids, crassifolins Q-W (1-7), along with five known analogues (8-12), were isolated from the roots of Croton crassifolius. Their structures were identified by comprehensive spectroscopic analysis (UV, IR, NMR, and HR-ESI-MS), and their absolute configurations were determined by ECD spectra and X-ray crystallography. The activities of compounds 1-5 against inflammatory cytokines IL-6 and TNF-α levels on LPS-induced RAW 264.7 macrophages were assessed, and compound 5 showed the most significant activity with the secretion levels of IL-6 and TNF-α at 32.78 and 12.53%, respectively. Moreover, compounds 1-5 were screened for their anti-angiogenesis using a human umbilical vein endothelial cells in vitro mode; the results showed all of them exhibited obvious anti-angiogenesis activities, in particular, compound 5 showed the strongest anti-angiogenesis effect in the range of 6.25-50 µM.

5.
China CDC Wkly ; 3(18): 375-377, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-34594887
6.
China CDC Wkly ; 3(18): 378-382, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-34594888

RESUMO

What is already known about this topic?: Occupational noise-induced hearing loss (NIHL) has been the second most common occupational disease in China. Noise energy is the main risk factor for occupational NIHL. Evidence shows the temporal structure of noise (as indicated by kurtosis metric) contribute to the development of NIHL. However, the role of the kurtosis metric in evaluating the risk of occupational NIHL associated with complex noise has been rarely reported. What is added by this report?: Noise temporal structure (as indicated by kurtosis) is an important risk factor for occupational NIHL in addition to noise energy. Kurtosis can be used to quantify complex noise exposure. A combination of noise kurtosis and noise energy can effectively evaluate the risk of occupational hearing loss associated with complex noise. What are the implications for public health practice?: Considering the effect of noise temporal structure on occupational NIHL, the existing international noise exposure standards (e.g. measurement method and noise exposure limit) for complex noise should be modified based on noise temporal structure. More effort is needed to reduce noise exposure, improve health screening, and monitor occupational NIHL.

7.
China CDC Wkly ; 3(18): 383-389, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-34594889

RESUMO

What is already known about this topic?: In recent decades, work-related musculoskeletal disorders (WMSDs) have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world. What is added by this report?: The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants, medical staff, and vegetable greenhouses in that order. Women workers were 1.5 times more likely to suffer from WMSDs than men workers. What are the implications for public health practice?: This study has found the prevalence and distribution characteristics of WMSDs in key industries in China. It is urgent to draw up relevant measures to prevent and control occupational populations with WMSDs.

9.
China CDC Wkly ; 3(20): 434-437, 2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34594907

RESUMO

On October 21, 2019, the "Notice on promoting the healthy enterprises" and "Specification of Healthy Enterprise Construction (trial)" were issued jointly by the National Patriotic Health Campaign Committee Office and six other government partners. As one of the objectives and tasks of the occupational health protection action (2019-2030), this multisectoral "Healthy Enterprise" Action Plan (HEAP) serves as the first "healthy cell" project carried out at the national level as an indispensable part of the Healthy China Initiative and the Healthy City Movement.It is of great significance to recognize the importance of the burden of disease linked to the exposure of occupational risks and the ability to identify the main areas of concern.This article interprets the process of how the healthy workplace or healthy enterprise was originated and evolved; how the theory was introduced and developed in China; and how the 4 main action indicators toward healthier and safer workplaces were formulated including the following: 1) developing the health policy system; 2) building healthy working environments; 3) providing health services; and 4) creating healthy culture. It concludes that the national "healthy enterprise" policy is a specific workplace-based public health practice in the field of occupational health and contributes to build a preventive culture in the context of the Healthy China Initiative. It aims to explore and summarize workplace health promotion models, methods, and experience suitable for China and to disseminate them across China.

10.
Cogn Sci ; 45(10): e13047, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34606131

RESUMO

The learning style myth is a commonly held myth that matching instruction to a student's "learning style" will result in improved learning, while providing mismatched instruction will result in suboptimal learning. The present study used a short online reasoning exercise about the efficacy of multimodal instruction to investigate the nature of learning styles beliefs. We aimed to: understand how learning style beliefs interact with beliefs about multimodal learning; characterize the potential complexity of learning style beliefs and understand how this short exercise might influence endorsements of learning styles. Many participants who believed in the learning style myth supported the efficacy of multimodal learning, and many were willing to revise their belief in the myth after the exercise. Personal experiences and worldviews were commonly cited as reasons for maintaining beliefs in learning styles. Findings reveal the complexity of learning style beliefs, and how they interact with evidence in previously undocumented ways.


Assuntos
Cognição , Aprendizagem , Humanos , Resolução de Problemas
11.
Chin Med J (Engl) ; 134(20): 2438-2446, 2021 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-34620748

RESUMO

BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19), human mobility restriction measures have raised controversies, partly because of the inconsistent findings. An empirical study is promptly needed to reliably assess the causal effects of the mobility restriction. The purpose of this study was to quantify the causal effects of human mobility restriction on the spread of COVID-19. METHODS: Our study applied the difference-in-difference (DID) model to assess the declines of population mobility at the city level, and used the log-log regression model to examine the effects of population mobility declines on the disease spread measured by cumulative or new cases of COVID-19 over time after adjusting for confounders. RESULTS: The DID model showed that a continual expansion of the relative declines over time in 2020. After 4 weeks, population mobility declined by -54.81% (interquartile range, -65.50% to -43.56%). The accrued population mobility declines were associated with the significant reduction of cumulative COVID-19 cases throughout 6 weeks (ie, 1% decline of population mobility was associated with 0.72% [95% CI: 0.50%-0.93%] reduction of cumulative cases for 1 week, 1.42% 2 weeks, 1.69% 3 weeks, 1.72% 4 weeks, 1.64% 5 weeks, and 1.52% 6 weeks). The impact on the weekly new cases seemed greater in the first 4 weeks but faded thereafter. The effects on cumulative cases differed by cities of different population sizes, with greater effects seen in larger cities. CONCLUSIONS: Persistent population mobility restrictions are well deserved. Implementation of mobility restrictions in major cities with large population sizes may be even more important.


Assuntos
COVID-19 , China/epidemiologia , Cidades , Humanos , SARS-CoV-2
12.
J Exp Clin Cancer Res ; 40(1): 325, 2021 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-34656164

RESUMO

BACKGROUND: The small tyrosine kinase inhibitors (TKIs) subversively altered the lung cancer treatments, but patients will inevitably face the therapy resistance and disease recurrence. We aim to explore the potential roles of non-coding RNAs in sensitizing the TKIs effects. METHODS: Multiple cellular and molecular detections were applied to confirm the mechanistic regulations and intracellular connections. RESULTS: We explored the specific gene features of candidates in association with resistance, and found that m6A controlled the stemness of EMT features through METTL3 and YTHDF2. The miR-146a/Notch signaling was sustained highly activated in a m6A dependent manner, and the m6A regulator of YTHDF2 suppressed TUSC7, both of which contributed to the resistant features. Functionally, the sponge type of TUSC7 regulation of miR-146a inhibited Notch signaling functions, and affected the cancer progression and stem cells' renewal in Erlotinib resistant PC9 cells (PC9ER) and Erlotinib resistant HCC827 cells (HCC827ER) cells. The Notch signaling functions manipulated the cMYC and DICER inner cytoplasm, and the absence of either cMYC or DICER1 lead to TUSC7 and miR-146a decreasing respectively, formed the closed circle to maintain the balance. CONCLUSION: PC9ER and HCC827ER cells harbored much more stem-like cells, and the resistance could be reversed by Notch signaling inactivation. The intrinsic miR-146 and TUSC7 levels are monitored by m6A effectors, the alternation of either miR-146 or TUSC7 expression could lead to the circling loop to sustain the new homeostasis. Further in clinics, the combined delivery of TKIs and Notch specific inhibitory non-coding RNAs will pave the way for yielding the susceptibility to targeted therapy in lung cancer.

13.
Technol Cancer Res Treat ; 20: 15330338211048051, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34657505

RESUMO

Objective: To evaluate the safety and efficacy of additional radiotherapy after endoscopic resection (ER) for stage I esophageal carcinoma (EC) with high-risk factors. Materials and methods: Patients with stage cT1N0M0 EC who underwent ER and additional radiotherapy between January 2010 and August 2019 at our institution were retrospectively included. Overall survival (OS), disease-free survival (DFS), cancer-specific survival (CSS), local control rate, regional control rate, common acute toxicities, esophageal stricture, and dysphagia were analyzed. Results: Thirty-one consecutive patients were included in the study. The median age was 62 years (range, 49-78). Thirty patients (96.8%) had squamous cell carcinoma, and one patient (3.2%) had adenosquamous cell carcinoma. Twenty-six patients (83.9%) had submucosal invasion, 15 patients (48.4%) had lymphovascular invasion, and one patient (3.2%) had a venous invasion. The 1-, 3-, and 5-year OS rates were 100.0%, 86.9%, and 68.5%, respectively. The corresponding DFS rates were 100.0%, 85.2%, and 75.8%, respectively. The corresponding CSS rates were 100.0%, 89.8%, and 78.6%, respectively. The local and regional control rates were 100.0% and 93.5%, respectively. No grade 4-5 acute toxicities were observed. Fifteen patients (48.4%) were endoscopically diagnosed with esophageal strictures after ER. At the last follow-up, 28 patients (90.5%) were able to eat a regular diet, one patient (3.2%) could eat a soft diet, one needed a semifluid diet, and only one (3.2%) had to eat a fluid diet. Conclusions: For patients with stage I EC, additional radiotherapy following ER is safe and effective, with the swallowing function well-preserved. Nevertheless, prospective studies are needed to verify these results.

14.
Chin Med J (Engl) ; 2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34653084

RESUMO

BACKGROUND: Intravenous thrombolysis (IVT) is an effective way for treating acute ischemic stroke (AIS). However, its effects have not been established among AIS patients with unclear stroke symptoms or with stroke onset for >4.5 h. METHODS: We searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and Google Scholar databases for randomized controlled trials that compared IVT (IVT group) and placebo or usual care (control group [CG]) in AIS patients with disease onset for >4.5 h. The outcomes of interest included the favorable functional outcome (defined as modified Rankin Scale [mRS] scores 0-1) at 90 days, the functional independence (defined as mRS scores 0-2) at 90 days, proportion of patients with symptomatic intracerebral hemorrhage (sICH) and death at 90 days. We assessed the risk of bias using the Cochrane tool. Pre-specified subgroup analyses were performed by age (≤70 years or >70 years), National Institute of Health Stroke Scale (NIHSS, ≤10 or >10) and time window (4.5-9.0 h or >9.0 h). RESULTS: Four trials involving 848 patients were eligible. The risk of bias of included trials was low. Patients in the IVT group were more likely to achieve favorable functional outcomes (45.8% vs. 36.7%; OR 1.48, 95% CI 1.12-1.96) and functional independence (63.8% vs. 55.7%; OR 1.43, 95% CI 1.08-1.90) at 90 days, but had higher risk of sICH (3.0% vs. 0.5%; OR 5.28, 95% CI 1.35-20.68) at 90 days than those in the CG. No significant difference in death at 90 days was found between the two groups (7.0% vs. 4.1%; OR, 1.80; 95% CI, 0.97-3.34). CONCLUSIONS: Use of IVT in patients with extended time window may improve their functional outcomes at 90 days, although IVT may induce increased risk of sICH. Care of these patients should well balance the potential benefits and harms of IVT.

15.
Artigo em Inglês | MEDLINE | ID: mdl-34653258

RESUMO

OBJECTIVE: To evaluate the efficiency, postoperative hysterectomy rate, and influencing factors for therapeutic effect of NovaSure endometrial ablation procedure in abnormal uterine bleeding (AUB) . METHODS: We conducted a retrospective cohort study of 2152 patients from department of Gynecology, the Third Xiangya Hospital, CSU from October 2010 to December 2018. RESULTS: From the first year to the eighth year after operation, annual effective rate was above 95.24%, and the differences were not statistically significant. There are statistically significant differences between the effective and the ineffective group with regard to age, intrauterine polyps, total length of the uterus, systemic coagulation disorder, and preoperative hemoglobin. A multivariate logistic regression analysis showed that the risk factors associated with systemic coagulation disorders (P=0.027) and long total uterine length (P=0.003) affected NovaSure efficacy in the treatment of AUB. By December 2019, the postoperative hysterectomy rate was 1.86% (40/2152) and the complication rate was 1.67% (36/2152). CONCLUSION: NovaSure is a reliable treatment for AUB and serious medical complications due to its simple operation, low amount of bleeding, quick postoperative recovery, and safe and effective short-term and long-term efficacy. However, it should be carefully selected for patients with a total uterus length exceeding 10 cm.

16.
Nat Cell Biol ; 23(10): 1057-1059, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34616020
17.
Funct Plant Biol ; 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34600597

RESUMO

There is limited information concerning the formation of dot-like browning appearing at the base of trichomes on mature leaves on the Chinese cabbage (Brassica campestris L. ssp. pekinensis). This study confirmed for the first time that enhanced autofluorescence can be induced in the base of trichomes when pressure stimuli is applied to trichomes; the enhanced autofluorescence gradually moves to the top of trichomes and the neighbouring mesophyll tissue within 15min. The excitation of autofluorescence in trichomes was found to be more effective in mature leaves compared to newly emergent leaves. Increased polyphenol oxidase (PPO) activities and reactive oxygen species (ROS) accumulation were also detected in the basal region of trichomes that were subjected to mechanical stimuli. Enhanced fluorescence was observed at the top of the trichomes in senescencing leaves. A browning in the base of the trichomes during leaf senescence was observed. In contrast, no browning occurred at the base of the trichomes in leaves that were subject to pressure stimuli. The blue fluorescence in the trichomes in senescent leaves arises mainly from the condensed cytoplasm. No direct evidence was able to prove that the enhanced autofluorescent substances in the trichomes during leaf senescence are the cause of the browning at the early growth stages.

18.
Entropy (Basel) ; 23(9)2021 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-34573745

RESUMO

This paper investigates the usage of logic and logic programming in the design of smart contracts. Our starting point is the logic-based programming language for smart contracts used in a recently proposed framework of quantum-secured blockchain, called Logicontract (LC). We then extend the logic used in LC by answer set programming (ASP), a modern approach to declarative logic programming. Using ASP enables us to write various interesting smart contracts, such as conditional payment, commitment, multi-party lottery and legal service. A striking feature of our ASP implementation proposal is that it involves post-quantum cryptographic primitives, such as the lattice-based public key encryption and signature. The adoption of the post-quantum cryptographic signature overcomes a specific limitation of LC in which the unconditionally secure signature, despite its strength, offers limited protection for users of the same node.

19.
World Neurosurg ; 2021 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-34587518

RESUMO

BACKGROUND: Vestibular schwannoma (VS) is the third most common benign intracranial tumor that can occur sporadically (SVS) or be associated with neurofibromatosis type 2 (NF2-VS). The aim of this study is to provide a comprehensive bioinformatic analysis of methylated differentially expressed genes (MDEGs) in NF2-VS. METHODS: Transcriptional sequencing datasets (GSE141801, GSE108524) and gene methylation microarrays (GSE56598) from the Gene Expression Omnibus (GEO) database were employed to identify and analyze MDEGs in NF2-VS. A protein-protein interaction (PPI) network was built and the hub genes and modules were identified. Finally, potential pharmacotherapy targeting MDEGs were extracted for NF2-VS. RESULTS: A total of 57 hypermethylation-low expression genes and 88 hypomethylation-high expression genes were identified. Pathways associated with aberrantly MDEGs included P13K-AKT, MAPK pathway and Ras, which were also involved in NF2-VS. Six hub genes namely, EGFR, CCND1, CD53, CSF1R, PLAU, and FGFR1 were identified from the PPI network. Modification of the above mentioned genes altered cell-to-cell communication, response to stimulus, cellular regulation and membrane and protein bindings. Thirty drugs targeting these pathways were selected based on the hub genes. CONCLUSIONS: Analysis of MDEGs may enrich the understanding of the molecular mechanisms of NF2-VS pathogenesis and lay the groundwork for potential biomarkers and therapeutic targets for NF2-VS.

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