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Obes Facts ; 11(6): 454-464, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30537756


BACKGROUND: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII). METHODS: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. RESULTS: In both sexes, we found an increase in skeletal muscle mass (SMM), (p = 0.008; 0.008). In men, there was mainly a decrease in visceral fat area (VFA), (p = 0.028) and in women there was decrease of total body fat (TBF), (p = 0.020) and non-significant decrease of VFA (p = 0.098). SMM inversely correlated with VFA in men (p = -0.001) and with TBF in women (p = -0.005 ). GV was decreased generally and correlated inversely with TBF in men only (p = -0.026). Physical activity was increased and correlated inversely with VFA in men (p = -0.002) and in women (p = -0.006). CONCLUSIONS: Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.

Tecido Adiposo/efeitos dos fármacos , Distribuição da Gordura Corporal , Diabetes Mellitus Tipo 1/tratamento farmacológico , Grelina/sangue , Sistemas de Infusão de Insulina , Insulina/administração & dosagem , Leptina/sangue , Músculo Esquelético/efeitos dos fármacos , Tecido Adiposo/metabolismo , Adulto , Idoso , Glicemia/efeitos dos fármacos , Glicemia/metabolismo , Composição Corporal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 1/patologia , Feminino , Hemoglobina A Glicada/efeitos dos fármacos , Hemoglobina A Glicada/metabolismo , Humanos , Injeções Subcutâneas , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/patologia , Tamanho do Órgão/efeitos dos fármacos , Circunferência da Cintura
Diabetes Res Clin Pract ; 81(2): 238-42, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18495284


BACKGROUND: Slovakia is a country with high prevalence of diabetes mellitus (DM) and coronary heart disease (CHD), but the reason of west-east gradient prevalence in Europe is not clear. METHODS: We analyzed 1517 subjects responding to structure of Slovak adult population according to age, sex and regions. Self-reporting CHD risk factors, waist circumference, body mass index (BMI), blood pressure, levels of fasting and 2h glucose, triglycerides, and HDL cholesterol were examined. Impaired fasting glucose (IFG) and DM were diagnosed according to American Diabetes Association (ADA) criteria and the metabolic syndrome (MS) according to NCEP/ATP III and International Diabetes Federation (IDF) criteria. RESULTS: We confirmed 7.0% DM prevalence, including 5.3% of known DM, 1.2% of new DM according to the ADA criteria, and 0.5% of additional new DM cases after oral glucose test (oGTT) in subjects with IFG. Prevalence of MS according to NCEP/ATP III criteria were 20.1% (15.9% in males and 23.9% in females) and 38.1% according to IDF criteria (39.7% in males and 36.6% in females). Low HDL was the most common MS component in the Slovak population (56% total, 45% in male and 66% in female subjects). CONCLUSIONS: DM prevalence in Slovakia is higher than in West European countries and equal to the Mediterranean countries. MS prevalence and its components are equal to European population with the exception of low HDL, which is one of the highest in Europe.

Diabetes Mellitus/epidemiologia , Síndrome Metabólica/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença das Coronárias/epidemiologia , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Eslováquia/epidemiologia , Inquéritos e Questionários