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1.
Oncol Rep ; 48(1)2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35642686

RESUMO

Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2 on p. 1835, which was designed to show how miR­10b promotes the migration and invasion of human bladder cancer cell lines in vitro, there appeared to be several overlapping panels such that certain of the data may have been derived from the same original sources, even though they were intended to show the results obtained under different experimental conditions. The authors have re­examined their original data, and have realized that the errors arose as a consequence of inadvertently misfiling and mishandling the data. The corrected version of Fig. 2 is shown below. Note that these errors did not affect the overall conclusions reported in the study. All the authors agree to the publication of this corrigendum, and are grateful to the Editor of Oncology Reports for allowing them the opportunity to publish it; furthermore, they apologize for any inconvenience caused to the readership of the Journal. [the original article was published in Oncology Reports 31: 1832­1838, 2014; DOI: 10.3892/or.2014.3048].

2.
Rheumatol Autoimmun ; 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-35651484

RESUMO

Background: We examined attitudes toward the COVID-19 vaccine, potential factors underlying these attitudes, and ways to increase vaccination willingness in autoimmune inflammatory rheumatic diseases (AIIRD) patients. Methods: A multicenter, web-based, observational survey using an online questionnaire was conducted among AIIRD patients aged ≥18 years from May 24, 2021, to June 3, 2021. Participants were 3104 AIIRD patients (2921 unvaccinated and 183 vaccinated). Results: Of the unvaccinated patients, 32.9% were willing to receive the COVID-19 vaccine, 45.0% were uncertain, and 14.8% were unwilling. When vaccination was recommended by physicians, patients' willingness increased to 93.8%. Participants' main concerns were that the vaccine may aggravate AIIRD disease (63.0%) and may cause vaccine-related adverse events (19.9%). Female patients were less likely to be vaccinated. However, patients who had children aged ≤18 years were more willing to be vaccinated. In addition, vaccination willingness was higher in patients with trust in the safety and efficacy of the COVID-19 vaccine. Notably, 183 (5.9%) patients were vaccinated. The major vaccination side effects were injection reaction, myalgia, and fatigue. At a median follow-up of 88 (38, 131) days, patients' disease activities were stable. Conclusions: The findings show that AIIRD patients were unwilling to receive the COVID-19 vaccine because of fears of potential disease exacerbation and additional adverse events. Sociodemographic characteristics and concerns about COVID-19 disease and vaccines had a significant effect on vaccination willingness.

3.
J Am Nutr Assoc ; : 1-12, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-35512758

RESUMO

OBJECTIVE: The impact of high-nitrate beetroot juice (BRJ) supplementation has seen a recent explosion of interest in sports science. This study examined the potential influence of 7-day BRJ supplementation on the endurance performance of winter triathletes. METHODS: Eighty young active winter triathletes (44 males, age = 21.50 ± 1.15 yrs; 36 females, age = 20.66 ± 1.45 yrs) participated in this study and were provided with either BRJ (6.5 mmol NO3-/70 mL) or a placebo (PL, 0.065 mmol NO3-/70 mL) for 7 days (a dose of ×3 per day) in a randomized, double-blind design. The athletes then completed a submaximal treadmill run, intraday cycling exhaustion testing, and a 10-km cross country (XC) skiing competition on the second day. RESULTS: There was a significant decrease in the oxygen uptake, respiratory exchange ratio, and blood lactic acid level (p < 0.05) between the BRJ and PL treatment groups during V3 speed running (males: 13.3 km·h-1, females: 11.6 km·h-1). BRJ treatment also remarkably increased the time to exhaustion (TTE) during cycling exhaustion testing (males: p = 0.02, females: p = 0.04). No significant differences were observed in medium- or low-speed submaximal treadmill runs and 10-km XC skiing performance. CONCLUSIONS: One week of daily nitrate-rich BRJ supplementation improved running economy at high speed during the submaximal treadmill running test and extended the TTE of athletes during cycling exhaustion testing. However, BRJ supplementation did not improve the performance in 10-km on-snow time trials in XC skiing. Regarding nutritional strategies to improve endurance performance in exercise training and competition, these results should be carefully considered owing to the different motor skill levels and competitive abilities of participants.

4.
Curr Pediatr Rep ; 10(2): 19-30, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35540721

RESUMO

Purpose of Review: A multisystem inflammatory condition occurring in children and adolescents with COVID-19 has become increasingly recognized and widely studied globally. This review aims to investigate and synthesize evolving evidence on its clinical characteristics, management, and outcomes in pediatric patients. Recent Findings: We retrieved data from PubMed, EMBASE, Cochrane Library, WHO COVID-19 Database, Google Scholar, and preprint databases, covering a timeline from December 1, 2019, to July 31, 2021. A total of 123 eligible studies were included in the final descriptive and risk factor analyses. We comprehensively reviewed reported multisystem inflammatory syndrome in children (MIS-C) cases from published and preprint studies of various designs to provide an updated evidence on epidemiology, clinical, laboratory and imaging findings, management, and short-term outcomes. Latest evidence suggests that African black and non-Hispanic white are the two most common ethnic groups, constituting 24.89% (95% CI 23.30-26.48%) and 25.18% (95% CI 23.51-26.85%) of the MIS-C population, respectively. Typical symptoms of MIS-C include fever (90.85%, 95% CI 89.86-91.84%), not-specified gastrointestinal symptoms (51.98%, 95% CI 50.13-53.83%), rash (49.63%, 95% CI 47.80-51.47%), abdominal pain (48.97%, 95% CI 47.09-50.85%), conjunctivitis (46.93%, 95% CI 45.17-48.69%), vomiting (43.79%, 95% CI 41.90-45.68%), respiratory symptoms (41.75%, 95% CI 40.01-43.49%), and diarrhea (40.10%, 95% CI 38.23-41.97%). MIS-C patients are less likely to develop conjunctivitis (OR 0.27, 95% CI 0.11-0.67), cervical adenopathy (OR 0.21, 95% CI 0.07-0.68), and rash (OR 0.44, 95% CI 0.26-0.77), in comparison with Kawasaki disease patients. Our review revealed that the majority of MIS-C cases (95.21%) to be full recovered while only 2.41% died from this syndrome. We found significant disparity between low- and middle-income countries and high-income countries in terms of clinical outcomes. Summary: MIS-C, which appears to be linked to COVID-19, may cause severe inflammation in organs and tissues. Although there is emerging new evidence about the characteristics of this syndrome, its risk factors, and clinical prognosis, much remains unknown about the causality, the optimal prevention and treatment interventions, and long-term outcomes of the MIS-C patients. Supplementary Information: The online version contains supplementary material available at 10.1007/s40124-022-00264-1.

5.
BMC Immunol ; 23(1): 23, 2022 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-35578178

RESUMO

BACKGROUND: Asthma is a common chronic airway disease in the world. The purpose of this study was to explore the expression of IL1-RL1 in sputum and its correlation with Th1 and Th2 cytokines in asthma. METHODS: We recruited 132 subjects, detected IL1-RL1 protein level in sputum supernatant by ELISA, and analyzed the correlation between the expression level of IL1-RL1 and fraction of exhaled nitric oxide (FeNO), IgE, peripheral blood eosinophil count (EOS#), and Th2 cytokines (IL-4, IL-5, IL-10, IL-13, IL-33 and TSLP) and Th1 cytokines (IFN-γ, IL-2, IL-8). The diagnostic value of IL1-RL1 was evaluated by ROC curve. The expression of IL1-RL1 was further confirmed by BEAS-2B cell in vitro. RESULTS: Compared with the healthy control group, the expression of IL1-RL1 in sputum supernatant, sputum cells and serum of patients with asthma increased. The AUC of ROC curve of IL1-RL1 in sputum supernatant and serum were 0.6840 (p = 0.0034), and 0.7009 (p = 0.0233), respectively. IL1-RL1 was positively correlated with FeNO, IgE, EOS#, Th2 cytokines (IL-4, IL-5, IL-10, IL-13, IL-33 and TSLP) and Th1 cytokines (IFN-γ, IL-2, IL-8) in induced sputum supernatant. Four weeks after inhaled glucocorticoids (ICS) treatment, the expression of IL1-RL1 in sputum supernatant and serum was increased. In vitro, the expression of IL1-RL1 in BEAS-2B was increased after stimulated by IL-4 or IL-13 for 24 h. CONCLUSION: The expression of IL1-RL1 in sputum supernatant, sputum cells and serum of patients with asthma was increased, and was positively correlated with some inflammatory markers in patients with asthma. IL1-RL1 may be used as a potential biomarker for the diagnosis and treatment of asthma.


Assuntos
Asma , Proteína 1 Semelhante a Receptor de Interleucina-1 , Asma/imunologia , Biomarcadores/metabolismo , Citocinas/metabolismo , Eosinófilos , Humanos , Imunoglobulina E/imunologia , Proteína 1 Semelhante a Receptor de Interleucina-1/biossíntese , Proteína 1 Semelhante a Receptor de Interleucina-1/imunologia , Interleucinas/imunologia , Óxido Nítrico/imunologia
6.
JMIR Public Health Surveill ; 8(4): e33394, 2022 04 06.
Artigo em Inglês | MEDLINE | ID: mdl-35384848

RESUMO

BACKGROUND: The issue of malnutrition in the Democratic Republic of Congo is severe. Meanwhile, the Water, Sanitation, and Hygiene program has been demonstrated to be effective in reducing the rates of growth stunting among children. OBJECTIVE: We aimed to explore the association between maternal exposure to mass media and stunting in children through water, sanitation, and hygiene behaviors. METHODS: Mediation analysis was conducted using data from the 2018 Multiple Indicators Cluster Surveys. RESULTS: Mothers' exposures to television and the internet in the Democratic Republic of Congo significantly decreases the risk of stunting in children by 5% and 10%, respectively, mediated by household water, sanitation, and hygiene facilities and practices. CONCLUSIONS: These findings could inform interventions and policies to reduce the rate of stunting rate children by promoting water, sanitation, and hygiene through mass media, especially through the internet and television.


Assuntos
Saneamento , Água , Criança , Feminino , Transtornos do Crescimento/epidemiologia , Transtornos do Crescimento/etiologia , Humanos , Higiene , Meios de Comunicação de Massa , Exposição Materna , Análise de Mediação
7.
Front Chem ; 10: 870564, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35464228

RESUMO

Recently, sodium-ion batteries (SIBs) have attracted extensive attention as potential alternatives to lithium-ion batteries (LIBs) due to the abundance, even distribution, low cost, and environmentally friendly nature of sodium. However, sodium ions are larger than lithium ions so that the anode materials of LIBs are not suitable for SIBs. Therefore, many negative electrode materials have been investigated. Among them, Sb2S3-based nanomaterials have gradually become a research focus due to their high theoretical specific capacity, good thermal stability, simple preparation, and low price. In this review, the research progress of Sb2S3-based nanomaterials in the SIB field in recent years is summarized, including Sb2S3, Sb2S3/carbon composites, Sb2S3/graphene composites, and Sb2S3/MxSy composites. Furthermore, the challenges and prospects for the development of Sb2S3-based nanomaterials are also put forward. We hope this review will contribute to the design and manufacture of high-performance SIBs and promote its practical application.

8.
Artigo em Inglês | MEDLINE | ID: mdl-35409650

RESUMO

This study aimed to investigate the association between early sexual initiation and suicide attempts (SAs) among Chinese young people. Our analysis included 9131 college students who had sexual experience from a national sample of 31 provincial administrative regions. Self-reported age at first intercourse was categorized as ≤15, 15-18, and ≥18 years, and the experience of SAs was recorded and analyzed. Compared with females whose sexual debut age was ≥18 years, those ≤15 years (defined as early sexual initiation) had higher odds of SAs in both the forced debut group (odds ratio (OR) 17.04, 95% confidence interval (CI) 4.87-59.66) and the voluntary debut group (OR 37.63, 95% CI 14.96-94.66). Early sexual initiators who lived in rural areas were more inclined to have SAs (female: OR 65.76, 95% CI 19.80-218.42; male: OR 15.39, 95% CI 1.64-144.19). Early sexual initiators who never had parent-child communication about sex were more likely to report having SAs (female: OR 37.81, 95% CI 12.28-116.46). Sexual debut during adolescence, particularly early sexual initiation, was a crucial risk factor for SAs among both sexes. Comprehensive sexuality education and smooth parental communication about sex will provide a supportive environment for young people and hence reduce the potential risks of SAs.


Assuntos
Comportamento Sexual , Tentativa de Suicídio , Adolescente , China/epidemiologia , Coito , Feminino , Humanos , Masculino , Educação Sexual
9.
Nat Genet ; 54(4): 403-411, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35393595

RESUMO

Facial morphology-a conspicuous feature of human appearance-is highly heritable. Previous studies on the genetic basis of facial morphology were performed mainly in European-ancestry cohorts (EUR). Applying a data-driven phenotyping and multivariate genome-wide scanning protocol to a large collection of three-dimensional facial images of individuals with East Asian ancestry (EAS), we identified 244 variants in 166 loci (62 new) associated with typical-range facial variation. A newly proposed polygenic shape analysis indicates that the effects of the variants on facial shape in EAS can be generalized to EUR. Based on this, we further identified 13 variants related to differences between facial shape in EUR and EAS populations. Evolutionary analyses suggest that the difference in nose shape between EUR and EAS populations is caused by a directional selection, due mainly to a local adaptation in Europeans. Our results illustrate the underlying genetic basis for facial differences across populations.


Assuntos
Estudo de Associação Genômica Ampla , Polimorfismo de Nucleotídeo Único , /genética , Face/anatomia & histologia , Estudo de Associação Genômica Ampla/métodos , Humanos , Herança Multifatorial/genética , Polimorfismo de Nucleotídeo Único/genética
10.
Micromachines (Basel) ; 13(3)2022 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-35334681

RESUMO

The contribution of this work is to propose a half-mode substrate integrated coaxial resonator (HMSICR) and its application in bandpass filter (BPF) design. The proposed HMSICR is formed by evenly bisecting a square substrate integrated coaxial resonator (SICR), which is a cavity composed of two dielectric substrates and three metal layers. The SICR's sidewalls are mimicked by periodically spaced thru-via arrays, and a circular patch is embedded in the middle metal layer of the SICR with the patch shorted to the cavity's bottom wall by a circular array of blind vias. This HMSICR can drastically lower the cavity's resonance frequency. The achieved frequency reduction rate of the proposed HMSICR, as compared with that of its conventional substrate integrated waveguide (SIW) cavity counterpart, reaches 70%. A sample four-HMSICR BPF is built for the circuit verification measurement. To further reduce the sample filter's area, the composing HMSICRs are vertically stacked in a back-to-back configuration. We believe that its obtained size-reduction rate reaches the highest record.

11.
Angew Chem Int Ed Engl ; 61(24): e202202671, 2022 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-35357773

RESUMO

Poor oxygen diffusion at multiphase interfaces in an air cathode suppresses the energy densities of zinc-air batteries (ZABs). Developing effective strategies to tackle the issue is of great significance for overcoming the performance bottleneck. Herein, inspired by the bionics of diving flies, a polytetrafluoroethylene layer was coated on the surfaces of Co3 O4 nanosheets (NSs) grown on carbon cloth (CC) to create a hydrophobic surface to enable the formation of more three-phase reaction interfaces and promoted oxygen diffusion, rendering the hydrophobic-Co3 O4 NSs/CC electrode a higher limiting current density (214 mA cm-2 at 0.3 V) than that (10 mA cm-2 ) of untreated-Co3 O4 NSs/CC electrode. Consequently, the assembled ZAB employing hydrophobic-Co3 O4 NSs/CC cathode acquired a higher power density (171 mW cm-2 ) than that (102 mW cm-2 ) utilizing untreated-Co3 O4 NSs/CC cathode, proving the enhanced interfacial reaction kinetics on air cathode benefiting from the hydrophobization engineering.

12.
BMC Pulm Med ; 22(1): 86, 2022 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-35287655

RESUMO

BACKGROUND: Baculoviral IAP repeat-containing 3 (BIRC3) which encodes a member of the IAP family of proteins upregulated in the asthma expression profile dataset. However, there was few research on studying the clinical implication of BIRC3 in asthma. OBJECTIVE: To validate BIRC3 expression and its clinical implications in induced sputum of asthma. METHODS: Based on the GSE76262 (118 asthma cases and 21 healthy controls) dataset, differentially expressed genes were screened using R software. Subsequently, BIRC3 mRNA and protein were clinically verified in induced sputum samples through quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Besides, the correlations between BIRC3 expression and asthmatic eosinophilic/allergic inflammation indicators (FeNO, IgE, and EOS%), pulmonary function (FEV1, FEV1% pred, FVC% pred, and FEV1/FVC), and inflammatory cytokines (IL-4, IL-5, IL-13, IL-25, IL-10, IL-33, and TSLP) were analyzed. Finally, BIRC3 mRNA was detected in human primary bronchial epithelial cells stimulated by cytokines (IL-4 or IL-13). RESULTS: BIRC3 was screened as a candidate gene in the GSE76262, which was highly expressed in asthma. Highly expressed BIRC3 was positively correlated with eosinophilic and allergic indicators, including FeNO, blood eosinophil, and serum IgE. Moreover, BIRC3 protein was positively associated with inflammation cytokines, like IL-4, IL-5, IL-13, IL-25, IL-10, IL-33, and TSLP, while negatively correlated with FEV1, FEV1%pred, FVC% pred, and FEV1/FVC. Furthermore, the expression of BIRC3 could be induced in primary bronchial epithelial cells treated by cytokines IL-4 or IL-13. CONCLUSIONS: BIRC3 significantly increased in induced sputum of asthma and positively correlated with airway eosinophilic and peripheral blood allergic inflammation, type 2 cytokines, and airway obstruction. Increased BIRC3 might be involved in the pathogenesis of asthma by affecting the eosinophilic and allergic inflammation.


Assuntos
Asma , Escarro , Proteína 3 com Repetições IAP de Baculovírus/genética , Proteína 3 com Repetições IAP de Baculovírus/metabolismo , Citocinas/metabolismo , Eosinófilos/metabolismo , Humanos , Testes de Função Respiratória , Escarro/metabolismo
13.
BMC Health Serv Res ; 22(1): 144, 2022 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-35120503

RESUMO

BACKGROUND: Diarrhoea is one of the leading causes of death among children under 5 years old in the Democratic Republic of the Congo (DRC). Despite positive effects on prognosis, there is limited literature about the healthcare-seeking behaviours of children with diarrhoea, especially in the DRC. This study used the Andersen Behavioural Model, a theoretical framework, which was commonly adopted to study healthcare utilisation, to investigate and predict factors associated with the use of healthcare to treat diarrhoea in the DRC. METHODS: Data collected from 2626 under-five children with diarrhoea in the last 2 weeks from the Multiple Indicators Cluster Survey conducted by the National Institute of Statistics in 2017-2018, in collaboration with the United Nations Children's Fund were used in this study. Both direct and indirect relationships among four latent variables: predisposing traits, enabling resources access, health needs, and health services use were measured using the structural equation modelling to test the Andersen behavioural model. The confirmatory Factor Analysis model was also modified based on the DRC context to explore this further. RESULTS: The modified model had the goodness of fit index (GFI) of 0.972, comparative fit index (CFI) of 0.953 and RMSEA of 0.043 (95% CI: 0. 040, 0.047). Health needs (especially diarrhoea) had the largest positive direct effect on healthcare utilisation (standardized regression coefficient [ß] = 0.135, P < 0.001), followed by "enabling resources" (ß = 0.051, P = 0.015). Health needs also emerged as a mediator for the positive effect of predisposing on utilisation (indirect effect, ß = 0.014; P = 0.009). CONCLUSION: Access to improved water and improved sanitation, as well as socioeconomic factors like household wealth, were significantly associated with health-seeking behaviours for diarrhoea treatment in the DRC. Besides, caregivers who own higher levels of educational attainments were more inclined to have positive health services uses during the treatments. Efforts are needed to enhance the oral rehydration therapy coupled with educating caregivers on its appropriate use.


Assuntos
Atenção à Saúde , Aceitação pelo Paciente de Cuidados de Saúde , Criança , Pré-Escolar , República Democrática do Congo/epidemiologia , Diarreia/epidemiologia , Diarreia/terapia , Humanos , Lactente , Fatores Socioeconômicos
14.
J Asthma ; : 1-9, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-35168451

RESUMO

Club cell 10-kDa protein (CC10) is a documented biomarker for airway obstructive diseases. Primarily produced by nonciliated club cells in the distal airway and in nasal epithelial cells, CC10 suppresses Th2 cell differentiation and Th2 cytokine production. In this study, we aimed to determine whether CC10 can also be used as an alternative biomarker for identifying Type 2 (T2) asthma.74 patients with asthma, and 24 healthy controls were enrolled in the study. T2-high asthma was defined as elevation in two or more biomarkers, such as sputum eosinophilia ≥ 3%, high blood eosinophils ≥ 300/µL, or high FeNO ≥ 30 ppb. T2-low asthma was defined as no elevation in biomarkers. Enzyme-linked immunosorbent assay (ELISA) was used to assess the CC10 levels in plasma.The plasma CC10 level in patients with T2-high asthma was lower than that of patients with T2-low asthma and healthy controls (P < 0.05). To distinguish between T2-high and T2-low phenotype in patients with asthma, a receiver-operating characteristic (ROC) analysis was performed. It showed a sensitivity of 58.1% and specificity of 78.0% when using 22.74 ng/ml of plasma CC10. Correlation analysis indicated that the plasma CC10 level was inversely correlated with sputum eosinophil, blood eosinophil, and FeNO, and positively correlated with log PD20. However, no correlation with sputum neutrophil percentages, macrophage percentages, IgE, or lung function was found.Plasma CC10 is potentially useful in predicting T2-high and T2-low asthma. Lower plasma CC10 was associated with enhanced airway hyperresponsiveness, and Type 2 inflammation.

15.
Small Methods ; 6(2): e2101276, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35174986

RESUMO

For the challenging pursuit of high energy efficiency and mechanical tolerance in flexible solid-state Zn-air batteries (FSZABs), a hydrogel electrolyte (HE) consisting of dual-network crosslinked polyacrylic acid-Fe3+ -chitosan (PAA-Fe3+ -CS) polymer host infiltrated with a mixed aqueous electrolyte of NH4 Cl and ZnCl2 is developed. The absorbed near-neutral electrolyte renders the HE high ionic conductivity but low corrosiveness to both electrocatalysts and Zn metal anode (ZMA), ensuring more stable Zn-OH-O2 chemistry compared to that in strong alkaline electrolyte and thus endowing the assembled FSZABs with a landmark cycle life up to 120 h (5 mA cm-2 ). More intriguingly, the CS molecular beams introduced into the PAA hydrogel backbone will precipitate and fold subjecting to the Hofmeister effect when saturated with the near-neutral electrolyte, which can effectively enhance the interfacial adhesion strength of the HE on both air cathode and ZMA, achieving reliable and robust bonding between them. Thus, the FSZABs simultaneously exhibited a superior tolerance to repeated mechanical deformation during operation, allowing more than 360 continuous bending-recovery cycles without any decline in voltage efficiency. The ingenious chemistry and interface synergetic engineering on the crucial HEs provides a rational methodology to realize boosted electrochemical and mechanical durability of FSZABs forward for future practical implementation.

17.
Glob Health Res Policy ; 7(1): 3, 2022 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-35067229

RESUMO

The current decolonizing global health movement is calling us to take a post-colonial perspective at the research and practice of global health, an area that has been re-defined by contemporary scholars and advocates with the purpose of promoting equity and justice. In this article, we summarize the main points of discussion from the Symposium organized by the editorial board of Global Health Research and Policy, convened in July 2021 in Wuhan, China. Experts participating in the symposium discussed what decolonizing global health means, how to decolonize it, and what criteria to apply in measuring its completion. Through the meeting, a consensus was reached that the current status quo of global health is still replete with various forms of colonial vestiges-ideologies and practices-, and to fully decolonize global health, systemic reforms must be taken that target the fundamental assumptions of global health: does investment in global health bring socioeconomic development, or is it the other way around? Three levels of colonial vestiges in global health were raised and one guiding principle was proposed when thinking of solutions for them. More theoretical discussion needs to be explored to guide practices to decolonize global health.


Assuntos
Colonialismo , Saúde Global , China , Justiça Social
18.
World J Urol ; 40(2): 513-518, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34766214

RESUMO

OBJECTIVE: To compare the outcomes of mini percutaneous nephrolithotomy (mPNL) and retrograde intrarenal surgery (RIRS) for the management of 2-3 cm lower pole renal calculi (LPC) in obese patients. PATIENTS AND METHODS: 120 obese patients with 2-3 cm LPC were randomly divided into mPNL group and RIRS group. Demography, clinical characteristics, perioperative complications, and stone free rate (SFR) were recorded. Stone-free status means no stone on computed tomography 3 months after surgery, or residual fragments were less than 3 mm. RESULTS: Baseline characteristics were similar between the two groups. The mean stone burden was 585.39 ± 131.06 mm2 in the mPNL group and 548.64 ± 123.55 mm2 in the RIRS group (P = 0.125). The SFR of mPNL group was significantly better than that of RIRS group (86.2% vs 61.4%, P = 0.002). Besides, the overall complication rate was 22.4% in the mPNL group and 7% in the RIRS group (P = 0.02). Patients performed with mPNL required longer length of hospital stay than those with RIRS (P = 0.001). There were no significant differences in operative time and stone composition between the two groups. CONCLUSION: In our study, both mPNL and RIRS are safe and effective techniques for the treatment of 2-3 cm LPC in obese patients. Compared to RIRS, mPNL has better SFR at the expense of the higher incidence of complications and prolonged length of hospital stay.


Assuntos
Cálculos Renais , Nefrolitotomia Percutânea , Nefrostomia Percutânea , Humanos , Cálculos Renais/complicações , Cálculos Renais/cirurgia , Tempo de Internação , Nefrolitotomia Percutânea/métodos , Nefrostomia Percutânea/métodos , Obesidade/complicações , Resultado do Tratamento
19.
J Gerontol B Psychol Sci Soc Sci ; 77(4): 750-758, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-34718577

RESUMO

OBJECTIVES: Bridge employment has been encouraged by many countries worldwide as societies age rapidly. However, the health impact on bridge employment is not consistent in previous studies. This study aims to explore the association between bridge employment and long-term health outcome among the Chinese population. METHODS: In this prospective cohort study, we used a subset of the China Kadoorie Biobank study, in which 163,619 participants who reached the statutory age of retirement at baseline (2004-2008) were included in this study. Mortality statistics were obtained from death registries in the Death Surveillance Points system annually. We used a Cox proportional hazard model to analyze the association between bridge employment and all-cause mortality. RESULTS: Overall, we found that compared to retired/nonemployed men and women, hazards of all-cause mortality were lower in older people with bridge employment (men: 0.82, 95% confidence interval [CI]: 0.77-0.88; women: 0.79, 95% CI: 0.74-0.94) in healthy populations. The protective effect of bridge employment was stronger among older adults living in rural areas and among those from a relatively low socioeconomic status. DISCUSSION: The lower risk of all-cause mortality associated with bridge employment was consistently observed among older men and women. Our findings may provide important insights from the health dimension on the retirement policy-making in China as a hyper-aging society.


Assuntos
Emprego , Longevidade , Idoso , China/epidemiologia , Estudos de Coortes , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Aposentadoria
20.
J Public Health (Oxf) ; 44(1): 36-50, 2022 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-33300571

RESUMO

BACKGROUND: The epidemiology of multiple chronic conditions in China is poorly understood. We investigated the prevalence of multimorbidity among the middle-aged and elderly population in China and analyzed its demographic and socioeconomic correlates. METHODS: Data were obtained from the baseline of the China Kadoorie Biobank Study, which recruited over 0.5 million participants between 2004 and 2008. We calculated the prevalence by the characteristics of multimorbidity. The demographic and socioeconomic correlates were analyzed using a multivariable logistic regression model. RESULTS: 15.9% of the participants were multimorbid. Although the prevalence of multimorbidity increased with age, the absolute number of people with multimorbidity was much higher among middle-aged adults (30-60 years, n = 42 041) than the elderly group (>60 years, n = 38 834). The odd of multimorbidity was higher in males (aOR =1.09, 95% CI: 1.07-1.11) and among those who were unemployed (aOR = 1.58, 95% CI: 1.55-1.62). Those who received the highest level of education were most likely to be multimorbid compared with those with no education (aOR = 1.14, 95% CI: 1.09-1.19). Such an association was similar when treating multimorbidity as multinomial variable. CONCLUSIONS: Multimorbidity is a public health concern, with higher prevalence among the elderly, males and those who belong to a lower socioeconomic stratum. Actions are needed to curb multimorbidity epidemic in China.

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