Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 95
Filtrar
1.
Drug Discov Ther ; 15(5): 261-267, 2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34719605

RESUMO

On March 1, 2019, the Ministry of Health, Labour and Welfare added bleeding symptoms to adverse reaction package inserts as a possible adverse event for a new anti-influenza drug, baloxavir marboxil, because 13 patients with bleeding symptoms were identified among influenza patients taking the drug. Nevertheless, aspects of the epidemiology of bleeding symptoms among influenza patients remain unclear. This study elucidated bleeding symptoms among influenza patients and hospitalized patients as severe cases. A survey was administered to all physicians in Japan during the 2019-2020 season for reporting of bleeding symptoms in influenza patients. The survey elicited information about outcomes, assuming associated underlying diseases and drugs in addition to administered drugs including acetaminophen and anti-influenza (antiviral) drugs. We received reports of 63 cases with bleeding symptoms, including 5 cases of hospitalized patients. Among all patients, 54% had been administered oseltamivir; 10% had been administered baloxavir marboxil. Among hospitalized patients, all had been administered acetaminophen; 40% of them had been administered oseltamivir, and one patient had been administered baloxavir marboxil. Accumulation of bleeding symptom cases is expected to be necessary to evaluate the association.

2.
Ticks Tick Borne Dis ; 12(6): 101821, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34525434

RESUMO

In Okinawa prefecture, Japan, the first case of severe fever with thrombocytopenia syndrome (SFTS) was confirmed in August 2016, and this case remains to be the only reported case of SFTS in Okinawa. The epidemiological investigation indicated that the patient had been infected on the main island of Okinawa, but source and route of infection were unknown. Therefore, to understand the possible source and route of SFTS virus (SFTSV) infection in Okinawa, we performed a seroepidemiological study of SFTSV among animals and dwellers in Okinawa and conducted a questionnaire survey to investigate risk factors for tick bites in Okinawa. Among the 1,035 serum samples from four different animal species, anti-SFTSV antibodies were detected in only 4.2% wild mongoose (Herpestes auropunctatus) serum samples. To our knowledge, this is the first study to report the detection of anti-SFTSV antibodies in wild mongooses. Meanwhile, all 1,104 human inhabitants tested negative for anti-SFTSV antibodies, suggesting that the frequency of SFTSV exposure is low in Okinawa. Logistic regression analysis of the questionnaire results showed that outdoor activity was associated with an increased risk of tick bite among Okinawa residents. Despite the current low frequency of SFTSV infection in animals and humans, endemic circulation of the virus in Okinawa should be carefully monitored in the area for preventing future infections.


Assuntos
Gatos , Cabras , Herpestidae , Phlebovirus/isolamento & purificação , Febre Grave com Síndrome de Trombocitopenia/epidemiologia , Febre Grave com Síndrome de Trombocitopenia/veterinária , Sus scrofa , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Doenças do Gato/epidemiologia , Doenças do Gato/virologia , Feminino , Doenças das Cabras/epidemiologia , Doenças das Cabras/virologia , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Soroepidemiológicos , Febre Grave com Síndrome de Trombocitopenia/virologia , Suínos , Doenças dos Suínos/epidemiologia , Doenças dos Suínos/virologia , Adulto Jovem
3.
Sci Rep ; 11(1): 13945, 2021 07 06.
Artigo em Inglês | MEDLINE | ID: mdl-34230563

RESUMO

Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and South Asia. In this study, we examined the trends in the causative pathogens of diarrhea and the corresponding gut microbiota in Ghana using microbiome analysis performed on diarrheic stools via 16S rRNA sequencing. In total, 80 patients with diarrhea and 34 healthy adults as controls, from 2017 to 2018, were enrolled in the study. Among the patients with diarrhea, 39 were norovirus-positive and 18 were rotavirus-positive. The analysis of species richness (Chao1) was lower in patients with diarrhea than that in controls. Beta-diversity analysis revealed significant differences between the two groups. Several diarrhea-related pathogens (e.g., Escherichia-Shigella, Klebsiella and Campylobacter) were detected in patients with diarrhea. Furthermore, co-infection with these pathogens and enteroviruses (e.g., norovirus and rotavirus) was observed in several cases. Levels of both Erysipelotrichaceae and Staphylococcaceae family markedly differed between norovirus-positive and -negative diarrheic stools, and the 10 predicted metabolic pathways, including the carbohydrate metabolism pathway, showed significant differences between rotavirus-positive patients with diarrhea and controls. This comparative study of diarrheal pathogens in Ghana revealed specific trends in the gut microbiota signature associated with diarrhea and that pathogen-dependent dysbiosis occurred in viral gastroenteritis.


Assuntos
Disbiose/microbiologia , Disbiose/virologia , Gastroenterite/microbiologia , Gastroenterite/virologia , Microbioma Gastrointestinal , Adolescente , Adulto , Bactérias/classificação , Biodiversidade , Estudos de Casos e Controles , Criança , Pré-Escolar , Diarreia/microbiologia , Diarreia/virologia , Fezes/microbiologia , Feminino , Gana , Humanos , Masculino , Filogenia , Rotavirus/fisiologia
5.
Vaccine ; 39(15): 2177-2182, 2021 04 08.
Artigo em Inglês | MEDLINE | ID: mdl-33736919

RESUMO

PURPOSE: The first outbreak of invasive meningococcal disease (IMD) in decades occurred in a high school dormitory in 2011. This report aims to describe the results of the IMD outbreak investigation and to discuss current issues of IMD in Japan. METHODS: We conducted an epidemiological and microbiological investigation against the IMD outbreak of serogroup B among students and staff in a high school dormitory. Information on patients was collected to analyze risk factors for IMD. Control measures and public health actions were summarized. RESULTS: Three cases of meningitis and two cases of bacteremia were identified. Freshmen (15-16 years old) living in the dormitory with preceding cough were high-risk populations in this outbreak. Pulsed-field gel electrophoresis, multilocus sequence typing, and porA gene sequencing results revealed that all isolates were closely related to each other and had deep similarities to the domestic circulating meningococcal strain. The outbreak was terminated after promptly implementing control measures. Based on the results of our investigation, from April 2013, national infectious disease surveillance started to target meningococcal bacteremia as part of IMD, in addition to meningococcal meningitis, which was newly designated as a category II school infectious disease under the School Health and Safety Act. CONCLUSIONS: This outbreak has enhanced public health measures against IMD in Japan. The development of national guidelines for appropriate public health interventions on the IMD outbreak response including chemoprophylaxis is still needed.


Assuntos
Meningite Meningocócica , Infecções Meningocócicas , Neisseria meningitidis Sorogrupo B , Neisseria meningitidis , Adolescente , Surtos de Doenças , Humanos , Japão/epidemiologia , Meningite Meningocócica/epidemiologia , Infecções Meningocócicas/epidemiologia , Neisseria meningitidis Sorogrupo B/genética , Instituições Acadêmicas , Sorogrupo
7.
J Gen Fam Med ; 22(2): 115, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33717793

RESUMO

We welcome their additional suggestion that the government should publish potential causes for and implications of the additional outbreak beyond the quarantine to the international scientific community so that similar outbreaks may be swiftly prevented. However, given the absence of government-driven publications, we published this report based on our independent investigation, which may be more reliable considering the inherently sensitive and political nature of the events.

8.
Influenza Other Respir Viruses ; 15(2): 293-314, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-32997395

RESUMO

BACKGROUND: Elderly populations are particularly vulnerable to influenza and often require extensive clinical support. In Japan, nationwide passive surveillance monitors seasonal influenza but does not capture the full disease burden. We synthesized existing evidence on the epidemiology, vaccine effectiveness (VE), and economic burden of seasonal influenza in the elderly population. METHODS: PubMed, EMBASE, and ICHUSHI were searched for articles on seasonal influenza in Japan, published between 1997 and 2018, in English or Japanese. Grey literature was also assessed. A random-effects meta-analysis characterized VE of influenza vaccines among studies reporting this information. RESULTS: Of 1,147 identified articles, 143 met inclusion criteria. Reported incidence rates varied considerably depending on study design, season, study setting and, most importantly, case definition. In nursing homes, the maximum reported attack rate was 55.2% and in the 16 articles reporting mortality rates, case fatality rates varied from 0.009% to 14.3%. Most hospitalizations were in people aged >60; healthcare costs were partially mitigated by vaccine administration. Meta-analysis estimated overall VE of 19.1% (95% CI: 2.3% - 33.0%) with a high proportion of heterogeneity (I2 : 89.1%). There was a trend of lower VE in older people (40.1% [-57.3-77.2] in the <65 group; 12.9% [-8.0-29.8] in those 65; P = .21). CONCLUSIONS: Despite differences between studies that make comparisons challenging, the influenza burden in elderly Japanese is significant. While vaccines are effective, current vaccination programs offer suboptimal protection. Health economic data and cost-effectiveness analyses were limited and represent areas for policy-relevant future research.


Assuntos
Vacinas contra Influenza , Influenza Humana , Idoso , Efeitos Psicossociais da Doença , Humanos , Influenza Humana/epidemiologia , Influenza Humana/prevenção & controle , Japão/epidemiologia , Estações do Ano , Vacinação
10.
Drug Discov Ther ; 14(1): 50-53, 2020 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-32101820

RESUMO

Our earlier study investigated the incidence of severe abnormal behavior associated with neuraminidase inhibitors (NIs), but some studies have specifically examined the association of oseltamivir use and moderately abnormal behavior. Therefore, this study was undertaken to assess associations between moderately abnormal behavior and administered drugs. All cases of patients with influenza who exhibited moderately abnormal behavior were reported to us by physicians of all sentinel clinics and hospitals for influenza throughout Japan. Open Data of the National Database of Electronic Medical Claims include the numbers of patients diagnosed as having influenza who were prescribed NI. Incidence by NI was tested using Fisher's exact test. We received 518 moderately abnormal cases in 5-9-year-olds and 207 moderately abnormal behavior cases in 10-19-year-olds. The incidence among NI ranged from 193 per one million influenza patients in laninamivir among 10-19-year-olds to 1021 for peramivir among 5-9-year-olds. Estimation results revealed the order of risk among NIs as peramivir, oseltamivir, zanamivir and laninamivir in moderate abnormal behavior. Because of data limitations, risk among patients with and without NI cannot be compared.


Assuntos
Inibidores Enzimáticos/efeitos adversos , Comportamento de Doença/efeitos dos fármacos , Influenza Humana/tratamento farmacológico , Influenza Humana/psicologia , Neuraminidase/antagonistas & inibidores , Ácidos Carbocíclicos , Adolescente , Antivirais/administração & dosagem , Antivirais/efeitos adversos , Criança , Ciclopentanos/administração & dosagem , Ciclopentanos/efeitos adversos , Inibidores Enzimáticos/administração & dosagem , Guanidinas/administração & dosagem , Guanidinas/efeitos adversos , Humanos , Japão , Oseltamivir/administração & dosagem , Oseltamivir/efeitos adversos , Piranos , Ácidos Siálicos , Adulto Jovem , Zanamivir/administração & dosagem , Zanamivir/efeitos adversos , Zanamivir/análogos & derivados
11.
Pediatr Infect Dis J ; 39(8): 678-683, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32101910

RESUMO

BACKGROUND: We investigated the association between age, duration of clinical symptoms and viral shedding in outpatient children infected with respiratory syncytial virus (RSV) in Japan. METHODS: Outpatients younger than 2 years of age, with suspected RSV infection between 2014 and 2018, were enrolled in the study. Following informed consent, nasal samples were collected at first and second clinic visits (with 0-9 days gap). RSV-A or -B infection and viral load were determined by real-time polymerase chain reaction. Clinical symptoms were recorded at first clinic visit, and fever and symptoms were recorded at home for up to 8 days. Association between clinical symptoms and patient characteristics, such as age, sex and birth weight, were analyzed using ordered logistic regression analysis. The association between viral reduction and estimated shedding period was examined using linear regression analysis. RESULTS: Among the 205 cases enrolled in the study, no difference was found in patient characteristics between RSV-A and -B infection. Duration of fever was prolonged with increased age. Duration of rhinorrhea and cough was shorter in females than in males and in groups with birth weight ≥3 kg than in those with <2.5 kg. Daily viral reduction increased and estimated viral elimination period decreased with age. CONCLUSIONS: Fever duration was found to increase while viral shedding decreased with patient age.


Assuntos
Nariz/virologia , Pacientes Ambulatoriais/estatística & dados numéricos , Infecções por Vírus Respiratório Sincicial/virologia , Infecções Respiratórias/virologia , Carga Viral/estatística & dados numéricos , Eliminação de Partículas Virais , Feminino , Humanos , Lactente , Japão , Modelos Logísticos , Masculino , Estudos Prospectivos , Vírus Sincicial Respiratório Humano/genética
12.
BMC Infect Dis ; 20(1): 77, 2020 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-31992256

RESUMO

BACKGROUND: The rates of newly diagnosed cases of sexually transmitted diseases, including genital chlamydial infection and gonorrhea, are important for prevention and control of these diseases. However, nationwide rates are not reported in Japan. METHODS: We used the number of cases of sexually transmitted diseases reported by nationwide sentinel surveillance in 2015, together with the number of all disease outpatients in September 2014 at all medical institutions, drawn from the Survey of Medical Institutions of Japan. The number of cases of sexually transmitted diseases in the total population was estimated using the ratio estimation method with the number of all disease outpatients as auxiliary information. This method is currently used for estimating influenza cases from sentinel surveillance data in Japan. RESULTS: The estimated number of newly diagnosed cases per 100,000 population in 2015 in Japan was 244 (95% confidence interval 211-277) for genital chlamydial infection, 87 (95% confidence interval 74-100) for genital herpes, 61 (95% confidence interval 29-93) for condyloma acuminatum, and 89 (95% confidence interval 64-113) for gonorrhea. CONCLUSION: We estimated the nationwide number of newly diagnosed cases of sexually transmitted diseases in Japan from sentinel surveillance data. This provides useful information for public health policy-making.


Assuntos
Doenças Sexualmente Transmissíveis/epidemiologia , Adolescente , Adulto , Infecções por Chlamydia/epidemiologia , Condiloma Acuminado/epidemiologia , Feminino , Gonorreia/epidemiologia , Herpes Genital/epidemiologia , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Vigilância de Evento Sentinela , Adulto Jovem
14.
Jpn J Infect Dis ; 72(4): 256-260, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-30814461

RESUMO

The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses with a bovine-like G8 genotype (DS-1-like G8P[8] strains) has been reported in several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P[8] strain (RVA/Human-wt/JPN/SO1162/2017/G8P[8]) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation, including genes from both genogroup 1 and 2: G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P[8] strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of previously reported DS-1-like G8P[8] strains. Thus, SO1162 was suggested to be a reassortant strain that acquired the VP1 gene from Southeast Asian DS-1-like G1P[8] strains on the genetic background of co-circulating DS-1-like G8P[8] strains. Our findings provide important insights into the evolutionary dynamics of emerging DS-1-like G8P[8] strains.


Assuntos
Vírus Reordenados/genética , Infecções por Rotavirus/virologia , Rotavirus/genética , Animais , Bovinos , Pré-Escolar , Evolução Molecular , Fezes/virologia , Genes Virais/genética , Genoma Viral/genética , Genótipo , Humanos , Japão , Filogenia , RNA Viral/genética , Vírus Reordenados/classificação , Vírus Reordenados/isolamento & purificação , Rotavirus/classificação , Rotavirus/isolamento & purificação , Análise de Sequência de DNA
15.
J Infect Chemother ; 25(6): 423-426, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30744989

RESUMO

BACKGROUND: Even though abnormal behavior related with influenza and neuraminidase inhibitors (NI) has been discussed, the risks of acetaminophen and co-administration of NI and acetaminophen have not been examined. This study assesses those risks. MATERIALS AND METHODS: All cases of patients with influenza who present with severe abnormal behavior are reported by physicians of all clinics and hospitals throughout Japan. The numbers of people diagnosed as having influenza, whether prescribed NI and acetaminophen or not, were extracted from the National Database of Electronic Medical Claims (NDBEMC). The study period was from September 2009 to March 2016. RESULTS: We found two consistent results among four combinations of age class and severity. The one was that patients who did not use NI or acetaminophen showed significantly higher incidence of abnormal behavior than zanamivir with acetaminophen, another one was that patients with oseltamivir only has higher incidence than zanamivir with acetaminophen. Concerning about acetaminophen, the use of it significantly decrease risk for severe and the most severe instances in 5-9-year-old patients with laninamivir and the severe instances in 10-19-year-old patients with zanamivir. DISCUSSION: We also demonstrated that acetaminophen alone or co-administered with NI does not seem to raise the risk of abnormal behavior in influenza patients.


Assuntos
Acetaminofen/efeitos adversos , Antivirais/efeitos adversos , Sintomas Comportamentais/epidemiologia , Inibidores Enzimáticos/efeitos adversos , Influenza Humana/tratamento farmacológico , Adolescente , Fatores Etários , Sintomas Comportamentais/induzido quimicamente , Criança , Quimioterapia Combinada/efeitos adversos , Quimioterapia Combinada/métodos , Feminino , Guanidinas , Humanos , Incidência , Influenza Humana/psicologia , Japão/epidemiologia , Masculino , Neuraminidase/antagonistas & inibidores , Oseltamivir/efeitos adversos , Piranos , Fatores de Risco , Ácidos Siálicos , Zanamivir/efeitos adversos , Zanamivir/análogos & derivados
16.
PLoS One ; 13(1): e0192085, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29377949

RESUMO

We investigated the genetic diversity, the circulation patterns, and risk for hospital admission of human respiratory syncytial virus (HRSV) strains in Japan between 2012 through 2015. During the study period, 744 HRSV-positive cases were identified by rapid diagnostic test. Of these, 572 samples were positive by real-time PCR; 400 (69.9%) were HRSV-A, and 172 (30.1%) were HRSV-B. HRSV-A and -B alternated as the dominant strain in the subsequent seasons. Phylogenetic tree analysis of the second hyper-variable region of the G protein classified the HRSV-A specimens into NA1 (n = 242) and ON1 (n = 114) genotypes and the HRSV-B specimens into BA9 (n = 60), and BA10 (n = 27). The ON1 genotype, containing a 72-nucleotide duplication in the G protein's second hyper-variable region, was first detected in the 2012-2013 season but it predominated and replaced the older NA1 HRSV-A in the 2014-2015 season, which also coincided with a record number of HRSV cases reported to the National Infectious Disease Surveillance in Japan. The risk of hospitalization was 6.9 times higher for the ON1 genotype compared to NA1. In conclusion, our data showed that the emergence and predominance of the relatively new ON1 genotype in Japan was associated with a record high number of cases and increased risk for hospitalization.


Assuntos
Hospitalização , Epidemiologia Molecular , Vírus Sincicial Respiratório Humano/genética , Genótipo , Humanos , Japão , Reação em Cadeia da Polimerase em Tempo Real , Fatores de Risco
17.
J Med Virol ; 90(5): 873-880, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29350418

RESUMO

Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. Consecutive patients <13 years old with acute febrile illness during a 2-year period were tested. HAdV strains were isolated from nasopharyngeal swabs, and molecular identification was performed by hexon, fiber, and species-specific PCR methods. Blood inflammatory markers, including the white blood cell (WBC) count, CRP, and 29 cytokines, were measured. A total of 187 patients were enrolled, and HAdV types were identified from 175 patients (93.5%). Species C (types 2, 1, 5, and 6, in order of frequency) was most common at 37.1%, followed by B (type 3) at 30.9% and E (type 4) at 26.9%. Species C was detected predominantly in 1-year-old, whereas B and E were in older ages. Species C and B had seasonal circulation patterns, but E was found in only one season during the 2-year study period. The WBC count was highest in patients with species C. Eleven of the 29 tested serum cytokines were detected. Seven kinds, including G-CSF, IL-6, and TNF-α, were elevated in species C infections, whereas IL-10 was lowest in species C. Species differences in inflammatory responses, especially regarding serum cytokines were described in common pediatric HAdV infections. Species C causes the strongest inflammatory responses in young children.


Assuntos
Infecções por Adenoviridae/patologia , Infecções por Adenoviridae/virologia , Adenoviridae/classificação , Inflamação/patologia , Infecções Respiratórias/patologia , Infecções Respiratórias/virologia , Adenoviridae/isolamento & purificação , Infecções por Adenoviridae/epidemiologia , Proteína C-Reativa/análise , Criança , Pré-Escolar , Estudos Transversais , Citocinas/sangue , DNA Viral/genética , Feminino , Humanos , Lactente , Recém-Nascido , Contagem de Leucócitos , Masculino , Epidemiologia Molecular , Nasofaringe/virologia , Reação em Cadeia da Polimerase , Estudos Prospectivos , Infecções Respiratórias/epidemiologia
18.
Artigo em Inglês | MEDLINE | ID: mdl-30766744

RESUMO

Outbreaks of infectious diseases can occur after natural disasters as vital services are disrupted and populations move into evacuation centres. National notifiable disease surveillance may be inadequate in these situations because of resource-consuming disease confirmation or system interruptions. Although syndromic surveillance has been used as an alternative in post-disaster situations, no systematic evaluations of it have been published. We evaluated the ad hoc paper-based syndromic surveillance system implemented in evacuation centres in Ibaraki prefecture after the 2011 Great East Japan Earthquake and Tsunami. We assessed the simplicity, acceptability, data quality, timeliness and portability of this system and reviewed its usefulness. We concluded that the system was simple, acceptable, portable and useful. The documentation and monitoring of disease events and trends were useful for developing interventions in evacuation centres and have since been used to improve post-disaster infectious disease and surveillance knowledge in Japan. We believe timeliness was a challenge due to the chain of data transmission and communication passing through an intermediary. Future implementations of this system could consider a more direct chain of data transmission and communication from collectors to analysers. Too few key informant interviewees and the inability to obtain original paper-based data from evacuation centres limited our findings; we conducted this evaluation four years after the response occurred. Future evaluations should be completed closer to when operations cease. The usefulness of the system suggests adopting it in future disasters. A simple, plain-language manual should be developed to improve future employment.


Assuntos
Terremotos , Vigilância de Evento Sentinela , Tsunamis , Doenças Transmissíveis/epidemiologia , Surtos de Doenças/estatística & dados numéricos , Humanos , Japão/epidemiologia
19.
Drug Discov Ther ; 12(6): 381-383, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30674775

RESUMO

The Fukushima research has examined data form a cohort study of 10,000 Japanese children under 18 years old with influenza during three months to demonstrate that the relative risk of A-type abnormal behavior of patients with oseltamivir was 30 times greater than without oseltamivir. By contrast, our research group found that patients who had been administered no neuraminidase inhibitors (NI) or those administered peramivir had higher risk of abnormal behavior than those administered oseltamivir, zanamivir, or laninamivir. A plausible explanation for this gap is that the two studies specifically examined different criteria to report abnormal behavior. In actually, some A-type abnormal behavior might not be life-threatening. Our definition of severe abnormal behavior is better matched to public health concerns and comparison among incidents according to the administered drug is more appropriate as an analytical procedure.


Assuntos
Sintomas Comportamentais/epidemiologia , Ciclopentanos/efeitos adversos , Guanidinas/efeitos adversos , Influenza Humana/tratamento farmacológico , Oseltamivir/efeitos adversos , Ácidos Carbocíclicos , Adolescente , Sintomas Comportamentais/induzido quimicamente , Criança , Estudos de Coortes , Ciclopentanos/farmacologia , Guanidinas/farmacologia , Humanos , Incidência , Influenza Humana/psicologia , Masculino , Oseltamivir/farmacologia , Projetos de Pesquisa , Índice de Gravidade de Doença
20.
J Infect Chemother ; 24(3): 177-181, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29273435

RESUMO

An earlier study using the number of abnormal behaviors reported to the study group as the numerator and the number of influenza patient prescribed each neuraminidase inhibitor (NI) estimated by respective pharmaceutical companies found no significant difference among incidence rates of the most severe abnormal behaviors by type of NI throughout Japan. However, the dataset for the denominator used in that earlier study was the estimated number of prescriptions. In the present study, to compare the incidence rates of abnormal behavior more precisely among influenza patients administered several sorts of NI or administered no NI, we used data obtained from the National Database of Electronic Medical Claims (NDBEMC) as the denominator to reach a definitive conclusion. Results show that patients not administered any NI (hereinafter un-administered) or those administered peramivir sometimes showed higher risk of abnormal behavior than those administered oseltamivir, zanamivir, or laninamivir. However, the un-administered or peramivir patients were fewer than those taking other NI. Therefore, accumulation of data through continued research is expected to be necessary to reach a definitive conclusion about the relation between abnormal behavior and NI in influenza patients. Since severe abnormal behaviors with all types of NI or of un-administered patients have been reported, there are some risks in the administration of NI or even in un-administered cases. Therefore, we infer that the policy mandating package inserts in all types of NI.


Assuntos
Antivirais/efeitos adversos , Inibidores Enzimáticos/efeitos adversos , Influenza Humana/tratamento farmacológico , Neuraminidase/antagonistas & inibidores , Comportamento Autodestrutivo/induzido quimicamente , Comportamento Autodestrutivo/epidemiologia , Adolescente , Antivirais/administração & dosagem , Antivirais/uso terapêutico , Criança , Pré-Escolar , Inibidores Enzimáticos/administração & dosagem , Inibidores Enzimáticos/uso terapêutico , Hospitais/estatística & dados numéricos , Humanos , Incidência , Japão/epidemiologia , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...