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1.
Inorg Chem ; 59(4): 2171-2177, 2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-31990539

RESUMO

Glutamate is a biomarker for many nervous system diseases, and sensitively detecting glutamate is meaningful in the clinic. Therefore, a unique 3D framework of Cd-MOF (1) is synthesized and characterized. A single-crystal X-ray study reveals that it is a two-fold interpenetration (4,4)-connected framework with a PtS topology, where a large 1D rhombic channel with a size of 8 × 14 Å exists and the total potential void volume can reach 62%. Luminescence results demonstrate that 1 has good luminescence stability and can sensitively detect glutamate in water with a detection limit of 1.15 × 10-7 mol/L, which makes it the most sensitive MOF-based luminescence sensor of glutamate to date. More importantly, it also can serve as a luminescence sensor to detect glutamate in serum, and the quenching concentration needs to be only 43.1 µmol/L, which is much lower than the harmful level of glutamate (400 µmol/L) in glioma patients' blood. Compound 1 can be used at least five cycles. These results show that 1 has a potential application in monitoring glutamate in clinical scenarios.

2.
Anal Chem ; 91(8): 5455-5460, 2019 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-30924344

RESUMO

pH value is a key parameter in reflecting the health status, reaction process, and water quality. The construction of highly sensitive pH luminescent ratiometric is important but challenging. Herein we designed and synthesized a unique triple-interpenetrated luminescent lanthanide-organic framework {[Eu(PPTA)0.5(NO3)(DMF)2]·H2O} n(V104) based on an amphoteric ligand 4,4',4'',4'''-(1,4-phenylenebis(pyridine-4,2,6-triyl))tetrabenzoic acid (H4PPTA). Compound V104 possesses high solvent and acid/alkaline stabilities. Luminescent investigations reveal that V104 exhibits dual emission peaks at 390 and 480 nm, and these two peaks can separately detect OH- and H+ among various anions and cations. Importantly, V104 can serve as a self-calibrated pH ratiometric to quantitatively detect pH value, and the sensitivity can reach 403.2% per pH for OH-, and 129.5% per pH for H+. Furthermore, by encapsulating magnetic γ-Fe2O3 nanoparticles in V104, the pH sensor can be readily separated from the analyte by external magnet and recycled at least four times, suggesting as-synthesized γ-Fe2O3@V104 has potential for monitoring pH fluctuations in water. To our knowledge, this is the first self-calibrated ratiometric pH-sensor based on two responsive wave bands which can separately detect OH- and H+.

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