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1.
Sensors (Basel) ; 22(11)2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35684852

RESUMO

Image super-resolution aims to reconstruct a high-resolution image from its low-resolution counterparts. Conventional image super-resolution approaches share the same spatial convolution kernel for the whole image in the upscaling modules, which neglect the specificity of content information in different positions of the image. In view of this, this paper proposes a regularized pattern method to represent spatially variant structural features in an image and further exploits a dynamic convolution kernel generation method to match the regularized pattern and improve image reconstruction performance. To be more specific, first, the proposed approach extracts features from low-resolution images using a self-organizing feature mapping network to construct regularized patterns (RP), which describe different contents at different locations. Second, the meta-learning mechanism based on the regularized pattern predicts the weights of the convolution kernels that match the regularized pattern for each different location; therefore, it generates different upscaling functions for images with different content. Extensive experiments are conducted using the benchmark datasets Set5, Set14, B100, Urban100, and Manga109 to demonstrate that the proposed approach outperforms the state-of-the-art super-resolution approaches in terms of both PSNR and SSIM performance.

2.
BMC Geriatr ; 22(1): 467, 2022 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-35641938

RESUMO

BACKGROUND: Despite known socioeconomic disparities in aging-related outcomes, the underlying physiologic mechanisms are understudied. This study applied propensity score weighting to estimate the effect of financial strain on inflammation-related aging biomarkers among a national sample of older adults. METHODS: Financial strain severe enough to lack money for housing, utilities, medical/prescription bills or food was measured among 4,593 community-dwelling National Health and Aging Trends Study participants aged ≥ 65 years in 2016. Inverse probability propensity score weights were generated based on 2015 background characteristics, including age, gender, race/ethnicity, income to poverty ratio, education, occupation, home ownership, retirement, Sect. 8 housing, Medicaid, food/energy assistance, childhood health, marital status, and U.S. region. Sampling weights additionally accounted for study design and non-response. RESULTS: In propensity score-weighted analyses adjusting for age, gender, race/ethnicity, 2017 income to poverty ratio and education, those with 2016 financial strain had 15% higher IL-6 (p = 0.026) and 20% higher CRP levels (p = 0.002) in 2017 than those who were not strained, but did not differ with regard to hemoglobin A1c or CMV. In weighted comparisons, those with financial strain did not differ from those without with regard any 2015 background characteristics. CONCLUSIONS: These results strengthen the etiologic evidence suggesting that financial strain increases inflammatory biomarkers among older adults. Importantly, inflammation is likely a key physiologic pathway contributing to socioeconomic disparities. Therefore, research is needed to address financial strain.


Assuntos
Envelhecimento , Inflamação , Idoso , Biomarcadores , Criança , Humanos , Inflamação/diagnóstico , Inflamação/epidemiologia , Pontuação de Propensão , Fatores Socioeconômicos , Estados Unidos/epidemiologia
3.
Comput Intell Neurosci ; 2022: 2835992, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35669654

RESUMO

The spread of Chinese martial arts is crucial for the world to understand Chinese culture. If only relying on one transmission method, it will lead to the difference of transmission and its lack of certain real time. This will lead to differences in the understanding of Chinese martial arts, which is also not conducive to the spread of Chinese glorious culture. Cross-media communication technology can solve this communication difference problem very well. The deep neural network method was used to fuse relevant features of Chinese martial arts, and it also analyzes the feasibility of neural network technology in cross-media communication. At the same time, this study uses deep neural network to study the timeliness of Chinese martial arts in the process of cross-media communication. The research results show that the convolutional neural network can effectively extract the characteristics of Chinese martial arts and carry out effective dissemination. However, the hybrid convolutional neural network with temporal features has higher accuracy in extracting Chinese martial arts features. This hybrid convolutional neural network is more conducive to the dissemination of Chinese martial arts through cross-media technology, which can ensure its timeliness. The maximum error of deep neural network technology in predicting Chinese martial arts culture is only 2.67%. This part of the error comes from the action characteristics of Chinese martial arts culture, which shows that neural network technology has good feasibility.


Assuntos
Artes Marciais , China , Comunicação , Humanos , Redes Neurais de Computação
4.
Plant Sci ; 322: 111347, 2022 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-35700842

RESUMO

Sophora japonica is a leguminous tree species native to China. To explore the nitrogen (N) source preference and its impact on stress tolerance, a hydroponic experiment was designed in which S. japonica seedlings were supplied with sole ammonium (NH4+) or sole nitrate (NO3-) nutrition under 75 mM NaCl-induced salt stress. The growth and N metabolism performance were investigated. In the absence of NaCl, plants fed NH4+ showed better root growth than those fed NO3-, but there was no difference in aerial part growth. Salinity inhibited the root growth of NH4+-fed plants and the shoot growth of NO3--fed plants, while the total N accumulation was suppressed under either N form. Specifically, in NH4+-fed plants, salinity significantly increased the net photosynthetic rate, root NH4+ content and root antioxidant enzyme activities. Higher nitrate reductase (NR) activities but lower glutamate synthetase (GS) activities were observed in both leaves and roots. Leaf AMT1.1 and AMT2.1a in NH4+-fed plants positively reacted to salt stress, whereas the expression of four AMTs was reduced or remained unchanged in roots. In contrast, salinity suppressed the net photosynthetic rate, antioxidant enzyme activities, and GS activity in the leaves of NO3--fed plants. Upregulation of NPF1.2, NPF2.11, NPF4.6 and NPF7.3, as well as unaltered NR activity, caused higher NO3- content in the leaves. Moreover, NR and glutamate synthase (GOGAT) activities together with the transcription of most NRTs were promoted by salinity in the roots of NO3--fed plants. Additionally, compared to those treated with NH4+, in response to salinity, NO3--treated seedlings showed more intensive repression of the net photosynthetic rate, chlorophyll content, and both shoot and root growth. Overall, these results suggest that S. japonica plants grew better in NH4+ medium than in NO3- medium, and the different N metabolism responses improved S. japonica tolerance to salinity with NH4+ application. This study provides new insights for understanding the mechanism of salt tolerance, breeding resistant varieties of S. japonica, and developing scientific fertilization management strategies during the seedling cultivation period.

5.
Cardiovasc Ther ; 2022: 9615674, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35692375

RESUMO

Purpose: L-carnitine (LC) is considered to have good therapeutic potential for myocardial infarction (MI), but its mechanism has not been clarified. The aim of the study is to elucidate the cardioprotective effects of LC in mice following MI and related mechanisms. Methods: ICR mice were treated with LC for 2 weeks after induction of MI with ligation of left anterior descending artery. Electrocardiographic (ECG) recording and echocardiography were used to evaluate cardiac function. H&E staining, TTC staining, and Masson staining were performed for morphological analysis and cardiac fibrosis. ELISA and immunofluorescence were utilized to detect biomarkers and inflammatory mediators. The key proteins in the Bax/Bcl-2 signaling pathway were also examined by Western blot. Results: Both echocardiography and histological measurement showed an improvement in cardiac function and morphology. Biomarkers such as LDH, NT-proBNP, cTnT, and AST, as well as the inflammatory cytokines IL-1ß, IL-6, and TNF-α, were decreased in plasma of mice receiving LC treatment after myocardial injury. In addition, the expression of α-SMA as well as the key proteins in the Bax/Bcl-2 signaling pathway in cardiac myocardium were much lower in mice with LC treatment compared to those without after MI. Conclusions: Our data suggest that LC can effectively ameliorate left ventricular (LV) remodeling after MI, and its beneficial effects on myocardial function and remodeling may be attributable at least in part to anti-inflammatory and inhibition of the Bax/Bcl-2 apoptotic signaling pathway.


Assuntos
Infarto do Miocárdio , Remodelação Ventricular , Animais , Apoptose , Carnitina/metabolismo , Carnitina/farmacologia , Carnitina/uso terapêutico , Modelos Animais de Doenças , Camundongos , Camundongos Endogâmicos ICR , Miocárdio/patologia , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Transdução de Sinais , Proteína X Associada a bcl-2/metabolismo
6.
EClinicalMedicine ; 48: 101440, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35706485

RESUMO

Background: Understanding lifecourse trajectories of body-mass index (BMI) is important for identifying groups at high risk of poor health and potential target points for intervention. This study aimed to describe BMI trajectories from childhood to mid-adulthood in four population-based cohorts established in the 1970s and 1980s and to identify childhood sociodemographic factors related to trajectory membership. Methods: Between Dec 17, 1970 and Dec 15, 1994, data were collected at the first visit from 9830 participants from the International Childhood Cardiovascular Cohort (i3C) Consortium, which includes participants from Australia (1985), Finland (1980) and the USA (1970-1994). Participants had at least three measures of height and weight, including one in childhood (6-18 years) and one in adulthood (>18 years), and were aged 30-49 years at last measurement. Latent Class Growth Mixture Modelling was used to identify lifecourse BMI trajectory groups and log multinomial regression models were fit to identify their childhood sociodemographic predictors. Findings: Five consistent BMI trajectory groups were identified amongst the four cohorts: persistently low (35.9-58.6%), improving from high (0.7-4.8%), progressing to moderate (9.3-43.7%), progressing to high (1.1-6.0%), and progressing to very high (0.7-1.3%). An additional three BMI trajectory groups were identified in some, but not all, cohorts: adult onset high (three cohorts; 1.8-20.7%), progressing to moderate-high (two cohorts; 5.2-13.8%), and relapsing yo-yoers (alternating upward and downward; one cohort; 1.3%). In pooled analyses, each predictor variable in childhood, including age, gender, parental education and race, was associated with increased likelihood of belonging to the most (e.g., improving from high) and least (e.g., progressing to very high) favourable BMI trajectory groups, suggesting a U-shaped (or inverse U-shaped) pattern of association. Interpretation: Five consistent BMI trajectory groups were identified across four cohorts from Australia, Finland, and the USA, mainly across two eras of birth. While most participants remained on a persistently low trajectory (50%), many demonstrated worsening BMI trajectories (47%), with only few demonstrating improving trajectories (<5%). Age, gender, parental education, and race appear to be important predictors of BMI trajectory group membership and need consideration in preventive and management strategies. Funding: This study was supported by funding from the National Institutes of Health, National Heart, Lung and Blood Institute (grant number R01 HL121230).

7.
Ann Med ; 54(1): 1646-1656, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35695551

RESUMO

BACKGROUND: Multiple assessment tools are used in arthroscopic training and play an important role in feedback. However, it is not fully recognized as to the standard way to apply these tools. Our study aimed to investigate the use of assessment tools in arthroscopic training and determine whether there is an optimal way to apply various assessment tools in arthroscopic training. METHODS: A search was performed using PubMed, Embase and Cochrane Library electronic databases for articles published in English from January 2000 to July 2021. Eligible for inclusion were primary research articles related to using assessment tools for the evaluation of arthroscopic skills and training environments. Studies that focussed only on therapeutic cases, did not report outcome measures of technical skills, or did not mention arthroscopic skills training were excluded. RESULTS: A total of 28 studies were included for review. Multiple assessment tools were used in arthroscopic training. The most common objective metric was completion time, reported in 21 studies. Technical parameters based on simulator or external equipment, such as instrument path length, hand movement, visual parameters and injury, were also widely used. Subjective assessment tools included checklists and global rating scales (GRS). Among these, the most commonly used GRS was the Arthroscopic Surgical Skill Evaluation Tool (ASSET). Most of the studies combined objective metrics and subjective assessment scales in the evaluation of arthroscopic skill training. CONCLUSIONS: Overall, both subjective and objective assessment tools can be used as feedback for basic arthroscopic skill training, but there are still differences in the frequency of application in different contexts. Despite this, combined use of subjective and objective assessment tools can be applied to more situations and skills and can be the optimal way for assessment. LEVEL OF EVIDENCE: Level III, systematic review of level I to III studies. Key messagesBoth subjective and objective assessment tools can be used as feedback for basic arthroscopic skill training.Combined use of subjective and objective assessment tools can be applied to more situations and skills and can be the optimal way for assessment.


Assuntos
Artroscopia , Competência Clínica , Artroscopia/educação , Humanos
8.
J Alzheimers Dis ; 2022 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-35723107

RESUMO

BACKGROUND: Metabolic dysfunction links to cognitive deficits in Alzheimer's disease (AD). Leptin is an anti-obesity hormone that modulates energy homeostasis and memory function. Although leptin deregulation is implicated in mouse models of AD-like brain pathology, clinical studies have shown inconsistent results regarding an association of leptin with the development of this neurodegenerative disorder. OBJECTIVE: We investigated the changes of plasma leptin and the correlation of sex-stratified circulating leptin with cognitive performance, AD-related biological markers, and metabolic status in patients with AD and cognitively unimpaired (CU) counterparts. METHODS: We used nonobese AD patients and CU controls in a University of Kansas Medical Center (KUMC) cohort. Plasma leptin levels, circulating AD-related molecules and metabolic profiles were examined and analyzed. RESULTS: In contrast to unchanged circulating leptin in females, male patients exhibited decreased plasma leptin levels compared with male CU counterparts. Moreover, plasma leptin showed no correlation with cognitive performance and AD blood biomarkers in patients with either sex. Of note, females but not males demonstrated an association of plasma leptin with body mass index, high density lipoprotein-cholesterol and its ratio with total cholesterol and triglycerides. CONCLUSION: Our findings suggest that leptin deficiency is associated with nonobese male AD patients, supporting systemic dysmetabolism in the development of this neurodegenerative disorder in certain populations. Although plasma leptin may have limited capacity to reflect disease severity or progression, future mechanistic studies on the regulation of leptin in nonobese patients with AD would deepen our understanding of the sex-related disparity of AD etiopathogenesis.

9.
World J Gastrointest Oncol ; 14(5): 1002-1013, 2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35646278

RESUMO

BACKGROUND: Previous studies have suggested that a low albumin-to-alkaline phosphatase ratio (AAPR) is associated with a lower survival rate in patients with various malignancies. However, the relationship between pretreatment AAPR and the prognosis of patients with gastric cancer (GC) remains unclear. AIM: To investigate the prognostic value of AAPR in distant metastatic GC. METHODS: A total of 191 patients with distant metastatic cancer from a single institute were enrolled in this study. Pretreatment clinical data, including serum albumin and alkaline phosphatase levels, were collected. A chi-square test or Fisher's exact test was applied to evaluate the correlations between AAPR and various clinical parameters in GC patients. The Kaplan-Meier method and Cox proportional hazards regression model were used to evaluate the prognostic efficacy of AAPR in metastatic GC patients. A two-sided P value lower than 0.05 was considered statistically significant. RESULTS: A receiver operating characteristic curve indicated that 0.48 was the optimal threshold value for AAPR. AAPR ≤ 0.48 was significantly associated with bone (P < 0.05) and liver metastasis (P < 0.05). Patients with high levels of AAPR had better survival in terms of overall survival (OS) and progression-free survival (PFS), regardless of the presence of liver/bone metastasis. Pretreatment AAPR was found to be a favorable predictor of OS and PFS based on a multivariate cox regression model. AAPR-M system, constructed based on AAPR and number of metastatic sites, showed superior predictive ability relative to the number of metastatic sites for predicting survival. CONCLUSION: Pretreatment AAPR may serve as an independent prognostic factor for predicting PFS and OS in patients with metastatic GC. Furthermore, AAPR may assist clinicians with individualizing treatment.

10.
Curr Med Sci ; 2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35678908

RESUMO

OBJECTIVE: Lianhuaqingwen and Shuanghuanglian are drug treatment options for Corona Virus Disease 2019 (COVID-19). In China, use of traditional Chinese medicine with Shuanghuanglian or Lianhuaqingwen (for them, forsythiaside is the active antiviral and antibacterial component) in combination with azithromycin is common for the treatment of pediatric pneumonia. It is important to understand the reason why the combination of these compounds is better than a single drug treatment. This study aimed to explore the pharmacokinetic interaction between forsythiaside and azithromycin. METHODS: Twelve male Sprague-Dawley rats were randomly divided into an experimental group (Forsythia suspensa extract and azithromycin) and a control group (a single dose of Forsythia suspensa extract in 5% glucose solution). Plasma samples were collected at scheduled time points, and the high-performance liquid chromatography combined with ultraviolet method was used to determine the plasma forsythiaside concentration. Non-compartmental analysis and population pharmacokinetic methods were used to investigate the forsythiaside pharmacokinetic difference between the experimental and control group. RESULTS: Compared with a single administration, the area under the curve and half-life of forsythiaside increased, and forsythiaside clearance decreased significantly after co-administration with azithromycin. The in vivo behavior of forsythiaside could be described by the one compartment model. The forsythiaside clearance decreased when combined with azithromycin. Visual evaluation and bootstrap results suggested that the final model was precise and stable. CONCLUSION: Co-administration of azithromycin can significantly decrease the forsythiaside clearance and increase drug exposure. A lower dose of azithromycin can obtain sufficient forsythiaside concentration to provide antiviral and antibacterial activity.

11.
Food Funct ; 13(11): 6433-6435, 2022 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-35608218

RESUMO

Correction for 'Glycyrrhizic acid promotes neural repair by directly driving functional remyelination' by Jing Tian et al., Food Funct., 2020, 11, 992-1005, https://doi.org/10.1039/C9FO01459D.

12.
J Asian Nat Prod Res ; : 1-7, 2022 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-35579284

RESUMO

A chemical study of 90% ethanol extract of the barks of Juglans cathayensis resulted in the isolation of three new nortriterpenoids, jugcathenoids A-C (1-3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated nortriterpenoids were tested in vitro for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds 1-3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC50 values less than 50 µM.

13.
Comput Intell Neurosci ; 2022: 1685430, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35634058

RESUMO

As the continous innovation of new media technology, the media environment of the entire society has undergone profound changes. Digital technology has had a profound impact on the way news is disseminated. It has made a significant impact on the collecting, creation, and distribution of news, as well as the way viewers receive it. As a result, the news media's operation and management style is continually modified. However, in the process of news dissemination, the situations involved are complex and changeable, which leads to different digital technology applications. Aiming at different complex situations in news dissemination under the vision of new media art, this work designs a neural network to optimize the distribution for the required digital technology application schemes. The main work of this paper has the following two points. First, it systematically investigates the current research status of news communication based on digital technology and analyzes the research trends of digital technology and news communication in complex contexts under the vision of new media art. Second, a new neural network is proposed for the optimal application of digital technology for news propagation in different complex situations. This neural network uses an improved particle swarm optimization algorithm and an improved network training strategy to improve the BP network, which can effectively solve the shortcomings of the BP network. A large number of experiments have proved the effectiveness and correctness of this method.


Assuntos
Tecnologia Digital , Redes Neurais de Computação , Algoritmos , Comunicação , Tecnologia
14.
Sci Total Environ ; 838(Pt 2): 156194, 2022 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-35618114

RESUMO

Plant litter decomposition is a crucial pathway for carbon (C) and nutrient cycling, and controls the net primary productivity in ecosystems worldwide. However, little is known about how multi-type litter (leaf and different diameter fine roots) decomposition rates and nutrient release change at the community level following whole-tree harvesting (WTH). In the present study, we followed decomposition of leaf and different diameter fine root (∅ < 0.5 mm, 0.5-1 mm, 1-2 mm) litters at plot level over 2 years in a secondary forest in the Qinling Mountains after 5 years of five different thinning treatments (0%, 15%, 30%, 45%, and 60%). Our results demonstrated that WTH had no effects on leaf and different diameter fine root litter decomposition at the plot level. Leaves had significantly higher decomposition rate than different diameter fine roots. There were significant positive correlations between decomposition rate of different diameter fine roots, but not related to leaf litter decomposition rate. WTH did not affect the nutrient release of leaf and different diameter fine root litters at the plot level. The nitrogen (N), phosphorous (P) and potassium (K) mass remaining in leaf litters were significantly higher than different diameter fine roots after 2 years decomposition, while different diameter fine roots had higher C mass remaining. Leaf and fine root litter decomposition rates were mainly influenced by stand and litter quality attributes. Nutrient release of leaf and fine root N, P and K were mainly predicted by litter quality characteristics, while there were no consistent driving factors for C release. Our results suggested that WTH had no effects on multi-type litter decomposition and nutrient release at plot level after 5 years of recovery. Moreover, leaf litters had excellent N, P and K nutrient preservation mechanisms, and C conservation in fine root litters.


Assuntos
Ecossistema , Árvores , Florestas , Nitrogênio/metabolismo , Folhas de Planta/metabolismo , Solo , Árvores/metabolismo
15.
Int Immunopharmacol ; 109: 108850, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35605525

RESUMO

Peripheral vascular disease usually leads to vascular injury and inflammatory reaction, and the main therapeutic measures are improving angiogenesis and restoring blood flow. Interleukin-33 (IL-33) is a pleiotropic cytokine implicated in immune responses and tissue repair. Here, we explore the effect of IL-33 in hindlimb ischemic injury and elucidate the potential mechanisms of action. The expression of IL-33 and its receptor ST2 were obviously elevated in ischemic hindlimb of mice underwent ligation surgery. Exogenous IL-33 apparently facilitated blood flow restoration in ischemic hindlimb, whereas ST2-deficient mice displayed severe defects in ischemic hindlimb repair. The activation of IL-33/ST2 signaling contributed to revascularization in ischemic hindlimb, which was related to modulation of proangiogenic function of endothelial cells. Further ex vivo and in vitro studies revealed that IL-33 clearly accelerated angiogenesis by Matrigel plug and tube formation assays. Mechanically, the angiogenic function of IL-33 is involved in regulation of Akt/eNOS pathway. All together, these findings imply that IL-33-mediated endothelial angiogenesis may represent a prospective effective therapy for hindlimb ischemic damage.


Assuntos
Interleucina-33 , Neovascularização Fisiológica , Animais , Modelos Animais de Doenças , Células Endoteliais/metabolismo , Membro Posterior/irrigação sanguínea , Proteína 1 Semelhante a Receptor de Interleucina-1/metabolismo , Interleucina-33/metabolismo , Isquemia/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Estudos Prospectivos , Fator A de Crescimento do Endotélio Vascular/metabolismo
16.
Exp Gerontol ; 165: 111835, 2022 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-35598697

RESUMO

Collagen is a major component of the skin's support system, allowing for its firmness, elasticity, and mechanical strength. Skin collagen production decreases as we age and is associated with increased sagging, wrinkling, and thinning. The Renin-Angiotensin System (RAS) is a key hormonal system that changes with age and affects multiple organ systems. The primary health benefits of Angiotensin (Ang) receptor type1 (AT1R) blockers are believed to arise from systemic effects on blood pressure. However, there is also a skin-specific RAS, though this system has been less well characterized. There are eight FDA-approved angiotensin receptor blockers (ARBs) on the market, although the impact of topical ARBs on aging skin is unknown. Here, we evaluated the topical penetration of gel formulations of eight ARBs using human cadaver skin. Our results show that valsartan achieved the highest skin penetration compared to other ARBs. We then treated human skin fibroblasts from 2-year-old and 57-year-old individuals with valsartan alone or in combination with the neprilysin inhibitor sacubitril. Sacubitril works synergistically with valsartan by inhibiting the degradation of angiotensin II, thereby increasing its bioavailability. Treatment of young and older adult human skin cells with valsartan and sacubitril led to a five-fold increase in collagen type-1 production in the young cells and a four-fold increase in collagen type-1 in older adult cells. This study demonstrates a potential novel application for the widely prescribed drug combination sacubitril-valsartan as a topical agent in aged skin.

17.
Molecules ; 27(10)2022 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-35630739

RESUMO

The execution of specific processing protocols endows Wuyi rock tea with distinctive qualities produced through signature metabolic processes. In this work, tea leaves were collected before and after each of three processing stages for both targeted and untargeted metabolomic analysis. Metabolic profiles of processing stages through each processing stage of rotation, pan-firing and roasting were studied. Overall, 614 metabolites were significantly altered, predominantly through nitrogen- enriching (N) pathways. Roasting led to the enrichment of 342 N metabolites, including 34 lipids, 17 organic acids, 32 alkaloids and 25 amino acids, as well as secondary derivatives beneficial for tea quality. This distinctive shift towards enrichment of N metabolites strongly supports concluding that this directed accumulation of N metabolites is how each of the three processing stages endows Wuyi rock tea with singular quality.


Assuntos
Metabolômica , Nitrogênio , Aminoácidos/metabolismo , Metaboloma , Metabolômica/métodos , Chá/química
18.
Artigo em Inglês | MEDLINE | ID: mdl-35511890

RESUMO

Losartan is an oral antihypertensive agent that is rapidly metabolized to EXP3174 (angiotensin-subtype-1-receptor-blocker) and EXP3179 (peroxisome-proliferator-activated-receptor-gamma [PPARγ] agonist), which was shown in animal studies to reduce inflammation, enhance mitochondrial energetics, and improve muscle repair and physical performance. We conducted an exploratory pilot study evaluating losartan treatment in prefrail older adults (age 70-90 years, N=25). Participants were randomized to control (placebo) or treatment (daily oral losartan beginning at 25 mg per day and increasing every eight weeks) for a total of 6 months. Fatigue, hyperkalemia, and hypotension were the most observed side effects of losartan treatment. Participants in the losartan group had an estimated 89% lower odds of frailty (95% CI: 18% to 99% lower odds, p=0.03), with a 0.3-point lower frailty score than the placebo group (95% CI: 0.01 to 0.5 lower, p=0.04). Frailty score was also negatively associated with serum losartan and EXP3179 concentrations. For every one standard deviation increase in EXP3179 (i.e., 0.0011 ng/µL, based on sample values above detection limit) and EXP3174 (i.e., 0.27 ng/µL, based on sample values above detection limit ), there was a 0.0035 N (95% CI: 0.0019 to 0.0051, p<0.001) and a 0.0027 N (95% CI: 0.00054 to 0.0043, p=0.007) increase in average knee strength, respectively.

19.
Polymers (Basel) ; 14(9)2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35566977

RESUMO

Great interests have recently been aroused in the independent associative domain of glycoside hydrolases that utilize insoluble polysaccharides-carbohydrate-binding module (CBM), which responds to binding while the catalytic domain reacts with the substrate. In this mini-review, we first provide a brief introduction on CBM and its subtypes including the classifications, potential sources, structures, and functions. Afterward, the applications of CBMs in substrate recognition based on different types of CBMs have been reviewed. Additionally, the progress of CBMs in paper industry as a new type of environmentally friendly auxiliary agent for fiber treatment is summarized. At last, other applications of CBMs and the future outlook have prospected. Due to the specificity in substrate recognition and diversity in structures, CBM can be a prosperous and promising 'tool' for wood and fiber processing in the future.

20.
Front Neurosci ; 16: 876121, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35546875

RESUMO

Background: Studies on differences in brain function activity between the first depressive episode (FDE) and recurrent depressive episodes (RDE) are scarce. In this study, we used regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) as indices of abnormal brain function activity. We aimed to determine the differences in these indices between patients with FDE and those with RDE, and to investigate the correlation between areas of abnormal brain function and clinical symptoms. Methods: A total of 29 patients with RDE, 28 patients with FDE, and 29 healthy controls (HCs) who underwent resting-state functional magnetic resonance imaging were included in this study. The ReHo and ALFF measurements were used for image analysis and further analysis of the correlation between different brain regions and clinical symptoms. Results: Analysis of variance showed significant differences among the three groups in ReHo and ALFF in the frontal, parietal, temporal, and occipital lobes. ReHo was higher in the right inferior frontal triangular gyrus and lower in the left inferior temporal gyrus in the RDE group than in the FDE group. Meanwhile, ALFF was higher in the right inferior frontal triangular gyrus, left anterior cingulate gyrus, orbital part of the left middle frontal gyrus, orbital part of the left superior frontal gyrus, and right angular gyrus, but was lower in the right lingual gyrus in the RDE group than in the FDE group. ReHo and ALFF were lower in the left angular gyrus in the RDE and FDE groups than in the HC group. Pearson correlation analysis showed a positive correlation between the ReHo and ALFF values in these abnormal areas in the frontal lobe and the severity of depressive symptoms (P < 0.05). Abnormal areas in the temporal and occipital lobes were negatively correlated with the severity of depressive symptoms (P < 0.05). Conclusion: The RDE and FDE groups had abnormal neural function activity in some of the same brain regions. ReHo and ALFF were more widely distributed in different brain regions and had more complex neuropathological mechanisms in the RDE group than in the FDE group, especially in the right inferior frontal triangular gyrus of the frontal lobe.

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