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1.
J Environ Sci (China) ; 124: 513-521, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36182160

RESUMO

Over the past decade, the emission standards and fuel standards in Beijing have been upgraded twice, and the vehicle structure has been improved by accelerating the elimination of 2.95 million old vehicles. Through the formulation and implementation of these policies, the emissions of carbon monoxide (CO), volatile organic compounds (VOCs), nitrogen oxides (NOx), and fine particulate matter (PM2.5) in 2019 were 147.9, 25.3, 43.4, and 0.91 kton in Beijing, respectively. The emission factor method was adopted to better understand the emissions characteristics of primary air pollutants from combustion engine vehicles and to improve pollution control. In combination with the air quality improvement goals and the status of social and economic development during the 14th Five-Year Plan period in Beijing, different vehicle pollution control scenarios were established, and emissions reductions were projected. The results show that the emissions of four air pollutants (CO, VOCs, NOx, and PM2.5) from vehicles in Beijing decreased by an average of 68% in 2019, compared to their levels in 2009. The contribution of NOx emissions from diesel vehicles increased from 35% in 2009 to 56% in 2019, which indicated that clean and energy-saving diesel vehicle fleets should be further improved. Electric vehicle adoption could be an important measure to reduce pollutant emissions. With the further upgrading of vehicle structure and the adoption of electric vehicles, it is expected that the total emissions of the four vehicle pollutants can be reduced by 20%-41% by the end of the 14th Five-Year Plan period.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Compostos Orgânicos Voláteis , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Pequim , Monóxido de Carbono/análise , China , Monitoramento Ambiental , Óxidos de Nitrogênio/análise , Material Particulado/análise , Emissões de Veículos/análise , Compostos Orgânicos Voláteis/análise
2.
Food Chem ; 400: 134043, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36058043

RESUMO

There has been an increasing demand for the rapid verification of fish authenticity and the detection of adulteration. In this work, we combined LIBS and Raman spectroscopy for the fish species identification for the first time. Two machine learning methods of SVM and CNN are used to establish the classification models based on the LIBS and Raman data obtained from 13 types of fish species. Data fusion strategies including low-level, mid-level and high-level fusions are used for the combination of LIBS and Raman data. It shows that all these data fusion strategies offer a significant improvement in fish classification compared with the individual LIBS or Raman data, and the CNN model works more powerfully than the SVM model. The low-level fusion CNN model provides a best classification accuracy of 98.2%, while the mid-level fusion involved with feature selection improves the computing efficiency and gains the interpretability of CNN.


Assuntos
Aprendizado de Máquina , Análise Espectral Raman , Lasers
4.
Ann Transl Med ; 10(16): 871, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36111012

RESUMO

Background: To build a model of an anatomical plate for oblique lumbar interbody fusion (OLIF) surgery based on previous anatomical parameters and verify the biomechanical effect with finite element analysis. Methods: The anatomical plate model was built with AutoCAD and Solidworks. Finite element models of the L2-3 and L4-5 segments were established with computed tomography images from a 46-year-old asymptomatic male individual. Six fixation technique models were created: (I) stand-alone (SA); (II) bilateral pedicle screws (BPS); (III) lateral rod-screw (LRS); (IV) lateral rod-screw plus facet screw (LRSFS); (V) two-screw lateral plate (TSLP); (VI) anatomical plate. The range of motion (ROM), the cage stress, and the instrument stress were calculated under different motion states. Results: In the L2-3 and L4-5 segment models, except for a slightly higher maximum cage stress in the extension state of the TSLP model and the right bending and rotation states of the BPS model, the maximum cage stress in each model was smaller than that of the SA model. In the L2-3 and L4-5 segments, each internal fixation limited the ROM in each motion state. The anatomical plate was more effective in reducing the maximum cage stress and vertebral ROM than the two-screw plate. Three-dimensional finite element analysis did not find a higher risk of construct failure for the anatomical plate model compared with the BPS internal fixation model. Conclusions: Anatomical plates can be considered as supplementary fixations using a single incision and position to improve the stability and rigidity of the construction and reduce the risk of complications.

5.
Psychol Rep ; : 332941221125773, 2022 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-36113419

RESUMO

This study explored the underlying mechanisms and boundary conditions of the relationship between transformational leadership and teacher burnout. Specifically, it investigated the mediating role of teacher self-efficacy and the moderating role of teacher emotional intelligence (EI) in this relationship. Data from 539 primary and secondary school teachers were analyzed using Structural Equation Model and hierarchical regression. The results indicate that transformational leadership predicted teacher burnout negatively, self-efficacy mediated the association of transformational leadership with burnout partially, and EI strengthened the association between transformational leadership and burnout. This study has important theoretical and managerial implications as it deepens the understanding of the association between transformational leadership and burnout in the educational field and provides practical suggestions on how to relieve teacher burnout in the school context.

6.
J Proteome Res ; 2022 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-36103633

RESUMO

BK virus (BKV) is one of the most common pathogens in post-transplantation infections. For kidney transplantation, BKV infection results in the impairment of allograft function and thus increases the risk of allograft loss. However, clinical evaluation of the prognosis of BKV-associated allograft impairment is difficult. In the present study, differential plasma proteins were screened using proteomic methods from ten patients with a transition from BKV-negative to BKV activation. We identified 12 differentially expressed proteins, and S100A8 and S100A9 were the top two upregulated proteins. Data from a cross-sectional study with 66 BKV-negative and 66 BKV-positive recipients of renal transplantation indicated that plasma S100A8/A9 was upregulated in BKV-infected recipients. Plasma S100A8/A9 positively correlated with the 1 month creatinine increase (ρ = 0.499, P = 0.021) and negatively correlated with the 1 month estimated glomerular filtration rate change (ρ = -0.618, P = 0.003) in recipients with BK viremia. Using least absolute shrinkage and selection operator regression models, we found that S100A8/A9 was an independent risk factor for the decrease in allograft function after BKV infection. In conclusion, S100A8/A9 is a potential host biomarker for the clinical evaluation of BKV-associated allograft function impairment in kidney transplantation.

7.
Mol Nutr Food Res ; : e2200486, 2022 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-36106654

RESUMO

SCOPE: Puberty timing, critical for adulthood wellbeing, is influenced by the environment, life-style and diets. However, differential puberty-interfering effects of soy and soy isoflavone were observed in both epidemiological and toxicological studies. Additionally, their impact on neuroendocrine function at various pre-pubertal developmental windows is unclear. METHODS AND RESULTS: This study investigated the effect of genistein, a typical soy isoflavone, at neonatal, lactational and post-weaning stages on the time of vaginal opening and determined the levels of neuroendocrine factors in female rats using immunofluorescence, immunochemistry, and enzyme-linked immunosorbent assays. A physiologically relevant dosage (10 mg/kg) was used to resemble human exposure. The results showed that genistein exposure at lactational stage significantly accelerated vaginal opening time, marginally increased hypothalamic gonadotropin-releasing hormone (GnRH) secretion, significantly enhanced kisspeptin receptor expression, and markedly elevated blood levels of GnRH, luteinizing hormone, and follicle-stimulating hormone, while neonatal and post-weaning exposures did not induce significant alternations. CONCLUSION: Lactational stage might be an important window for genistein to impact reproductive development and neuroendocrine regulations. This article is protected by copyright. All rights reserved.

8.
J Inflamm Res ; 15: 4873-4890, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36046663

RESUMO

Background: Ischemic injury in stroke is followed by extensive neurovascular inflammation and changes in ischemic penumbra gene expression patterns. However, the key molecules involved in the inflammatory response during the acute phase of ischemic stroke remain unclear. Methods: Gene expression profiles of two rat ischemic stroke-related data sets, GSE61616 and GSE97537, were downloaded from the GEO database for Gene Set Enrichment Analysis (GSEA). Then, GEO2R was used to screen differentially expressed genes (DEGs). Furthermore, 170 differentially expressed intersection genes were screened and analyzed for Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Candidate genes and miRNAs were obtained by DAVID, Metascape, Cytoscape, STRING, and TargetScan. Finally, the rat middle cerebral artery occlusion-reperfusion (MCAO/R) model was constructed, and qRT-PCR was used to verify the predicted potential miRNA molecule and its target genes. Results: GO and KEGG analyses showed that 170 genes were highly associated with inflammatory cell activation and cytokine production. After cluster analysis, seven hub genes highly correlated with post-stroke neuroinflammation were obtained: Cxcl1, Kng1, Il6, AnxA1, TIMP1, SPP1, and Ccl6. The results of TargetScan further suggested that miR-340-5p may negatively regulate SPP1, AnxA1, and TIMP1 simultaneously. In the ischemic penumbra of rats 24 h after MCAO/R, the level of miR-340-5p significantly decreased compared with the control group, while the concentration of SPP1, AnxA1, and TIMP1 increased. Time-course studies demonstrated that the mRNA expression levels of SPP1, AnxA1, and TIMP1 fluctuated dramatically throughout the acute phase of cerebral ischemia-reperfusion (I/R). Conclusion: Our study suggests that differentially expressed genes SPP1, TIMP1, and ANXA1 may play a vital role in the inflammatory response during the acute phase of cerebral ischemia-reperfusion injury. These genes may be negatively regulated by miR-340-5p. Our results may provide new insights into the complex pathophysiological mechanisms of secondary inflammation after stroke.

9.
Materials (Basel) ; 15(17)2022 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-36079507

RESUMO

The geopolymerization of aluminosilicate materials in alkaline environments is a complex physicochemical process that greatly influences the microstructure and engineering performances. This work aims to reveal the geopolymerization process of metakaolin-based geopolymer (MKG) in the first 5 d. Physicochemical characteristics of different evolution stages are disposed of in chronological order. The evolutions of electrical resistivity, dehydration process, volume deformation, and ionic concentration are comprehensively analyzed. Results show that chemical dissolution produces large dismantled fragments rather than small free monomers. The formation of a solid matrix follows the "spatial filling rule", which means that gels grow by locking swelling fragments to form a framework, then densely filling residual space. Based on chemical models, early geopolymerization of MKG can be divided into six stages from the physicochemical perspective as dismantling, locking fixation, free filling, limited filling, second dissolution, and local mending. Those findings expand the understanding of the phase evolution of the early geopolymerization process; thus, the microstructure of MKG can be better manipulated, and its engineering performances can be improved.

10.
Sensors (Basel) ; 22(17)2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36080912

RESUMO

Transportation Mode Detection (TMD) is an important task for the Intelligent Transportation System (ITS) and Lifelog. TMD, using smartphone built-in sensors, can be a low-cost and effective solution. In recent years, many studies have focused on TMD, yet they support a limited number of modes and do not consider similar transportation modes and holding places, limiting further applications. In this paper, we propose a new network framework to realize TMD, which combines structural and spatial interaction features, and considers the weights of multiple sensors' contributions, enabling the recognition of eight transportation modes with four similar transportation modes and four holding places. First, raw data is segmented and transformed into a spectrum image and then ResNet and Vision Transformers (Vit) are used to extract structural and spatial interaction features, respectively. To consider the contribution of different sensors, the weights of each sensor are recalibrated using an ECA module. Finally, Multi-Layer Perceptron (MLP) is introduced to fuse these two different kinds of features. The performance of the proposed method is evaluated on the public Sussex-Huawei Locomotion-Transportation (SHL) dataset, and is found to outperform the baselines by at least 10%.


Assuntos
Redes Neurais de Computação , Smartphone , Meios de Transporte
11.
Hum Genet ; 2022 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-36098810

RESUMO

The craniovertebral junction (CVJ) is an anatomically complex region of the axial skeleton that provides protection of the brainstem and the upper cervical spinal cord. Structural malformation of the CVJ gives rise to life-threatening neurological deficits, such as quadriplegia and dyspnea. Unfortunately, genetic studies on human subjects with CVJ malformation are limited and the pathogenesis remains largely elusive. In this study, we recruited 93 individuals with CVJ malformation and performed exome sequencing. Manual interpretation of the data identified three pathogenic variants in genes associated with Mendelian diseases, including CSNK2A1, MSX2, and DDX3X. In addition, the contribution of copy number variations (CNVs) to CVJ malformation was investigated and three pathogenic CNVs were identified in three affected individuals. To further dissect the complex mutational architecture of CVJ malformation, we performed a gene-based rare variant association analysis utilizing 4371 in-house exomes as control. Rare variants in LGI4 (carrier rate = 3.26%, p = 3.3 × 10-5) and BEST1 (carrier rate = 5.43%, p = 5.77 × 10-6) were identified to be associated with CVJ malformation. Furthermore, gene set analyses revealed that extracellular matrix- and RHO GTPase-associated biological pathways were found to be involved in the etiology of CVJ malformation. Overall, we comprehensively dissected the genetic underpinnings of CVJ malformation and identified several novel disease-associated genes and biological pathways.

12.
Sci China Life Sci ; 2022 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-36066811

RESUMO

Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

13.
Front Cell Dev Biol ; 10: 954431, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36072340

RESUMO

The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role of the cellular courier. Recent studies have led to the revision of the canonical function of transfer RNAs (tRNAs), which indicates that tRNAs also serve as a source for short non-coding RNAs called tRNA-derived small RNAs (tsRNAs). tsRNAs play key roles in cellular processes by modulating complicated regulatory networks beyond translation and are widely involved in multiple diseases. Herein, the biogenesis and classification of tsRNAs were firstly clarified. tsRNAs are generated from pre-tRNAs or mature tRNAs and are classified into tRNA-derived fragments (tRFs) and tRNA halves (tiRNA). The tRFs include five types according to the incision loci: tRF-1, tRF-2, tRF-3, tRF-5 and i-tRF which contain 3' tiRNA and 5' tiRNA. The functions of tsRNAs and their regulation mechanisms involved in disease processes are systematically summarized as well. The mechanisms can elaborate on the specific regulation of tsRNAs. In conclusion, the current research suggests that tsRNAs are promising targets for modulating pathological processes, such as breast cancer, ischemic stroke, respiratory syncytial virus, osteoporosis and so on, and maintain vital clinical implications in diagnosis and therapeutics of various diseases.

14.
Opt Lett ; 47(17): 4367-4370, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36048655

RESUMO

Photovoltaic integrated luminescent solar concentrators (LSCs) can be embedded in modern buildings to serve as power-generation units. In this Letter, we demonstrate and develop a Monte Carlo ray-tracing model and a numerical description for the performance and loss evaluation of LSCs based on colloidal quantum dots. The performance differences between bulk and thin-film LSCs are systematically analyzed at different sizes and concentrations. It is found that large-area thin-film LSCs generally perform better, which is attributed to the suppression of scattering and the retention of quantum yield by this structure with twice the performance of bulk LSCs.

15.
J Digit Imaging ; 2022 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-36085330

RESUMO

The accuracy of computed tomography angiography (CTA) image interpretation depends on the radiologist. This study aims to develop a new method for automatically detecting intracranial aneurysms from CTA images using deep learning, based on a convolutional neural network (CNN) implemented on the DeepMedic platform. Ninety CTA scans of patients with intracranial aneurysms are collected and divided into two datasets: training (80 subjects) and test (10 subjects) datasets. Subsequently, a deep learning architecture with a three-dimensional (3D) CNN model is implemented on the DeepMedic platform for the automatic segmentation and detection of intracranial aneurysms from the CTA images. The samples in the training dataset are used to train the CNN model, and those in the test dataset are used to assess the performance of the established system. Sensitivity, positive predictive value (PPV), and false positives are evaluated. The overall sensitivity and PPV of this system for detecting intracranial aneurysms from CTA images are 92.3% and 100%, respectively, and the segmentation sensitivity is 92.3%. The performance of the system in the detection of intracranial aneurysms is closely related to their size. The detection sensitivity for small intracranial aneurysms (≤ 3 mm) is 66.7%, whereas the sensitivity of detection for large (> 10 mm) and medium-sized (3-10 mm) intracranial aneurysms is 100%. The deep learning architecture with a 3D CNN model on the DeepMedic platform can reliably segment and detect intracranial aneurysms from CTA images with high sensitivity.

16.
BMC Musculoskelet Disord ; 23(1): 848, 2022 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-36071416

RESUMO

BACKGROUND: This study aimed to compare the biomechanical differences between anterior cervical discectomy and fusion (ACDF) with multiple-level separate plates and conventional long plates by using finite element analysis. METHODS: The following four finite element models were created to simulate various fixations: (1) C4-6 ACDF with multiple plates, (2) C4-6 ACDF with a single plate, (3) C3-6 ACDF with multiple plates, and (4) C3-6 ACDF with a single plate. The maximum Von-mises stress of the cage and fixation, compressive force of the adjacent intervertebral discs and range of motion (ROM) of different segments in the four models were calculated and analyzed. RESULTS: For C4-6 ACDF, the maximum Von-mises stress of the cage and fixation was lower in the multiple plate fixation model in all motion states. Similarly, for the C3-6 ACDF models, the peak stress of the C3-4 and C5-6 cages was lower with multiple plates fixation in all motions but the stress of the C4-5 cage in the multiple plates model was slightly higher in flexion, bending and rotation. Besides, applying multiple plates in C3-6 ACDF models resulted in a decreased maximum stress of the fixation under different motions except for bending. In both the C4-6 ACDF and C3-6 ACDF models, the ROM values of the adjacent motion segments were lower in the multiple plates models in extension, bending and rotation. In the C4-6 ACDF models, the peak stress on the adjacent intervertebral discs in the multiple plates models was slightly smaller. In C3-6 ACDF models, the maximum stress on the adjacent intervertebral discs was larger in the single-plate model under flexion, bending and rotation movements. CONCLUSION: Multiple plates fixation has a positive effect on increasing stiffness and maintaining the ROM of adjacent segments, indicating lower risk of construct failure and adjacent segment degeneration. Further studies are required to confirm its efficacy in clinical practice.


Assuntos
Vértebras Cervicais , Fusão Vertebral , Fenômenos Biomecânicos , Vértebras Cervicais/cirurgia , Discotomia/métodos , Análise de Elementos Finitos , Humanos , Fusão Vertebral/efeitos adversos , Fusão Vertebral/métodos
17.
Front Genet ; 13: 958290, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36147483

RESUMO

Cancer occurrence and progression may be facilitated by aberrant expression of ATPase H+ transporting accessory protein 1 (ATP6AP1). However, the clinical relevance of ATP6AP1 in breast cancer remains unclear. In this study, we investigated the association between ATP6AP1 and breast cancer. Data collected from patients with breast cancer from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were used in this study. To determine the relationship between ATP6AP1 and breast cancer survival rates, Kaplan-Meier analysis was used. To determine the prognostic value of ATP6AP1, a receiver operating characteristic (ROC) curve was constructed. To identify the major pathways involving ATP6AP1, we performed functional enrichment analysis using gene set enrichment analysis (GSEA). We analyzed the association between ATP6AP1 expression and tumor immunity using the ESTIMATE algorithm and single-sample GSEA (ssGSEA). A nomogram based on a Cox regression analysis was constructed to predict the impact of ATP6AP1 on prognosis. ATP6AP1 expression was significantly upregulated in breast cancer tissues. Moreover, patients with elevated ATP6AP1 expression had shorter total survival rates than those with lower expression levels (p = 0.032). The area under the receiver operating characteristic curve for ATP6AP1 was 0.939. Gene set enrichment analysis revealed that reaction iron uptake and transport, proteasome degradation, glutathione metabolism, and pyruvate metabolism were enriched in the ATP6AP1 high expression phenotype. The relationship between immune infiltration cells and ATP6AP1 expression, including macrophages, B cells, dendritic cells, cytotoxic cells, NK cells, and T cells, was found to be negative, suggesting that ATP6AP1 overexpression results in immunosuppression. Based on the Cox regression analyses, the calibration plot of the nomogram demonstrated effective performance in predicting breast cancer patients. ATP6AP1 may facilitate breast cancer progression by inhibiting antitumor immunity and promoting iron metabolism and may be a biomarker for breast cancer prognosis.

18.
Chiropr Man Therap ; 30(1): 34, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-36050701

RESUMO

BACKGROUND: Myofascial pain syndrome (MPS) is a condition with local and referred pain characterized by trigger points (taut bands within the muscle). Ischemic compression is a noninvasive manual therapy technique that has been employed for the treatment of MPS in past decades. However, little attention has been devoted to this topic. OBJECTIVES: The present review was designed to explore the efficacy of ischemic compression for myofascial pain syndrome by performing a descriptive systematic review and a meta-analysis to estimate the effect of ischemic compression on MPS. METHODS: A systematic review and meta-analysis concerning randomized controlled trials (RCTs) with myofascial pain subjects who received ischemic compression versus placebo, sham, or usual interventions. Five databases (PubMed, The Cochrane Library, Embase, Web of Science, Ovid) were searched from the earliest data available to 2022.1.2. The standardized mean difference (SMD) and the 95% confidence interval (CI) were used for statistics. Version 2 of the Cochrane risk of tool 2 (RoB 2) was used to assess the quality of the included RCTs. RESULTS: Seventeen studies were included in the systematic review, and 15 studies were included in the meta-analysis. For the pressure pain threshold (PPT) index, 11 studies and 427 subjects demonstrated statistically significant differences compared with the control at posttreatment (SMD = 0.67, 95% CI [0.35, 0.98], P < 0.0001, I2 = 59%). For visual analog scale (VAS) or numeric rating scale (NRS) indices, 7 studies and 251 subjects demonstrated that there was no significant difference between ischemic compression and controls posttreatment (SMD = - 0.22, 95% CI [- 0.53, 0.09], P = 0.16, I2 = 33%). CONCLUSION: Ischemic compression, as a conservative and noninvasive therapy, only enhanced tolerance to pain in MPS subjects compared with inactive control. Furthermore, there was no evidence of benefit for self-reported pain. The number of currently included subjects was relatively small, so the conclusion may be changed by future studies. Big scale RCTs with more subjects will be critical in future.


Assuntos
Síndromes da Dor Miofascial , Humanos , Síndromes da Dor Miofascial/tratamento farmacológico , Dor , Medição da Dor/métodos , Limiar da Dor
19.
Global Spine J ; : 21925682221130045, 2022 Sep 26.
Artigo em Inglês | MEDLINE | ID: mdl-36164680

RESUMO

STUDY DESIGN: A retrospective observational study. OBJECTIVE: To describe a novel outcome indication system, the posterior compression score (PCS), and investigate its clinical value in cervical ossification of the posterior longitudinal ligament (OPLL) patients treated with laminoplasty. METHODS: A total of 282 OPLL patients who underwent laminoplasty from January 2013 to December 2018 were reviewed. The patients were divided into high-score (HS) or low-score (LS) groups based on whether the PCS was over 8. Propensity score matching analysis with a caliper of .1 was used to attenuate the potential selection bias. Clinical measurements, including the Japanese Orthopedic Association (JOA) score, visual analog scale (VAS), neck disability index (NDI), and radiological measurements, including C2-C7 lordotic angle and range of motion (ROM), were compared between the groups. RESULTS: The mean follow-up period was 29.87 ± 9.17 months. There were no significant differences between the two groups regarding patients' baseline demographical and clinical characteristics after propensity score matching. No significant differences were found in the operative time, blood loss, postoperative VAS score for neck and arm pain, postoperative C2-C7 lordotic angle, or postoperative ROM (P > .05). However, the postoperative JOA score and recovery rate were significantly higher in the HS group than in the LS group, while the postoperative NDI was significantly lower in the HS group (P < .05). CONCLUSION: OPLL patients with higher PCS scores displayed better clinical outcomes. The novel PCS system is suggested to be a reliable scoring system for surgical outcome evaluation in patients with cervical OPLL.

20.
Sci Total Environ ; 852: 158467, 2022 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-36057305

RESUMO

Freeze-thaw action has the potential to facilitate the mobilization of colloid-associated contaminants in soil. However, the differences in colloid-associated contaminants following autumn freeze-thaw (AFT) events and spring freeze-thaw (SFT) events remain unclear. In this study, the potential influence mechanisms of AFT and SFT on both the generation and migration of colloids and colloid-associated cadmium (Cd) in soil were explored. Higher aggregate stabilities were found in soils after AFT compared with after SFT. After SFT, lower Cd concentrations were found in soil aggregates of 0.25-0.50 mm and <0.106 mm and higher concentrations were found in 0.106-0.25 mm aggregates. Moreover, SFT generated higher amounts of colloidal Cd than AFT, while AFT increased the total Cd concentration in leachates. Additionally, compared with SFT, AFT led to higher Cd concentrations in dissolved and colloid-associated forms in leachates. These findings demonstrate that higher amounts of colloid and fewer loadings of Cd in colloids in Cd contaminated soil can be found after SFT events. Thus, to better understand the environmental risk of contaminants in areas subject to seasonal freeze-thaw cycles, the differences between freeze-thaw processes in spring and autumn should be considered.

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