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1.
Oral Maxillofac Surg ; 2021 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-34401975

RESUMO

The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as "spongiotic hyperplasia of the oral mucosa." The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34ßE12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term "spongiotic hyperplasia of the oral mucosa" is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions.

2.
BMJ Open ; 11(6): e042376, 2021 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-34145006

RESUMO

OBJECTIVES: To assess the association between the Human Development Index (HDI) and covariates on the mortality-to-incidence ratio (MIR) of lips and oral cavity cancer (LOCC) in Mexico. DESIGN: Ecological study. SETTING: Data from 32 Mexican states for year 2019. PARTICIPANTS: Data set of male and female populations from Mexico. EXPOSURES: Socioeconomic conditions based on HDI and covariates related to healthcare system capacity (total health spending per capita, school dropout and ratio of medical personnel in direct contact with patients). PRIMARY AND SECONDARY OUTCOME MEASURES: MIR of LOCC by state and sex was calculated from the Global Burden of Disease Study website for year 2019. Data for calculating HDI 2019 by state and covariates were obtained from the National Institute of Statistics and Geography. A multiple regression model was constructed to measure the effects of HDI and covariates on LOCC-MIR. RESULTS: Among the states with the highest HDI (>0.780), Colima had the highest aged-standardised rates per 100.000 in men for incidence (5.026) and mortality (3.118). The greatest burden of the disease was found on men, with the highest Men:Women MIR in Colima (3.10) and Baja California Sur (2.73). The highest MIR (>0.65) was found among the states with the lowest HDI (Oaxaca and Chiapas). For each unit of increase of the HDI there was a decrease in the LOCC- MIR of -0.778, controlling for the covariates. The most suitable regression model explained the 57% (F (p): 0.000) of the variance. CONCLUSIONS: Men were most affected by LOCC in Mexican states. The highest MIRs of LOCC were found in the states with the highest HDI. But a worse prognosis of the disease, expressed as a higher MIR, is expected in contexts with lower HDI in the country, even with lower MIRs.


Assuntos
Lábio , Neoplasias Bucais , Idoso , Feminino , Humanos , Incidência , Masculino , México/epidemiologia , Neoplasias Bucais/epidemiologia , Fatores Socioeconômicos
4.
Sci Rep ; 10(1): 22280, 2020 12 17.
Artigo em Inglês | MEDLINE | ID: mdl-33335223

RESUMO

The metal alloys used in dentistry are made mainly of nickel (Ni), titanium (Ti), and other elements such as molybdenum (Mo), zirconium (Zr), iron (Fe), tin (Sn), chrome (Cr), carbon (C), copper (Cu) and niobium (Nb) which can release metal ions in unstable environments. The aim of this work was determine the salivary pH before and during orthodontic treatment; evaluate the release of metal ions, mainly Ni and Ti, in urine and saliva using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES); and evaluate the corrosion using Scanning Electronic Microscopy (SEM). In this study, we selected 35 individuals under orthodontic treatment, from whom saliva and urine samples were collected in 3 stages: (a) basal, (b) at 3 and (c) 6 months after the placement of the fixed appliances. SEM analyzed the Ni-Ti (0.016″) and stainless steel (SS) (0.016 × 0.022″) archs after 1 month of being in contact with the oral cavity. Statistical analysis was performed with Stata using the ANOVA model of repeated measures with a p < 0.05. A statistically significant difference in the concentration of Ni in saliva were found between 3 and 6 months of intervention and Ti in urine was found 3 and 6 months.


Assuntos
Ligas Dentárias/uso terapêutico , Níquel/uso terapêutico , Saliva/efeitos dos fármacos , Titânio/uso terapêutico , Adolescente , Ligas/química , Ligas/uso terapêutico , Criança , Cobre/uso terapêutico , Cobre/urina , Ligas Dentárias/efeitos adversos , Feminino , Humanos , Íons/urina , Ferro/uso terapêutico , Ferro/urina , Masculino , Molibdênio/uso terapêutico , Molibdênio/urina , Níquel/efeitos adversos , Níquel/urina , Nióbio/uso terapêutico , Nióbio/urina , Aço Inoxidável/química , Titânio/efeitos adversos , Titânio/urina , Zircônio/uso terapêutico , Zircônio/urina
6.
J Epidemiol Glob Health ; 9(4): 223-232, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31854163

RESUMO

To evaluate the relationship between the Human Development Index (HDI) and its components with oral cancer (OC) in Latin America. Ecological study in 20 Latin American countries in 2010 and 2017, which evaluated the relationship between the Age-Standardized Rates (ASRs) of incidence and mortality from oral cancer and the following indicators: HDI, with its components (income, education, and health indexes); and the Gini and Theil-L indexes. Among the countries with the highest HDI, men from Brazil and Cuba had the highest incidence and mortality ASRs per 100,000 inhabitants (ASR incidence >7.5 and mortality >4.5). Among those with the lowest HDI, Haiti was the most affected country (ASR incidence >4.1 and mortality >3.0). The highest male:female ratio was in Paraguay in both years (incidence >3.5 and mortality >4.0). Mortality from oral cancer is negatively related to the global HDI in both years, with regression coefficients (95% confidence interval) being -5.78 (-11.77, 0.20) in 2010 and -5.97 (-11.38, -0.56) in 2017; and separate (independent) from the income [-4.57 (-9.92, 0.77) in 2010 and -4.84 (-9.52, -0.17) in 2017] and health indexes [-5.81 (-11.10, -0.52) and -6.52 (-11.32, -1.72) in 2017] (p < 0.05) in the countries with lower HDI. Oral cancer incidence and mortality rates vary both among and within Latin American countries according to sex, with a greater burden on men. The HDI is negatively related to mortality from oral cancer in the countries of medium and low HDI.


Assuntos
Escolaridade , Indicadores Básicos de Saúde , Renda , Neoplasias Bucais/epidemiologia , Feminino , Humanos , Incidência , América Latina/epidemiologia , Masculino
7.
Rev Esp Salud Publica ; 932019 Jul 22.
Artigo em Espanhol | MEDLINE | ID: mdl-31328723

RESUMO

OBJECTIVE: Mortality from oral cancer, the prevalence of the main risk factors and the implementation of policies to control current trends and the distribution of data among the countries of Latin America. The objective of this study was to describe the trends of mortality from oral cancer between 2000 and 2017, by sex, in 20 countries in Latin America, and to know the effect of measures to control tobacco consumption and alcohol consumption on the Mortality from oral cancer. METHODS: Ecological study that evaluates the relationship between the rates standardized by the age of cancer by oral sex, the prevalence of tobacco consumption and alcohol consumption, and the implementation of control policies. To calculate the annual percentage change of the rates, the Prais-Winsten regression was used; and the effect of measures of control of risk factors on oral cancer mortality is assessed by Spearman correlations. RESULTS: The greatest decreases in oral cancer mortality were in men in Brazil (APC -7.83, -14.25,-0.93). Mortality from cancer the oral relationship between men and the prevalence of tobacco consumption and alcohol consumption (r = 0.358, r 0.537) (p <0.01), and between the non-implementation of control policies of smoking (r = 0.738) (p= 0.003), the restrictions on the hours and days of sale of alcohol (r = 0.777, p = 0.001), and the states on sponsorship and promotion of alcohol sales (r =0.739 , p =0.040). CONCLUSIONS: The effect of the implementation of control policies is evidenced by a greater relationship with oral cancer mortality in the countries with the least progress in their execution.


Assuntos
Consumo de Bebidas Alcoólicas/prevenção & controle , Carcinoma de Células Escamosas/mortalidade , Política de Saúde , Promoção da Saúde , Neoplasias Bucais/mortalidade , Prevenção do Hábito de Fumar , Adulto , Idoso , Consumo de Bebidas Alcoólicas/epidemiologia , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/prevenção & controle , Feminino , Humanos , América Latina/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/etiologia , Neoplasias Bucais/prevenção & controle , Prevalência , Fatores de Risco , Fumar/epidemiologia , Espanha
8.
Rev. esp. salud pública ; 93: 0-0, 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-189494

RESUMO

OBJETIVO: La mortalidad por cáncer oral, la prevalencia de los principales factores de riesgo y la implementación de las políticas para su control presentan tendencias y distribución desiguales entre los países de América Latina. El objetivo de este trabajo fue describir las tendencias de la mortalidad por cáncer oral entre 2000 y 2017, según sexos, en 20 países de América Latina, y conocer el efecto de las medidas de control del consumo de tabaco y el consumo de alcohol sobre la mortalidad por cáncer oral. MÉTODOS: Estudio ecólogico que evaluó la relación entre las tasas estandarizadas por edad del fallecimiento por cáncer oral según el sexo, la prevalencia del consumo de tabaco y del consumo de alcohol,y la implementación de las políticas de control. Para calcular la variación porcentual de cambio anual de las tasas, se usó la regresión Prais-Winsten; y el efecto de las medidas de control de los factores de riesgo sobre la mortalidad por cáncer oral se evalúo mediante correlaciones de Spearman. RESULTADOS: Los mayores descensos en la mortalidad por cáncer oral fueron en los hombres de Brasil (APC -7,83; -14,25; -0,93). La mortalidad por cáncer oral mostró relación positiva entre hombres y la prevalencia del consumo de tabaco y del consumo de alcohol (r=0,358, r=0,537) (p<0,01), y entre la no implementación de las políticas de control de tabaquismo (r=0,738) (p=0,003), las restricciones en los horarios y días de venta de alcohol (r=0,737, p=0,001), y los reglamentos sobre patrocinio y promoción de venta de alcohol (r=0,739, p=0,040). CONCLUSIONES: El efecto de la implementación de las políticas de control se evidencia en una mayor relación con la mortalidad por cáncer oral en los países con menor avance en su ejecución


OBJECTIVE: Mortality from oral cancer, the prevalence of the main risk factors and the implementation of policies to control current trends and the distribution of data among the countries of Latin America. The objective of this study was to describe the trends of mortality from oral cancer between 2000 and 2017, by sex, in 20 countries in Latin America, and to know the effect of measures to control tobacco consumption and alcohol consumption on the Mortality from oral cancer. METHODS: Ecological study that evaluates the relationship between the rates standardized by the age of cancer by oral sex, the prevalence of tobacco consumption and alcohol consumption, and the implementation of control policies. To calculate the annual percentage change of the rates, the Prais-Winsten regression was used; and the effect of measures of control of risk factors on oral cancer mortality is assessed by Spearman correlations. RESULTS: The greatest decreases in oral cancer mortality were in men in Brazil (APC -7.83, -14.25,-0.93). Mortality from cancer the oral relationship between men and the prevalence of tobacco consumption and alcohol consumption (r = 0.358, r 0.537) (p <0.01), and between the non-implementation of control policies of smoking (r = 0.738) (p= 0.003), the restrictions on the hours and days of sale of alcohol (r = 0.777, p = 0.001), and the states on sponsorship and promotion of alcohol sales (r =0.739 , p =0.040). CONCLUSIONS: The effect of the implementation of control policies is evidenced by a greater relationship with oral cancer mortality in the countries with the least progress in their execution


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Consumo de Bebidas Alcoólicas/prevenção & controle , Carcinoma de Células Escamosas/mortalidade , Política de Saúde , Promoção da Saúde , Neoplasias Bucais/mortalidade , Prevenção do Hábito de Fumar , Consumo de Bebidas Alcoólicas/epidemiologia , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/prevenção & controle , América Latina/epidemiologia , Neoplasias Bucais/etiologia , Neoplasias Bucais/prevenção & controle , Prevalência , Fatores de Risco , Fumar/epidemiologia
9.
Med Oral Patol Oral Cir Bucal ; 17(3): e383-8, 2012 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-22143732

RESUMO

OBJECTIVE: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM). STUDY DESIGN: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67. RESULTS: The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells. CONCLUSION: S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis.


Assuntos
Melanoma/patologia , Neoplasias Bucais/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/análise , América Latina , Antígeno MART-1/análise , Masculino , Melanoma/química , Antígenos Específicos de Melanoma/análise , Pessoa de Meia-Idade , Neoplasias Bucais/química , Proteínas S100/análise , Adulto Jovem
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