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1.
Braz J Cardiovasc Surg ; 32(3): 215-224, 2017 May-Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28832801

RESUMO

OBJECTIVE: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.


Assuntos
Aorta Abdominal/fisiopatologia , Aneurisma da Aorta Abdominal/etiologia , Aneurisma da Aorta Abdominal/fisiopatologia , MicroRNAs/fisiologia , Aneurisma da Aorta Abdominal/terapia , Humanos , Ilustração Médica , Fatores de Risco , Fatores Sexuais
2.
Rev. bras. cir. cardiovasc ; 32(3): 215-224, May-June 2017. tab, graf
Artigo em Inglês | LILACS-Express | ID: biblio-897914

RESUMO

Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.

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