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1.
Food Chem ; 304: 125397, 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-31479996

RESUMO

Branched polyethyleneimine functionalized reduced graphene oxide (BPEIGn) was prepared by a one-step reaction, catalyzed by NaOH, using branched polyethyleneimine (BPEI) and graphene oxide (GO) without reductant hydrazine hydrate or sodium borohydride. The branched polyethylenimine acted as both a grafting agent and a reducing agent of GO. An competitive electrochemical immunosensor based on the Au/sodium mercaptopropanesulfonate/BPEIGn/gold nanoparticles/melamine (Au/MPS/BPEIGn/AuNPs/Mel) modified electrode was constructed for the determination of melamine. The double amplification of BPEIGn and AuNPs increased the sensitivity of the sensor. The melamine was detected by differential pulse voltammetry (DPV) in buffer solution (pH 7.4) containing K3(Fe(CN)6]/K4[Fe(CN)6]. Under optimized conditions, the proposed melamine immunosensor showed a linear relationship in the concentration range of 1 × 10-6 to 1 µM, with a detection limit of 2.66 × 10-7 µM.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31698705

RESUMO

The relationship between religion and happiness has been seriously understudied in non-Western and non-Islamic societies. Taking religious identity and religious practice as strata, the 2015 Chinese General Social Survey (CGSS) data were used to examine the predicting power of health, politics, and social relationships with regard to happiness in four different groups, as follows: People with a religious identity and practice, people with no religious identity but with a practice, people with a religious identity but no practice, and people with neither a religious identity nor practice. Multiple regression analyses were conducted using the Ordinary Least Squares method. The results demonstrate the influence of the independent variables in the four groups, thus confirming the expectation that different religious practices, as well as identities, play a vital role in moderating the degree of happiness. Physical and mental health are significant predictors of happiness regardless of different religious situations, with the effect of mental health here found to be greater in magnitude on happiness than that of physical health. Political participation was not found to be related to happiness, but having a left-wing political attitude did emerge as strongly predicting happiness. The results concerning social relationships further consolidate the hypothesis that religious practice should be taken into consideration separately from religious identity. This study indicates the importance of further investigating religious practice as an independent factor in religious studies in the context of Chinese society.

3.
Artigo em Inglês | MEDLINE | ID: mdl-31653053

RESUMO

PURPOSE: Very few studies have examined the influential factors of survivors' feelings of happiness in the context of nuclear accidents. This paper aims to fill this gap with reference to the recovery process in Fukushima City following the 2011 Tohoku Earthquake Tsunami in Japan. METHODS: Open access data were sourced from the 2015 Social Survey on Living and Disaster Recovery (SSLDR) (N = 1439) of Fukushima citizens. Pearson's Chi-square Test and the t-test were employed to examine gender differences with regard to happiness and exploratory variables. Following this, a multiple linear regression analysis was conducted to investigate the determinants of happiness. RESULTS: The results showed that, compared to females, male respondents were unhappier and reported more property loss and less neighborhood connectedness. Individuals' mental and physical health and neighborhood connectedness were found to be significantly correlated with their happiness. However, the disaster-related variables of people's evaluation of recovery achievement, concerns around the health impacts of radiation, property loss in the disaster, and experiences of casualty, had no effects on happiness. CONCLUSION: These findings indicate that policies and countermeasures dealing with disaster recovery over the long term should continuously focus on health issues and social relationships.

4.
Exp Gerontol ; 128: 110743, 2019 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-31629801

RESUMO

Parkinson's disease is the second most common neurodegenerative disease. Its main pathological feature is the substantial nigra-striatum dopaminergic neuronal dysfunction, which causes insufficient release of DA, induces motor symptoms, and is accompanied by nonmotor symptoms. Schisandrol A belongs to lignan components and has anti-inflammatory, antioxidant and neuroprotective effects. In this experiment, we injected 6-OHDA into medial forebrain bundle of C57BL/6J male mice to establish the model. The motor function of mice was examined by open field test and pole test, the depression-like behavior of mice was examined by sucrose preference test and the memory function was examined by Y maze. We found that schisandrol A (20 mg/kg/d) could significantly improve the motor symptoms, and alleviate the depression-like symptoms and memory dysfunction of PD mice induced by 6-OHDA. Then we studied the neuroprotective mechanism of schisandrol A by H.E., ELISA assay kits and Western blot. Results showed that schisandrol A may enhance the PI3K/AKT pathway, inhibit the IKK/IκBα/NF-κB pathway, reduce neuronal inflammation and oxidative stress, and enhance the survival of DA neurons in the brain of mice. These results indicate that schisandrol A is expected to be a potential drug for improving Parkinson's disease.

5.
Cell Death Dis ; 10(9): 641, 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31488810

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

6.
Phytother Res ; 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31468620

RESUMO

The present study was undertaken to explore the interactions between sleep deprivation (SD) and Schisandrae Chinensis Fructus (SCF) treatment in the antidepressant-like effects. We observed that SD aggravated the anxiety-like behavior induced by chronic unpredictable mild stress (CUMS) in the elevated plus maze test. However, the forced swimming test and sucrose preference test showed that SD (12 hr) alleviated the depressive symptoms and SD (72 hr) has the opposite effects. Administration of SCF showed a promising therapeutic effect on depression and anxiety induced by CUMS and SD. Moreover, SCF could potential strengthen the antidepressant-like effects of SD (12 hr) according to the behavioral tests. In addition, the BDNF level in hippocampus was elevated by SD (12 hr) and SCF treatment and together with the upregulation of TrkB/CREB/ERK and PI3K/AKT/GSK3ß/mTOR signaling pathways. Besides, the protein levels of p70S6K and PSD95, which are downstream targets of mTOR, also increased by the treatment. These results indicated that the antidepressant-like effect of SCF in the CUMS depends on the activation of BDNF and the modulation of TrkB/CREB/ERK and PI3K/AKT/GSK3ß/mTOR signaling cascades, and SD (12 hr) shared a common etiology consisting of complex bidirectional interactions with SCF.

7.
Cell Death Dis ; 10(8): 598, 2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31395859

RESUMO

Myeloid-derived suppressor cells (MDSCs) comprise a critical component of the tumor environment and CXCR2 reportedly plays a key role in the pathophysiology of various inflammatory diseases. Here, CXCR2 expression on granulocyte and macrophage progenitor cells (GMPs) was found to participate in myeloid cell differentiation within the tumor environment. In CXCR2-deficient tumor-bearing mice, GMPs exhibited fewer macrophage and dendritic cell progenitor cells than wild-type tumor-bearing mice, thereby decreasing monocytic MDSCs (mo-MDSCs) expansion. CXCR2 deficiency increased SAP18 expression in tumor-bearing mice, which reduced STAT3 phosphorylation through restraining ERK1/2 activation. Our findings reveal a critical role for CXCR2 in regulating hematopoietic progenitor cell differentiation under tumor conditions, and SAP18 is a key negative regulator in this process. Thus, inhibiting CXCR2 expression may alter the tumor microenvironment and attenuate tumor progression.

8.
PLoS One ; 14(7): e0215585, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31306422

RESUMO

Tick-borne pathogens (TBPs) seriously affect cattle production and can be economically damaging. The epidemiology of these organisms in the Chongqing municipality of China is not well described. This study aimed to investigate the prevalence and risk factors of TBPs including Anaplasma spp., Babesia spp. and Theileria spp. in cattle in Chongqing municipality. The results showed that 43.48% (150/345) of cattle were infected with at least one TBP, of which single infections were detected in 104 (30.14%), double infections in 34 cattle (9.86%) and triple infections in 12 (3.48%) of the cattle. The overall prevalence of Anaplasma spp., Theileria spp. and B. bigemina were 22.32%, 23.19% and 7.24%, respectively. Among these, the prevalence of A. bovis, A. central, A. phagocytophilum, A. platys, A. marginale, T. sinensisi and T. orientalis were 8.41%, 7.83%, 4.93%, 4.35%, 2.61%, 22.32% and 2.60%, respectively. We could not detect B. bovis, T. annulata, T. luwenshuni or T. uilenbergi in cattle. Cattle ≥1-year-old were more likely to be infected with Theileria spp. [adjusted odd ratio (AOR) = 2.70, 95% CI = 1.12-6.56)] compared with younger cattle, while cattle ≥1-year-old had reduced susceptibility to B. bigemina (AOR = 0.14, 95% CI = 0.03-0.60). Cattle living at higher altitude (≥500 m) were more susceptible to B. bigemina (AOR = 6.97, 95% CI = 2.08-23.35) and Theileria spp. infection (AOR = 1.87, 95% CI = 1.06-3.32). The prevalence of Theileria spp. on farms with cats was significantly higher than that without cats (AOR = 2.56, 95% CI = 1.12-5.88). Infection with A. bovis and A. central were significantly associated with A. phagocytophilum infection. Furthermore, there were significant associations between A. bovis and A. central infection, T. sinensisi and A. marginale infection, and B. bigemina and T. orientalis infection. This study provides new data on the prevalence of Anaplasma spp., Babesia spp. and Theileria spp. in cattle in Chongqing, and for the first time we reveal a possible relationship between the afore-mentioned pathogens, which will help in formulating appropriate control strategies for these pathogens in this area.

9.
BMC Evol Biol ; 19(1): 157, 2019 07 27.
Artigo em Inglês | MEDLINE | ID: mdl-31351448

RESUMO

BACKGROUND: Cetaceans exhibit an exceptionally wide range of body size, yet in this regard, their genetic basis remains poorly explored. In this study, 20 body-size-related genes for which duplication, mutation, or deficiency can cause body size change in mammals were chosen to preliminarily investigate the evolutionary mechanisms underlying the dramatic body size variation in cetaceans. RESULTS: We successfully sequenced 20 body-size-related genes in six representative species of cetaceans. A total of 46 codons from 10 genes were detected and determined to be under strong positive selection, 32 (69.6%) of which were further found to be under radical physiochemical changes; moreover, some of these sites were localized in or near important functional regions. Interestingly, positively selected genes were well matched with body size evolution: for small cetaceans, strong evidence of positive selection was detected at ACAN, OBSL1, and GRB10, within which mutations or duplications could cause short stature; positive selection was found in large cetaceans at CBS and EIF2AK3, which could promote growth, and at the PLOD1 gene, within which mutations could cause tall stature. Importantly, relationship analyses revealed that the evolutionary rate of CBS was positively related to body length and body mass with statistical significance. Additionally, we identified 32 cetacean-specific amino acid changes in 10 genes. CONCLUSIONS: This is the first study to investigate the molecular basis of dramatic body size variation in cetaceans. Our results provide evidence of the positive selection of several body-size-related genes in cetaceans, as well as divergent selection between large or small cetaceans, which suggest cetacean body size variation possibly associated with these genes. In addition, cetacean-specific amino acid changes might have played key roles in body size evolution after the divergence of cetaceans from their terrestrial relatives. Overall, the evolutionary pattern of these body-size-related genes could provide new insights into genetic mechanisms for the body size variation in cetaceans.


Assuntos
Tamanho Corporal/genética , Cetáceos/genética , Evolução Molecular , Animais , Filogenia , Análise de Regressão , Seleção Genética , Especificidade da Espécie
10.
Clin Lab ; 65(6)2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31232014

RESUMO

BACKGROUND: Previous research showed that virus infection is correlated with the occurrence, development, and prognosis of AA. This study was designed to explore the influence of virus infection on the immune functionality and immunosuppressive therapy (IST) efficiency of newly diagnosed SAA patients. METHODS: Fifty-six newly diagnosed SAA patients combined with virus infection treated in the Hematology Department of Tianjin Medical University General Hospital from October 2004 to July 2014 were studied. Various immune parameters were tested and compared for SAA patients with and without virus infection. RESULTS: When compared with SAA patients without corresponding virus infection, SAA patients with CMV-IgM, PVB19-IgM, and EBV infection had increased CD8+ T cell percentage, decreased CD4+/CD8+ T cell ratios, and increased CD8+HLA-DR+/CD8+ percentage. The absolute value of CD8+ T cell of CMV-IgM group had increased as well. The CMV-IgM and PVB19-IgM groups showed decreased CD4+ T cell percentage, and decreased CD4+HLA-DR+/CD8+HLA-DR+ ratio. The PVB19-IgM group exhibited decreased CD4+HLA-DR+/CD4+ percentage, increased Th1 percentage and increased pDC percentage. Patients with EB virus infection showed lower NK cell percentage. Three years after IST, the treatment is significantly less effective for the SAA patients combined with virus infection than those without. CONCLUSIONS: CMV, PVB19, and EBV infection worsen the immune functionality abnormality of newly diagnosed SAA patients and reduce the IST efficiency.

11.
Arch Oral Biol ; 105: 1-4, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31195182

RESUMO

OBJECTIVE: The aim of this study is to investigate the role of long non-coding RNAs (lncRNA), mortal obligate RNA transcript (MORT), in human periodontal ligament stem cells. DESIGN: Periodontal ligament tissues were collected from 48 periodontitis patients underwent tooth extraction and 38 people in similar age and gender distributions who experienced orthodontic treatment. After treatment, periodontitis patients were followed up for 2 years. MORT in periodontal ligament stem cells (PDLSCs) was detected by qRT-PCR. Proliferation of PDLSCs was detected by CCK-8 assay. RESULTS: The proliferation rate of PDLSCs isolated from periodontitis-affected teeth was significantly higher than PDLSCs from healthy teeth. Overexpression of MORT inhibited the proliferation of both types of periodontal ligament stem cells. After treatment, periodontitis patients were followed up for 2 years and patients with high level of MORT expression showed relatively lower recurrence rate comparing to low expression group. CONCLUSION: MORT is involved in the proliferation of human PDLSCs and affects the recurrence of periodontitis.

12.
Dalton Trans ; 48(16): 5450-5458, 2019 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-30957800

RESUMO

Six metal-organic frameworks with the combination of a novel tripodal ligand tris[4-(1H-imidazol-1-yl)phenyl]phosphine oxide (tipo) and different polycarboxylates, namely [Zn2(bpdc)2(tipo)(H2O)]·5H2O (1), [Cd(tipo)2][Cd2(bdc)3]·4H2O (2), [Cd2(ndc)2(tipo)2]·3H2O (3), [Cd2(bpedc)2(tipo)2]·15H2O (4), [Cd2(hfdc)2(tipo)2]·10H2O (5) and [Ni2(tipo)2(bpedc)(H2O)4]·2NO3·2DMF (6), were synthesized and structurally characterized. Compound 1 featured a 2D → 3D parallel polycatenation of a 3,3,4-connected net with an unusual 4 degrees of catenation and an index of separation of 2. Compound 2 showed an unprecedented polycatenation of charged networks 2D kgd and 3D pcu constructed by different organic ligands. Compound 3 exhibited a combination of a 2D → 3D parallel polycatenation of the sql net and polythreading. Compound 4 featured a 4-fold interpenetration of a 3,5-connected 3,5T1 net. Compound 5 displayed an unusual 2-fold interpenetration of the sdd net. Compound 6 presented a 2-fold interpenetration of the 3,4-connected bey net with a cationic framework. The luminescence properties of 1-5 in the solid state were investigated. Also, compound 6 showed a tendency for rapid selective dye capture and highly efficient Cr2O72- removal from aqueous solution.

13.
J Cell Biochem ; 120(9): 14360-14371, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30983015

RESUMO

The atherosclerosis in the arterial system of the extremities is considered as the major pathogenesis of peripheral arterial disease. The present work aimed to explore the potential role of long noncoding RNA activated by tumor growth factor-ß (lncRNA-ATB) on the dysfunction of endothelial cells. Human microvascular endothelial cells (HMEC-1) were transfected with lncRNA-ATB expressing vectors, and then the formation of tubes and expression of proteins associated with angiogenesis were analyzed using microscope and reverse transcription-quantitative polymerase chain reaction (RT-qPCR)/Western blot analysis. Cell viability, migration, and microRNA-195 (miR-195) expression were examined by Cell Counting Kit-8 assay, modified Boyden chambers, Western blot analysis, and RT-qPCR. The interaction between lncRNA-ATB and miR-195 was determined by RT-qPCR, dual-luciferase reporter assay, and biotin-avidin pull-down assay. Finally, expression of key kinases in the PI3K/AKT and MEK/ERK pathways was determined by Western blot analysis. We found vascular tubulogenesis was induced spontaneously when HMEC-1 cells were cultured in Matrigel-coated plates. lncRNA-ATB overexpression increased cell viability, migration and formation of tubes, along with upregulation of matrix metalloproteinase-2 (MMP-2), MMP-9, and vascular endothelial growth factor. Then, we found lncRNA-ATB worked as a molecular sponge for miR-195, and the effects of lncRNA-ATB on HMEC-1 cells were reversed by miR-195 overexpression while were augmented by miR-195 inhibition. Phosphorylated levels of key kinases in the PI3K/AKT and MEK/ERK pathways were increased by lncRNA-ATB via miR-195. In conclusion, lncRNA-ATB enhanced cell viability, migration and angiogenesis in HMEC-1 cells through sponging miR-195. Moreover, the PI3K/AKT and MEK/ERK pathways were activated by lncRNA-ATB via miR-195.

14.
Environ Pollut ; 250: 1-7, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30981178

RESUMO

Plastic film mulching is a common practice to increase crop yield in dryland, while the wide use of plastic film has resulted in ubiquitous phthalate esters (PAEs) releasing into the soil. PAEs in soil could be taken up and accumulated by dietary intake of food crops such as wheat, thus imposing health risks to residents. In the present study, samples from a long-term location-fixed field experiment were examined to clarify the accumulation of PAEs in soil and wheat, and to assess the human health risks from PAEs via dietary intake of wheat grain under plastic film mulching cultivation in dryland. Results showed that concentrations of PAEs in grains from mulching plots ranged from 4.1 to 12.6 mg kg-1, which were significantly higher than those in the control group. There was a positive correlation for the PAE concentrations between wheat grains and field soils. Concentrations of PAEs in the soil were in the range of 1.8-3.5 mg kg-1 for the mulching treatment, and 0.9-2.7 mg kg-1 for the control group. Di-n-butyl phthalate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) were detected in all soil and grain samples, and DEHP was found to be the dominant PAE compound in grains. Based on DEHP concentrations in wheat grains, the values of carcinogenic risk for adults were higher than the recommended value 10-4. Results indicated that wheat grains from film mulching plots posed a considerable non-carcinogenic risk to residents, with children being the most sensitive resident group. Findings of this work call the attention to the potential pollution of grain crops growing in the plastic film mulching crop production systems.


Assuntos
Dibutilftalato/análise , Dietilexilftalato/análise , Grão Comestível/química , Plásticos/química , Poluentes do Solo/análise , Triticum/metabolismo , Criança , Produção Agrícola/métodos , Dibutilftalato/metabolismo , Dietilexilftalato/metabolismo , Humanos , Medição de Risco , Solo/química , Poluentes do Solo/metabolismo
15.
Curr Pharm Des ; 25(3): 236-241, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30864496

RESUMO

Abnormal activation of the immune system plays an important role in the pathogenesis of aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune network, leading to bone marrow failure. The known pathogenesis is an increase of the myeloid dendritic cell (mDC)/ plasmacytoid dendritic cell (pDC) ratio, which causes the ratio of T helper (Th)1/Th2 to be skewed in favor of Th1 and eventually leads to an abnormal activation of cytotoxic T lymphocyte (CTL). The antigens that stimulate T cells in the context of AA remain unknown. In this process, regulatory T (Treg), Th17, natural killer (NK) cell, memory T cell and negative hematopoietic regulatory factors are also involved. In addition, genetic background (e.g., chromosomal abnormalities, telomere attrition, somatic cell mutations), abnormal bone marrow hematopoietic microenvironment and viral infection may also contribute to the pathogenesis of AA. This review summarizes the recent studies of the pathogenesis of AA and the current status of AA research.

17.
Cell Biochem Funct ; 37(2): 62-71, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30773655

RESUMO

Osteogenesis is the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. MicroRNAs (miRNAs) are short noncoding RNAs that target specific genes to mediate translational activities. In this study, we investigated how miR-224 regulates the osteoblastic differentiation of human MSCs (hMSCs) as well as the underlying mechanism. The results revealed the upregulation of miR-224 during hMSC differentiation. In vitro experiments showed that the downregulation of miR-224 suppressed the differentiation of hMSCs into osteoblasts. However, upregulation of miR-224 was concomitant with increased expression of relevant genes and augmented activity of alkaline phosphatase. Furthermore, the results indicated that Rac1 acted as the bona fide target of miR-224 and that Rac1 depletion promoted osteogenic differentiation in miR-224-silenced hMSCs. In addition, we found that both JAK/STAT3 and Wnt/ß-catenin pathways were repressed by Rac1 depletion using quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blotting, and immunofluorescence. Our data indicate a novel molecular mechanism in relation to hMSCs differentiation into osteoblasts, which may facilitate bone anabolism via miR-224. SIGNIFICANCE OF THE STUDY: In this study, we mainly explored the effects of miR-224 on hMSCs differentiation into osteoblasts. We find that induced miR-224 expression in hMSCs is considered closely associated with specific osteogenesis-related genes, alkaline phosphatase activity, and matrix mineralization, indicating that miR-224 may serve as a promising biomarker for osteogenic differentiation. Our data indicate a novel molecular mechanism in relation to hMSCs differentiation into osteoblasts, which may facilitate bone anabolism via miR-224.


Assuntos
Diferenciação Celular , Células-Tronco Mesenquimais/metabolismo , MicroRNAs/metabolismo , Osteoblastos/metabolismo , Transdução de Sinais , Proteínas rac1 de Ligação ao GTP/metabolismo , Linhagem Celular Transformada , Humanos , Células-Tronco Mesenquimais/citologia , MicroRNAs/genética , Osteoblastos/citologia , Proteínas rac1 de Ligação ao GTP/genética
18.
Medicine (Baltimore) ; 98(3): e14149, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30653151

RESUMO

To investigate if variations in immune and hematopoietic parameters correlated with immunosuppressive therapy (IST) in severe aplastic anemia (SAA) patients.A total of 115 SAA patients who received IST were included. Their immune and hematopoietic functionality changes had been evaluated at 0, 0.5, 1, 2, and 3-year(s) IST.For SAA patients with complete remission (CR), the CD4/CD8T cell ratio continued to increase after a year of IST. The T helper (Th)1/Th2 ratio continued to decrease after 6 months of IST, as did the activated CD8 T cell percentage. The myeloid dendritic cell (mDC)/plasmacytoid dendritic cell (pDC) ratio after 3 years of IST was significantly lower compared to that of untreated patients. The mDC/pDC and Th1/Th2 ratios exhibited positive correlation. The activated CD8 T cell percentage and the number of peripheral blood neutrophils showed inverse correlation. For SAA patients with partial remission (PR), the CD4T cell percentage increased at 1-year post-IST, but the later changes were not statistically significant. The other immune indexes of patients in partial remission group and nonremission (NR) group showed no obvious recovery. For all SAA patients, the percentage of T regulatory cells in CD4 lymphocyte was higher in post-IST group compared to the pretreatment group.For SAA patients responded well to IST, increase in peripheral neutrophils and improvement in bone marrow myeloid cells were first observed followed reduction in the activated CD8 T cell percentage, Th1/Th2 ratio, CD4/CD8T ratio, along with mDC/pDC ratio, all of which negatively correlated with the hematopoietic parameters. This demonstrates that IST prompts improvements of hematopoietic functionalities of the SAA patients by regulating their immune functionalities.


Assuntos
Anemia Aplástica/tratamento farmacológico , Hematopoese/efeitos dos fármacos , Imunossupressores/efeitos adversos , Subpopulações de Linfócitos T/efeitos dos fármacos , Adolescente , Adulto , Anemia Aplástica/imunologia , Anemia Aplástica/fisiopatologia , Medula Óssea/efeitos dos fármacos , Criança , Estudos de Coortes , Feminino , Citometria de Fluxo , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Adulto Jovem
19.
Sci Total Environ ; 660: 177-187, 2019 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-30640086

RESUMO

Remote sensing based vegetation index provides a practical method for the monitoring of vegetation dynamics at regional and global scales. Here, using a long-term remotely sensed normalized difference vegetation index (NDVI) dataset, we quantified the vegetation changes in the Loess Plateau (LP) over the last three decades (1982-2015), which includes the period before the Chinese"Grain for Green Program"(GGP) was launched (1982-1999), and the period after the GGP (1999-2015). The correlations between the NDVI and four climate related variables, i.e., precipitation, temperature, root-soil moisture (RSM), and a drought proxy-standardized evapotranspiration deficit index (SEDI), were also examined. The results indicated that, (i) the GGP strongly changed the vegetation in the LP. The growing-season mean NDVI (GSM-NDVI) and the annual mean NDVI (AM-NDVI) decreased slightly before the GGP launched in 1999, with slopes of -3.38×10-3 and-8.00×10-4year-1, respectively. However, they showed slight and significant (p<0.05) increases after the GGP, with slopes of 4.75×10-3 and 2.32×10-3year-1, respectively. (ii) Climate change (i.e., warming and drying) resulted in adverse effects on vegetation in the LP during the period before the GGP. However, the observed changes (i.e., wetting and reduced drought) exerted positive effects on the vegetation during the period after the GGP. (iii) Inter-annual variations of spatially averaged NDVI over the LP were primarily determined by RSM rather than any other climate related variables. In the southeastern LP, the inter-annual variation of GSM-NDVI was mainly determined by precipitation and SEDI, while the inter-annual variation of AM-NDVI was mainly caused by SEDI and RSM. Inter-annual variations of both GSM-NDVI and AM-NDVI were mainly determined by SEDI and RSM in the northwestern LP, and by temperature in the southwestern LP.


Assuntos
Agricultura/métodos , Biota , Mudança Climática , Monitoramento Ambiental , Pradaria , Plantas , China
20.
Drug Des Devel Ther ; 13: 183-203, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30643386

RESUMO

Objective: To systematically evaluate the efficacy and safety of sodium cantharidinate and vitamin B6 (SC/B6) combined with conventional medical treatment (CMT) for the treatment of patients with advanced digestive system neoplasms (DSNs). Methods: The Cochrane Library, Embase, PubMed, Web of Science, Chinese Scientific Journal Database (VIP), China National Knowledge Infrastructure, and Wanfang databases were searched for clinical trials using SC/B6 for DSNs. Outcome measures, including therapeutic efficacy, quality of life (QoL), and adverse events, were extracted and systematically evaluated. Results: Data from 24 trials including 1,825 advanced DSN patients were included. Compared with CMT alone, its combination with SC/B6 significantly improved the patients' overall response rate (OR =2.25, 95% CI =1.83-2.76, P<0.00001), disease control rate (OR =2.41, 95% CI =1.85-3.15, P<0.00001), and QoL improvement rate (OR =2.75, 95% CI =2.13-3.55, P<0.00001). Moreover, adverse events caused by chemotherapy, including leukopenia, nausea and vomiting, gastrointestinal side effects, hepatotoxicity, diarrhea, transaminase disorder, myelosuppression, anorexia, and anemia, were significantly alleviated (P<0.05) when SC/B6 was applied to DSN patients. Nephrotoxicity, thrombocytopenia, hand-foot syndrome, and oral mucositis were not significantly alleviated in patients receiving combination therapy (P>0.05). Conclusion: The combination of SC/B6 and CMT is more effective in treating DSNs than CMT alone. This combination alleviates the adverse effects associated with chemotherapy and improves the QoL of DSN patients, and its application in the clinic is worth promoting.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Cantaridina/análogos & derivados , Neoplasias do Sistema Digestório/tratamento farmacológico , Segurança do Paciente , Vitamina B 6/uso terapêutico , Administração Oral , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Cantaridina/administração & dosagem , Cantaridina/efeitos adversos , Cantaridina/uso terapêutico , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Vitamina B 6/administração & dosagem , Vitamina B 6/efeitos adversos
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