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Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(2): 226-228, 2019 May 07.
Artigo em Chinês | MEDLINE | ID: mdl-31184067


OBJECTIVE: To perform epidemiological survey and laboratory diagnosis of a Plasmodium ovale malaria case imported into Hefei City, so as to provide scientific evidence for the prevention and control of imported malaria in the future. METHODS: The epidemiological history and clinical data of the imported malaria case were collected and analyzed. RESULTS: The patient returned to China from Mozambique, and was admitted to the hospital due to repeated fever several months after returning to China. Rapid diagnostic test (RDT) suggested non-P. falciparum infection, and microscopy displayed normal or slightly swelled malaria parasite-infected erythrocytes, unapparent serrated changes, increased cytoplasm in large trophozoite with irregular morphology, and almost no vacuoles. qPCR assay revealed P. ovale infection. CONCLUSIONS: Clinical medical professionals should improve their awareness of malaria diagnosis in people with a history of living or working in overseas malaria-epidemic areas, and early and rational administration of antimalarials should be given promptly to prevent the spread of malaria epidemics.

Antimaláricos , Malária , Plasmodium ovale , Animais , Antimaláricos/uso terapêutico , China , Doenças Transmissíveis Importadas/diagnóstico , Doenças Transmissíveis Importadas/tratamento farmacológico , Doenças Transmissíveis Importadas/parasitologia , Doenças Transmissíveis Importadas/patologia , Humanos , Malária/diagnóstico , Malária/tratamento farmacológico , Malária/parasitologia , Malária/patologia , Moçambique
Biochem Biophys Res Commun ; 514(3): 826-834, 2019 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-31079918


Recent studies have implied that activation of AMP-dependent protein kinase (AMPK) could protect myocardial cells from oxygen glucose deprivation-re-oxygenation (OGD/R). The aim of the present study is to test whether GSK621, a novel and direct AMPK activator, could exert myocardial cell protection against OGD/R. We show that in AC16 human myocardial cells and primary murine myocardiocytes GSK621 dose-dependently activated AMPK signaling. GSK621 pretreatment potently inhibited OGD/R-induced viability reduction, cell death and apoptosis in AC16 cells and primary myocardiocytes. Furthermore, GSK621 attenuated OGD/R-induced reactive oxygen species production and oxidative injury in the myocardial cells. AMPKα1 knockdown (via targeted shRNA), knockout (via a CRISPR/Cas9 construct) or dominant negative mutation (T172A) not only blocked GSK621-induced AMPK activation, but also nullified GSK621-mediated myocardial cell protection against OGD/R. Further studies demonstrated that GSK621 activated AMPK downstream Nrf2 signaling. Contrarily, Nrf2 silencing by targeted shRNAs almost abolished GSK621-induced anti-OGD/R myocardial cell protection. We conclude that GSK621 protects myocardial cells from OGD/R through activation of AMPK-dependent signaling.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 30(5): 493-499, 2018 May 30.
Artigo em Chinês | MEDLINE | ID: mdl-30567017


OBJECTIVE: To investigate the status of Oncomelania hupensis snails in Anhui Province in 2016, so as to provide the evidence for formulating the 13th Five-Year Plans for Schistosomiasis Control. METHODS: In 2016, a snail survey was conducted in Anhui Province according to the National Programme of the Oncomelania Snail Survey, covering all snail habitats or historical snail habitats and suspected environments of snail breeding, and the results of the survey were analyzed. RESULTS: In 2016, 22 848 environments were surveyed, and no schistosome-infected snails were found. There were 17 927 historical snail habitats in whole province, among which, the environments without changes, changed partly and changed completely accounted for 71.2%, 19.3% and 9.5%, respectively. The area of historical snail habitats was 1.410 billion m2. There were 4 830 environments with snail habitats covering an area of 0.265 billion m2 in 38 counties of 7 cities, including newly emerging area of 1 287.65 hm2 and reemerging area of 1 375.32 hm2. The density of living snails was 0.392 0 snails/0.1 m2, and the rate of frame with living snails was 12.93%. The type of marshland and lake regions, and the type of hilly and mountainous regions accounted for 22.4% and 77.6% of number of snail habitats, and accounted for 86.7% and 13.3% of areas of snail habitats, respectively. Among the different types of vegetation in snail habitats, grass was superior owe to accounting for 82.2% of the number of snail habitats, 57.3% of the area with snail habitats, and the highest density of living snails (0.413 9 snails/0.1 m2). Among the different types of environments in snail habitats, the ditch was superior owe to accounting for 56.8% of the number of snail habitats, the highest density of living snails (0.570 3 snails/0.1m2) and the highest rate of frame with living snails (18.57%), and the beach was superior owe to accounting for 87.8% of the area with snail habitats. In Anhui Province, the first year of snails and schistosome-infected snails being found was 1950 and 1952, respectively, and the latest year of schistosome-infected snails being found was 2012. The map showed that the most environments with snail habitats were distributed along the Yangtze River in Anhui Province. CONCLUSIONS: For the first time, the investigation has built the database and map of snail spatial distribution, which truly reflect the historic and current status of snail distribution in Anhui Province and can provide the evidence for formulating the 13th Five-Year Plans for Schistosomiasis Control and improving the schistosomiasis prevention and control work in the future.

Schistosoma/fisiologia , Caramujos , Distribuição Animal , Animais , China/epidemiologia , Lagos , Rios , Esquistossomose/epidemiologia , Esquistossomose/prevenção & controle , Caramujos/parasitologia