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1.
Phys Rev Lett ; 104(17): 172001, 2010 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-20482102

RESUMO

Differential cross sections and photon-beam asymmetries for the gamma(p)-->K{+}Lambda(1520) reaction have been measured with linearly polarized photon beams at energies from the threshold to 2.4 GeV at 0.6or=5/2 or by a new reaction process, for example, an interference effect with the phi photoproduction having a similar bump structure in the cross sections.

2.
Phys Rev Lett ; 103(1): 012001, 2009 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-19659135

RESUMO

Photoproduction of Lambda(1520) with liquid hydrogen and deuterium targets was examined at photon energies below 2.4 GeV in the SPring-8 LEPS experiment. For the first time, the differential cross sections were measured at low energies and with a deuterium target. A large asymmetry of the production cross sections from protons and neutrons was observed at backward K+/0 angles. This suggests the importance of the contact term, which coexists with t-channel K exchange under gauge invariance. This interpretation was compatible with the differential cross sections, decay asymmetry, and photon beam asymmetry measured in the production from protons at forward K+ angles.

3.
Phys Rev Lett ; 102(1): 012501, 2009 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-19257183

RESUMO

The Sigma(1385) resonance, or Sigma;{*}, is well known as part of the standard baryon decuplet with spin J=3/2. Measurements of the reaction gammap-->K;{+}Sigma;{*0} are difficult to extract due to overlap with the nearby Lambda(1405) resonance. However, the reaction gamman-->K;{+}Sigma;{*-} has no overlap with the Lambda(1405) due to its charge. Here we report the first measurement of cross sections and beam asymmetries for photoproduction of the Sigma;{*-} from a deuteron target. The cross sections at forward angles range from 0.4 to 1.2 mub, with a broad maximum near E_{gamma} approximately 1.8 GeV. The beam asymmetries are negative, in contrast with positive values for the gamman-->K;{+}Sigma;{-} reaction.

4.
Phys Rev Lett ; 97(8): 082003, 2006 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-17026294

RESUMO

Differential cross sections and photon-beam asymmetries have been measured for the gamma n --> K+ Sigma- and gamma p --> K+Sigma0 reactions separately using liquid deuterium and hydrogen targets with incident linearly polarized photon beams of E gamma = 1.5-2.4 GeV at 0.6 < cos ThetacmK< 1. The cross section ratio of sigma K+ Sigma-/sigma K+ Sigma0, expected to be 2 on the basis of the isospin 1/2 exchange, is found to be close to 1. For the K+ Sigma- reaction, large positive asymmetries are observed, indicating the dominance of K* exchange. The large difference between the asymmetries for the K+ Sigma- and K+ Sigma0 reactions cannot be explained by simple theoretical considerations based on Regge model calculations.

5.
Phys Rev Lett ; 95(18): 182001, 2005 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-16383894

RESUMO

Photoproduction of a phi meson on protons was studied by means of linearly polarized photons at forward angles in the low-energy region from threshold to Egamma = 2.37 GeV. The differential cross sections at t = -|t|min do not increase smoothly as Egamma increases but show a local maximum at around 2.0 GeV. The angular distributions demonstrate that phi mesons are photoproduced predominantly by helicity-conserving processes, and the local maximum is not likely due to unnatural-parity processes.

6.
J Antimicrob Chemother ; 48(4): 573-7, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11581241

RESUMO

We examined the effects of a combination of roxithromycin and imipenem on a biofilm model of Staphylococcus aureus. Treatment with roxithromycin alone and imipenem alone did not decrease the number of viable bacterial cells compared with the control. However, a combination treatment of roxithromycin and imipenem significantly decreased the number of viable bacterial cells on day 8 after inoculation in the in vivo model (P < 0.01). On days 5 and 8 after inoculation, numerous polymorphonuclear leucocytes and macrophages invaded the bacterial clusters in the roxithromycin- and roxithromycin/imipenem-treated groups, but did not invade the control or imipenem-treated groups. The present study indicated that a combination of roxithromycin and imipenem is a potentially effective treatment for S. aureus biofilm-associated skin infections as it can induce the invasion of polymorphonuclear leucocytes into the biofilm.


Assuntos
Antibacterianos/uso terapêutico , Biofilmes/efeitos dos fármacos , Imipenem/uso terapêutico , Roxitromicina/uso terapêutico , Staphylococcus aureus/efeitos dos fármacos , Tienamicinas/uso terapêutico , Animais , Biofilmes/crescimento & desenvolvimento , Modelos Animais de Doenças , Quimioterapia Combinada , Humanos , Camundongos , Infecções Cutâneas Estafilocócicas/tratamento farmacológico , Infecções Cutâneas Estafilocócicas/microbiologia , Staphylococcus aureus/crescimento & desenvolvimento , Resultado do Tratamento
7.
Clin Exp Dermatol ; 26(6): 504-6, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11678876

RESUMO

We describe a rare case of pemphigus foliaceus associated with familial myasthenia gravis (MG). A 35-year-old woman developed MG during oral corticosteroid treatment for pemphigus foliaceus. She had been operated on for a thyroid gland tumour that was confirmed histopathologically to be papillary carcinoma without metastasis. At the time of treatment, her mother had had MG for 30 years and undergone thymectomy 22 years ago. A specific ELISA technique showed that antidesmoglein 1 antibody was present in the daughter. There are many reports of multiple diseases such as pemphigus, thymoma, malignancy, and other autoimmune diseases associated with MG. However, familial MG following pemphigus foliaceus has not been reported previously.


Assuntos
Carcinoma Papilar/complicações , Miastenia Gravis/genética , Pênfigo/complicações , Neoplasias da Glândula Tireoide/complicações , Adulto , Cloreto de Ambenônio/uso terapêutico , Anticorpos/análise , Carcinoma Papilar/tratamento farmacológico , Carcinoma Papilar/imunologia , Inibidores da Colinesterase/uso terapêutico , Complemento C3/análise , Proteínas do Citoesqueleto/imunologia , Desmoplaquinas , Quimioterapia Combinada , Epiderme/imunologia , Feminino , Técnica Direta de Fluorescência para Anticorpo , Humanos , Imunoglobulina G/análise , Miastenia Gravis/tratamento farmacológico , Miastenia Gravis/imunologia , Pênfigo/tratamento farmacológico , Pênfigo/imunologia , Prednisolona/uso terapêutico , Neoplasias da Glândula Tireoide/tratamento farmacológico , Neoplasias da Glândula Tireoide/imunologia
9.
Br J Dermatol ; 142(6): 1213-8, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10848750

RESUMO

We report an 80-year-old man with the lamina lucida type of linear IgA disease, with IgA autoantibodies reactive with 200-kDa and 280-kDa epidermal proteins. The patient presented with widespread bullous lesions on his trunk and extremities without mucosal involvement. Histopathology of lesional skin showed a subepidermal blister with papillary microabscesses of neutrophils and a few eosinophils. Direct immunofluorescence microscopy of perilesional skin showed linear deposits of IgA and C3 at the basement membrane zone. The patient's serum contained IgA autoantibodies that bound exclusively to the epidermal side of 1 mol L-1 NaCl split skin as determined by indirect immunofluorescence microscopy. Circulating IgA autoantibodies to 200- and 280-kDa antigens were detected in the patient's serum by immunoblot analysis using extracts from normal human epidermis and human epidermal keratinocytes. These two antibodies, eluted from individual nitrocellulose membranes, reacted with the epidermal side of 1 mol L-1 NaCl split skin on indirect immunofluorescence microscopy, and bound to hemidesmosomes as determined by immunoperoxidase electron microscopy. This observation suggests the presence of hitherto uncharacterized 200- and 280-kDa hemidesmosomal proteins distinct from BPAG1, BPAG2 and beta4 integrin as target antigens in linear IgA disease.


Assuntos
Autoanticorpos/análise , Doenças Autoimunes/imunologia , Epiderme/imunologia , Imunoglobulina A/análise , Dermatopatias Vesiculobolhosas/imunologia , Idoso , Idoso de 80 Anos ou mais , Autoantígenos/imunologia , Western Blotting , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Masculino
10.
Clin Exp Allergy ; 29(8): 1110-7, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10457116

RESUMO

BACKGROUND: Heavy colonization of atopic dermatitis (AD) with Staphylococcus aureus is well documented. This phenomenon suggests that S. aureus in AD lesions influences the disease processes of AD. OBJECTIVE: We describe the importance of the presence of S. aureus and staphylococcal enterotoxins A and B (SEA, SEB) in AD lesions. METHODS: We investigated the colonizing features of S. aureus in AD lesions using electron microscopy, the distribution of SEB in the eczematous skin of AD using immunofluorescence, the effects of SEA and SEB on normal human epidermal keratinocytes in organ culture, and the presence of specific IgE antibodies to SEA and/or SEB in serum of AD patients by enzyme immunoassay. RESULTS: S. aureus in AD lesions colonized on and in the horny layers of the eczematous skin. SEB produced by S. aureus was distributed mainly on the dermal-infiltrated cells, especially on eosinophils. SEA and SEB stimulated expression of ICAM-1 and HLA-DR in normal human keratinocytes. More than half of the AD patients in the present study had specific IgE antibodies to SEA and/or SEB in their serum. CONCLUSION: S. aureus and SEs have important roles in the exacerbation and prolongation of AD.


Assuntos
Dermatite Atópica/imunologia , Dermatite Atópica/microbiologia , Enterotoxinas/imunologia , Staphylococcus aureus/imunologia , Adolescente , Adulto , Idoso , Quimiocina CCL5/biossíntese , Quimiocina CCL5/genética , Criança , Pré-Escolar , Enterotoxinas/biossíntese , Feminino , Antígenos HLA-DR/metabolismo , Humanos , Imunoglobulina E/sangue , Lactente , Molécula 1 de Adesão Intercelular/metabolismo , Interferon gama/farmacologia , Queratinócitos/imunologia , Queratinócitos/microbiologia , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Técnicas de Cultura de Órgãos , Infecções Cutâneas Estafilocócicas/imunologia , Staphylococcus aureus/isolamento & purificação , Staphylococcus aureus/metabolismo
11.
J Cutan Pathol ; 26(1): 25-30, 1999 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10189241

RESUMO

Six cases of spiny keratoderma were analyzed with hair specific antikeratin antibodies (AE13, AE14) and by electron microscopy. The keratotic column exhibited a different keratin birefringence and the underlying viable epidermis was less eosinophilic than the surrounding epidermis. AE13, which is specific for hair cortex, was positive in the lower column and variably positive in the viable epidermis, often beyond the columnar lesion. AE14 was negative in the lesion. Electron microscopy demonstrated features of keratinization of normal hair cortex, i.e. by the accretion of keratin filaments without production of keratohyalin or trichohyalin granules. Cementsomes (lamellar granules) and marginal bands were not produced as they are not formed in normal cortical keratinization. It was suggested that spiny keratoderma represents an ectopic hair formation of palms and soles.


Assuntos
Ceratodermia Palmar e Plantar/metabolismo , Ceratodermia Palmar e Plantar/patologia , Idoso , Idoso de 80 Anos ou mais , Anticorpos Monoclonais/análise , Anticorpos Monoclonais/imunologia , Feminino , Cabelo/química , Dermatoses da Mão/metabolismo , Dermatoses da Mão/patologia , Humanos , Imuno-Histoquímica , Queratinas/análise , Queratinas/imunologia , Queratinas/metabolismo , Masculino , Pessoa de Meia-Idade , Pele/química , Pele/patologia , Pele/ultraestrutura
12.
J Am Acad Dermatol ; 40(4): 637-9, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10188690

RESUMO

Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with antiepiligrin cicatricial pemphigoid have been shown to react specifically with the alpha3 chain of laminin 5. We describe the first patient with anti-epiligrin cicatricial pemphigoid in whom circulating IgG autoantibodies directed against the beta3 and gamma2-chains of laminin 5 were detected. Treatment with oral prednisolone was beneficial in controlling the disease.


Assuntos
Autoanticorpos/sangue , Moléculas de Adesão Celular/imunologia , Imunoglobulina G/imunologia , Penfigoide Mucomembranoso Benigno/imunologia , Idoso , Humanos , Masculino , Microscopia Imunoeletrônica , Penfigoide Mucomembranoso Benigno/diagnóstico
13.
Am J Contact Dermat ; 10(1): 7-11, 1999 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10072348

RESUMO

BACKGROUND: Adult atopic dermatitis (AD) with severe and refractory eruptions on the face, neck, and upper trunk, although quite rare in western countries, has increased in Japan. OBJECTIVE: We have tried to clarify the possible causative factors for this particular type of AD, predominantly seen in Japan. METHODS: Eighty-seven AD patients (37 men and 50 women) who had severe and refractory facial and neck lesions were patch tested with topical medicaments, cosmetics, and skin-management products. RESULTS: Thirty-seven (42. 5%) patients showed positive reactions to more than one of those products: 14 patients to shampoo, rinse, or soap; 11 to topical nonsteroidal anti-inflammatory agents (NSAIDs); 7 to cosmetics; and 6 to corticosteroids. CONCLUSION: We believe that topical NSAIDs, (which are often prescribed for the treatment of AD in Japan and rarely used for the treatment of eczamatous skin disorders in western countries), as well as common detergents, play important roles in the increased prevalence of AD patients with severe and refractory lesions on the face, neck, and upper trunk in Japan.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Cosméticos/efeitos adversos , Dermatite Atópica/etiologia , Dermatoses Faciais/induzido quimicamente , Irritantes/efeitos adversos , Administração Tópica , Adolescente , Corticosteroides/administração & dosagem , Corticosteroides/efeitos adversos , Adulto , Anti-Inflamatórios não Esteroides/administração & dosagem , Criança , Pré-Escolar , Cosméticos/administração & dosagem , Dermatite Atópica/epidemiologia , Dermatoses Faciais/epidemiologia , Feminino , Humanos , Irritantes/administração & dosagem , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Pescoço , Testes do Emplastro , Tórax
14.
J Cutan Pathol ; 25(9): 469-74, 1998 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9821076

RESUMO

Urokinase-type plasminogen activator (uPA) has been well documented in the development of pemphigus acantholysis. The function of its receptor (uPA-R) in pemphigus acantholysis has only recently attracted attention. Increased expression of uPA-R has been demonstrated in pemphigus vulgaris. In this study, we have further explored the functional involvement of uPA-R in pemphigus acantholysis. Our results show that uPA-R expression is significantly increased in acantholytic foci of pemphigus vulgaris and pemphigus foliaceus but not in bullous pemphigoid or normal skin specimens; the expression of uPA-R in cultured human keratinocytes is subjected to regulation by pemphigus vulgaris IgG but not by pemphigoid IgG or normal human IgG; furthermore, anti-uPA-R monoclonal antibody effectively inhibits pemphigus vulgaris IgG induced acantholysis in skin organ cultures. These data suggest that uPA-R may play an important role in the pathogenesis of pemphigus acantholysis.


Assuntos
Acantólise/metabolismo , Pênfigo/metabolismo , Ativadores de Plasminogênio/metabolismo , Receptores de Superfície Celular/metabolismo , Acantólise/imunologia , Adulto , Células Cultivadas , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Imunoglobulina G/isolamento & purificação , Imunoglobulina G/farmacologia , Queratinócitos/imunologia , Queratinócitos/metabolismo , Técnicas de Cultura de Órgãos , Pênfigo/imunologia , Ativadores de Plasminogênio/imunologia , Receptores de Superfície Celular/imunologia , Receptores de Ativador de Plasminogênio Tipo Uroquinase , Regulação para Cima
15.
J Dermatol ; 25(6): 353-61, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9675341

RESUMO

Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles, with a distinct histology characteristic of a parakeratotic column above a hypogranular epidermis. We report six cases discovered within a year and review the present literature on spiny keratoderma. The average age of the patients was 57 years. Fifty-seven percent of the patients were male and forty-three percent were female. The duration of lesions ranged from 4 months to 40 years. Symptoms were variable, however, lesions were often unnoticed by the patient. The location of the lesions involved the palms and soles or the palms alone. Past medical history was significant for hypertension and hyperlipidemia treated with HMG-CoA reductase inhibitors. Lesions often occurred in patients involved in manual labor. Spiny keratoderma is a relatively common under-reported dermatosis found most often in older patients with history of manual labor and is possibly related to treatment with HMG-CoA reductase inhibitors.


Assuntos
Dermatoses do Pé/patologia , Dermatoses da Mão/patologia , Ceratose/patologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Dermatite Ocupacional/patologia , Epiderme/patologia , Feminino , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Hiperlipidemias/complicações , Hiperlipidemias/tratamento farmacológico , Hipertensão/complicações , Masculino , Pessoa de Meia-Idade , Paraceratose/patologia , Fatores Sexuais , Fatores de Tempo
16.
J Cutan Pathol ; 25(2): 100-5, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9521499

RESUMO

The histogenesis of apocrine and eccrine neoplasms has always interested dermatopathologists. In addition, the histologic differential diagnosis of eccrine carcinoma from metastatic adenocarcinoma is of practical importance. We describe a novel monoclonal antibody IKH-4 which stains the eccrine secretory coil, but not the apocrine secretory segment. Positive staining was observed in eccrine hidradenoma, eccrine poroma, eccrine spiradenoma, papillary eccrine adenoma, eccrine hidrocystoma, syringoma, eccrine carcinoma, and in 1 case of syringocystadenoma papilliferum. Negative staining was observed in apocrine adenocarcinoma, hidradenoma papilliferum, erosive adenomatosis of the nipple, and primary and metastatic adenocarcinomas. IKH-4 antibody was useful in differentiating eccrine from apocrine neoplasms and in differentiating eccrine carcinoma from metastatic adenocarcinomas.


Assuntos
Adenocarcinoma/patologia , Adenocarcinoma/secundário , Anticorpos Monoclonais/análise , Glândulas Apócrinas/patologia , Glândulas Écrinas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenocarcinoma/química , Animais , Anticorpos Monoclonais/imunologia , Glândulas Apócrinas/química , Glândulas Écrinas/química , Glândulas Écrinas/imunologia , Imuno-Histoquímica , Camundongos , Camundongos Endogâmicos BALB C , Pele/química , Pele/patologia , Neoplasias Cutâneas/química , Neoplasias Cutâneas/patologia , Coloração e Rotulagem/métodos , Neoplasias das Glândulas Sudoríparas/química
18.
Artigo em En | Desastres | ID: des-11249

RESUMO

The finite beam element with the use of the adaptively shifted integration (ASI) technique is suitable for elastic-plastic analyses of framed structures, because a plastic hinge can be set at an appropriate position. In this paper the ASI technique is applied to a degenerated Timoshenko beam element that is generally used. The developed element is applied to the analyses of the steel damper for base isolation systems of large scale buildings (AU)


Assuntos
Terremotos , Comportas , Aço , Métodos de Análise , Simulação por Computador , Métodos
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