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1.
Opt Express ; 29(21): 34051-34065, 2021 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-34809203

RESUMO

It is a challenge to retrieve atmospheric sulphur hexafluoride (SF6) with high resolution solar spectra because it has only one single retrieval micro window and has interfered with many factors in the retrieval. Optical misalignment is one of the key factors that affect the accuracy of SF6 retrieval. In this study, we first present a long term time series of the SF6 total column over Hefei, China, between January 2017 and December 2020, retrieved by mid-infrared (MIR) solar spectra recorded by ground-based high-resolution Fourier transform infrared spectroscopy (FTIR). The sensitivities of the total column, root mean square of fitting residual (RMS), total error budgets, degrees of freedom for signal (DOFs), and vertical mixing ratio (VMR) profile with respect to different levels of optical misalignment for SF6 retrieval were assessed. The SF6 total column is sensitive to optical misalignment. In order to avoid inconsistencies in the total column due to optical misalignment, we use the true instrumental line shape (ILS) derived from regular low-pressure HBr cell measurements to retrieve the time series of SF6. The total column of SF6 over Hefei presents strong seasonal dependent features. The maximum monthly average value of (3.57 ± 0.21) × 1014 molecules*cm-2 in summer is (7.60 ± 3.50) × 1013 molecules*cm-2 (21.29 ± 9.80) % higher than the minimum monthly average value of (2.81 ± 0.14) × 1014 molecules*cm-2 in winter. The annual average SF6 total columns in 2017-2020 are (3.02 ± 0.17), (3.50 ± 0.18), (3.25 ± 0.18), and (3.08 ± 0.16) × 1014 molecules*cm-2, respectively, which are close to each other. It indicates that SF6 total column over Hefei is stable in the past four years. Our study can improve the current understanding for ground-based high-resolution remote sensing of SF6 and also contribute to generate new reliable remote sensing data in this sparsely monitored region for investigations of climate change, global warming, and air pollution.

2.
Opt Express ; 29(17): 26509-26525, 2021 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-34615085

RESUMO

Photoacoustic (PA) spectroscopic technique has become a popular tool for trace gas detection and is especially suitable for in situ measurement of sulfur hexafluoride (SF6) decomposition components in gas insulated switchgear (GIS). However, the concentrations of SF6 decomposition components are generally very low and the resulting PA signals are too weak to be accurately retrieved with traditional methods. In this study, we proposed a Lyapunov exponent based chaotic oscillator algorithm to retrieve the weak PA signals of SF6 decomposition components. Retrieval of weak PA signals from strong noise background was achieved for both simulation and measurement perspectives. The results were compared with those based on phase-locked amplification technique. Both simulation and measurement results concluded that the proposed chaotic oscillator algorithm is superior to the phase-locked amplification in terms of accuracy, sensitivity and stability. Since most trace gases have weak absorption signatures in the atmosphere (below 1%), this study can provide valuable insights in dealt with such weak signals in remote sensing of atmosphere.

3.
Chem Sci ; 12(13): 4836-4840, 2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-34163735

RESUMO

A method for remote radical C-H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed in situ as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,n-hydrogen atom transfer. Unactivated secondary and tertiary C-H bonds at ß, γ, and δ positions can be functionalized in a predictable manner.

4.
Opt Express ; 29(4): 4958-4977, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33726041

RESUMO

High-resolution solar absorption spectra, observed by ground-based Fourier Transform Infrared spectroscopy (FTIR), are used to retrieve vertical profiles and partial or total column concentrations of many trace gases. In this study, we present the tropospheric CO2 columns retrieved by mid-infrared solar spectra over Hefei, China. To reduce the influence of stratospheric CO2 cross-dependencies on tropospheric CO2, an a posteriori optimization method based on a simple matrix multiplication is used to correct the tropospheric CO2 profiles and columns. The corrected tropospheric CO2 time series show an obvious annual increase and seasonal variation. The tropospheric CO2 annual increase rate is 2.71 ± 0.36 ppm yr-1, with the annual peak value in January, and CO2 decreases to a minimum in August. Further, the corrected tropospheric CO2 from GEOS-Chem simulations are in good agreement with the coincident FTIR data, with a correlation coefficient between GEOS-chem model and FTS of 0.89. The annual increase rate of XCO2 observed from near-infrared solar absorption spectra is in good agreement with the tropospheric CO2 but the annual seasonal amplitude of XCO2 is only about 1/3 of dry-air averaged mole fractions (DMF) of tropospheric CO2. This is mostly attributed to the seasonal variation of CO2 being mainly dominated by sources near the surface.

5.
Sci Total Environ ; 764: 142886, 2021 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-33757247

RESUMO

During the outbreak of the coronavirus disease 2019 (COVID-19) in China in January and February 2020, production and living activities were drastically reduced to impede the spread of the virus, which also caused a strong reduction of the emission of primary pollutants. However, as a major species of secondary air pollutant, tropospheric ozone did not reduce synchronously, but instead rose in some region. Furthermore, higher concentrations of ozone may potentially promote the rates of COVID-19 infections, causing extra risk to human health. Thus, the variation of ozone should be evaluated widely. This paper presents ozone profiles and tropospheric ozone columns from ultraviolet radiances detected by TROPOospheric Monitoring Instrument (TROPOMI) onboard Sentinel 5 Precursor (S5P) satellite based on the principle of optimal estimation method. We compare our TROPOMI retrievals with global ozonesonde observations, Fourier Transform Spectrometry (FTS) observation at Hefei (117.17°E, 31.7°N) and Global Positioning System (GPS) ozonesonde sensor (GPSO3) ozonesonde profiles at Beijing (116.46°E, 39.80°N). The integrated Tropospheric Ozone Column (TOC) and Stratospheric Ozone Column (SOC) show excellent agreement with validation data. We use the retrieved TOC combining with tropospheric vertical column density (TVCD) of NO2 and HCHO from TROPOMI to assess the changes of tropospheric ozone during the outbreak of COVID-19 in China. Although NO2 TVCD decreased by 63%, the retrieved TOC over east China increase by 10% from the 20-day averaged before the lockdown on January 23, 2020 to 20-day averaged after it. Because the production of ozone in winter is controlled by volatile organic compounds (VOCs) indicated by monitored HCHO, which did not present evident change during the lockdown, the production of ozone did not decrease significantly. Besides, the decrease of NOx emission weakened the titration of ozone, causing an increase of ozone.


Assuntos
Poluentes Atmosféricos , COVID-19 , Ozônio , Poluentes Atmosféricos/análise , Pequim , China/epidemiologia , Controle de Doenças Transmissíveis , Surtos de Doenças , Monitoramento Ambiental , Humanos , Ozônio/análise , SARS-CoV-2
6.
Mamm Genome ; 31(7-8): 197-204, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32556998

RESUMO

Prostate cancer, the second most common cancer among male adults, affects millions globally. We sought to investigate the expression and contribution of Eukaryotic translation initiation factor 3 subunit b (EIF3B) in prostate cancer. Expression of EIF3B was analyzed in both human prostate patient tissues and prostate cancer cell lines. Small interfering RNA (siRNA) knockdown of EIF3B was introduced into prostate cancer cell line PC-3 and LNCaP, followed by examination of cell viability, proliferation and apoptosis using the MTT, cell counting and terminal deoxynucleotidyl transferase dUTP nick end labeling assays, respectively. An in vivo xenograft tumor mouse model was employed to address the role of EIF3B in tumorigenesis as well. Finally, a gene microarray analysis was performed to search for differentially expressed genes upon EIF3B knockdown. EIF3B was upregulated in prostate tumor tissues and prostate cancer cell lines. EIF3B knockdown inhibited viability and proliferation of prostate cancer cells, as well as promoted cell apoptosis. In the in vivo mouse model, inoculation of EIF3B knockdown PC-3 cells displayed inhibited growth of xenograft tumors. In addition, potential signaling pathways that might be involved in EIF3B action in prostate cancer were identified by the gene microarray. EIF3B is a novel oncogenic factor in prostate cancer both in vitro and in vivo, which could be employed as a novel therapeutic target in the treatment against prostate cancer.


Assuntos
Fator de Iniciação 3 em Eucariotos/genética , Fator de Iniciação 3 em Eucariotos/metabolismo , Proteínas Oncogênicas/genética , Proteínas Oncogênicas/metabolismo , Neoplasias da Próstata/etiologia , Animais , Apoptose/genética , Linhagem Celular Tumoral , Proliferação de Células , Modelos Animais de Doenças , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Técnicas de Silenciamento de Genes , Xenoenxertos , Humanos , Masculino , Camundongos , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/patologia , Transdução de Sinais
7.
Opt Express ; 28(6): 8041-8055, 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32225437

RESUMO

In this study, the characterization of Hydrogen Chloride (HCl) seasonal variations and inter-annual linear trend are presented for the first time over the polluted region at Hefei (117°10'E, 31°54'N), China. The time series of HCl were retrieved by the mid-infrared (MIR) solar spectra recorded by the ground-based high-resolution Fourier transform infrared spectroscopy (FTIR) between July, 2015 and April, 2019. The magnitude of HCl reaches a peak in January (2.70 ± 0.16) × 1015 molecules*cm-2 and a minimum in September (2.27 ± 0.09) × 1015 molecules*cm-2. The four-year time series of HCl total column show a negative linear trend of (-1.83 ± 0.13) %. The FTIR data are compared with GEOS-Chem data in order to evaluate the performance of the GEOS-Chem model to simulate HCl. In general, total column FTIR data and GEOS-Chem model data are in a good agreement with a correlation coefficient of 0.82. GEOS-Chem model data present a good agreement with FTIR data in seasonal variation and inter-annul trend. The maximum differences occur in January and April with mean differences of 4%-6%. We also present HCl time series observed by 6 NDACC stations (Bremen, Toronto, Rikubetsu, Izana, Reunion.maido, Lauder) in low-middle-latitude sites of the northern and southern hemispheres and Hefei stations in order to investigate the seasonal and annual trends of HCl in low-middle-latitude sites. The HCl total column at the northern hemisphere stations reached the maximum in the late winter or early spring and the minimum in the early winter or late autumn. In general, the seasonal variations of HCl over Hefei is similar to that in other northern hemisphere mid-latitude FTIR stations.

8.
Org Lett ; 22(4): 1490-1494, 2020 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-32027141

RESUMO

A photoinduced, copper-catalyzed, highly enantioselective dual alkylation/arylation and alkynylation of alkene is reported. A single chiral copper(I) complex serves to enable photoredox catalysis and induce enantioselectivity during the reaction. This reaction couples three different components under mild reaction conditions, exhibits a broad substrate scope, and provides facile access to chiral propargylic systems, including those featuring valuable fluorinated substituents.

9.
Chemistry ; 26(2): 419-422, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31705679

RESUMO

A photoinduced decarboxylative three-component coupling reaction involving amine, maleic anhydride, and fluorinated alkyl iodides has been developed, leading to synthetically valuable fluoroalkyl-containing acrylamides with a high E selectivity. A broad array of substrates including monoprotected amino acid are capable coupling partners. Preliminary mechanistic studies suggest a stepwise process. This reaction represents the first example of photoinduced decarboxylative difunctionalization of maleic anhydride.

10.
Opt Express ; 27(16): A1225-A1240, 2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31510516

RESUMO

We present the trend and seasonal variability of stratospheric NO2 column for the first time over the polluted atmosphere at Hefei, China, retrieved using Fourier transform infrared spectroscopy (FTIR) between 2015 and 2018. The FTIR observed stratospheric NO2 columns over Hefei show a peak in June and reach a minimum in January. The mean stratospheric NO2 column concentration in June is (3.49 ± 0.25) × 1015 molecules*cm-2, and is 39.20% ± 8.95% higher than that in January with a mean value of (2.51 ± 0.21) × 1015 molecules*cm-2. We find a negative trend of (-0.34 ± 0.05) %/yr in the FTIR observations of stratospheric NO2 column. The FTIR data are compared to the satellite OMI observations to assess the new data set quality and also applied to evaluate the GEOS-Chem model simulations. We find in general the OMI observations and GEOS-Chem model results are in good agreement with the coincident FTIR data, and they all show similar seasonal cycles with strong correlation coefficients of 0.84-0.86. The annual average OMI minus FTIR difference is (1.48 ± 5.33) × 1014 molecules*cm-2 (4.82% ± 17.37%), and average GEOS-Chem minus FTIR difference is (2.36 ± 2.33) × 1014 molecules*cm -2 (7.66% ± 7.49%). Their maximum differences occur in April and May with mean differences of 12-16%. We also found negative trends in the stratospheric NO2 column over Hefei for 2015-2018 with both OMI observations (-0.91 ± 0.09%/yr) and GEOS-Chem model results (-0.31 ± 0.05%/yr), demonstrating some consistency among them.

11.
Org Lett ; 20(19): 6250-6254, 2018 10 05.
Artigo em Inglês | MEDLINE | ID: mdl-30246540

RESUMO

A new and general method for the synthesis of ß-azidosulfonates has been achieved through Cu(I)-mediated radical oxidative sulfonylation-azidation of alkenes with sodium sulfinates. Under identical conditions, azido fluoroalkyated products could be readily obtained instead using CF3SO2Na or CHF2SO2Na as reagents. The starting materials of sulfinate compounds, alkenes, and azidotrimethylsilane are stable and cheap. This method can be easily adapted for large-scale preparation.

12.
Gene ; 676: 322-328, 2018 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-30149063

RESUMO

Really interesting new gene finger protein (RING) finger protein 121 (RNF-121) is an E3 ubiquitin ligase involved in the regulation of several signaling pathways. Among those signaling pathways, nuclear factor-κB (NF-κB) signaling pathway is known to play a critical role in tumorigenesis. However, the relevance between RNF121 and cancer development remains poorly understood. In this study, we found that RNF121 was less expressed in tumor tissues than adjacent normal tissues of renal cell carcinoma (RCC) patients. Overexpression of RNF121 inhibited the growth of human RCC cells (768-O cell line) in vivo. Moreover, RNF121 impeded the proliferation, migration and invasion of human RCC cells in vitro. In addition, we found that RNF121 activated NF-κB signaling pathway via promoting IκBα degradation in human RCC cells. Our findings reveal a previously unrecognized role of RNF121 in RCC development, and provide new insights into RCC prognosis and therapy.


Assuntos
Carcinoma de Células Renais/genética , Regulação para Baixo , Neoplasias Renais/genética , Proteínas de Membrana/genética , Animais , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células , Regulação Neoplásica da Expressão Gênica , Humanos , Proteínas I-kappa B/metabolismo , Camundongos , Transplante de Neoplasias , Proteólise , Transdução de Sinais
13.
Sci Total Environ ; 612: 1593-1609, 2018 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-28359568

RESUMO

We presented the characterization of urban CO2 column abundance (XCO2) in Hefei, China using a portable low resolution spectrometer (PLRS). An optimized correction spectrum was introduced in the spectral fitting to improve CO2 retrieval. A pronounced seasonal cycle and diurnal variation were observed with a precision of ~0.12%. The CO2 concentrations in winter are about 5-10ppm higher than those in summer. Most diurnal variations exhibited downward trends. The measurement in the early morning is about 2-5ppm higher than the late afternoon observation. The causes of the seasonal and diurnal trends were systematic analyzed. The coincident CO2 time series were compared with the Greenhouse Gases Observing SATellite (GOSAT) data and the GEOS-Chem global 3-D tropospheric chemistry model data. We found the ground based (g-b) PLRS data are systematically higher than the GOSAT and the GEOS-Chem data. Compared to the GOSAT data, the g-b PLRS data are 0.26ppm (0.07%) higher with a standard deviation of 1.70ppm (0.43%). Compared to the smoothed GEOS-Chem model data, the g-b PLRS data shows a 1.31ppm (0.33%) higher with a standard deviation of 5.30ppm (0.87%). The g-b PLRS generally reproduced the seasonal cycle observed by GOSAT and GEOS-Chem model with correlation coefficients (r) of 0.82 and 0.64, respectively.

14.
Guang Pu Xue Yu Guang Pu Fen Xi ; 37(1): 48-53, 2017 01.
Artigo em Chinês | MEDLINE | ID: mdl-30192467

RESUMO

CO(2) retrievals with high quality facilitate resolving the sources and sinks of CO(2) are helpful in predicting the trend in climate change and understanding the global carbon cycle. Based on a nonlinear least squares spectral fitting algorithm, we investigate the optimization method for CO2 products derived from ground-based high resolution Fourier transform infrared spectra. The CO(2) vertical column densities (VCDs) are converted into column-averaged dry air mole fraction XCO(2) by using the fitted O(2) VCDs, and thus the system errors (e. g. pointing errors, ILS errors, zero-level offset) are corrected greatly. The virtual daily variation which is related to air mass factor is corrected with an empirical model. The spectra screening rule proposed in this paper can greatly improve the XCO2 quality. The CO(2) retrievals before and after the optimized method are compared using a typical CO(2) daily time series. After using the optimized method, the fitting error is reduced by 60%, and the two-hours-averaged precision is ~0.071% (equals to ~0.28 ppm), which is perfectly in line with the TCCON (the total carbon column observing network) threshold, i. e., less than 0.1%.

15.
Guang Pu Xue Yu Guang Pu Fen Xi ; 36(9): 2725-31, 2016 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-30084585

RESUMO

Ring effect is defined as the phenomenon that the depth of solar Fraunhofer lines in scattered light is less than those observed in direct sunlight. The aerosol could change the light path and the scattering properties in the atmospheric, and influence Raman Scattering Possibility of the photons, and finally affect the filling-up effect. Aerosol parameters (aerosol optical depth, boundary layer height, single scattering albedo, asymmetric factor) could be obtained by observation of the Ring effect in different aerosol condition. The Ring effect is measured by ground-based MAX-DOAS instrument under clear days and the measurement results is compared with McAritim results. The comparison has a good agreement. Radiation transfer model McArtim is used to study the sensitivity of the Ring effect to the aerosol parameters. The study shows that in most conditions, aerosol optical depth (AOD) and boundary layer (bh) height has a great influence to RSP, and in 90 degree elevation angle, RSP has a decrease of 24.6% when AOD varies from 0.1 to 1, and a decrease of 4.4% when bh varies from 1km to 3 km. The study shows RSP is more sensitive to AOD and boundary layer height, which may provide a new method for aerosol profile.

16.
J Endourol ; 28(3): 353-9, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24229434

RESUMO

PURPOSE: To compare the performance of voluminous benign prostatic hyperplasia patients who have received laparoscopic simple prostatectomy (LSP) with the patients who have received bipolar transurethral resection of the prostate (B-TURP) in their perioperative and 3-year follow-up period. METHODS: Ninety patients with prostate volumes >80 mL (range 80-130 mL) were randomly assigned to either LSP or B-TURP surgery type. The patients were followed up at 1, 3, 6, 12, 24, and 36 months postoperatively. Perioperative and follow-up characteristics were then recorded and compared. RESULTS: More blood loss, greater resected adenoma volume, and shorter catheterization duration were recorded in LSP group than that of B-TURP group (140.1±81.5 vs 93.1±54.0 mL; 65.3±13.8 vs 49.0±12.7 mL; 3.3±1.2 vs 3.8±1.0 days; p<0.05). None of the patients in LSP group reported complications out of 30 days, while 1 case of urethral stricture, 36 cases of retrograde ejaculation, 1 case of bladder neck contracture, and 2 cases of recurrence were recorded in B-TURP group. At 1, 3, 6, and 12 months postoperatively, there were no significant differences in terms of postvoid residual urine volume, maximal urinary flow rate (Qmax), and International Prostate Symptom Score between the two groups (p>0.05). In contrast, the differences became significant at 24 and 36 months (p<0.05). CONCLUSIONS: Compared with B-TURP, LSP with Madigan technique is accompanied by less residual adenoma, shorter catheterization time, and more blood loss. Further, the risk of late complications is lower with LSP and, in terms of functional outcomes, LSP appears to be better than B-TURP beyond 2 years.


Assuntos
Laparoscopia/métodos , Complicações Pós-Operatórias/epidemiologia , Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/métodos , Micção/fisiologia , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Seguimentos , Humanos , Incidência , Laparoscopia/efeitos adversos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/fisiopatologia , Prostatectomia/efeitos adversos , Prostatectomia/métodos , Hiperplasia Prostática/diagnóstico , Hiperplasia Prostática/fisiopatologia , Estudos Retrospectivos , Fatores de Tempo , Ressecção Transuretral da Próstata/efeitos adversos , Resultado do Tratamento
17.
Guang Pu Xue Yu Guang Pu Fen Xi ; 32(12): 3381-4, 2012 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-23427572

RESUMO

Using photodiode array (PDA) detector and spectrometer, a method on the basis of algorithm of nondispersive ultraviolet (NDUV) is described to measure and analyze nitric oxide (NO) gas. With the introduction of light source impact factor and absorption spectrum impact factor, fitting equation and correlation coefficient between absorbance and concentration was acquired through comparative analysis on the total intensity of nitric oxide absorption and non-absorption spectrum, which are collected in different integration times and within different wavelength width. The results show that second order fitting correlation coefficient related to absorbance and concentration is above 0.999 9 and the error of concentrations between the concentration calculated by fitting equation and the standard concentration is less than 3% through using suitable fitting order, fitting wavelength width and analysis method.

18.
Guang Pu Xue Yu Guang Pu Fen Xi ; 32(11): 2950-5, 2012 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-23387156

RESUMO

The cloud effect correction is very significant to satellite remote sensing of atmospheric trace gases from near-infrared spectrum, even with a small amount of cloud, the remaining effects can still cause retrieval error even reaching up to 100%. Atmospheric carbon monoxide (CO) is one of the most important pollutants in the troposphere. This study, takeing CO as the example, described the cloud effect and the cloud correction on retrieval result from SCIAMACHY measurement. To validate the correction method, we compared both corrected and uncorrected results with the independent ground based FTIR measurements. After the correction, the agreement between satellite observations and FTIR measurements further improves.

19.
Guang Pu Xue Yu Guang Pu Fen Xi ; 31(10): 2719-24, 2011 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-22250543

RESUMO

A method of interference correction for nondispersive infrared multi-component gas analysis was described. According to the successive integral gas absorption models and methods, the influence of temperature and air pressure on the integral line strengths and linetype was considered, and based on Lorentz detuning linetypes, the absorption cross sections and response coefficients of H2O, CO2, CO, and NO on each filter channel were obtained. The four dimension linear regression equations for interference correction were established by response coefficients, the absorption cross interference was corrected by solving the multi-dimensional linear regression equations, and after interference correction, the pure absorbance signal on each filter channel was only controlled by the corresponding target gas concentration. When the sample cell was filled with gas mixture with a certain concentration proportion of CO, NO and CO2, the pure absorbance after interference correction was used for concentration inversion, the inversion concentration error for CO2 is 2.0%, the inversion concentration error for CO is 1.6%, and the inversion concentration error for NO is 1.7%. Both the theory and experiment prove that the interference correction method proposed for NDIR multi-component gas analysis is feasible.

20.
World J Urol ; 27(3): 385-7, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19082604

RESUMO

OBJECTIVES: We assessed the feasibility of extraperitoneal laparoscopic prostatectomy in pilots in China. MATERIALS AND METHODS: Extraperitoneal laparoscopic retropubic prostatectomy has been performed in 45 patients with prostatic weight more than 60 g between May 2005 and May 2008. The laparoscopic approach was standard in all cases as follows: creation of a preperitoneal workspace, haemostatic control of lateral venous vesicoprostatic pedicles, transversal anterior incision of the prostate capsule, prostatic adenomectomy and retrieval of the specimen. RESULTS: The average prostate resected weight was 78.2 +/- 16.3 g. Mean operative time was 105.4 +/- 26.5 min. Conversion to open prostatectomy was not required. The transfusion was essential in three cases. During a 6 months follow-up period for 40 cases, the mean score of IPSS decreased from 25.5 +/- 2.4 to 6.2 +/- 2.1, Q(max) increased from 6.1 +/- 2.8 to 18.7 +/- 3.4 ml/s. None of the patients presented with urinary incontinence. CONCLUSIONS: In our experience, laparoscopic extraperitoneal adenomectomy (Millin's procedure) is feasible with minimal invasion and is a simple straightforward technique.


Assuntos
Laparoscopia , Prostatectomia/métodos , Hiperplasia Prostática/cirurgia , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Pessoa de Meia-Idade
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