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1.
Mikrochim Acta ; 187(4): 234, 2020 03 16.
Artigo em Inglês | MEDLINE | ID: mdl-32180011

RESUMO

This review (with 145 refs.) summarizes the progress that has been made in the use of zeolitic imidazolate frameworks in chemical sensing and biosensing. Zeolitic imidazolate frameworks (ZIFs) are a type of porous material with zeolite topological structure that combine the advantages of zeolite and traditional metal-organic frameworks. Owing to the structural flexibility of ZIFs, their pore sizes and surface functionalization can be reasonably designed. Following an introduction into the field of metal-organic frameworks and the zeolitic imidazolate framework (ZIF) subclass, a first large section covers the various kinds and properties of ZIFs. The next large section covers electrochemical sensors and assays (with subsections on methods for gases, electrochemiluminescence, electrochemical biomolecules). This is followed by main sections on ZIF-based colorimetric and luminescent sensors, with subsections on sensors for metal ions and anions, for gases, and for organic biomolecules. The last section covers SERS-based assays. Several tables are presented that give an overview on the wealth of methods and materials. A concluding section summarizes the current status, addresses current challenges, and gives an outlook on potential future trends. Graphical abstract In recent years, ZIFs and their composites have been widely used as probes in chemical sensing, and these probes have shown great advantages over other materials. This review describes the current progress on ZIFs toward electrochemical, luminescence, colorimetric, and SERS-based sensing applications, highlighting the different strategies for designing ZIFs and their composites and potential challenges in this field.

2.
J Control Release ; 322: 42-52, 2020 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-32145267

RESUMO

Personalized medicine should ideally be prescribed to every individual because of the unique characteristics (e.g., biological, physical, and medical) of each individual. It is, however, challenging to provide personalized medicine for the mass population of specific individuals effectively and efficiently. This manuscript describes a method of fabricating fully customizable drug tablets for personalized medicine by the 3D printing technology. This method involves the versatile fabrication of the tablets via the specifically designed 3D printed molds of different shapes and sizes, and an intuitive 1-dimensional release of drug that relates the shape of the drug-containing matrix to the release profile. The customization includes all the aspects of varying dosage, duration, release profiles, and combination of multiple drugs. In particular, it has previously been technically difficult to devise a single platform that fabricates carriers that release drug with any desired type of release profiles. This method of fabricating fully customizable tablets is simple, inexpensive, and efficient. Detailed selection and investigation of the materials ensured that the tablet and the method of fabrication are safe (e.g., biocompatible, FDA-approved ingredients used) and other desirable features (e.g., sustained release and high dosage) are achieved. These desirable characteristics of the method thus allow fully customizable drug tablets to be fabricated efficiently on the spot after the diagnosis of individual patients; at the same time, the method can be made widely accessible to the mass population. Hence, the concept of personalized medicine can truly be realized.

3.
Respir Med ; 163: 105881, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32056835

RESUMO

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). As a new inflammatory biomarker of CVD, rare attention has been paid to the roles of lipoprotein-associated phospholipase (Lp-PLA2) in OSAS studies. In this study, we aimed to investigate the correlation between Lp-PLA2 and concomitant CVD in OSAS patients. METHODS: In this prospective study, 152 OSAS patients were further divided into mild, moderate, and severe OSAS subgroups. They presented heart failure, coronary artery disease, or arrhythmia were confirmed with CVD. Thirty-one subjects without OSAS were recruited for the control group. The relationship between Lp-PLA2 and concomitant CVD in OSAS patients was analyzed. RESULTS: Serum Lp-PLA2 values were significantly higher in the severe and moderate OSAS group compared with mild OSAS and OSAS negative groups (P = 0.025). Significant increase was noticed in serum Lp-PLA2 levels in CVD patients compared with those without in severe-moderate-mild OSAS (P < 0.05). In logistic regression analysis, the level of Lp-PLA2 was proved as a significant independent predictor for CVD (OR = 1.117, P = 0.008). The ROC analysis indicated that the best cut-off value of Lp-PLA2 for predicting CVD in OSAS patients was 238.09 ng/ml. The positive and negative predictive values were 72.5% and 70.5%, respectively. The sensitivity was 46.8% and the specificity was 87.8%. CONCLUSIONS: Lp-PLA2 might be associated with the severity of OSAS and the occurrence of CVD in OSAS patients. Lp-PLA2 is expected to be a promising biomarker candidate in predicting CVD in patients with OSAS due to test convenience.

4.
Br J Radiol ; : 20190505, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32101462

RESUMO

OBJECTIVE: Percutaneous transluminal balloon angioplasty (PTA) is recommended as the first choice to treat stenosis of Brescia-Cimino arteriovenous fistulas (B-C AVFs). The ability to predict which B-C AVFs are at risk for recurrent stenosis post-PTA would allow closer monitoring of patients, and possibly result in surgical intervention rather than repeat PTA. The purpose of this study was to identify predictive factors of primary patency after PTA in B-C AVFs. METHODS: Patients diagnosed with B-C AVF primary stenosis and treated by PTA between November 2013 and March 2018 were included in the study. Patient and stenotic lesion characteristics and PTA procedure factors were included in the analysis. The Kaplan-Meier method was used to analyze the primary patency rate. Cox proportional hazard regression analysis was used to identify factors predictive of decreased primary patency. RESULTS: 74 patients (35 males, 39 females) with a mean age of 61.68 ± 11.44 years (range, 36-84 years) were included in the study. The mean B-C AVF age was 16.34 ± 12.93 months (range, 2-84 months), and the median primary patency time was 7.79 ± 0.48 months. Cox proportional hazard regression analysis revealed stenosis location at the inflow artery [hazard ratio (HR)=3.83, 95% confidence interval (CI): 1.46-10.09] or anastomosis (HR = 1.90, 95% CI: 1.09-3.32), dilation >2 times during PTA (HR = 2.30, 95% CI: 1.22-4.34), and residual stenosis >30% (HR = 2.42, 95% CI: 1.26-4.63) were significantly associated with decreased patency. CONCLUSION: In conclusion, the primary patency rate of PTA for B-C AVF dysfunction is reduced by dilation >2 times, residual stenosis >30%, and stenosis located at the inflow artery or anastomosis. These results may help in tailoring surveillance programs, multiple PTA, or a proximal re-anastomosis surgery in patients with AVF dysfunction. ADVANCES IN KNOWLEDGE: A number of studies have been conducted to examine the predictors of primary patency after PTA, however, no definitive conclusions have been reached. Our study revealed that stenosis location at the inflow artery or anastomosis, dilation >2 times during PTA, and residual stenosis >30% were the predictors of primary patency after PTA, which may help in tailoring surveillance programs, multiple PTA, or a proximal re-anastomosis surgery in patients with arteriovenous fistulas dysfunction.

5.
Ear Nose Throat J ; : 145561320902859, 2020 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-32050792

RESUMO

OBJECTIVE: To investigate the effect of drug treatment combined with psychological intervention on mental disorders in patients with persistent moderate-severe allergic rhinitis. METHODS: Sixty patients with persistent moderate-severe allergic rhinitis who met the criteria were randomly divided into 2 groups: control group and experimental group. The control group was only given medication, whereas the experimental group was given psychological intervention on the basis of the same medication. Cognitive behavioral therapy was used for psychological intervention. After 12 weeks of treatment, Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and rhinoconjunctivitis quality of life questionnaire (RQLQ) were used to evaluate the changes in anxiety, depression, and quality of life before and after treatment. RESULTS: The SAS and SDS scores of the control group after treatment were lower than those before treatment, and the difference was statistically significant. Similarly, the SAS and SDS scores of the experimental group after treatment were lower than those before treatment with statistically significant difference. In addition, after treatment, the SAS and SDS scores of the experimental group were statistically lower than those of the control group. The results of RQLQ showed that the scores of each dimension in the control group after treatment were lower than those before treatment, and the difference was statistically significant. Similar results were found in the experimental group. After treatment with these 2 different schemes, the RQLQ scores of sleep, nonnasal/eye symptoms, and emotion in the experimental group were statistically lower than those in the control group. CONCLUSION: Drug therapy or drug therapy combined with psychological intervention can alleviate anxiety and depression of patients with persistent moderate-severe allergic rhinitis and improve their quality of life. Moreover, based on the effect of improving mental disorder and quality of life of patients, drug therapy combined with psychological intervention is better than drug treatment alone.

6.
Eur J Radiol ; 124: 108785, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32004731

RESUMO

PURPOSE: To test whether the whole-tumor radiomics analysis of DKI and DTI images could predict IDH and MGMTmet genotypes of astrocytomas. METHOD: Sixty-two astrocytomas were enrolled. 364 radiomics features of whole tumor were extracted from mean-kurtosis (MK), and mean-diffusivity (MD) images, respectively. The multivariable logistic regression was used to select the most meaningful radiomics features for predicting IDH and MGMTmet genotypes. A radiomics model was built by logistic linear regression. A combined model was established based on selected radiomic, radiological and clinical features. To assess the difference between the models, the Z-test was performed. RESULTS: The radiomics model built using the three most informative radiomics features for each genotype yielded an AUC of 0.831 ((95 % confidence interval [CI]: 0.721-0.918) for predicting IDH genotype, and 0.835 (95 %CI: 0.686-0.951) for MGMTmet genotype. A combined model for predicting IDH based on the radiomics score, age, and degree of edema reached an AUC of 0.885 (95 %CI: 0.802-0.955) and a combined model for predicting MGMTmet based on radiomics score and edema degree reached an AUC of 0.859 (95 %CI: 0.751-0.945) which was not significantly higher than the radiomics only model (P =  0.081). CONCLUSIONS: The radiomics models via an objective whole-tumor analysis of MK and MD maps were independent imaging biomarkers for predicting IDH and MGMTmet genotypes, and the combined model further improved the performance for IDH, but not for MGMTmet.

7.
Inorg Chem ; 2020 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-32083477

RESUMO

Combining electron and energy transfer processes is very significant for efficient photocatalytic oxidation of organic molecules. The first synthesized MOF, Co2(L)(2,6-NDC)2·xguest (FJI-Y10, L = bis(N-pyridyl) tetrachloroperylene peryleneimide, 2,6-NDC = 2,6-naphthalenedicarboxylic acid, FJI = Fujian Institute), shows a 2-fold interpenetrated pcu net, in which the 2,6-NDC ligand connects typical Co2(COO)4 paddle wheel clusters to form square lattices pillared by new PDI-type ligand L. FJI-Y10 as a heterogeneous and recyclable photocatalyst is applied for photo-oxidation of benzylamine and its derivatives with an excellent yield of 100%, which is much higher than that (59%) of the equivalent L ligand as a homogeneous photocatalyst under the same reaction conditions. Such a high-efficiency photocatalytic activity attributes to the combination of charge and energy transfer processes in catalyst FJI-Y10 during the catalytic process.

8.
J Phys Chem B ; 124(3): 504-510, 2020 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-31888335

RESUMO

Lipid raft microdomain of the plasma membrane is implicated in various biological and pathological processes. The involvement of lipid raft in T cell receptor (TCR) signal transduction has been widely studied, whereas the role of these structures in immunoreceptor signaling by DAP12 in natural killing (NK) cells remains largely unknown. Here, we demonstrate that phosphatidylinositol 4,5-bisphosphate (PIP2) lipid localized to lipid raft boundary in our coarse-grained (CG) model raft-forming membrane, and this negatively charged lipid recruits DAP12 homodimer into lipid raft boundary through protein-lipid interaction between the basic-rich regions and signaling immunoreceptor tyrosine-based activation motifs (ITAMs) of DAP12 and PIP2. Furthermore, our results reveal that the protein-lipid interaction can be disrupted by Ca2+, which competitively binds to PIP2 instead of DAP12. As a result, the cytoplasmic region of DAP12 homodimer is dissociated from the membrane back to the nonraft domain, and the ITAMs are exposed to allow further downstream signaling. These findings provide fundamental insights to understand the mechanism of signal transduction in NK cells regulated by membrane microenvironment.

9.
Am J Physiol Cell Physiol ; 318(3): C640-C648, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31940246

RESUMO

Zinc (Zn) has antioxidant effect in different types of organs and is closely associated with human health. Endometrial receptivity is one of the most important factors in the embryo implantation and development. However, the regulatory mechanism of Zn in endometrium tissue is still unclear. In the study, we found that plasma Zn level is significantly associated with female infertility, which severely affects female reproductive health. Primary endometrial stromal cells were isolated from female endometrium and cultured in the laboratory. Zn chelator TPEN treatment reduced the expression of stem cell markers CD73, CD90, and CD105 and generated reactive oxygen species in endometrial stromal cells. However, pretreatment of Zn (zinc sulfate) is able to prevent TPEN-induced oxidative stress in vitro. By transcriptional profiling and gene ontology analysis, we found that Zn increased the cellular pluripotency signaling and extracellular matrix-receptor interaction, but reduced autophagy, endocytosis, and the nitrogen metabolism pathway. We further discovered the antioxidant function of Zn through the peroxisome proliferator-activated receptor gamma coactivator 1α/nuclear factor erythroid-2-related factor signaling pathway in endometrial stromal cells. Zn supplementation may open up an effective therapeutic approach for patients with oxidative stress-related endometrial diseases.

10.
Int J Radiat Biol ; : 1-8, 2020 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-31906777

RESUMO

Purpose: Microcystis aeruginosa often threaten human health and safety for the toxin and unpleasant odor and removal difficulties during water treatment process. In order to remove it, a novel method high energy was studied in this research.Materials and methods: The electron beam generated by an accelerator was applied to irradiate M. aeruginosa at various doses of 1, 2, 3, 4 and 5 kGy. The effects of irradiation on M. aeruginosa characteristics and mechanism have been researched through surveying the changes in pH and conductivity, changes of algae cell community structure and respiration rate, and changes of protein and exopolysaccharides production were also detected.Result: The data showed that exposure to 2-5 kGy radiation could make pH decrease. Microcystis aeruginosa increased through its own photosynthesis and physiological regulation. The increasing damage to algal cells led to the exosmosis of the contents, which increased the electrical conductivity of algae liquid and decreased the area of algae cells colony. 2-5 kGy irradiation decreased protein content and destroy the antioxidant system and thus reduced the secretion of extracellular polysaccharidesConclusions: 2-5 kGy radiation could control the algae growth and produced obvious effect. The respiration rate decreased obviously that made M. aeruginosa lose activity in a short time. The results proved that irradiation could change the algae growth and affect its life characteristic efficiently in a short time.

11.
J Am Chem Soc ; 142(5): 2532-2540, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31910340

RESUMO

Mitomycin C (MMC) has been using for the treatment of a variety of digestive tract cancers. However, its nonspecific DNA-alkylating ability usually causes severe side effects, thus largely limiting its clinical applications. The utilization of an efficient active targeted drug delivery technique would address this issue. Accordingly, we report the design and development of aptamer-mitomycin C conjugates that use different cross-linking chemistry. The targeted delivery ability and cytotoxicity of these conjugates were carefully studied. It is worth noting that a linker-dependent cytotoxicity effect was observed for these conjugates. The use of a reductant-sensitive disulfide bond cross-linking strategy resulted in significantly enhanced cytotoxicity of MMC against the target cancer cell lines. Importantly, this cytotoxicity enhancement was suited to different types of aptamers, demonstrating the success of our design. Mechanistic studies of the enhanced cytotoxicity effect indicated that the target recognition, specific binding, and receptor-mediated internalization of aptamer were also critical for the observed effect.

12.
Phys Chem Chem Phys ; 22(5): 2841-2848, 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-31967121

RESUMO

Quantitative determination of atmospheric CO2 concentration by remote sensing relies on accurate line parameters. Lamb dips of the lines up to J'' = 72 in the 30013-00001 band at 1605 nm were measured using a comb-locked cavity ring-down spectrometer, and the positions were determined with an accuracy of a few kHz. A simple effective Hamiltonian model can fit the rotational energies in the 30013 state ideally within the experimental accuracy, indicating that the vibrational state is well-isolated and can be regarded as free from perturbations. From a comparison between other bands using a similar analysis, we conclude that the transitions in the 30013-00001 band could be more suitable as reference lines for sensing applications with the potentially improved line parameter accuracy.

13.
Medicine (Baltimore) ; 99(4): e18607, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31977852

RESUMO

Systemic inflammatory response markers are associated with poor survival in many types of malignances. This study aimed to evaluate the prognostic value of preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and C-reactive protein (CRP) in patients with non-small cell lung cancer (NSCLC).We retrospectively evaluated 254 NSCLC patients who underwent radical surgery between January 2012 and April 2014 in the Sichuan Provincial Cancer Hospital. The cut-off values of NLR, PLR, LMR, and CRP were determined according to the receiver operating characteristic curve, and the correlation of NLR, PLR, LMR, and CRP with prognosis was analyzed based on the cut-off value.The cut-off value for NLR, PLR, LMR, and CRP were 3.18, 122, 4.04, and 8.8, respectively. Univariate analysis showed that age (P = .022), tumor-node-metastasis (TNM) stage (P < .001), T stage (P = .001), and N stage (P < .001) were significantly correlated with disease-free survival (DFS), while age (P = .011), TNM stage (P < .001), T stage (P = .008), N stage (P < .001), and PLR (P = .001) were significantly correlated with overall survival (OS). In multivariate analysis, age (hazard ratio [HR]: 1.564, 95% confidence interval [CI]: 1.087-2.252, P = .016) and TNM stage (HR: 1.704, 95% CI: 1.061-2.735, P = .027) remained independent risk factors affecting DFS, while age (HR: 1.721, 95% CI: 1.153-2.567, P = .008), TNM stage (HR: 2.198, 95% CI: 1.263-3.824, P = .005), and PLR (HR: 1.850, 95% CI: 1.246-2.746, P = .002) were independent risk factors affecting OS.The preoperative PLR is superior to NLR, LMR, and CRP as a biomarker for evaluating the prognosis of patients undergoing curative surgery for NSCLC.


Assuntos
Plaquetas/metabolismo , Carcinoma Pulmonar de Células não Pequenas/patologia , Inflamação/metabolismo , Neoplasias Pulmonares/patologia , Linfócitos/metabolismo , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais , Proteína C-Reativa/metabolismo , Carcinoma Pulmonar de Células não Pequenas/sangue , Feminino , Humanos , Neoplasias Pulmonares/sangue , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de Neoplasias , Neutrófilos/metabolismo , Análise de Sobrevida
14.
Acta Pharmacol Sin ; 41(2): 229-236, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31431733

RESUMO

In chronic infectious diseases caused by gram-negative bacteria, such as osteomyelitis, septic arthritis, and periodontitis, osteoclastic activity is enhanced with elevated inflammation, which disturbs the bone homeostasis and results in osteolysis. Lipopolysaccharide (LPS), as a bacteria product, plays an important role in this process. Recent evidence shows that an antimalarial drug artesunate attenuates LPS-induced osteolysis independent of RANKL. In this study we evaluated the effects of artesunate on LPS-induced osteoclastogenesis in vitro and femur osteolysis in vivo, and explored the mechanisms underlying the effects of artesunate on LPS-induced osteoclast differentiation independent of RANKL. In preosteoclastic RAW264.7 cells, we found that artesunate (1.56-12.5 µM) dose dependently inhibited LPS-induced osteoclast formation accompanied by suppressing LPS-stimulated osteoclast-related gene expression (Fra-2, TRAP, Cathepsin K, ß3-integrin, DC-STAMP, and Atp6v0d2). We showed that artesunate (3.125-12.5 µM) inhibited LPS-stimulated nuclear factor of activated T cells c1 (NFATc1) but not NF-κB transcriptional activity; artesunate (6.25, 12.5 µM) significantly inhibited LPS-stimulated NFATc1 protein expression. Furthermore, artesunate treatment markedly suppressed LPS-induced Ca2+ influx, and decreased the expression of PP2B-Aα (calcineurin) and pPLCγ1 in the cells. In addition, artesunate treatment significantly decreased the expression of upstream signals TLR4 and TRAF6 during LPS-induced osteoclastogenesis. Administration of artesunate (10 mg/kg, ip) for 8 days effectively inhibited serum TNF-α levels and ameliorated LPS (5 mg/kg, ip)-induced inflammatory bone loss in vivo. Taken together, artesunate attenuates LPS-induced inflammatory osteoclastogenesis by inhibiting the expression of TLR4/TRAF6 and the downstream PLCγ1-Ca2+-NFATc1 signaling pathway. Artesunate is a valuable choice to treat bone loss induced by gram-negative bacteria infection or inflammation in RANKL-independent pathway.

15.
Stem Cells Dev ; 29(3): 133-143, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31822215

RESUMO

Stress urinary incontinence (SUI) after prostate surgery is primarily caused by urethral sphincter damage. There are few effective therapeutic approaches for male SUI due to both insufficient study of the structure of the external urethral sphincter (EUS) and incomplete understanding of the resident EUS stem/progenitor cells. The goals of this study were to localize and to determine the distribution of tissue-resident stem/progenitor cells in the male EUS throughout EUS development and to understand the anatomic temporal patterns of the EUS. Newborn Sprague Dawley rats were intraperitoneally injected with the thymidine analogue, 5-ethynyl-2-deoxyuridine (EdU), and the EUS was harvested at five time points (1, 2, 3, 4, and 8 weeks postinjection). The tissue was then processed for EdU staining and immunofluorescence staining for stem cell markers Ki67 and proliferating cell nuclear antigen. We counted the EdU+ label-retaining cells (LRCs) at each time point and colocalized with each stem cell marker, also we isolated and cultured the cells in vitro. The results revealed that the number of EdU+ LRCs in each EUS cross-section decreased over time and that the LRCs were located immediately under the basal membrane of laminin, densely adherent to the muscle fibers. In addition, the thickness of the striated muscle layer developed much faster than the smooth muscle layer during EUS development. By 4 weeks, the structure of the EUS layers was well differentiated. The EUS resident stem/progenitor cells were isolated with MACS® MicroBeads system, and myogenesis was confirmed. In this study, we defined both the time-course development of the EUS and the distribution of resident stem/progenitor cells. This information is crucial for forthcoming studies regarding male micturition and for development of novel therapeutic approaches for postoperative male SUI.

16.
Toxicol Appl Pharmacol ; 386: 114813, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31715269

RESUMO

Pristimerin, a triterpenoid, has exhibited potential anti-inflammatory and anti-tumor activities. Nevertheless, the role and mechanism of pristimerin in intestinal inflammation and colon cancer require further investigation. Here, we found that pristimerin protected mice from dextran sulfate sodium (DSS)-induced colitis, restoring epithelial damage and reducing tissue inflammation and inflammatory cell infiltration. In addition, pristimerin dramatically reduced the number and size of the tumors in a azoxymethane (AOM)/DSS-induced colitis-associated colorectal cancer (CAC) model. Furthermore, we found that pristimerin suppressed Wnt/ß-catenin signaling by RNA-Seq. Pristimerin inhibited Wnt/ß-catenin signaling via activation of GSK3ß, thereby suppressing Wnt target gene expression in colon cancer HCT116 and HT-29 cells. In HCT116 colon cancer xenografts and APCmin/+ mice, which undergo spontaneous intestinal tumorigenesis, administration of pristimerin reduced the tumor progression and decreased the expression of phosphorylated GSK3ß Ser 9, ß-catenin, cyclin D1 and c-Myc. These results suggest that pristimerin is a potent agent for preventing colon inflammation and carcinogenesis.

17.
Zhongguo Dang Dai Er Ke Za Zhi ; 21(12): 1164-1171, 2019 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-31874653

RESUMO

OBJECTIVE: To investigate the effect of placement of peripherally inserted central catheter (PICC) via the upper versus lower extremity veins in neonates through a Meta analysis. METHODS: CNKI, Wanfang Data, VIP Data, CBMdisc, PubMed, Web of Knowledge, Embase, Medline, Cochrane Library and Google Scholar were searched for control studies on the effect of PICC placement via the upper versus lower extremity veins in neonates. RevMan 5.3 was used to perform a Meta analysis of the studies which met the inclusion criteria. RESULTS: A total of 18 studies were included, among which there were 8 randomized controlled trials and 10 cohort studies, with 4 890 subjects in total. Compared with those undergoing PICC placement via the upper extremity veins, the neonates undergoing PICC placement via the lower extremity veins had significantly lower incidence rates of complications (RR=0.83, 95%CI: 0.75-0.92, P<0.05), catheter-related infections (RR=0.77, 95%CI: 0.60-0.99, P<0.05), catheter malposition (RR=0.28, 95%CI: 0.18-0.42, P<0.05), extravasation of the infusate (RR=0.52, 95%CI: 0.40-0.70, P<0.05), and unplanned extubation (RR=0.82, 95%CI: 0.69-0.98, P<0.05). They also had a significantly higher first-attempt success rate of puncture (RR=1.17, 95%CI: 1.05-1.30, P<0.05) and a significantly shorter PICC indwelling time (MD=-0.93, 95%CI: -1.26-0.60, P<0.05). CONCLUSIONS: The above evidence shows that PICC placement via the lower extremity veins has a better effect than PICC placement via the upper extremity veins in neonates.


Assuntos
Cateterismo Venoso Central , Cateterismo Periférico , Estudos de Coortes , Humanos , Recém-Nascido , Extremidade Inferior , Estudos Retrospectivos
18.
Opt Express ; 27(20): 28507-28522, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31684601

RESUMO

Pulsating behavior is a universal phenomenon in versatile fields. In nonlinear dissipative systems, the solitons also pulsate under proper conditions and show many interesting dynamics. However, the pulsation dynamics are generally concerned with single-soliton cases. Herein, by utilizing real-time spectroscopy technique, namely, dispersive Fourier-transform (DFT), we reveal the distinct dynamical diversity of pulsating solitons in a fiber laser. In particular, the weak to strong explosive behaviors of pulsating solitons, as well as the rogue wave generation during explosions are observed. Moreover, the concept of soliton pulsation is extended to the multi-soliton case. It is found that the simultaneous pulsations of energy, separation and relative phase difference could be observed for solitons inside the molecule, while the pulsations of each individual in a multi-soliton bunch could be regular or irregular. These findings will shed new insights into the complex nonlinear behavior of solitons in ultrafast fiber lasers as well as dissipative optical systems.

19.
Artigo em Inglês | MEDLINE | ID: mdl-31694255

RESUMO

The total fertility rate of the Chinese population has declined dramatically over the last three decades. Research has substantiated the causal link between particulate matter (PM) and adverse health effects. However, the impact of PM on the birth intentions or fertility behavior of the childbearing population remains understudied. The paper analyzes the impact of PM2.5 concentration (a mixture of extremely small solid particles and liquid droplets found in the air) on the second birth intentions of the Chinese floating population. We used urban migrant population matching data at the prefectural level for the analysis. The unique datasets were derived from the Chinese Floating Population Dynamic Survey in 2014 administered by the National Health Commission, the National Prefecture-level City Matching Data administered by the National Bureau of Statistics of China, and the air pollution index PM2.5 collected by the Green Peace Organization. The results show that PM2.5 concentration has a negative impact on the second birth intentions of the floating population. This impact exhibits marked regional heterogeneity: the desire for a second birth across migrant groups living in south China decreases if PM2.5 concentration goes up, while migrants coming from, and living in, north China show strong intentions to have a second birth despite an increase in PM2.5 concentration in northern cities. The results have direct implications for the Chinese government at various levels to play a vital role in making and implementing environmental policies on the mitigation of smog to effectively safeguard the health of individuals and communities and potentially raise China's fertility rate.

20.
Fitoterapia ; 139: 104408, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31698058

RESUMO

One new pseudoguaianolide (1), one new megastigmane (6), and one new ent-abietane diterpene (9), together with seven known compounds (2-5, 7, 8, and 10) were isolated from the aerial parts of Euphorbia thymifolia. The structures of the new compounds and their relative configurations were determined by spectroscopic data analysis. The absolute configurations of compounds 1, 6, and 9 were determined by single-crystal X-ray crystallographic analysis, modified Mosher's method and calculated ECD experiment, respectively. All compounds were tested for their inhibitory effects against LPS-induced NO production in BV-2 microglial cells, and pseudoguaianolides (1-5) showed significant activity with IC50 values of 0.41-15.32 µM.


Assuntos
Diterpenos/farmacologia , Euphorbia/química , Fármacos Neuroprotetores/farmacologia , Sesquiterpenos/farmacologia , Animais , Linhagem Celular Tumoral , China , Cicloexanonas , Diterpenos/isolamento & purificação , Glucosídeos , Camundongos , Microglia/efeitos dos fármacos , Estrutura Molecular , Fármacos Neuroprotetores/isolamento & purificação , Óxido Nítrico , Norisoprenoides , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Componentes Aéreos da Planta/química , Sesquiterpenos/isolamento & purificação
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