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1.
BMJ ; 367: l5721, 2019 11 08.
Artigo em Inglês | MEDLINE | ID: mdl-31704711

RESUMO

The studyCoomarasamy A, Devall AJ, Cheed V, et al. A randomised trial of progesterone in women with bleeding in early pregnancy N Engl J Med 2019;380:1815-24.This project was funded by the NIHR Health Technology Assessment Programme (project number 12/167/26).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000792/miscarriage-not-prevented-by-routine-use-of-progesterone.


Assuntos
Aborto Espontâneo , Feminino , Humanos , Gravidez , Progesterona , Avaliação da Tecnologia Biomédica
2.
BMJ ; 366: l4235, 2019 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-31292128

RESUMO

The studyGazzard G, Konstantakopoulou G, Garway-Heath E, et al. Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet 2019; doi:10.1016/S0140-6736(18)32213-XThis project was funded by the NIHR Health Technology Assessment Programme (project number 09/104/40) and was sponsored by the Moorfields Eye Hospital NHS Foundation Trust.To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000774/early-glaucoma-laser-eye-treatment-trabeculoplasty.


Assuntos
Glaucoma de Ângulo Aberto/cirurgia , Terapia a Laser/métodos , Hipertensão Ocular/cirurgia , Glaucoma de Ângulo Aberto/tratamento farmacológico , Humanos , Terapia a Laser/efeitos adversos , Hipertensão Ocular/tratamento farmacológico , Soluções Oftálmicas , Complicações Pós-Operatórias , Prostaglandinas Sintéticas/efeitos adversos , Prostaglandinas Sintéticas/uso terapêutico , Anos de Vida Ajustados por Qualidade de Vida , Resultado do Tratamento
3.
BMJ ; 364: l1029, 2019 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-30910804

RESUMO

The studyFOCUS Trial Collaboration. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. Lancet 2019;393:256-74.The study was funded by the UK Stroke Association and the NIHR Health Technology Assessment Programme project number 13/04/30.To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000729/a-commonly-used-antidepressant-doesnt-improve-recovery-after-stroke.

4.
BMJ ; 364: l1025, 2019 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-30885906

RESUMO

The studyJolliffe D, Greenberg L, Hooper R, Mathyssen C, Rafiq R, de Jongh R, Camargo C, Griffiths C, Janssens W, Martineau A. Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 2019. doi:10.1136/thoraxjnl-2018-212092This project was funded by the National Institute for Health Research Health Technology Appraisal programme (project number 13/03/25).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000737/treating-vitamin-d-deficiency-may-reduce-exacerbations-of-copd.

5.
BMJ ; 364: k4411, 2019 03 13.
Artigo em Inglês | MEDLINE | ID: mdl-30867157

RESUMO

The studyEffect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb: the WOLLF randomised clinical trial.Costa ML, Achten J, Bruce J, et al; UK WOLLF CollaborationPublished on 9 October 2018 JAMA 2018;319:2280-8.This project was funded by the National Institute for Health Research Health Technology Assessment Programme (project number 10/57/20).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000655/negative-pressure-dressings-are-no-better-than-standard-dressings-for-open-fractures.


Assuntos
Bandagens/tendências , Fraturas Expostas/terapia , Extremidade Inferior/lesões , Tratamento de Ferimentos com Pressão Negativa/métodos , Bandagens/normas , Avaliação da Deficiência , Pessoas com Deficiência/psicologia , Pessoas com Deficiência/estatística & dados numéricos , Fraturas Expostas/complicações , Fraturas Expostas/microbiologia , Fraturas Expostas/cirurgia , Humanos , Extremidade Inferior/patologia , Tratamento de Ferimentos com Pressão Negativa/instrumentação , Tratamento de Ferimentos com Pressão Negativa/normas , Qualidade de Vida , Avaliação da Tecnologia Biomédica , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/patologia , Ferimentos e Lesões/terapia
6.
BMJ ; 364: k5339, 2019 02 19.
Artigo em Inglês | MEDLINE | ID: mdl-30782586

RESUMO

The studyHome treatment of COPD exacerbation selected by DECAF score: a non-inferiority, randomised controlled trial and economic evaluationEchevarria C, Gray J, Hartley T, Miller J, Simpson AJ, Gibson GJ, Bourke SCPublished on 24 April 2018 Thorax 2018;73:713-22This project was funded by the National Institute for Health Research-Research for Patient Benefit Programme (project number PB-PG-0213-30105).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000691/hospital-at-home-treatment-for-copd-flare-ups.


Assuntos
Alta do Paciente , Doença Pulmonar Obstrutiva Crônica , Análise Custo-Benefício , Humanos
7.
Biotechnol J ; 14(2): e1700740, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29781114

RESUMO

Over the last several years, continuous manufacturing of pharmaceuticals has evolved from bulk APIs and solid oral dosages into the more complex realm of biologics. The development of continuous downstream processing techniques has allowed biologics manufacturing to realize the benefits (e.g., improved economics, more consistent quality) that come with continuous processing. If relevant processing techniques and principles are selected, the opportunity arises to develop continuous manufacturing designs for additional pharmaceutical products including liposomal drug formulations. Liposome manufacturing has some inherent aspects that make it favorable for a continuous process. Other aspects such as formulation refinement, materials of construction, and aseptic processing need development, but present an achievable challenge. This paper reviews the current state of continuous manufacturing technology applicable to liposomal drug product manufacturing and an assessment of the challenges and potential of this application.


Assuntos
Produtos Biológicos/isolamento & purificação , Reatores Biológicos , Indústria Farmacêutica/tendências , Lipossomos/isolamento & purificação , Tecnologia Farmacêutica/tendências , Produtos Biológicos/economia , Reatores Biológicos/economia , Reatores Biológicos/normas , Custos e Análise de Custo , Indústria Farmacêutica/economia , Indústria Farmacêutica/normas , Lipossomos/economia , Controle de Qualidade , Tecnologia Farmacêutica/economia , Tecnologia Farmacêutica/normas , Fluxo de Trabalho
8.
J Transl Med ; 8: 62, 2010 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-20573230

RESUMO

BACKGROUND: Changes in clinical practice are brought about by the weight of clinical evidence for and against an intervention. Clinical evidence of efficacy relies on the dissemination of research results, usually by publication in medical journals which is often seen as a pre-requisite for progression of an intervention through further clinical trials or implementation studies. HOW FAR HAS RESEARCH PROGRESSED ALONG THE TRANSLATIONAL PATHWAY?: We undertook an exploratory exercise to determine where basic and translational medical research is currently published. Original research articles (329 in total) published in high impact general and specialist medical journals were classified into different stages of research within the translational medicine pathway. WHERE IS TRANSLATIONAL RESEARCH PUBLISHED?: The general medical journals had the broadest spread of published research over the translational pathway. The specialist journals tended to be positioned to disseminate the research findings of early stage translational research from basic science results through to early stages of clinical testing. CONCLUSION: It is not possible for one journal to satisfy all the needs of the reader and the author along the translational medicine pathway. For an intervention to progress along the translational pathway background information should be readily accessible in the article. This pathway is currently being actively managed by the funding agencies but the next challenge is to ensure the pathway operates efficiently and does not allow promising innovations to languish and to provide a smoother transition for interventions to reach the clinic in a quicker timescale. It is clear that the dissemination of results in the right place at the right time is crucial to the transition of an intervention from the laboratory to clinical practice.


Assuntos
Publicações Periódicas como Assunto , Editoração , Pesquisa Médica Translacional
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