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2.
JACC Clin Electrophysiol ; 5(7): 789-800, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31068260

RESUMO

OBJECTIVES: This study describes the use of septal coronary venous mapping to facilitate substrate characterization and ablation of intramural septal ventricular arrhythmia (VA). BACKGROUND: Intramural septal VA represents a challenge for substrate definition and catheter ablation. METHODS: Between 2015 and 2018, 12 patients with structural heart disease, recurrent VA, and suspected intramural septal substrate underwent a septal coronary venous procedure in which mapping was performed by advancement of a wire into the septal perforator branches of the anterior interventricular vein. A total of 5 patients with idiopathic VA were also included as control subjects to compare substrate characteristics. RESULTS: Patients were 63 ± 14 years of age, and 11 (92%) were men. Most patients with structural heart disease had nonischemic cardiomyopathy (83%). Six patients underwent ablation for premature ventricular contractions (PVC) and 6 for ventricular tachycardia. All patients had larger septal unipolar voltage abnormalities than bipolar voltage abnormalities (mean area 35.3 ± 16.8 cm2 vs. 10.7 ± 8.4 cm2, respectively; p = 0.01), Patients with idiopathic VA had normal voltage. Septal coronary venous mapping revealed low-voltage, fractionated, and multicomponent electrograms in sinus rhythm in all patients with substrate compared to that in patients with idiopathic VA (amplitude 0.9 ± 0.9 mV vs. 4.4 ± 3.7 mV, respectively; p = 0.007; and duration 147 ± 48 ms vs. 92 ± 10 ms, respectively; p = 0.03). Ablation targeted early activation, pace map match, and/or good entrainment sites from intraseptal recording. Over a mean follow-up of 339 ± 240 days, the PVC and insertable cardioverter-defibrillator therapies burden were significantly reduced (from a mean of 22 ± 11% to 4 ± 8%; p = 0.005; and a mean 5 ± 2 to 1 ± 1; p = 0.001, respectively). Most patients (80%) with idiopathic VA remained arrhythmia free. CONCLUSIONS: In patients with suspected intramural septal VA, mapping of the septal coronary veins may be helpful to characterize the arrhythmia substrate, identify ablation targets, and guide endocardial ablation.

3.
Heart Rhythm ; 16(8): 1174-1181, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31085181

RESUMO

BACKGROUND: In patients with ischemic ventricular tachycardia (VT), substrate may be "protected" by the posteromedial papillary muscle (PMPM), explaining failure of endocardial-only ablation. OBJECTIVE: We sought to characterize the arrhythmogenic substrate and ablation approach in patients with ischemic VT mapped to the inferior left ventricle in which endocardial ablation failed because of inaccessible substrate underlying the PMPM. METHODS: We included 10 patients with recurrent ischemic VT, evidence of inferior scar, and failed endocardial ablation. In all patients, epicardial mapping was performed via a percutaneous (n = 9) or surgical (n = 1) approach, and VT elimination was achieved by ablation opposite to the PMPM. Clinical characteristics, electrocardiographic characteristics, and procedural data were analyzed. RESULTS: In all patients, intracardiac echocardiography showed hyperechoic scar below the PMPM, and 5 exhibited a pattern characterized by subendocardial basal scar that became intramural and epicardial at distal segments. In 4 patients, VT remained inducible despite endocardial scar isolation, manifested by the absence of electrograms, dissociated potentials, and/or exit block. Eleven inducible VTs were mapped to the epicardium underlying the PMPM: 8 had a right bundle branch block configuration with variable transition, while 3 exhibited left bundle branch block with negative concordance. An inferior QS pattern was present in 10 of 11 VTs. Noninducibility was achieved in 8 patients, and 7 patients remained arrhythmia-free after a mean follow-up of 27 ± 23 months. CONCLUSION: In patients with inferior ischemic scar, VT may arise from the area underneath the PMPM, limiting endocardial ablation. Intracardiac echocardiography accurately defines the substrate distribution, and an epicardial approach may eliminate VT. A pattern of "basal-endocardial/apical-epicardial" ischemic involvement is described.

4.
Rev. colomb. cardiol ; 26(2): 107-110, mar.-abr. 2019. graf
Artigo em Espanhol | LILACS-Express | ID: biblio-1058392

RESUMO

Resumen Se hizo ablación tridimensional de aleteo auricular, dependiente del istmo cavotricuspídeo, en un paciente con cirugía previa de válvula tricúspide. El uso de ecocardiografía intracardiaca permitió identificar una estructura sacular en el aspecto septal del istmo. Después de la ablación en este punto, el aleteo terminó y se confirmó bloqueo bidireccional. Este reporte sugiere, además, que el miocardio auricular ligado al anillo valvular, sirve como vía de conducción crítica del aleteo auricular.


Abstract A three-dimensional ablation of an atrial flutter, dependent on the cavo-tricuspid isthmus, was performed on a patient with previous tricuspid valve surgery. The use of intracardiac echocardiography enabled a saccular structure to be identified in the septal aspect of the isthmus. After the ablation in this point, the flutter stopped and a two-directional block was confirmed. This report suggests, furthermore, that the atrial myocardium together with the valvular ring, serves as a critical conduction pathway of the atrial flutter.

7.
Rev. colomb. cardiol ; 24(5): 511-511, sep.-oct. 2017. graf
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-900572

RESUMO

Resumen La afectación cardíaca en pacientes con sarcoidosis está siendo cada vez más reconocida y se asocia con mal pronóstico. Aunque en su patogénesis están implicados los factores ambientales y genéticos, la etiología de la sarcoidosis cardíaca no es clara. Las manifestaciones clínicas incluyen alteraciones de la conducción aurículo-ventricular, arritmias e insuficiencia cardíaca congestiva. Es una entidad extremadamente difícil de diagnosticar debido a que las manifestaciones clínicas son inespecíficas, y la sensibilidad y la especificidad de las modalidades de diagnóstico son limitadas. El tratamiento cardíaco óptimo no ha sido bien definido, y aunque los corticoides siguen siendo el pilar del manejo, hay poca evidencia de la dosis o la duración de la terapia. Se expone el caso de una paciente con sarcoidosis cardíaca aislada, que debutó con extrasístoles ventriculares y progresó a falla cardiaca y arritmias ventriculares sostenidas.


Abstract Cardiac involvement is increasingly being observed in patients with sarcoidosis and is associated with a poor prognosis. Although environmental and genetic factors play a part in its pathogenesis, the aetiology of cardiac sarcoidosis is still not clear. The clinical signs include anomalies in atrial-ventricular conduction, arrhythmias, and congestive cardiac failure. It is an extremely difficult condition to diagnose as the clinical signs are vague, and the sensitivity and specificity of the diagnostic models are limited. There is no well-defined optimum cardiac treatment, and although corticosteroids continue to be the mainstay of its management, there is little evidence on the dose or duration of the treatment. It is presented a case of a patient with isolated cardiac sarcoidosis that debuted with ventricular extrasystoles and progressed to cardiac failure and sustained ventricular arrhythmias.


Assuntos
Humanos , Miocardite , Bloqueio de Ramo , Bloqueio Cardíaco , Taquicardia
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