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1.
BMC Pediatr ; 20(1): 455, 2020 09 30.
Artigo em Inglês | MEDLINE | ID: mdl-32998691

RESUMO

BACKGROUND: Childhood obesity represents a serious global health crisis. Apelin and its receptor system are widely distributed throughout the central nervous system and have been demonstrated to serve a role modulating feeding behaviour and energy homeostasis. The purposes of this study were to examine apelin concentrations and anthropometric-cardiometabolic parameters in obese and non-obese children and to identify associations of APLN T-1860C and APLNR G212A polymorphisms with apelin levels and obesity among Thai children. METHODS: This case-control study included an analysis of 325 Thai children: 198 children with obesity and 127 healthy non-obese children. Anthropometric-cardiometabolic variables and apelin concentration were measured. Genotyping of APLN T-1860C and APLNR G212A was performed using the polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: The obese group had significantly lower apelin and HDL-C levels but significantly higher triglycerides and glucose (TyG) index values, TG/HDL-C ratio and TC/HDL-C ratio than the non-obese group (p < 0.01). Apelin level was negatively correlated with body size phenotypes and cardiometabolic parameters (p < 0.05). The APLN T-1860C polymorphism (OR = 4.39, 95% CI = 1.25-15.28) and apelin concentration (OR = 0.45, 95% CI = 0.23-0.92) were significantly associated with obesity among female children (p < 0.05) only, after adjusting for potential covariates. However, the APLNR G212A polymorphism showed no significant relationship with apelin concentration or obesity. CONCLUSION: These findings in Thai children suggest that apelin concentrations are related to obesity and cardiometabolic parameters. Furthermore, the APLN T-1860C polymorphism may influence susceptibility to obesity among female children.


Assuntos
Apelina/genética , Obesidade Pediátrica/genética , Receptores de Apelina/genética , Estudos de Casos e Controles , Criança , Feminino , Humanos , Tailândia
2.
Ethiop J Health Sci ; 30(2): 199-208, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32165809

RESUMO

Background: The prevalence of metabolic syndrome (MS) has been continually increasing in developing countries especially in Thailand. Although insulin resistance and central obesity are initially considered as significant risk factors, the other causal factors leading to the development of MS continue to challenge the investigators. The aims of this study were to evaluate the prevalence of MS in Pathum Thani province, Thailand and to investigate the relationship between MS and risk factors. Methods: This cross-sectional study was performed with 202 Thai volunteers. Anthropometric-biochemical variables and blood pressures in each subject were measured. Results: Almost one-third (32.7%) of the participants were diagnosed with MS based on the harmonized criteria, and one of the most significant risk factors is the elevated blood pressure. Weight, BMI, waist and hip circumferences, waist-hip ratio, blood pressure, glucose, triglycerides and uric acid were significantly higher in subjects with MS subjects. However, HDL-C levels were significantly lower in subjects with MS, compared to subjects without MS (p<0.001). The results of regression model after adjustment for age and gender showed that the increased serum uric acid level (OR=1.31, 95%CI: =1.04-1.66), cigarette smoking (OR=3.72, 95%CI: =1.51-9.15) and physical activity (OR=0.36, 95%CI: =0.19-0.67) were significantly related to MS. Conclusions: These findings suggest that the decrease of uric acid level, the promotion of physical activity and smoking cessation may decrease the risk of developing MS among Thais.


Assuntos
Estilo de Vida , Síndrome Metabólica/sangue , Síndrome Metabólica/epidemiologia , Ácido Úrico/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Exercício Físico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Fumar/epidemiologia , Tailândia/epidemiologia , Adulto Jovem
3.
J Health Popul Nutr ; 38(1): 1, 2019 01 03.
Artigo em Inglês | MEDLINE | ID: mdl-30606264

RESUMO

BACKGROUND: An oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS. METHODS: Metabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings. RESULTS: Subjects with MS had lower SOD and CAT levels than those without MS (p < 0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p < 0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05). CONCLUSIONS: These findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.


Assuntos
Antioxidantes/análise , Biomarcadores/sangue , Inflamação/sangue , Síndrome Metabólica/sangue , Adulto , Antropometria , Ácido Ascórbico/sangue , Catalase/sangue , Feminino , Glutationa Peroxidase/sangue , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Superóxido Dismutase/sangue , Tailândia
4.
Asia Pac J Clin Nutr ; 27(4): 935-944, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30045441

RESUMO

BACKGROUND AND OBJECTIVES: The genetic variations of vitamin D receptor (VDR) have revealed its association with the risk of metabolic syndrome (MetS). In Thailand, evidence of this association has not been obtained. Thus, this study aimed to investigate the association of VDR gene polymorphism with MetS and related diseases as well as the possible linkage disequilibrium (LD) and haplotypes of VDR in Thai adults. METHODS AND STUDY DESIGN: Four single nucleotide polymorphisms (SNPs) of VDR gene, rs2228570, rs1544410, rs7975232 and rs731236, were genotyped using PCR-RFLP method in 259 MetS and 261 control groups. RESULTS: Genotypes AA of rs1544410, TG of rs7975232 and TG+TT of rs7975232 were significantly associated with an increased risk of MetS [OR 10.8 (2.07-56.1), p=0.005], [OR 1.83 (1.16-2.87), p=0.009] and [OR 1.78 (1.17-2.72), p=0.007], respectively, using GG as a reference. Moreover, genotype AA of rs1544410 showed a strong association compared with GG+AG [OR 11.4 (2.20-59.2), p=0.004]. Diseases related to MetS also had significant associations with two SNPs of the VDR gene (rs1544410 and rs7975232). In addition, LD among rs1544410, rs7975232 and rs731236 was detected. Haplotype CATT significantly increased the risk of MetS [OR 4.32 (1.32- 14.1), p=0.016], although haplotype TGGT reduced the risk [OR 0.68 (0.48-0.98), p=0.042]. CONCLUSIONS: The SNPs rs1544410 and rs7975232 were mainly implicated in the increased risk of MetS in the Thai population. LD and haplotypes of VDR gene related to MetS were also discovered. These SNPs of VDR gene are remarkable genetic factors involved in the development of MetS.


Assuntos
Predisposição Genética para Doença , Variação Genética , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/genética , Receptores de Calcitriol/genética , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polinésia/epidemiologia , Adulto Jovem
5.
Biomark Med ; 12(5): 465-473, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29504805

RESUMO

AIM: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. MATERIALS & METHODS: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. RESULTS: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004). CONCLUSION: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.


Assuntos
Síndrome Metabólica/sangue , Síndrome Metabólica/genética , Polimorfismo de Nucleotídeo Único , Proteína de Ligação a Vitamina D/sangue , Proteína de Ligação a Vitamina D/genética , Adulto , Idoso , Feminino , Predisposição Genética para Doença/genética , Globulinas/metabolismo , Humanos , Masculino , Síndrome Metabólica/diagnóstico , Pessoa de Meia-Idade
6.
Southeast Asian J Trop Med Public Health ; 47(6): 1306-14, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29634196

RESUMO

Studies have shown that polymorphisms of adiponectin gene (ADIPOQ) are associated with risk of developing type 2 diabetes mellitus (T2DM). However, no studies have investigated the association between genetic variants of ADIPOQ and pre-diabetes, a group at higher risk for developing T2DM. A total of 75 pre-diabetes and 130 normal subjects were recruited from volunteers in Bangkok, Thailand. Individuals with pre-diabetes were selected based on American Diabetes Association diagnostic criteria. Six ADIPOQ polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique. ADIPOQ polymorphism rs266729 C>G is significantly associated with pre-diabetes (p = 0.006). CG/GG genotypes were found among 60% and 40% of pre-diabetes and normal subjects, respectively. SNP rs266729 C>G was associated with increased pre-diabetes risk (OR = 2.64; 95% CI: 1.18-5.89, p = 0.018). No significant differences were found between pre-diabetes and normal subjects for other ADIPOQ polymorphisms. However, haplotype analysis revealed that haplotype GGTAAT is significantly associated with pre-diabetes when compared with GCGAAC reference haplotype (OR = 22.31; 95% CI: 1.37-361.93, p = 0.03). Our data indicate that ADIPOQ rs266729 C>G polymorphism may contribute to the genetic risk of pre-diabetes and provide preliminary data useful in genetic screening for pre-diabetes among Thais.


Assuntos
Adiponectina/genética , Polimorfismo Genético , Estado Pré-Diabético/genética , Adulto , Estudos de Casos e Controles , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tailândia
7.
J Med Assoc Thai ; 98(10): 1028-34, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26638595

RESUMO

OBJECTIVE: Compare tobacco use, exposure to second-hand smoke, and smoking cessation training among third-year medical technology students in Thailand between 2006 and 2011. MATERIAL AND METHOD: The medical technology student survey was carried out with Global Health Professions Student Survey (GHPSS) between October and November 2011. The population of the present study was all students in nine medical technology schools. There were 773 students enrolled in this study yielding a response rate of 95.1%. RESULTS: The prevalence of current cigarette smokers had decreased from 2006 to 2011 (4.8% to 1.4%, respectively). Rates of exposure to second-hand smoke at home were 36.3% in 2006 and 39.7% in 2011, while rates of exposure to second-hand smoke in other places did not change. Most students recognized that they should give patients counseling to quit smoking, but only 20.6% in 2006 and 28.4% in 2011 of them had received formal training in tobacco cessation counseling. CONCLUSION: There were low percentages of current cigarette smoking but high percentages of exposure to second-hand smoke among medical technology students. The percentage of cessation training was still low among students. Therefore, medical technology schools should provide formal training in tobacco cessation for all students to help improve their ability in providing advice to patients.


Assuntos
Abandono do Hábito de Fumar/estatística & dados numéricos , Fumar/epidemiologia , Estudantes de Ciências da Saúde/estatística & dados numéricos , Poluição por Fumaça de Tabaco/estatística & dados numéricos , Tabagismo/epidemiologia , Adulto , Atitude Frente a Saúde , Aconselhamento/estatística & dados numéricos , Feminino , Humanos , Masculino , Prevalência , Faculdades de Medicina , Prevenção do Hábito de Fumar , Tailândia/epidemiologia , Poluição por Fumaça de Tabaco/prevenção & controle , Tabagismo/prevenção & controle , Adulto Jovem
8.
J Med Biochem ; 34(2): 170-178, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28356829

RESUMO

BACKGROUND: Metabolic syndrome (MS) is a clinical constellation comprising risk factors associated with developing cardiovascular disease and type 2 diabetes. Resistin has been suggested as a linkage between obesity, inflammation and type 2 diabetes. This study aimed to investigate resistin concentrations and hematological-biochemical parameters in MS subjects and controls, and to determine whether two resistin gene (RETN) polymorphisms (-420C>G & +299G>A) are linked to resistin levels and MS among Thais. METHODS: This case-control study was performed with 322 Thai volunteers: 160 MS subjects and 162 controls. Anthropometric parameters and hematological-biochemical variables were determined. The RETN -420C>G (rs1862513) and +299G>A (rs3745367) polymorphisms were genotyped by PCR-RFLP technique. RESULTS: The resistin levels of the MS group were significantly higher than those of the control group. Resistin levels were positively correlated with anthropometric parameters and WBC count in the MS group. According to RETN -420C>G polymorphism, MS subjects with the G allele (CG/GG) (3.9 µg/L) had significantly higher resistin concentrations than in subjects with the CC genotype (2.4 µg/L); with regard to RETN +299G>A polymorphism, carriers with the A allele (GA/AA) (3.8 µg/L) had significantly higher resistin levels than subjects with the GG genotype (2.7 µg/L), after adjusting for potential covariates. However, the RETN -420C>G and +299G>A polymorphisms were not found to be associated with MS, hematological-biochemical parameters and anthropometric variables. CONCLUSIONS: These findings suggest resistin levels are linked with MS and the RETN -420C>G and +299G>A polymorphisms have impacted the circulating resistin concentrations. However, these two RETN polymorphisms probably do not influence susceptibility to MS among Thais.

9.
Asia Pac J Clin Nutr ; 23(1): 167-73, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24561985

RESUMO

The metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to identify links between two polymorphisms, -11377C>G (rs266729) and +45T>G (rs2241766) of the adiponectin gene, in relation to adiponectin levels and the metabolic syndrome. Three hundres and thirty-two Thai volunteers: 164 metabolic-syndrome subjects and 168 healthy control subjects were investigated. The adiponectin and HDL-C levels of the metabolic-syndrome group were significantly lower than the control group (p<0.001). Decreased concentration of adiponectin was associated with -11377C>G polymorphism (p<0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p<0.001). However, +45T>G polymorphism of the adiponectin gene was found not to be related to adiponectin level or metabolic syndrome. Therefore, -11377C>G polymorphism was related to the metabolic syndrome susceptibility, and this polymorphism impacted on circulating adiponectin concentrations among Thais.


Assuntos
Adiponectina/sangue , Adiponectina/genética , Síndrome Metabólica/sangue , Síndrome Metabólica/genética , Polimorfismo Genético/genética , Adulto , Glicemia/análise , Pressão Sanguínea , Índice de Massa Corporal , HDL-Colesterol/sangue , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Humanos , Insulina/sangue , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Tailândia , Triglicerídeos/sangue , Circunferência da Cintura , Relação Cintura-Quadril
10.
Diabetol Metab Syndr ; 6(1): 6, 2014 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-24444121

RESUMO

BACKGROUND: Metabolic syndrome is a cluster of metabolic risk factors including dyslipidemia, impaired glucose tolerance, hypertension and central obesity. BDNF (Brain-derived neurotrophic factor) and leptin have been implied in the energy homeostasis. The purposes of this study were to examine concentrations of leptin, BDNF and biochemical parameters in metabolic-syndrome subjects and healthy controls, and also to search for associations of leptin gene (LEP) G2548A, leptin receptor gene (LEPR) Gln223Arg, and BDNF gene (BDNF) Val66Met polymorphisms with leptin levels, BDNF levels and metabolic syndrome among Thais. METHODS: The case-controlled design was performed using 322 Thai volunteers (160 metabolic-syndrome subjects; 162 controls) during the health screening program. Metabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. The levels of leptin, BDNF, insulin, glucose and lipids were measured in samples. Genotyping of LEP G2548A, LEPR Gln223Arg and BDNF Val66Met was carried out using polymerase chain reaction-restriction fragment length polymorphism technique. RESULTS: Serum leptin levels were significantly higher in the metabolic-syndrome group than the control group (p < 0.01), but the BDNF difference between them was not significant. Significant associations of LEPR Gln223Arg polymorphism were found with leptin and glucose levels (p < 0.05), after adjusting for potential covariates. This LEPR polymorphism in the metabolic-syndrome group was also significantly more frequent than in the control group (p < 0.05). However, other gene polymorphisms, LEP G2548A and BDNF Val66Met, showed no significant relationship with leptin levels, BDNF levels or metabolic syndrome. CONCLUSION: These findings suggest leptin levels are linked with metabolic syndrome. LEPR Gln223Arg polymorphism impacted leptin concentrations, and this gene polymorphism may influence susceptibility to metabolic syndrome among Thais.

11.
Int J Vitam Nutr Res ; 84(1-2): 35-44, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25835234

RESUMO

This study aims to investigate serum amyloid A, homocysteine, and biochemical-anthropometric measurements in post-menopausal women with and without metabolic syndrome (MS), and determine whether serum amyloid A and homocysteine are linked to MS among this group. This study was performed with 405 post-menopausal Thai volunteers with a mean age of 57.95±5.90 years (135 subjects with MS and 270 subjects without MS). The levels of serum amyloid A, homocysteine, vitamins, glucose, and lipids were measured. Homocysteine levels were significantly higher in the group with MS than in that without MS (p<0.001), whereas for serum amyloid A, vitamin A, vitamin E and vitamin B12, there were no significant differences. There were significant differences between the groups in folate, HDL-C, and anthropometric measurements (p<0.001). Thirty seven percent of the group with MS and 14.1% of the group without MS were classified as having hyperhomocysteinemia (p<0.001). Furthermore, logistic regression analysis revealed that hyperhomocysteinemia (odds ratio (OR): 2.67, 95% confidence interval (95%CI): 1.57-4.58), low folate (OR: 1.79, 95%CI: 1.11-2.89), and BMI (OR: 1.25, 95%CI: 1.16-1.33) were significantly related to MS. These findings suggest that increased homocysteine levels and decreased folate concentrations may influence susceptibility to MS and this effect may be an early event in the development of cardiovascular diseases among post-menopausal women. Therefore, there is a need to evaluate homocysteine levels, especially among post-menopausal Thai women.


Assuntos
Homocisteína/sangue , Síndrome Metabólica/sangue , Pós-Menopausa/sangue , Proteína Amiloide A Sérica/análise , Vitamina A/sangue , Vitamina E/sangue , Antropometria , Índice de Massa Corporal , Estudos Transversais , Feminino , Ácido Fólico/sangue , Deficiência de Ácido Fólico/sangue , Humanos , Hiper-Homocisteinemia/complicações , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco , Tailândia
12.
J Mol Neurosci ; 49(3): 544-9, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22740151

RESUMO

The nicotine in cigarette smoke can stimulate the dopaminergic reward pathways. The catechol O-methyltransferase gene (COMT) and dopamine receptor 2 gene (DRD2) are dopamine-related genes. Genetic polymorphisms in these two genes are potential candidates in determining an individual's predisposition to cigarette smoking. The purposes of this study were to examine the association between two polymorphisms in COMT Val (108/158) Met and DRD2 Taq1B and anthropometric-biochemical parameters and to ascertain the association between these polymorphisms and cigarette smoking. The levels of anthropometric-biochemical parameters were determined. COMT Val (108/158) Met and DRD2 Taq1B polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism technique. With regard to COMT Val (108/158) Met and DRD2 Taq1B polymorphisms, no differences were found in anthropometric-biochemical variables, except for thiocyanate concentration. Smoking status was significantly associated with COMT Val (108/158) Met polymorphism, but not associated with DRD2 Taq1B polymorphism. Logistic regression analysis showed that COMT Val (108/158) Met gene polymorphism, educational status, parental smoking, and alcohol consumption had statistically significant impacts on cigarette smoking. The results suggest that COMT Val (108/158) Met genetic polymorphisms, but not DRD2 Taq1B, may influence susceptibility to cigarette smoking among Thai males.


Assuntos
Catecol O-Metiltransferase/genética , Polimorfismo de Nucleotídeo Único , Receptores de Dopamina D2/genética , Fumar/genética , Adulto , Consumo de Bebidas Alcoólicas/genética , Substituição de Aminoácidos , Antropometria , Catecol O-Metiltransferase/fisiologia , Desoxirribonucleases de Sítio Específico do Tipo II , Escolaridade , Saúde da Família , Frequência do Gene , Predisposição Genética para Doença/genética , Genótipo , Humanos , Masculino , Estado Civil/estatística & dados numéricos , Polimorfismo de Fragmento de Restrição , Receptores de Dopamina D2/fisiologia , Recompensa , Fatores de Risco , Fumar/sangue , Fumar/epidemiologia , Tailândia/epidemiologia
13.
J Med Assoc Thai ; 94(12): 1533-9, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22295743

RESUMO

OBJECTIVE: To determine the concentrations of malondialdehyde, biochemical, and hematological parameters among methamphetamine abusers compared with a healthy control group and to evaluate the association between malondialdehyde and biochemical-hematological parameters. MATERIAL AND METHOD: The concentrations of malondialdehyde, lipids, liver enzymes, albumin, blood urea nitrogen, creatinine, and hematological measurements were determined in 60 methamphetamine abusers and 60 controls. RESULTS: Significantly higher levels of malondialdehyde were found in the methamphetamine abusers than the controls [2.45 (2.12-2.81) vs. 1.41 (1.15-2.08)]. The levels ofalanine aminotransferase and alkaline phosphatase and white blood cell and platelet counts of the methamphetamine abusers were significantly elevated (p-value < 0.05) compared with the controls. Meanwhile, the levels of hemoglobin, hematocrit, albumin and body mass index were significantly lower among the methamphetamine-abusing group than the control group (p-value < 0.05). It was found that higher numbers of methamphetamine tablets per day were associated with higher malondialdehyde concentrations in methamphetamine abusers, and that malondialdehyde concentration inversely correlated with albumin level (r = -0.458, p-value < 0.05). Stepwise multiple regression analysis revealed that number of methamphetamine tablets per day, white blood cell count and albumin level were independent predictors of malondialdehyde level (p-value < 0.05). CONCLUSION: Methamphetamine abuse is related to increased lipid peroxidation, changes in inflammatory marker level, increase in liver enzymes, and decrease in hemoglobin and hematocrit concentrations. These effects may be early signs of the development of diseases associated with methamphetamine abuse.


Assuntos
Transtornos Relacionados ao Uso de Anfetaminas/sangue , Malondialdeído/sangue , Metanfetamina , Adulto , Índice de Massa Corporal , Humanos , Peroxidação de Lipídeos , Fígado/enzimologia , Metanfetamina/administração & dosagem , Análise Multivariada , Comprimidos
14.
Int J Vitam Nutr Res ; 80(3): 216-24, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21234863

RESUMO

The aims of this study were first to detect the levels of adiponectin, insulin, albumin, glucose, alanine aminotransferase (ALT), lipids, homeostasis model assessment for insulin resistance (HOMA-IR), and anthropometric variables in type 2 diabetes mellitus (T2DM) as well as healthy control groups, and to determine whether two adiponectin gene polymorphisms, at the position -11377C > G as well as +45T > G, are associated with serum levels of adiponectin and other variables; then to search for the association between these two single nucleotide polymorphisms (SNPs) of the adiponectin gene and T2DM. We investigated 93 T2DM patients and 90 healthy volunteers. Compared with the healthy control group, the T2DM group had significantly lower adiponectin levels. Waist circumference, total cholesterol, ALT, glucose, insulin, and HOMA-IR scores were significantly higher in the T2DM group than in the control group. The polymorphism of the adiponectin gene at position -11377C > G among type 2 diabetes subjects showed that the adiponectin concentration was significantly lower in CG/GG genotypes (6.2 µg/mL) than the CC genotype (7.8 µg/mL), whereas SNP +45T > G was not associated with adiponectin levels. Adiponectin gene polymorphisms at position -11377C > G and +45T > G were significantly more frequent in type 2 diabetes patients than in the control group (p = 0.022; p = 0.045, respectively). However, multivariate logistic regression analysis showed that the strong impact on T2DM was found for -11377C > G gene polymorphism (p = 0.023) and waist circumference (p < 0.001). Therefore, the single nucleotide polymorphism of -11377C > G in adiponectin promoter region has impact on the lower adiponectin concentrations, and may influence susceptibility to T2DM in Thais.


Assuntos
Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/genética , Predisposição Genética para Doença , Adiponectina/sangue , Adiponectina/genética , Idoso , Glicemia/análise , Índice de Massa Corporal , Feminino , Estudos de Associação Genética , Heterozigoto , Humanos , Insulina/sangue , Resistência à Insulina , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Regiões Promotoras Genéticas/genética , Tailândia , Circunferência da Cintura
15.
J Clin Biochem Nutr ; 44(1): 104-10, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19177195

RESUMO

The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes. We performed a case-control study in representative sample of 200 Thai volunteers, 105 controls and 95 type 2 diabetes subjects. The purposes of the present study were to investigate the association between two SNPs (single nucleotide polymorphisms) in the resistin gene, at positions +299(G>A) and -420(C>G), and biochemical parameters; to determine whether these polymorphisms are linked to increased risk of type 2 diabetes. At position +299(G>A) of the resistin gene, the resistin concentration among type 2 diabetes subjects was significantly higher in GA/AA genotypes (3.40 ng/ml) than the GG genotype (1.99 ng/ml). Resistin gene polymorphism at position +299(G>A) in type 2 diabetes patients was significantly more frequent than in the control group (p = 0.004). Polymorphism at position -420(C>G) showed no significant relationship with type 2 diabetes (p = 0.095). Logistic regression analysis was shown that +299(G>A) gene polymorphism was increased risk factors for type 2 diabetes (p = 0.013). In conclusion, these finding suggest that resistin gene polymorphism at position +299(G>A) has impact on the increased resistin concentrations and may influence susceptibility to type 2 diabetes in Thais.

16.
Artigo em Inglês | MEDLINE | ID: mdl-18041313

RESUMO

This cross-sectional study was carried out among smokers and nonsmokers from suburban and urban residential areas in Bangkok, Thailand. One hundred eighty-six smokers and 102 nonsmokers, who voluntarily participated in the study, were investigated. The levels of alpha-2-macroglobulin (A2M), albumin, total protein, and other biochemical and hematological parameters as well as body mass index (BMI) measurements were taken. The levels of A2M, BUN and WBC counts were significantly higher in smokers than nonsmokers. Total protein and albumin concentrations were significantly lower in smokers than nonsmokers, but the levels of other biochemical parameters did not differ between the two groups. The relationship between BMI and median A2M levels in the smoker and nonsmoker groups showed the higher the BMI, the lower the serum A2M levels. Smokers had a higher percentage of hyperalpha-2-macroglobulinemia than nonsmokers. A2M concentrations correlated inversely with BMI, BUN, albumin, total cholesterol, triglycerides, and the quantity of cigarettes smoked for the total period of smoking (cigarette pack-years). Multiple regression analysis revealed that albumin and cigarette pack-years were the most closely related variables to A2M concentrations among smokers. These findings suggest cigarette smoking affects inflammation markers, increasing A2M and WBC and decreasing albumin. This effect may be the mechanism responsible for the development of chronic disease states associated with smoking since cigarette smoke contains many toxic compounds harmful to health.


Assuntos
Proteínas Sanguíneas/metabolismo , Fumar/sangue , alfa-Macroglobulinas/metabolismo , Adulto , Índice de Massa Corporal , Estudos Transversais , Humanos , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Albumina Sérica/metabolismo , Tailândia
17.
Artigo em Inglês | MEDLINE | ID: mdl-17877229

RESUMO

In this study, low-density lipoprotein cholesterol (LDL-C) levels by direct measurement and estimation using the Friedewald formula, were compared among 1,016 Thai patients. The study assessed blood samples from out-patients sent to the Clinical Chemistry Laboratory, Department of Clinical Pathology, Rajvithi Hospital, Ministry of Public Health, for measurement of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, January 2004-December 2005. Patients' ages ranged 8-89 years, 573 (56.4%) were females. Linear regression analysis showed the two methods had highly significant correlation coefficients (p<0.001). Upon comparing the two methods, at TG levels of 151-200 mg/dl, bias was 18.3 mg/dl; and for TG levels of 201-300 mg/dl, bias was lower at 11.4 mg/dl; for TG levels of 301-400 mg/dl, bias increased to 20.9 mg/dl. The direct assay meets currently established analytical performance targets and may be useful for the diagnosis and management of hyperlipidemic patients. The Friedewald formula did not give a homogeneous performance when estimating LDL-C levels in samples with different TG levels.


Assuntos
Algoritmos , LDL-Colesterol/análise , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , LDL-Colesterol/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tailândia
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