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Int J Nanomedicine ; 14: 1359-1383, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30863066


Slp forms a crystalline array of proteins on the outermost envelope of bacteria and archaea with a molecular weight of 40-200 kDa. Slp can self-assemble on the surface of liposomes in a proper environment via electrostatic interactions, which could be employed to functionalize liposomes by forming Slp-coated liposomes for various applications. Among the molecular characteristics, the stability, adhesion, and immobilization of biomacromolecules are regarded as the most meaningful. Compared to plain liposomes, Slp-coated liposomes show excellent physicochemical and biological stabilities. Recently, Slp-coated liposomes were shown to specifically adhere to the gastrointestinal tract, which was attributed to the "ligand-receptor interaction" effect. Furthermore, Slp as a "bridge" can immobilize functional biomacromol-ecules on the surface of liposomes via protein fusion technology or intermolecular forces, endowing liposomes with beneficial functions. In view of these favorable features, Slp-coated liposomes are highly likely to be an ideal platform for drug delivery and biomedical uses. This review aims to provide a general framework for the structure and characteristics of Slp and the interactions between Slp and liposomes, to highlight the unique properties and drug delivery as well as the biomedical applications of the Slp-coated liposomes, and to discuss the ongoing challenges and perspectives.

Tecnologia Biomédica/métodos , Sistemas de Liberação de Medicamentos , Lipossomos/química , Glicoproteínas de Membrana/química , Lipossomos/ultraestrutura , Eletricidade Estática
Artigo em Inglês | MEDLINE | ID: mdl-24125394


We introduce a simple method to estimate the accuracy of exact solutions under initial value conditions proposed by Petrov and Kudrin [Phys. Rev. Lett. 104, 190404 (2010)]. We demonstrate that even for a sufficiently weak nonlinearity, the initial value condition difference between linear and nonlinear case may be evident. Our result may be used as a criterion of employing the exact solution to deal with initial value problems of cylindrical electromagnetic wave propagation in a nonlinear nondispersive medium.