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1.
Crit Rev Food Sci Nutr ; : 1-23, 2022 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-35930027

RESUMO

Pulses, as a sustainable source of nutrients, are an important choice for human diets, but vast quantities of seed coats generated in pulses processing are usually discarded or used as low-value ruminant feed. It has been demonstrated that pulses seed coats are excellent sources of dietary nutrients and phytochemicals with potential health benefits. With growing interest in the sustainable use of resources and the circular economy, utilization of pulses seed coats to recover these valuable components is a core objective for their valorization and an important step toward agricultural sustainability. This review comprehensively provides a comprehensive insight on the nutritional and phytochemical profiles presented in pulses seed coats and their health benefits obtained from the findings of in vitro and in vivo studies. Furthermore, in the food industry, pulses seed coats can be acted as potential food ingredients with nutritional, antioxidant and antimicrobial characteristics or as the matrix or active components of films for food packaging and edible coatings. A better understanding of pulses seed coats may provide a reference for increasing the overall added value and realizing the pulses' sustainable diets.

2.
Chem Sci ; 13(27): 8095-8103, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35919440

RESUMO

Highly reactive organometallic nanoclusters in situ generated in metal-catalyzed reactions are pivotal in the comprehension of catalytic mechanisms. Herein, we develop a two-step synthetic method to achieve three unprecedented aryl dicarbanion-bonded Ag13 nanoclusters by using protective macrocyclic ligands. Firstly, various aryl dicarbanion-Ag4 cluster intermediates are acquired via a silver-mediated annulation reaction within a macrocyclic ligand. These Ag4 cluster precursors are released from the surrounding macrocycle by protonation, and further undergo an inter-cluster coupling to generate bipyridine products and low-valence silver atoms. The remaining resurgent diide-Ag4 clusters assemble with low-valence silver atoms to yield a series of organometallic Ag13 nanoclusters. These Ag13 nanoclusters feature a unique open-shell electronic structure as well as a chiral cluster architecture due to the asymmetric arrangements of surrounding aryl dianion ligands. Furthermore, the pyridyl diide ligands on the surface of the nanocluster further experience an intra-cluster oxidative coupling to produce bipyridine coupling products and large nanoparticles. The coupling reaction-driven cluster-to-cluster transformation is comprehensively tracked by high resolution mass spectroscopy. This work is not only reminiscent of the detailed evolution of cluster species upon the occurrence of coupling reactions, but also reproduces novel inter- and intra-cluster coupling steps at different reaction stages.

3.
Front Bioeng Biotechnol ; 10: 909388, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35923575

RESUMO

Lymphatic metastasis influences clinical treatment and prognosis of patients with non-small-cell lung cancer (NSCLC). There is an urgency to understand the molecular features and mechanisms of lymph node metastasis. We analyzed the molecular features on pairs of the primary tumor and lymphatic metastasis tissue samples from 15 NSCLC patients using targeted next-generation sequencing. The potential metastasis-related genes were screened from our cohort based on cancer cell fraction. After filtering with gene functions, candidate metastasis-related events were validated in the MSK cohort with Fisher's exact test. The molecular signature and tumor mutational burden were similar in paired samples, and the average mutational concordance was 42.0% ± 28.9%. Its metastatic mechanism is potentially a linear progression based on the metastatic seeding theory. Furthermore, mutated ataxia telangiectasia mutated and Rad3-related (ATR) and tet methylcytosine dioxygenase 2 (TET2) genes were significantly enriched in lymphatic metastases (p ≤ 0.05). Alterations in these two genes could be considered metastasis-related driving events. Mutated ATR and TET2 might play an active role in the metastasis of lymph nodes with NSCLC. More case enrollment and long-term follow-up will further verify the clinical significance of these two genes.

4.
Dalton Trans ; 2022 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-35894183

RESUMO

Cu-Modified La2Si2O7/TiO2 composite materials were prepared by the molten salt method and a solid-phase reduction strategy. Due to the surface plasmon resonance (SPR) of copper, the optical response from the UV to the visible region and near-infrared is increased. In the meantime, it enhances the absorption of visible light by the titanium dioxide and acts as a plasma catalyst. The combination enhances the photothermal properties of the composite. The particle size of Cu/La2Si2O7/TiO2 is in the range of 100 to 230 nm. Results show that the composite has a good photothermal effect. The 1 mg ml-1 solution can be warmed up to 63.1 °C at 0.5 W cm-2 laser power density with a maximum temperature difference of 45 °C. It has potential applications in solar energy conversion, photothermal catalysis, etc.

5.
J Hazard Mater ; 439: 129639, 2022 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-35908399

RESUMO

Paired handwipe and urine samples were collected from adult (n = 130) and child (n = 82) residents of a typical urban community in southern China to examine relationships between external and internal exposure as well as the contribution of dermal absorption to the exposure of phthalates. The concentrations and composition profiles of phthalates were similar in handwipes from both adults and children, and contained mainly di-2-ethylhexyl phthalate (DEHP), di-n-butyl phthalate (DnBP) and di-iso-butyl phthalate (DiBP), consistent with profiles of phthalates in air and dust. The major metabolites of these phthalates, i.e., mono-n-butyl phthalate (mnBP) from DnBP, mono-iso-butyl phthalate (miBP) from DiBP and three metabolites of DEHP (namely mEHP, mEHHP and mEOHP) were widely detected in paired urine samples. Positive correlations were found between contamination levels of DiBP and DnBP in handwipes and their corresponding urinary metabolites, whereas no significant correlation was observed for DEHP. This suggests that dermal absorption might be an important exposure pathway particularly for low molecular weight phthalates. Our study shows that dermal absorption is a non-negligible exposure pathway for phthalates, to which children are particularly sensitive since the contribution of dermal uptake to the internal exposure of phthalates was higher in children than adults.

6.
Brief Bioinform ; 2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35880623

RESUMO

Adoption of recently developed methods from machine learning has given rise to creation of drug-discovery knowledge graphs (KGs) that utilize the interconnected nature of the domain. Graph-based modelling of the data, combined with KG embedding (KGE) methods, are promising as they provide a more intuitive representation and are suitable for inference tasks such as predicting missing links. One common application is to produce ranked lists of genes for a given disease, where the rank is based on the perceived likelihood of association between the gene and the disease. It is thus critical that these predictions are not only pertinent but also biologically meaningful. However, KGs can be biased either directly due to the underlying data sources that are integrated or due to modelling choices in the construction of the graph, one consequence of which is that certain entities can get topologically overrepresented. We demonstrate the effect of these inherent structural imbalances, resulting in densely connected entities being highly ranked no matter the context. We provide support for this observation across different datasets, models as well as predictive tasks. Further, we present various graph perturbation experiments which yield more support to the observation that KGE models can be more influenced by the frequency of entities rather than any biological information encoded within the relations. Our results highlight the importance of data modelling choices, and emphasizes the need for practitioners to be mindful of these issues when interpreting model outputs and during KG composition.

7.
Front Plant Sci ; 13: 897739, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35795344

RESUMO

Three species of rice migratory pests (Cnaphalocrocis medinalis, Sogatella furcifera, and Nilaparvata lugens) cause severe yield and economic losses to rice food every year. It is important that these pests are timely and accurately monitored for controlling them and ensuring food security. Insect radar is effective monitoring equipment for migratory pests flying at high altitude. But insect radar is costly and has not been widely used in fields. Searchlight trap is an economical device, which uses light to trap migratory pests at high altitude. But the trapped pests need to be manually identified and counted from a large number of non-target insects, which is inefficient and labor-intensive. In order to replace manual identification of migratory pests, we develop an intelligent monitoring system of migratory pests based on searchlight trap and machine vision. This system includes a searchlight trap based on machine vision, an automatic identification model of migratory pests, a Web client, and a cloud server. The searchlight trap attracts the high-altitude migratory insects through lights at night and kills them with the infrared heater. All trapped insects are dispersed through a multiple layers of insect conveyor belts and a revolving brush. The machine vision module collects the dispersed insect images and sends them to the cloud server through 4G network. The improved model YOLO-MPNet based on YOLOv4 and SENet channel attention mechanism is proposed to detect three species of migratory pests in the images. The results show that the model effectively improves the detection effect of three migratory pests. The precision is 94.14% for C. medinalis, 85.82% for S. furcifera, and 88.79% for N. lugens. The recall is 91.99% for C. medinalis, 82.47% for S. furcifera, and 85.00% for N. lugens. Compared with some state-of-the-art models (Faster R-CNN, YOLOv3, and YOLOv5), our model shows a low false detection and missing detection rates. The intelligent monitoring system can real-timely and automatically monitor three migratory pests instead of manually pest identification and count, which can reduce the technician workload. The trapped pest images and historical data can be visualized and traced, which provides reliable evidence for forecasting and controlling migratory pests.

8.
Front Pediatr ; 10: 890719, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35903167

RESUMO

Purpose: Early childhood developmental delay remains problematic worldwide in terms of weight and the five domains of child development, including gross motor, fine motor, cognition, language, and social domains. Based on the World Health Organization (WHO) guideline and the theoretical domain framework, this study identified five key socioeconomic factors, such as parenting time during hospitalization, parental educational level, medical spending, distance to hospital, and medical insurance coverage, to describe how these five factors are associated with improved outcomes of developmental quotient (DQ) values and the weight of infants in a tertiary hospital. Methods: In this prospective observational study, clinical and socioeconomic data were collected. Clinical data included the weight and DQ values of infants and other data relevant to the birth of infants. A National Developmental Scale was used to observe infants in five domains and calculate the DQ values of infants. These five domains include gross motor, fine motor, cognition, language, and social domains. Parenting time during hospitalizations was observed by a research nurse. Other socioeconomic factors were reported by parents and verified with system information. Results: A total of 75 infants' parents were approached, of which 60 were recruited. The age of infants ranged from 75 to 274 days at the first admission. Increments of their weight and DQ values improved from -0.5 to 2.5 kg and from -13 to 63, respectively. More than half of the parents (54.1%) were at the level of minimum secondary education although the results were not statistically significant. However, there was a positive correlation between weight improvement and parenting time during hospitalization (r(58) = 0.258, p < 0.05), medical spending (r(58) = 0.327, p < 0.05), distance to hospital (r(58) = 0.340, p < 0.01), but there was a negative association with medical insurance coverage (r(58) =-0.256, p < 0.05). There was also a significant relationship between the improved DQ value and distance to hospital (r(58)= 0.424, p < 0.01). Conclusion: Parenting time during hospitalization, medical spending, distance to hospital, and medical insurance coverage are important factors for early childhood developmental delay in relation to possible hospital intervention and improved accessibility to health services for families in rural areas. Therefore, changes in the current medical scheme are needed because a universal medical subsidy among regions will reduce the financial burden of families and provide families with more access to the necessary health services that their children need.

9.
J Phys Chem Lett ; 13(29): 6806-6819, 2022 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-35857377

RESUMO

Perovskite light-emitting diodes (PeLEDs) featuring excellent electroluminescent (EL) characteristics and facile production have been emerging as promising candidates for next-generation high-definition displays. In recent years, tremendous advances have been achieved in the EL efficiency of PeLEDs. However, their poor operational stability impedes practical applications. Particularly, the severe spectral instability of pure-blue and pure-red PeLEDs lags far behind the requirements of commercial displays. In this Perspective, the critical factors related to device degradation are first summarized, including perovskite crystal defects, unbalanced charge injection, Auger recombination, and Joule heating. Then, the recent progress in improving the operational and spectral stabilities is reviewed in categories. Considering the present achievements, we provide potential research directions for further development of stable PeLEDs.

10.
Environ Pollut ; 308: 119713, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35809707

RESUMO

Primitive electronic waste (e-waste) dismantling activities have been shown to be an important emissions source for a variety of toxic organic compounds, including carcinogenic polycyclic aromatic hydrocarbons (PAHs). Previous studies have found that some nitrated PAHs (NPAHs) are more toxic than their parent PAHs, however, little attention has been paid to the formation of PAH derivatives during e-waste processing and there is a lack of comprehensive data from field observations. In this study, the spatial distribution, temporal trends and atmospheric fate of NPAHs and hydroxylated PAHs (OH-PAHs) were investigated at typical e-waste dismantling sites, with monitoring data collected over three consecutive years. Compared to background levels, higher levels of NPAHs and OH-PAHs were found in air samples from an e-waste dismantling industrial park, with their seasonal and annual changes shown to be affected by e-waste dismantling activities. Atmospheric PM2.5 particles were found to have high relative abundances of NPAHs (76.9%-95.1%) and OH-PAHs (73.3%-91.6%), with particle-bound concentrations ranging from 20.1 to 88.8 and 37.1 to 107 pg m-3, respectively. The most abundant NPAH isomers were found to be 9-Nitroanthracene and 2-Nitrofluoranthene, while OH-PAH isomers containing 2-4 rings were predominant. Source identification was performed based on the specific diagnostic ratios of NPAH isomers, confirming that NPAH and OH-PAH emissions have multiple sources, including emissions related to the e-waste dismantling process, atmospheric photochemical reactions and traffic emissions. Further research on the fate of such derivatives and their potential use as markers for source identification, is urgently required.


Assuntos
Poluentes Atmosféricos , Resíduo Eletrônico , Hidrocarbonetos Policíclicos Aromáticos , Poluentes Atmosféricos/análise , China , Monitoramento Ambiental , Nitratos , Óxidos de Nitrogênio , Hidrocarbonetos Policíclicos Aromáticos/análise
11.
Cell Death Dis ; 13(7): 621, 2022 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-35851270

RESUMO

Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to investigate the role of angiopoietin-like protein 8 (ANGPTL8) in pathological cardiac hypertrophy. We found that serum ANGPTL8 levels were significantly increased in hypertensive patients with cardiac hypertrophy and in mice with cardiac hypertrophy induced by Ang II or TAC. Furthermore, the secretion of ANGPTL8 from the liver was increased during hypertrophic processes, which were triggered by Ang II. In the Ang II- and transverse aortic constriction (TAC)-induced mouse cardiac hypertrophy model, ANGPTL8 deficiency remarkably accelerated cardiac hypertrophy and fibrosis with deteriorating cardiac dysfunction. Accordingly, both recombinant human full-length ANGPTL8 (rANGPTL8) protein and ANGPTL8 overexpression significantly mitigated Ang II-induced cell enlargement in primary neonatal rat cardiomyocytes (NRCMs) and H9c2 cells. Mechanistically, the antihypertrophic effects of ANGPTL8 depended on inhibiting Akt and GSK-3ß activation, and the Akt activator SC-79 abolished the antihypertrophic effects of rANGPTL8 in vitro. Moreover, we demonstrated that ANGPTL8 directly bound to the paired Ig-like receptor PIRB (LILRB3) by RNA-seq and immunoprecipitation-mass screening. Remarkably, the antihypertrophic effects of ANGPTL8 were largely blocked by anti-LILRB3 and siRNA-LILRB3. Our study indicated that ANGPTL8 served as a novel negative regulator of pathological cardiac hypertrophy by binding to LILRB3 (PIRB) and inhibiting Akt/GSK3ß activation, suggesting that ANGPTL8 may provide synergistic effects in combination with AT1 blockers and become a therapeutic target for cardiac hypertrophy and heart failure.


Assuntos
Insuficiência Cardíaca , Hormônios Peptídicos , Proteína 8 Semelhante a Angiopoietina , Proteínas Semelhantes a Angiopoietina/genética , Proteínas Semelhantes a Angiopoietina/metabolismo , Angiotensina II/metabolismo , Angiotensina II/farmacologia , Animais , Antígenos CD/metabolismo , Cardiomegalia/metabolismo , Modelos Animais de Doenças , Glicogênio Sintase Quinase 3 beta/metabolismo , Insuficiência Cardíaca/metabolismo , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Miócitos Cardíacos/metabolismo , Hormônios Peptídicos/genética , Hormônios Peptídicos/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Ratos , Receptores Imunológicos/metabolismo , Transdução de Sinais
12.
Org Lett ; 24(26): 4816-4819, 2022 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-35748771

RESUMO

Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine (1). The unique molecular scaffold of 1 is synthesized by the nonribosomal peptide synthetase-polyketide synthase hybrid AcdB, which unusually incorporates 3-hydroxy-l-kynurenine as a building block. AcdB subsequently performs one round of chain elongation using malonyl-CoA, which is followed by the chain release to furnish the tricyclic system of 1.


Assuntos
Alcaloides , Policetídeo Sintases , Família Multigênica , Peptídeo Sintases/química , Policetídeo Sintases/química
13.
Natl Sci Rev ; 9(5): nwab122, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35668749

RESUMO

Spin defects in silicon carbide (SiC) with mature wafer-scale fabrication and micro/nano-processing technologies have recently drawn considerable attention. Although room-temperature single-spin manipulation of colour centres in SiC has been demonstrated, the typically detected contrast is less than 2[Formula: see text], and the photon count rate is also low. Here, we present the coherent manipulation of single divacancy spins in 4H-SiC with a high readout contrast ([Formula: see text]) and a high photon count rate (150 kilo counts per second) under ambient conditions, which are competitive with the nitrogen-vacancy centres in diamond. Coupling between a single defect spin and a nearby nuclear spin is also observed. We further provide a theoretical explanation for the high readout contrast by analysing the defect levels and decay paths. Since the high readout contrast is of utmost importance in many applications of quantum technologies, this work might open a new territory for SiC-based quantum devices with many advanced properties of the host material.

14.
Front Chem ; 10: 921113, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35755262

RESUMO

In this study, four kinds of chemical substances (2,3,5,6-tetramethylpyrazine, ß-ionone, citronellal, and paeonol), three kinds of plant essential oils (tea tree essential oil, lavender essential oil, and myrrh essential oil), and their combinations were selected to explore their synergistic effects on tobacco beetle [Lasioderma serricorne (Fabricius) (Coleoptera: Anobiidae)] adults by the behavioral test and laboratory simulation test. Behavioral test results showed that some of the combinations revealed a synergistic effect on tobacco beetle adults, especially the sexual attractant +2,3,5,6-tetramethylpyrazine + ß-ionone + citronellal + paeonol (SABCD, one portion of sexual attractant, and 1 mg/L synergistic substances) combination and the food attractant +2,3,5,6-tetramethylpyrazine + paeonol (FAD, 1 ml of food attractant and 1 mg/L synergistic substances) combination showed the best behavioral effect on tobacco beetle adults with average dwell times of 120.97 and 126.74 s, respectively, compared to those of other combinations. Meanwhile, SABCD had the highest selection rate [89.47%, about 1.5 times that of the sexual attractant (S)] on tobacco beetle adults compared with those of other combinations. In addition, laboratory simulation test results showed that the SABCD combination had the highest average selection rate (37.31%, about 2 times that of S) on tobacco beetle adults at 1 mg/L. However, our results showed that there was no significant difference in the indoor simulation results of food attractant synergistic substances. Our results will provide guidance for the development of new pesticides for tobacco beetle adults.

15.
Clin Transl Gastroenterol ; 13(6): e00493, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35758823

RESUMO

INTRODUCTION: Prophylactic antitubercular therapy (ATT) is widely prescribed in patients with Crohn's disease (CD) receiving antitumor necrosis factor (anti-TNF) treatment. However, antitubercular agents have been demonstrated to possess profibrotic effects. We aimed to evaluate whether ATT accelerated disease progression in patients with CD receiving anti-TNF treatment. METHODS: A retrospective, multicenter study was performed in CD patients presented with inflammatory behavior (B1) and treated with anti-TNF agents. Disease progression was defined as the development of a stricturing (B2) or penetrating (B3) phenotype. ATT users were propensity score-matched with non-ATT users. Survival and multivariable Cox analyses were used to identify factors associated with disease progression. RESULTS: We enrolled 441 patients, including 295 ATT users and 146 non-ATT users, with a median follow-up of 3.15 years (interquartile range: 1.6-4.7). The cumulative rates of disease progression in the ATT group were constantly higher than those in the non-ATT group after 1-, 3-, 5-, and 10-year follow-ups, respectively (P = 0.031). Multivariable Cox analysis identified ATT as an independent risk factor for disease progression using both the whole (hazard ratio = 2.22; 95% confidence interval: 1.11-4.48; P = 0.025) and propensity score-matched cohorts (hazard ratio = 2.35; 95% confidence interval: 1.07-5.14; P = 0.033). In subgroup analysis, patients receiving ATT ≥4.5 months had a significantly higher rate of disease progression compared with patients receiving ATT <4.5 months (P = 0.005) and non-ATT treatment (P = 0.036). DISCUSSION: Prophylactic ATT with duration over 4.5 months was associated with disease progression in patients with CD receiving anti-TNF treatment.


Assuntos
Doença de Crohn , Antituberculosos/uso terapêutico , Doença de Crohn/diagnóstico , Doença de Crohn/tratamento farmacológico , Doença de Crohn/prevenção & controle , Progressão da Doença , Humanos , Estudos Retrospectivos , Inibidores do Fator de Necrose Tumoral/efeitos adversos
16.
Natl Sci Rev ; 9(6): nwac077, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35769232

RESUMO

The 2D semiconductor of MoS2 has great potential for advanced electronics technologies beyond silicon. So far, high-quality monolayer MoS2 wafers have been available and various demonstrations from individual transistors to integrated circuits have also been shown. In addition to the monolayer, multilayers have narrower band gaps but improved carrier mobilities and current capacities over the monolayer. However, achieving high-quality multi-layer MoS2 wafers remains a challenge. Here we report the growth of high-quality multi-layer MoS2 4-inch wafers via the layer-by-layer epitaxy process. The epitaxy leads to well-defined stacking orders between adjacent epitaxial layers and offers a delicate control of layer numbers up to six. Systematic evaluations on the atomic structures and electronic properties were carried out for achieved wafers with different layer numbers. Significant improvements in device performances were found in thicker-layer field-effect transistors (FETs), as expected. For example, the average field-effect mobility (µ FE) at room temperature (RT) can increase from ∼80 cm2·V-1·s-1 for monolayers to ∼110/145 cm2·V-1·s-1 for bilayer/trilayer devices. The highest RT µ FE of 234.7 cm2·V-1·s-1 and record-high on-current densities of 1.70 mA·µm-1 at V ds = 2 V were also achieved in trilayer MoS2 FETs with a high on/off ratio of >107. Our work hence moves a step closer to practical applications of 2D MoS2 in electronics.

17.
Nat Commun ; 13(1): 3292, 2022 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-35672329

RESUMO

New phase of matter usually emerges when a given symmetry breaks spontaneously, which can involve charge, spin, and valley degree of freedoms. Here, we report an observation of new correlated insulators evolved from spin-polarized states to valley-polarized states in twisted double bilayer graphene (TDBG) driven by the displacement field (D). At a high field |D | > 0.7 V/nm, we observe valley polarized correlated insulators with a big Zeeman g factor of ~10, both at v = 2 in the moiré conduction band and more surprisingly at v = -2 in the moiré valence band. Moreover, we observe a valley polarized Chern insulator with C = 2 emanating at v = 2 in the electron side and a valley polarized Fermi surface around v = -2 in the hole side. Our results demonstrate a feasible way to realize isospin control and to obtain new phases of matter in TDBG by the displacement field, and might benefit other twisted or non-twisted multilayer systems.

18.
Zhongguo Zhong Yao Za Zhi ; 47(10): 2833-2840, 2022 May.
Artigo em Chinês | MEDLINE | ID: mdl-35718504

RESUMO

The clinical comprehensive evaluation of Chinese patent medicine is an important direction in the evaluation of traditional Chinese medicine(TCM), which positively promotes the development of TCM industry. The evaluation system of Chinese patent medicine is helpful to comprehensively evaluate the clinical value of different Chinese patent medicine in the same category, different dosage forms, and specifications, from different manufacturers on the basis of evidence and value. The establishment of a scientific and reasonable comprehensive evaluation index system for Chinese patent medicine is an important prerequisite to ensure clinical value. However, there has been neither a recognized systematic review on the clinical comprehensive evaluation of Chinese patent medicine nor a methodological system used for reference. The evidence and value: impact on decision-making(EVIDEM), developed by the international research team, is used to evaluate the comprehensive value of medical interventions. EVIDEM provides a methodological tool for scientific decision-making to evaluate evidence and value for health technologies on the basis of the multi-criteria decision analysis(MCDA) model and health technology assessment(HTA). Based on the ongoing EVIDEM research, the present study put forward that EVIDEM-based clinical comprehensive evaluation of Chinese patent medicine consisted of four aspects, seven modules, and ten steps, which is expected to references and practical experience for the follow-up comprehensive evaluation of Chinese patent medicine in the TCM field.


Assuntos
Medicamentos de Ervas Chinesas , Medicamentos sem Prescrição , China , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Tradicional Chinesa , Avaliação da Tecnologia Biomédica
19.
Inorg Chem ; 61(24): 9205-9212, 2022 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-35723505

RESUMO

A new noncentrosymmetric (NCS) quaternary sulfide, SrAgAsS4, was obtained via the strategy of aliovalent substitution based on centrosymmetric (CS) SrGa2S4. The new compound features two-dimensional [AgAsS4]2- layers, which are composed of alternately connected [AsS4] tetrahedra and [AgS4] tetrahedra. Importantly, SrAgAsS4 exhibits a strong phase-matched second-harmonic generation response (1.35 × AgGaS2 at 2100 nm) and has a suitable birefringence (0.15@2100 nm) and moderate band gap (2.31 eV). The first-principles calculations revealed the significant contribution of [AsS4] and [AgS4] tetrahedra to its optical properties. This work will promote the application of the aliovalent substitution strategy in the design of NCS-structure-based functional materials.

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